{"id":"https://openalex.org/W4403737419","doi":"https://doi.org/10.3390/ijms252111420","title":"TGF-\u03b2-Induced PAUF Plays a Pivotal Role in the Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cell Line Panc-1","display_name":"TGF-\u03b2-Induced PAUF Plays a Pivotal Role in the Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cell Line Panc-1","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403737419","doi":"https://doi.org/10.3390/ijms252111420","pmid":"https://pubmed.ncbi.nlm.nih.gov/39518973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11546992"},"language":"en","primary_location":{"id":"doi:10.3390/ijms252111420","doi":"https://doi.org/10.3390/ijms252111420","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms252111420","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms252111420","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Miso Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089022","display_name":"Scripps Korea Antibody Institute","ror":"https://ror.org/007f41232","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210089022"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Miso Lee","raw_affiliation_strings":["Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I4210089022"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hyejun Ham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089022","display_name":"Scripps Korea Antibody Institute","ror":"https://ror.org/007f41232","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210089022"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyejun Ham","raw_affiliation_strings":["Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I4210089022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100672972","display_name":"Jiyeong Lee","orcid":"https://orcid.org/0000-0002-1987-4109","observed_orcids":["https://orcid.org/0000-0002-1987-4109"]},"institutions":[{"id":"https://openalex.org/I4210089022","display_name":"Scripps Korea Antibody Institute","ror":"https://ror.org/007f41232","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210089022"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiyeong Lee","raw_affiliation_strings":["Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I4210089022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034178960","display_name":"Eun Soo Lee","orcid":"https://orcid.org/0000-0002-1973-0930","observed_orcids":["https://orcid.org/0000-0002-1973-0930"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Soo Lee","raw_affiliation_strings":["Department of Internal Medicine, Research Institute of Metabolism and Inflammation, Yonsei University Wonju College of Medicine, Wonju 26426, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Institute of Metabolism and Inflammation, Yonsei University Wonju College of Medicine, Wonju 26426, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070489050","display_name":"Choon Hee Chung","orcid":"https://orcid.org/0000-0003-1144-7206","observed_orcids":["https://orcid.org/0000-0003-1144-7206"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Choon Hee Chung","raw_affiliation_strings":["Department of Internal Medicine, Research Institute of Metabolism and Inflammation, Yonsei University Wonju College of Medicine, Wonju 26426, Gangwon-do, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-1144-7206","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Institute of Metabolism and Inflammation, Yonsei University Wonju College of Medicine, Wonju 26426, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005622095","display_name":"Deok-Hoon Kong","orcid":"https://orcid.org/0000-0003-1411-4423","observed_orcids":["https://orcid.org/0000-0003-1411-4423"]},"institutions":[{"id":"https://openalex.org/I4210089022","display_name":"Scripps Korea Antibody Institute","ror":"https://ror.org/007f41232","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210089022"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Deok-Hoon Kong","raw_affiliation_strings":["Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I4210089022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021597083","display_name":"Jeong-Ran Park","orcid":"https://orcid.org/0000-0001-5254-4665","observed_orcids":["https://orcid.org/0000-0001-5254-4665"]},"institutions":[{"id":"https://openalex.org/I4210089022","display_name":"Scripps Korea Antibody Institute","ror":"https://ror.org/007f41232","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210089022"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jeong-Ran Park","raw_affiliation_strings":["Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I4210089022"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069790854","display_name":"Dong\u2010Keon Lee","orcid":"https://orcid.org/0000-0002-9066-3494","observed_orcids":["https://orcid.org/0000-0002-9066-3494"]},"institutions":[{"id":"https://openalex.org/I4210089022","display_name":"Scripps Korea Antibody Institute","ror":"https://ror.org/007f41232","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210089022"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dong-Keon Lee","raw_affiliation_strings":["Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-9066-3494","affiliations":[{"raw_affiliation_string":"Division of Research Program, Scripps Korea Antibody Institute, Chuncheon 24341, Gangwon-do, Republic of Korea","institution_ids":["https://openalex.org/I4210089022"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021597083","https://openalex.org/A5069790854"],"corresponding_institution_ids":["https://openalex.org/I4210089022"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":0.6672,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59916993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"25","issue":"21","first_page":"11420","last_page":"11420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":1.0},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8619999885559082},{"id":"https://openalex.org/keywords/panc-1-cells","display_name":"PANC-1 cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/bxpc-3-cells","display_name":"BxPC-3 cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/smad-binding-element","display_name":"Smad binding element","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6707719564437866},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5390121340751648},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.5349249839782715},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5348554849624634},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46621519327163696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42697083950042725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37467673420906067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3744843900203705},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35451099276542664},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.31423670053482056},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19735035300254822},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08844029903411865}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms252111420","doi":"https://doi.org/10.3390/ijms252111420","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms252111420","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11546992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11546992","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11546992/pdf/ijms-25-11420.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:39518973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39518973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms252111420","doi":"https://doi.org/10.3390/ijms252111420","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms252111420","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2752497954","display_name":null,"funder_award_id":"2E33310","funder_id":"https://openalex.org/F4320322091","funder_display_name":"Korea Institute of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320322091","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403737419.pdf","grobid_xml":"https://content.openalex.org/works/W4403737419.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1448090449","https://openalex.org/W1528120845","https://openalex.org/W1557175253","https://openalex.org/W1804495077","https://openalex.org/W1964750695","https://openalex.org/W1966027561","https://openalex.org/W1974737986","https://openalex.org/W1978785485","https://openalex.org/W1994798295","https://openalex.org/W1997656209","https://openalex.org/W2002784328","https://openalex.org/W2005983388","https://openalex.org/W2011826559","https://openalex.org/W2031075581","https://openalex.org/W2034028219","https://openalex.org/W2035653659","https://openalex.org/W2041098455","https://openalex.org/W2043367201","https://openalex.org/W2047992261","https://openalex.org/W2053333794","https://openalex.org/W2054683516","https://openalex.org/W2062268212","https://openalex.org/W2067785100","https://openalex.org/W2076583198","https://openalex.org/W2086692663","https://openalex.org/W2093093483","https://openalex.org/W2096778246","https://openalex.org/W2100522747","https://openalex.org/W2102868284","https://openalex.org/W2103031848","https://openalex.org/W2109834815","https://openalex.org/W2117692326","https://openalex.org/W2140050140","https://openalex.org/W2140551998","https://openalex.org/W2150416393","https://openalex.org/W2154568166","https://openalex.org/W2157141799","https://openalex.org/W2159526033","https://openalex.org/W2164615751","https://openalex.org/W2433880588","https://openalex.org/W2571166948","https://openalex.org/W2579645469","https://openalex.org/W2592339836","https://openalex.org/W2604377396","https://openalex.org/W2886478251","https://openalex.org/W2945040739","https://openalex.org/W2949637147","https://openalex.org/W2951581858","https://openalex.org/W3016044799","https://openalex.org/W3040121443","https://openalex.org/W3210638807","https://openalex.org/W4210584761","https://openalex.org/W4211181525","https://openalex.org/W4223640931","https://openalex.org/W4229004448","https://openalex.org/W4235438234","https://openalex.org/W4297540742","https://openalex.org/W4393164529","https://openalex.org/W6674940467"],"related_works":["https://openalex.org/W7168188125","https://openalex.org/W3025166766","https://openalex.org/W4379983755","https://openalex.org/W4297540742","https://openalex.org/W2315738957","https://openalex.org/W2043367201","https://openalex.org/W2011102827","https://openalex.org/W2782165312","https://openalex.org/W3026029040","https://openalex.org/W2887660752"],"abstract_inverted_index":{"Pancreatic":[0],"adenocarcinoma":[1,19],"upregulated":[2],"factor":[3],"(PAUF)":[4],"was":[5,38,128],"initially":[6],"identified":[7],"as":[8],"a":[9,42,89,112,185],"secreted":[10],"protein":[11],"that":[12,106,156,178],"is":[13],"substantially":[14],"expressed":[15],"in":[16,31,45,64,82,92,95,121,131,146,164,188],"pancreatic":[17],"ductal":[18],"(PDAC).":[20],"PAUF":[21,37,58,80,93,108,122,141,157,183],"also":[22,104],"affects":[23],"invasiveness,":[24],"motility,":[25],"and":[26,49,60,87,144,166],"the":[27,46,55,107,140,159,170,193],"proliferation":[28],"of":[29,34,51,172,182],"cells":[30,67,99,117,149,168],"several":[32,83],"types":[33],"cancer.":[35],"Recently,":[36],"reported":[39],"to":[40],"play":[41],"pivotal":[43],"role":[44,63,187],"TLR4-mediated":[47],"migration":[48],"invasion":[50],"PDAC":[52,66,84],"cells.":[53,135],"However,":[54],"mechanism":[56],"inducing":[57],"expression":[59,81,94,138,145],"its":[61],"functional":[62],"TGF-\u03b2-stimulated":[65,132],"have":[68],"not":[69,129],"yet":[70],"been":[71],"studied.":[72],"Thus,":[73],"we":[74],"first":[75],"assessed":[76],"whether":[77],"TGF-\u03b2":[78],"regulates":[79],"cell":[85],"lines":[86],"found":[88,105,155],"significant":[90],"increase":[91,120],"Smad":[96],"signaling-positive":[97],"Panc-1":[98,116,165],"treated":[100,150],"with":[101,151],"TGF-\u03b2.":[102,152],"We":[103,153],"promoter":[109,123,142],"region":[110],"contains":[111],"Smad-binding":[113],"element.":[114],"TGF-\u03b2-treated":[115],"showed":[118],"an":[119],"activity,":[124],"but":[125],"this":[126],"effect":[127],"observed":[130],"Smad4-null":[133],"BxPC-3":[134,148,167],"Restoring":[136],"Smad4":[137],"increased":[139],"activity":[143],"Smad4-overexpressing":[147],"further":[154],"aggravated":[158],"TGF-\u03b2-induced":[160],"epithelial-mesenchymal":[161],"transition":[162],"(EMT)":[163],"via":[169],"activation":[171],"MEK-ERK":[173,195],"signaling.":[174],"These":[175],"results":[176],"indicate":[177],"TGF-\u03b2/Smad":[179],"signaling-mediated":[180],"upregulation":[181],"plays":[184],"crucial":[186],"EMT":[189],"progression":[190],"by":[191],"activating":[192],"TGF-\u03b2-mediated":[194],"signaling":[196],"pathway.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-10-25T00:00:00"}