{"id":"https://openalex.org/W4403729268","doi":"https://doi.org/10.1038/s41531-024-00820-0","title":"CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants","display_name":"CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403729268","doi":"https://doi.org/10.1038/s41531-024-00820-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/39448669","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11502890"},"language":"en","primary_location":{"id":"doi:10.1038/s41531-024-00820-0","doi":"https://doi.org/10.1038/s41531-024-00820-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-024-00820-0","pdf_url":"https://www.nature.com/articles/s41531-024-00820-0.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41531-024-00820-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017793662","display_name":"Stefanie Lerche","orcid":"https://orcid.org/0000-0002-5508-004X","observed_orcids":["https://orcid.org/0000-0002-5508-004X"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Lerche","raw_affiliation_strings":["Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany","German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081698001","display_name":"Isabel Wurster","orcid":"https://orcid.org/0000-0003-0157-5722","observed_orcids":["https://orcid.org/0000-0003-0157-5722"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabel Wurster","raw_affiliation_strings":["Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany","Edmond J. Safra Fellow in Movement Disorders, New York, NY, USA","German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"raw_affiliation_string":"Edmond J. Safra Fellow in Movement Disorders, New York, NY, USA","institution_ids":[]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068582387","display_name":"Enza Maria Valente","orcid":"https://orcid.org/0000-0002-0600-6820","observed_orcids":["https://orcid.org/0000-0002-0600-6820"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enza Maria Valente","raw_affiliation_strings":["Department of Molecular Medicine, University of Pavia, Pavia, Italy","IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091396775","display_name":"Micol Avenali","orcid":"https://orcid.org/0000-0002-7880-9921","observed_orcids":["https://orcid.org/0000-0002-7880-9921"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Micol Avenali","raw_affiliation_strings":["Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063691318","display_name":"Daniela Samaniego","orcid":"https://orcid.org/0000-0001-8362-0747","observed_orcids":["https://orcid.org/0000-0001-8362-0747"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniela Samaniego","raw_affiliation_strings":["Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210102407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054024923","display_name":"Marta Mart\u00ednez\u2010Vicente","orcid":"https://orcid.org/0000-0001-7053-2625","observed_orcids":["https://orcid.org/0000-0001-7053-2625","https://orcid.org/0000-0003-2595-6247","https://orcid.org/0000-0002-6601-9674"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Mart\u00ednez-Vicente","raw_affiliation_strings":["Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210102407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068455380","display_name":"Jorge Hern\u00e1ndez\u2010Vara","orcid":"https://orcid.org/0000-0002-9129-5224","observed_orcids":["https://orcid.org/0000-0002-9129-5224"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jorge Hern\u00e1ndez-Vara","raw_affiliation_strings":["Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210102407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022347865","display_name":"Ariadna Laguna","orcid":"https://orcid.org/0000-0002-9732-6677","observed_orcids":["https://orcid.org/0000-0002-9732-6677"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210102407","display_name":"Vall d'Hebron Institut de Recerca","ror":"https://ror.org/01d5vx451","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210102407","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Ariadna Laguna","raw_affiliation_strings":["Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA","Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I4387154804"]},{"raw_affiliation_string":"Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain","institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I4210102407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058392877","display_name":"Andrea Sturchio","orcid":"https://orcid.org/0000-0002-1067-2834","observed_orcids":["https://orcid.org/0000-0002-1067-2834"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andrea Sturchio","raw_affiliation_strings":["Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036364090","display_name":"Per Svenningsson","orcid":"https://orcid.org/0000-0001-6727-3802","observed_orcids":["https://orcid.org/0000-0001-6727-3802"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Svenningsson","raw_affiliation_strings":["Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109853359","display_name":"Nicholas P. France","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas P. France","raw_affiliation_strings":["ESCAPE Bio, South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ESCAPE Bio, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025279301","display_name":"Carrolee Barlow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrolee Barlow","raw_affiliation_strings":["ESCAPE Bio, South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ESCAPE Bio, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085902677","display_name":"Sethu Sankaranarayanan","orcid":"https://orcid.org/0000-0002-3380-6532","observed_orcids":["https://orcid.org/0000-0002-3380-6532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sethu Sankaranarayanan","raw_affiliation_strings":["ESCAPE Bio, South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ESCAPE Bio, South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004204996","display_name":"Kathrin Brockmann","orcid":"https://orcid.org/0000-0002-7515-8596","observed_orcids":["https://orcid.org/0000-0002-7515-8596"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kathrin Brockmann","raw_affiliation_strings":["Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. kathrin.brockmann@uni-tuebingen.de","German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany. kathrin.brockmann@uni-tuebingen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. kathrin.brockmann@uni-tuebingen.de","institution_ids":["https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany. kathrin.brockmann@uni-tuebingen.de","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5004204996"],"corresponding_institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210141865","https://openalex.org/I8087733"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":1.1312,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77611704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"198","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.6890000104904175},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":1.0},{"id":"https://openalex.org/keywords/gba1-variants","display_name":"GBA1 variants","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7120000123977661},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/heterozygous-carriers","display_name":"heterozygous carriers","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.9724154472351074},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7772282361984253},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.7761250734329224},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7051239609718323},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5689540505409241},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5173215866088867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4311607778072357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4222419559955597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40997493267059326},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36386144161224365},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33320099115371704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1945115029811859}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1038/s41531-024-00820-0","doi":"https://doi.org/10.1038/s41531-024-00820-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-024-00820-0","pdf_url":"https://www.nature.com/articles/s41531-024-00820-0.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4593604/v1","doi":"https://doi.org/10.21203/rs.3.rs-4593604/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4593604/v1","pdf_url":"https://www.researchsquare.com/article/rs-4593604/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11502890","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11502890","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Parkinsons Dis","raw_type":"Text"},{"id":"pmid:39448669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39448669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Parkinson's disease","raw_type":"Journal Article"},{"id":"pmh:oai:frl.publisso.de:frl:6506632","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11502890","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11502890/pdf/41531_2024_Article_820.pdf","source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Parkinson's Disease, 10(1):198","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:pub.dzne.de:272861","doi":null,"is_oa":true,"landing_page_url":"https://pub.dzne.de/search?p=id:%22DZNE-2024-01279%22","pdf_url":"https://pub.dzne.de/record/272861/files/DZNE-2024-01279.pdf","source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Parkinson's Disease 10(1), 198 (2024). doi:10.1038/s41531-024-00820-0","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0432f15037794f51a76f397dcdb3ce10","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0432f15037794f51a76f397dcdb3ce10","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-6 (2024)","raw_type":"article"},{"id":"doi:10.15496/publikation-107093","doi":"https://doi.org/10.15496/publikation-107093","is_oa":true,"landing_page_url":"https://doi.org/10.15496/publikation-107093","pdf_url":null,"source":{"id":"https://openalex.org/S7407053000","display_name":"Universit\u00e4tsbibliothek T\u00fcbingen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1038/s41531-024-00820-0","doi":"https://doi.org/10.1038/s41531-024-00820-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-024-00820-0","pdf_url":"https://www.nature.com/articles/s41531-024-00820-0.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.44999998807907104}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2076520454","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2713491764","display_name":"Proyecto VHIP-GBA (Vall d\u2019Hebron Iniciative for Parkinson associated to GBA): desde la recolecci\u00f3n de muestras biol\u00f3gicas a los estudios translacionales y terap\u00e9uticos.","funder_award_id":"PI20/00728","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3780677934","display_name":"El eje cerebro-periferia en pacientes con enfermedad de Parkinson: desde la fisiopatolog\u00eda hasta los biomarcadores y los enfoques terap\u00e9uticos","funder_award_id":"PI21/01603","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6113104723","display_name":null,"funder_award_id":"FKZ031L0137B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321112","display_name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","ror":"https://ror.org/03a1kwz48"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321980","display_name":"Kommunfullm\u00e4ktige, Stockholms Stad","ror":"https://ror.org/02v91xy81"},{"id":"https://openalex.org/F4320323170","display_name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","ror":"https://ror.org/043j0f473"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403729268.pdf","grobid_xml":"https://content.openalex.org/works/W4403729268.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2017411361","https://openalex.org/W2031365272","https://openalex.org/W2093274439","https://openalex.org/W2145962946","https://openalex.org/W2170281382","https://openalex.org/W2322128806","https://openalex.org/W2618015181","https://openalex.org/W2746979715","https://openalex.org/W2779236324","https://openalex.org/W2781740238","https://openalex.org/W3128633971","https://openalex.org/W3208054825","https://openalex.org/W4232010579","https://openalex.org/W4287378346","https://openalex.org/W4308555113"],"related_works":["https://openalex.org/W7165594332","https://openalex.org/W2243715715","https://openalex.org/W3216778464","https://openalex.org/W4399264670","https://openalex.org/W7123558106","https://openalex.org/W2952002410","https://openalex.org/W2512191280","https://openalex.org/W4290026893","https://openalex.org/W4324129127","https://openalex.org/W7160855942"],"abstract_inverted_index":{"Variants":[0],"in":[1,4,14,44,67],"GBA1":[2,32,46],"result":[3],"dysregulated":[5],"sphingolipids.":[6],"We":[7,37],"investigated":[8],"five":[9],"CSF":[10,58],"d18:1":[11,59],"sphingolipid":[12,42],"species":[13,43],"a":[15],"longitudinal":[16],"multicenter":[17],"cohort":[18],"comprising":[19],"people":[20],"with":[21,26,29],"Parkinson's":[22,68],"Disease":[23],"and":[24,30,34,49],"Dementia":[25],"Lewy":[27],"bodies":[28],"without":[31],"variants":[33],"healthy":[35],"controls.":[36],"found":[38],"no":[39,50],"increase":[40],"of":[41,54],"heterozygous":[45],"variant":[47],"participants":[48],"effect":[51],"on":[52],"development":[53],"cognitive":[55],"impairment.":[56],"Thus,":[57],"sphingolipids":[60],"are":[61],"not":[62],"suitable":[63],"as":[64],"state":[65],"markers":[66],"Disease.":[69]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-10-25T00:00:00"}