{"id":"https://openalex.org/W4403733152","doi":"https://doi.org/10.1080/00222348.2024.2419773","title":"Thermodynamics of Polymer Drug Interactions: An Influential Factor for the Development of a Stable Drug Delivery System","display_name":"Thermodynamics of Polymer Drug Interactions: An Influential Factor for the Development of a Stable Drug Delivery System","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403733152","doi":"https://doi.org/10.1080/00222348.2024.2419773"},"language":"en","primary_location":{"id":"doi:10.1080/00222348.2024.2419773","doi":"https://doi.org/10.1080/00222348.2024.2419773","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00222348.2024.2419773","pdf_url":null,"source":{"id":"https://openalex.org/S118630506","display_name":"Journal of Macromolecular Science Part B","issn_l":"0022-2348","issn":["0022-2348","1525-609X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Macromolecular Science, Part B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101592502","display_name":"Dilpreet Singh","orcid":"https://orcid.org/0000-0002-7563-6287","observed_orcids":["https://orcid.org/0000-0002-7563-6287"]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Dilpreet Singh","raw_affiliation_strings":["University Centre for Research and Development, Chandigarh University","University Institute of Pharma Sciences, Chandigarh University","University Centre for Research and Development, Chandigarh University, Mohali, India","University Institute of Pharma Sciences, Chandigarh University, Mohali, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Centre for Research and Development, Chandigarh University","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"University Centre for Research and Development, Chandigarh University, Mohali, India","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University, Mohali, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113426658","display_name":"V. Sai Krishna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vrinda Krishna","raw_affiliation_strings":["University Institute of Pharma Sciences, Chandigarh University","University Institute of Pharma Sciences, Chandigarh University, Mohali, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University, Mohali, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nitya Kumari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nitya Kumari","raw_affiliation_strings":["University Institute of Pharma Sciences, Chandigarh University","University Institute of Pharma Sciences, Chandigarh University, Mohali, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University, Mohali, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anoushka Banerjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anoushka Banerjee","raw_affiliation_strings":["University Institute of Pharma Sciences, Chandigarh University","University Institute of Pharma Sciences, Chandigarh University, Mohali, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University, Mohali, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110715707","display_name":"Prithviraj Kapoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prithviraj Kapoor","raw_affiliation_strings":["University Institute of Pharma Sciences, Chandigarh University","University Institute of Pharma Sciences, Chandigarh University, Mohali, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"University Institute of Pharma Sciences, Chandigarh University, Mohali, India","institution_ids":["https://openalex.org/I101407740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101592502"],"corresponding_institution_ids":["https://openalex.org/I101407740"],"apc_list":null,"apc_paid":null,"fwci":0.3282,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.34132383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"65","issue":"2","first_page":"303","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3725999891757965,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.13420000672340393,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.12809999287128448,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-polymer-interactions","display_name":"drug-polymer interactions","score":0.9980000257492065},{"id":"https://openalex.org/keywords/noncovalent-interactions","display_name":"non-covalent interactions","score":0.8489999771118164},{"id":"https://openalex.org/keywords/van-der-waals-forces","display_name":"van der Waals interactions","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":1.0},{"id":"https://openalex.org/keywords/ionic-interactions","display_name":"ionic interactions","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hydrophobic-effect","display_name":"hydrophobic effect","score":0.8679999709129333},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9120000004768372},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.6269999742507935},{"id":"https://openalex.org/keywords/micelles","display_name":"micelles","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.9990000128746033},{"id":"https://openalex.org/keywords/isothermal-titration-calorimetry","display_name":"isothermal titration calorimetry","score":0.9869999885559082},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"surface plasmon resonance","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6916633248329163},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6754111051559448},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.576956570148468},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.5442535877227783},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5276105403900146},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3129284977912903},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15099114179611206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10595899820327759},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09972509741783142},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09522822499275208}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/00222348.2024.2419773","doi":"https://doi.org/10.1080/00222348.2024.2419773","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00222348.2024.2419773","pdf_url":null,"source":{"id":"https://openalex.org/S118630506","display_name":"Journal of Macromolecular Science Part B","issn_l":"0022-2348","issn":["0022-2348","1525-609X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Macromolecular Science, Part B","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W93847062","https://openalex.org/W203284752","https://openalex.org/W1967985930","https://openalex.org/W1968135216","https://openalex.org/W1971792242","https://openalex.org/W1983002345","https://openalex.org/W1989814214","https://openalex.org/W2002117373","https://openalex.org/W2005005276","https://openalex.org/W2007262243","https://openalex.org/W2018293999","https://openalex.org/W2029287870","https://openalex.org/W2030564211","https://openalex.org/W2038928872","https://openalex.org/W2041809213","https://openalex.org/W2044146593","https://openalex.org/W2046796898","https://openalex.org/W2052278157","https://openalex.org/W2054473187","https://openalex.org/W2059991844","https://openalex.org/W2062913215","https://openalex.org/W2063644741","https://openalex.org/W2066615805","https://openalex.org/W2073399385","https://openalex.org/W2085451934","https://openalex.org/W2089245007","https://openalex.org/W2089905805","https://openalex.org/W2090545729","https://openalex.org/W2095242270","https://openalex.org/W2108886196","https://openalex.org/W2118373652","https://openalex.org/W2128385043","https://openalex.org/W2137092218","https://openalex.org/W2259363028","https://openalex.org/W2271489867","https://openalex.org/W2591309385","https://openalex.org/W2595433325","https://openalex.org/W2734970798","https://openalex.org/W2751525012","https://openalex.org/W2901419844","https://openalex.org/W2902440871","https://openalex.org/W2903919345","https://openalex.org/W2909149226","https://openalex.org/W2913690990","https://openalex.org/W2914147192","https://openalex.org/W2926626316","https://openalex.org/W2941845783","https://openalex.org/W2999128310","https://openalex.org/W3070843563","https://openalex.org/W4211014354","https://openalex.org/W4388522928","https://openalex.org/W4388915162","https://openalex.org/W4390788032","https://openalex.org/W4391004133","https://openalex.org/W4392572205"],"related_works":["https://openalex.org/W4402102634","https://openalex.org/W2165291424","https://openalex.org/W1635957015","https://openalex.org/W4412108349","https://openalex.org/W1983002345","https://openalex.org/W7203552705","https://openalex.org/W2322919619","https://openalex.org/W2946377975","https://openalex.org/W2212686033","https://openalex.org/W4285164945"],"abstract_inverted_index":{"Polymer-drug":[0],"interactions":[1,26,64,69],"play":[2],"a":[3],"pivotal":[4],"role":[5,46],"in":[6,49,94],"the":[7,30,37,45,71,78,82,86,89,95,120],"design":[8,97],"and":[9,21,27,33,65,77,107,123,141,161,172],"optimization":[10],"of":[11,36,47,81,98],"drug":[12,72,100,163],"delivery":[13,83,101,164],"systems.":[14],"Thermodynamic":[15],"principles,":[16],"such":[17,103,131],"as":[18,104,132],"enthalpy,":[19],"entropy":[20],"free":[22],"energy,":[23],"govern":[24],"these":[25,129,148],"significantly":[28],"influence":[29],"stability,":[31],"efficacy":[32],"release":[34,75],"profiles":[35],"drug-polymer":[38,50,113],"complexes.":[39],"In":[40],"this":[41,153],"review":[42,116],"we":[43,151],"explore":[44],"thermodynamics":[48],"binding,":[51],"focusing":[52],"on":[53,111],"non-covalent":[54],"interactions,":[55,130],"including":[56],"van":[57],"der":[58],"Waals":[59],"forces,":[60],"hydrogen":[61],"bonding,":[62],"ionic":[63],"hydrophobic":[66],"effects.":[67,175],"These":[68],"affect":[70],"encapsulation":[73],"efficiency,":[74],"kinetics":[76],"overall":[79],"stability":[80],"system.":[84],"Understanding":[85],"balance":[87],"between":[88],"various":[90],"thermodynamic":[91,149],"forces":[92],"helps":[93],"rational":[96],"advanced":[99],"platforms,":[102],"nanoparticles,":[105],"micelles":[106],"hydrogels,":[108],"which":[109],"rely":[110],"optimized":[112],"affinity.":[114],"Our":[115],"further":[117],"delves":[118],"into":[119,157],"experimental":[121],"techniques":[122],"modeling":[124],"approaches":[125],"used":[126],"to":[127],"characterize":[128],"isothermal":[133],"titration":[134],"calorimetry":[135],"(ITC),":[136],"molecular":[137],"dynamics":[138],"(MD)":[139],"simulations":[140],"surface":[142],"plasmon":[143],"resonance":[144],"(SPR).":[145],"By":[146],"examining":[147],"foundations,":[150],"believe":[152],"article":[154],"provides":[155],"insights":[156],"developing":[158],"more":[159],"efficient":[160],"stable":[162],"systems":[165],"that":[166],"ensure":[167],"targeted":[168],"release,":[169],"enhanced":[170],"bioavailability":[171],"reduced":[173],"side":[174]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2024-10-25T00:00:00"}
