{"id":"https://openalex.org/W4403733581","doi":"https://doi.org/10.1080/20415990.2024.2415281","title":"Comprehensive insights into glioblastoma multiforme: drug delivery challenges and multimodal treatment strategies","display_name":"Comprehensive insights into glioblastoma multiforme: drug delivery challenges and multimodal treatment strategies","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403733581","doi":"https://doi.org/10.1080/20415990.2024.2415281","pmid":"https://pubmed.ncbi.nlm.nih.gov/39445563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11703381"},"language":"en","primary_location":{"id":"doi:10.1080/20415990.2024.2415281","doi":"https://doi.org/10.1080/20415990.2024.2415281","is_oa":false,"landing_page_url":"https://doi.org/10.1080/20415990.2024.2415281","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11703381/pdf/ITDE_16_2415281.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108483933","display_name":"Ashish Dhiman","orcid":"https://orcid.org/0009-0009-5341-9394","observed_orcids":["https://orcid.org/0009-0009-5341-9394"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashish Dhiman","raw_affiliation_strings":["Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India"],"raw_orcid":"https://orcid.org/0009-0009-5341-9394","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006125872","display_name":"Dhwani Rana","orcid":"https://orcid.org/0000-0002-1591-9226","observed_orcids":["https://orcid.org/0000-0002-1591-9226"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dhwani Rana","raw_affiliation_strings":["Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India"],"raw_orcid":"https://orcid.org/0000-0002-1591-9226","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070755475","display_name":"Derajram M. Benival","orcid":"https://orcid.org/0000-0002-3527-9158","observed_orcids":["https://orcid.org/0000-0002-3527-9158"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Derajram Benival","raw_affiliation_strings":["Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India"],"raw_orcid":"https://orcid.org/0000-0002-3527-9158","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India","institution_ids":["https://openalex.org/I4210102411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004720675","display_name":"Kalpna Garkhal","orcid":"https://orcid.org/0009-0002-5284-2077","observed_orcids":["https://orcid.org/0009-0002-5284-2077"]},"institutions":[{"id":"https://openalex.org/I4210102411","display_name":"National Institute of Pharmaceutical Education and Research - Ahmedabad","ror":"https://ror.org/01dphnv87","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210102411"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kalpna Garkhal","raw_affiliation_strings":["Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India"],"raw_orcid":"https://orcid.org/0009-0002-5284-2077","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research-Ahmedabad (NIPER-A), Gandhinagar, 382355, Gujarat, India","institution_ids":["https://openalex.org/I4210102411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004720675","https://openalex.org/A5070755475"],"corresponding_institution_ids":["https://openalex.org/I4210102411"],"apc_list":null,"apc_paid":null,"fwci":0.5086,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.41939494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"87","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.40209999680519104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6029999852180481},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.9350000023841858},{"id":"https://openalex.org/keywords/surface-modification","display_name":"surface modification","score":0.8259999752044678},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7889999747276306},{"id":"https://openalex.org/keywords/theranostics","display_name":"theranostics","score":0.8939999938011169},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.972000002861023},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.8466167449951172},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6038070321083069},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5196244120597839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5155753493309021},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.4577755630016327},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35663023591041565},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32439422607421875},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3091575503349304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19270890951156616},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.17835217714309692},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15204280614852905}],"mesh":[{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/20415990.2024.2415281","doi":"https://doi.org/10.1080/20415990.2024.2415281","is_oa":false,"landing_page_url":"https://doi.org/10.1080/20415990.2024.2415281","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11351594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11703381","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11703381/pdf/ITDE_16_2415281.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:39445563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39445563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic delivery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11703381","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11703381/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Deliv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11351594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11703381","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11703381/pdf/ITDE_16_2415281.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403733581.pdf","grobid_xml":"https://content.openalex.org/works/W4403733581.grobid-xml"},"referenced_works_count":214,"referenced_works":["https://openalex.org/W1485411688","https://openalex.org/W1496291653","https://openalex.org/W1577410398","https://openalex.org/W1585705786","https://openalex.org/W1762620449","https://openalex.org/W1773423842","https://openalex.org/W1795588153","https://openalex.org/W1812734324","https://openalex.org/W1892429132","https://openalex.org/W1915728046","https://openalex.org/W1961515348","https://openalex.org/W1964956174","https://openalex.org/W1966597723","https://openalex.org/W1966720603","https://openalex.org/W1968482535","https://openalex.org/W1975679096","https://openalex.org/W1976970322","https://openalex.org/W1978506065","https://openalex.org/W1978661277","https://openalex.org/W1981412372","https://openalex.org/W1987395974","https://openalex.org/W1988003567","https://openalex.org/W1988986134","https://openalex.org/W1990357364","https://openalex.org/W1997160008","https://openalex.org/W1997995247","https://openalex.org/W1998941426","https://openalex.org/W2000347606","https://openalex.org/W2000546531","https://openalex.org/W2001244335","https://openalex.org/W2001544973","https://openalex.org/W2001779636","https://openalex.org/W2003138971","https://openalex.org/W2008871739","https://openalex.org/W2013818651","https://openalex.org/W2017331060","https://openalex.org/W2018522439","https://openalex.org/W2018573261","https://openalex.org/W2018777412","https://openalex.org/W2020398834","https://openalex.org/W2020697271","https://openalex.org/W2020724953","https://openalex.org/W2023928301","https://openalex.org/W2025314771","https://openalex.org/W2028267884","https://openalex.org/W2029755294","https://openalex.org/W2030613469","https://openalex.org/W2033987226","https://openalex.org/W2034307627","https://openalex.org/W2036044314","https://openalex.org/W2040745597","https://openalex.org/W2043973455","https://openalex.org/W2044903986","https://openalex.org/W2045594601","https://openalex.org/W2046414976","https://openalex.org/W2048409518","https://openalex.org/W2054189154","https://openalex.org/W2055313070","https://openalex.org/W2058865733","https://openalex.org/W2066685510","https://openalex.org/W2070248960","https://openalex.org/W2073439757","https://openalex.org/W2074544404","https://openalex.org/W2076226743","https://openalex.org/W2082097131","https://openalex.org/W2082511674","https://openalex.org/W2088376140","https://openalex.org/W2088467380","https://openalex.org/W2088926532","https://openalex.org/W2089028118","https://openalex.org/W2089155556","https://openalex.org/W2089773350","https://openalex.org/W2090737037","https://openalex.org/W2093390598","https://openalex.org/W2096287682","https://openalex.org/W2096570138","https://openalex.org/W2097694070","https://openalex.org/W2099431752","https://openalex.org/W2100567246","https://openalex.org/W2100723895","https://openalex.org/W2105100844","https://openalex.org/W2105924558","https://openalex.org/W2108485077","https://openalex.org/W2110634891","https://openalex.org/W2111032368","https://openalex.org/W2111631341","https://openalex.org/W2112245495","https://openalex.org/W2114596635","https://openalex.org/W2114858436","https://openalex.org/W2121585125","https://openalex.org/W2122534769","https://openalex.org/W2125575764","https://openalex.org/W2126363249","https://openalex.org/W2126961173","https://openalex.org/W2129656894","https://openalex.org/W2130433105","https://openalex.org/W2130511906","https://openalex.org/W2135296895","https://openalex.org/W2139169365","https://openalex.org/W2140746183","https://openalex.org/W2142084832","https://openalex.org/W2142100401","https://openalex.org/W2145479354","https://openalex.org/W2149768128","https://openalex.org/W2155606275","https://openalex.org/W2158681922","https://openalex.org/W2161083472","https://openalex.org/W2163458899","https://openalex.org/W2164042520","https://openalex.org/W2164475208","https://openalex.org/W2167650288","https://openalex.org/W2170665695","https://openalex.org/W2171332611","https://openalex.org/W2171634952","https://openalex.org/W2171827583","https://openalex.org/W2172208581","https://openalex.org/W2187976253","https://openalex.org/W2205491921","https://openalex.org/W2242877993","https://openalex.org/W2254160163","https://openalex.org/W2255479470","https://openalex.org/W2270804882","https://openalex.org/W2281134225","https://openalex.org/W2295603197","https://openalex.org/W2296365997","https://openalex.org/W2328946792","https://openalex.org/W2334882569","https://openalex.org/W2344644350","https://openalex.org/W2395300225","https://openalex.org/W2412876070","https://openalex.org/W2416890084","https://openalex.org/W2416949193","https://openalex.org/W2435053065","https://openalex.org/W2509099384","https://openalex.org/W2523123787","https://openalex.org/W2525716840","https://openalex.org/W2549628327","https://openalex.org/W2550611657","https://openalex.org/W2584466409","https://openalex.org/W2590677577","https://openalex.org/W2591624943","https://openalex.org/W2592433924","https://openalex.org/W2597618526","https://openalex.org/W2600434382","https://openalex.org/W2616129231","https://openalex.org/W2748074339","https://openalex.org/W2749025438","https://openalex.org/W2749722012","https://openalex.org/W2749956623","https://openalex.org/W2757935580","https://openalex.org/W2772361005","https://openalex.org/W2778283729","https://openalex.org/W2790708193","https://openalex.org/W2791781448","https://openalex.org/W2792416781","https://openalex.org/W2794683780","https://openalex.org/W2802876981","https://openalex.org/W2803361339","https://openalex.org/W2895525350","https://openalex.org/W2900546114","https://openalex.org/W2910072132","https://openalex.org/W2911956394","https://openalex.org/W2917266686","https://openalex.org/W2921471094","https://openalex.org/W2931418311","https://openalex.org/W2937210178","https://openalex.org/W2939500465","https://openalex.org/W2944042754","https://openalex.org/W2969908486","https://openalex.org/W2970204123","https://openalex.org/W2970619429","https://openalex.org/W2984250052","https://openalex.org/W3003231037","https://openalex.org/W3003773438","https://openalex.org/W3008142620","https://openalex.org/W3024689868","https://openalex.org/W3032489997","https://openalex.org/W3033027852","https://openalex.org/W3043362096","https://openalex.org/W3047866476","https://openalex.org/W3112776175","https://openalex.org/W3133400804","https://openalex.org/W3133923534","https://openalex.org/W3133978623","https://openalex.org/W3154329837","https://openalex.org/W3158110844","https://openalex.org/W3159142974","https://openalex.org/W3161018481","https://openalex.org/W3161392453","https://openalex.org/W3162159844","https://openalex.org/W3178165673","https://openalex.org/W3185822531","https://openalex.org/W3186244585","https://openalex.org/W3194238004","https://openalex.org/W3208212881","https://openalex.org/W3212391360","https://openalex.org/W3217619411","https://openalex.org/W4205343457","https://openalex.org/W4210747713","https://openalex.org/W4220717719","https://openalex.org/W4241932028","https://openalex.org/W4256250511","https://openalex.org/W4281875217","https://openalex.org/W4285094438","https://openalex.org/W4293246700","https://openalex.org/W4298122470","https://openalex.org/W4301595791","https://openalex.org/W4307947510","https://openalex.org/W4312058708","https://openalex.org/W4313787430","https://openalex.org/W4385813104","https://openalex.org/W4385824721","https://openalex.org/W4391564035","https://openalex.org/W4400902277"],"related_works":["https://openalex.org/W4403097156","https://openalex.org/W7165564756","https://openalex.org/W4391493341","https://openalex.org/W4393646152","https://openalex.org/W4407226369","https://openalex.org/W3120170115","https://openalex.org/W4405873649","https://openalex.org/W4412583644","https://openalex.org/W4412891390","https://openalex.org/W4378696047"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"is":[3],"one":[4],"of":[5,56,76],"the":[6,26,45,51,74,109],"most":[7],"common":[8],"and":[9,81,91,115],"malignant":[10],"brain":[11,47],"tumors,":[12],"with":[13,105],"a":[14],"high":[15],"prevalence":[16],"in":[17,69,79,99],"elderly":[18],"population.":[19],"Most":[20],"chemotherapeutic":[21],"agents":[22,78],"fail":[23],"to":[24,30,43,112],"reach":[25],"tumor":[27,48],"site":[28],"due":[29],"various":[31],"challenges.":[32],"However,":[33],"smart":[34],"nanocarriers":[35,57,80],"have":[36,84],"demonstrated":[37],"excellent":[38],"drug-loading":[39],"capabilities,":[40],"enabling":[41],"them":[42],"cross":[44],"blood":[46],"barrier":[49],"for":[50,63,88,103],"GBM":[52],"treatment.":[53,92],"Surface":[54],"modification":[55],"has":[58],"significantly":[59],"enhanced":[60],"their":[61],"potential":[62],"targeting":[64],"therapeutics.":[65],"Moreover,":[66],"recent":[67,97],"innovations":[68],"drug":[70],"therapies,":[71],"such":[72],"as":[73],"incorporation":[75],"theranostic":[77],"antibody-drug":[82],"conjugates,":[83],"offered":[85],"newer":[86],"insights":[87],"both":[89],"diagnosis":[90],"This":[93],"review":[94],"focuses":[95],"on":[96,108],"advances":[98],"new":[100],"therapeutic":[101,114],"interventions":[102],"GBM,":[104],"an":[106],"emphasis":[107],"nanotheranostics":[110],"systems":[111],"maximize":[113],"diagnostic":[116],"outcomes.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-10-25T00:00:00"}
