{"id":"https://openalex.org/W4403731978","doi":"https://doi.org/10.1101/2024.10.23.619933","title":"Depletion of BBSome Subunits Alters Receptor Endocytosis and Promotes EMT via TGF-\u03b2 Signalling","display_name":"Depletion of BBSome Subunits Alters Receptor Endocytosis and Promotes EMT via TGF-\u03b2 Signalling","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403731978","doi":"https://doi.org/10.1101/2024.10.23.619933"},"language":"en","primary_location":{"id":"doi:10.1101/2024.10.23.619933","doi":"https://doi.org/10.1101/2024.10.23.619933","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.23.619933","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.10.23.619933","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017407973","display_name":"Carlos Solarat","orcid":"https://orcid.org/0000-0003-3726-7924","observed_orcids":["https://orcid.org/0000-0003-3726-7924"]},"institutions":[{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Solarat","raw_affiliation_strings":["CINBIO, Universidade de Vigo, Vigo, Spain","Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","University of Vigo"],"raw_orcid":"https://orcid.org/0000-0003-3726-7924","affiliations":[{"raw_affiliation_string":"CINBIO, Universidade de Vigo, Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","institution_ids":[]},{"raw_affiliation_string":"University of Vigo","institution_ids":["https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114394790","display_name":"J. Barra-Carneiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Barra-Carneiro Jose","raw_affiliation_strings":["CINBIO, Universidade de Vigo, Vigo, Spain","Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","University of Vigo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINBIO, Universidade de Vigo, Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","institution_ids":[]},{"raw_affiliation_string":"University of Vigo","institution_ids":["https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114394791","display_name":"S. Vila-Almu\u00ed\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vila-Almu\u00ed\u00f1a Sara","raw_affiliation_strings":["CINBIO, Universidade de Vigo, Vigo, Spain","Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","University of Vigo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINBIO, Universidade de Vigo, Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","institution_ids":[]},{"raw_affiliation_string":"University of Vigo","institution_ids":["https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148196236","display_name":"Cristian Alvela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alvela Cristian","raw_affiliation_strings":["CINBIO, Universidade de Vigo, Vigo, Spain","Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","University of Vigo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINBIO, Universidade de Vigo, Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","institution_ids":[]},{"raw_affiliation_string":"University of Vigo","institution_ids":["https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031119579","display_name":"Pablo Barbeito","orcid":"https://orcid.org/0000-0003-0758-0012","observed_orcids":["https://orcid.org/0000-0003-0758-0012"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["DK","ES"],"is_corresponding":false,"raw_author_name":"Barbeito Pablo","raw_affiliation_strings":["CINBIO, Universidade de Vigo, Vigo, Spain","Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","University of Copenhaguen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINBIO, Universidade de Vigo, Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","institution_ids":[]},{"raw_affiliation_string":"University of Copenhaguen","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148258369","display_name":"Margarita Soloshenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]},{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB","RU"],"is_corresponding":false,"raw_author_name":"Soloshenko Margarita","raw_affiliation_strings":["Research Centre for Medical Genetics, 115522, Moscow, Russia","Cancer Research UK Scotland Centre, Institute of Genetics and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Medical Genetics, 115522, Moscow, Russia","institution_ids":["https://openalex.org/I4210126689"]},{"raw_affiliation_string":"Cancer Research UK Scotland Centre, Institute of Genetics and Cancer","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210158898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010394848","display_name":"Maria Schr\u00f8der Holm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Schr\u00f8der Holm Maria","raw_affiliation_strings":["Department of Biology, Section of Cell Biology and Physiology, The August Krogh Building, University of Copenhagen, Copenhagen, Denmark","University of Copenhagen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Section of Cell Biology and Physiology, The August Krogh Building, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"University of Copenhagen","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034012806","display_name":"Noor Gammoh","orcid":"https://orcid.org/0000-0001-9402-9581","observed_orcids":["https://orcid.org/0000-0001-9402-9581"]},"institutions":[{"id":"https://openalex.org/I2802581871","display_name":"Edinburgh Cancer Research","ror":"https://ror.org/05a7t9b67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I2802581871","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["ES","GB"],"is_corresponding":true,"raw_author_name":"Gammoh Noor","raw_affiliation_strings":["Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK","University of Vigo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK","institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I4210158898","https://openalex.org/I98677209"]},{"raw_affiliation_string":"University of Vigo","institution_ids":["https://openalex.org/I6289922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044711408","display_name":"S\u00f8ren T. Christensen","orcid":"https://orcid.org/0000-0001-5004-304X","observed_orcids":["https://orcid.org/0000-0001-5004-304X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christensen S\u00f8ren Tvorup","raw_affiliation_strings":["Department of Biology, Section of Cell Biology and Physiology, The August Krogh Building, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Section of Cell Biology and Physiology, The August Krogh Building, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148286083","display_name":"Diana Valverde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Valverde Diana","raw_affiliation_strings":["CINBIO, Universidade de Vigo, Vigo, Spain","Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINBIO, Universidade de Vigo, Vigo, Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IIS Galicia Sur), Hospital \u00c1lvaro Cunqueiro, Vigo, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5034012806"],"corresponding_institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I4210158898","https://openalex.org/I6289922","https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bardet-biedl-syndrome","display_name":"Bardet-Biedl syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bbsome","display_name":"BBSome","score":0.902999997138977},{"id":"https://openalex.org/keywords/bbs1","display_name":"BBS1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bbs4","display_name":"BBS4","score":1.0},{"id":"https://openalex.org/keywords/ciliopathy","display_name":"ciliopathies","score":0.843999981880188},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9369999766349792},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9819999933242798},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.8230000138282776},{"id":"https://openalex.org/keywords/retinal-epithelial-cells","display_name":"retinal epithelial cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.9139999747276306},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7950000166893005},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cilia","display_name":"cilia","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7244472503662109},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7118281722068787},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49874424934387207},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.473189115524292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46917110681533813},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4569743871688843},{"id":"https://openalex.org/C2909521502","wikidata":"https://www.wikidata.org/wiki/Q14903945","display_name":"Smad2 Protein","level":4,"score":0.4366248548030853},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.26377421617507935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21867850422859192},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1115250289440155}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1101/2024.10.23.619933","doi":"https://doi.org/10.1101/2024.10.23.619933","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.23.619933","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-10825783/v1","doi":"https://doi.org/10.21203/rs.3.rs-10825783/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10825783/v1","pdf_url":"https://www.researchsquare.com/article/rs-10825783/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2024.10.23.619933","doi":"https://doi.org/10.1101/2024.10.23.619933","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.23.619933","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7044209274","display_name":"Estudio exhaustivo de las distrofias hereditarias de la retina: mejora del diagn\u00f3stico molecular, aproximaciones terap\u00e9uticas, ensayos cl\u00ednicos y medida de su impacto en los pacientes.","funder_award_id":"PI22/00287","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320330134","display_name":"Centro Singular de Investigaci\u00f3n de Galicia","ror":"https://ror.org/04wx4nj18"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1787157135","https://openalex.org/W1973260880","https://openalex.org/W1977709885","https://openalex.org/W1978391747","https://openalex.org/W1979105890","https://openalex.org/W2002043029","https://openalex.org/W2002153732","https://openalex.org/W2002855657","https://openalex.org/W2003083523","https://openalex.org/W2007304463","https://openalex.org/W2009396278","https://openalex.org/W2012034410","https://openalex.org/W2025738186","https://openalex.org/W2031584736","https://openalex.org/W2035618305","https://openalex.org/W2035660316","https://openalex.org/W2053451133","https://openalex.org/W2067872995","https://openalex.org/W2090789702","https://openalex.org/W2096086497","https://openalex.org/W2111274886","https://openalex.org/W2138633908","https://openalex.org/W2141026112","https://openalex.org/W2149212063","https://openalex.org/W2167279371","https://openalex.org/W2168056473","https://openalex.org/W2169046343","https://openalex.org/W2172267451","https://openalex.org/W2191047704","https://openalex.org/W2211808103","https://openalex.org/W2213837941","https://openalex.org/W2213972028","https://openalex.org/W2220167740","https://openalex.org/W2226595663","https://openalex.org/W2258772674","https://openalex.org/W2290479358","https://openalex.org/W2296334129","https://openalex.org/W2315264211","https://openalex.org/W2460554611","https://openalex.org/W2523854043","https://openalex.org/W2535768551","https://openalex.org/W2734540391","https://openalex.org/W2769989706","https://openalex.org/W2770898385","https://openalex.org/W2773921103","https://openalex.org/W2789266701","https://openalex.org/W2790683847","https://openalex.org/W2891497275","https://openalex.org/W2895602084","https://openalex.org/W2899760200","https://openalex.org/W2913985590","https://openalex.org/W2962242811","https://openalex.org/W2972524442","https://openalex.org/W3009746164","https://openalex.org/W3037858919","https://openalex.org/W3047565580","https://openalex.org/W3126606140","https://openalex.org/W3129118038","https://openalex.org/W3157614340","https://openalex.org/W3189231398","https://openalex.org/W4200171924","https://openalex.org/W4281606388","https://openalex.org/W4366280060","https://openalex.org/W4388835038","https://openalex.org/W4391884040"],"related_works":["https://openalex.org/W7165145845","https://openalex.org/W7125600777","https://openalex.org/W1936537021","https://openalex.org/W4388835038","https://openalex.org/W2013906880","https://openalex.org/W2014507013","https://openalex.org/W4220657179","https://openalex.org/W4404668796","https://openalex.org/W7136098657","https://openalex.org/W807932216"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Ciliopathies":[2],"are":[3],"genetic":[4],"disorders":[5],"caused":[6],"by":[7],"defects":[8],"in":[9,50,82,191,210],"the":[10,15,42,102,153,174,196],"structure":[11],"or":[12],"function":[13],"of":[14,44,96,105,198],"cilia":[16,89],"and":[17,46,69,77,90,98,110,152,173,188,215,220],"their":[18],"related":[19],"structures.":[20],"Bardet-Biedl":[21],"syndrome":[22],"(BBS)":[23],"is":[24],"a":[25,203],"complex":[26],"ciliopathy":[27],"with":[28,94,124,179],"varied":[29],"symptoms,":[30],"probably":[31],"due":[32],"to":[33,87,226],"altered":[34],"membrane":[35,56,104],"receptor":[36,92,163,200],"signalling":[37,216],"pathways.":[38],"Methods:":[39],"We":[40],"investigated":[41],"role":[43,197],"BBS1":[45,106,117,136,192,219],"BBS4":[47,119,158,221],"gene":[48],"deficiencies":[49],"retinal":[51,208],"epithelial":[52],"cells":[53,138,160,194],"using":[54],"surface":[55],"proteomics,":[57],"co-immunoprecipitation,":[58],"AlphaFold":[59,111],"structural":[60,112],"modelling,":[61],"endocytic":[62,126],"trafficking":[63,201],"colocalization":[64],"assays,":[65],"autophagy":[66],"flux":[67,146,168],"analysis,":[68],"epithelial-to-mesenchymal":[70],"transition":[71],"(EMT)":[72],"functional":[73],"assays":[74],"including":[75],"migration":[76,190],"wound":[78],"healing.":[79],"Results:":[80],"Deficiencies":[81],"these":[83],"BBSome":[84],"components":[85,127],"led":[86],"shorter":[88],"disrupted":[91],"endocytosis,":[93],"accumulation":[95],"TGF-\u03b2-pathway":[97],"EMT-associated":[99],"proteins":[100],"on":[101],"plasma":[103],"KO":[107,137,159,193,222],"cells.":[108],"Co-immunoprecipitation":[109],"modelling":[113],"indicated":[114],"that":[115,147,169],"neither":[116],"nor":[118],"forms":[120],"stable":[121],"physical":[122],"complexes":[123],"core":[125],"(EEA1,":[128],"RAB11,":[129],"RAB7,":[130],"LAMP2),":[131],"suggesting":[132],"an":[133],"indirect":[134],"mechanism.":[135],"showed":[139,161],"sustained":[140],"TGFBR1":[141],"recycling,":[142,164],"low":[143],"basal":[144,166],"autophagic":[145,167,214],"increases":[148],"upon":[149,171],"TGF-\u03b2":[150,227],"stimulation,":[151,172],"most":[154],"pronounced":[155],"mesenchymal":[156],"phenotype.":[157],"reduced":[162,180],"elevated":[165],"declines":[170],"strongest":[175],"canonical":[176],"TGF-\u03b2/SMAD":[177],"activation":[178],"non-canonical":[181],"ERK1/2":[182],"signalling.":[183],"Conclusions:":[184],"Increased":[185],"EMT":[186],"markers":[187],"enhanced":[189],"highlight":[195],"BBSome-dependent":[199],"as":[202],"potential":[204],"therapeutic":[205],"target":[206],"for":[207],"degeneration":[209],"BBS.":[211],"The":[212],"divergent":[213],"phenotypes":[217],"between":[218],"reveal":[223],"subunit-specific":[224],"contributions":[225],"pathway":[228],"dysregulation.":[229]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-10-25T00:00:00"}
