{"id":"https://openalex.org/W4403728568","doi":"https://doi.org/10.2337/db24-0393","title":"Long-term Nerve Regeneration in Diabetic Keratopathy Mediated by a Novel NGF Delivery System","display_name":"Long-term Nerve Regeneration in Diabetic Keratopathy Mediated by a Novel NGF Delivery System","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403728568","doi":"https://doi.org/10.2337/db24-0393","pmid":"https://pubmed.ncbi.nlm.nih.gov/39446568","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11664026"},"language":"en","primary_location":{"id":"doi:10.2337/db24-0393","doi":"https://doi.org/10.2337/db24-0393","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db24-0393","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11664026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lin Cong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Cong","raw_affiliation_strings":["1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","2School of Ophthalmology, Shandong First Medical University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"2School of Ophthalmology, Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054583978","display_name":"Benxiang Qi","orcid":"https://orcid.org/0009-0008-6784-8707","observed_orcids":["https://orcid.org/0009-0008-6784-8707"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Benxiang Qi","raw_affiliation_strings":["1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","2School of Ophthalmology, Shandong First Medical University, Qingdao, China","3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"2School of Ophthalmology, Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016831321","display_name":"Shijiu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210159816","display_name":"Shandong Eye Hospital","ror":"https://ror.org/05htkf588","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159816"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijiu Chen","raw_affiliation_strings":["1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","4Eye Hospital of Shandong First Medical University, Jinan, China","5Department of Medicine, Qingdao University, Qingdao, China","4Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"4Eye Hospital of Shandong First Medical University, Jinan, China","institution_ids":["https://openalex.org/I4210159816","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"5Department of Medicine, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"4Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China","institution_ids":["https://openalex.org/I4210159816","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066589676","display_name":"Ruiling Liu","orcid":"https://orcid.org/0000-0002-9580-7653","observed_orcids":["https://orcid.org/0000-0002-9580-7653"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiling Liu","raw_affiliation_strings":["6Henan Key Laboratory of Engineering Antibody Medicine, Medical College of Henan University, Kaifeng, China","1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","2School of Ophthalmology, Shandong First Medical University, Qingdao, China","3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Henan Key Laboratory of Engineering Antibody Medicine, Medical College of Henan University, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"2School of Ophthalmology, Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068349486","display_name":"Su\u2010Xia Li","orcid":"https://orcid.org/0000-0002-0781-0300","observed_orcids":["https://orcid.org/0000-0002-0781-0300"]},"institutions":[{"id":"https://openalex.org/I4210159816","display_name":"Shandong Eye Hospital","ror":"https://ror.org/05htkf588","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159816"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suxia Li","raw_affiliation_strings":["1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","2School of Ophthalmology, Shandong First Medical University, Qingdao, China","4Eye Hospital of Shandong First Medical University, Jinan, China","4Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"2School of Ophthalmology, Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"4Eye Hospital of Shandong First Medical University, Jinan, China","institution_ids":["https://openalex.org/I4210159816","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"4Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, China","institution_ids":["https://openalex.org/I4210159816","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037001394","display_name":"Qingjun Zhou","orcid":"https://orcid.org/0000-0002-7770-9275","observed_orcids":["https://orcid.org/0000-0002-7770-9275"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingjun Zhou","raw_affiliation_strings":["1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","2School of Ophthalmology, Shandong First Medical University, Qingdao, China","3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"2School of Ophthalmology, Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073365279","display_name":"Yihai Cao","orcid":"https://orcid.org/0000-0003-1308-0065","observed_orcids":["https://orcid.org/0000-0003-1308-0065"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yihai Cao","raw_affiliation_strings":["7Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden","6Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"6Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081718830","display_name":"Bi Ning Zhang","orcid":"https://orcid.org/0000-0002-4308-3729","observed_orcids":["https://orcid.org/0000-0002-4308-3729"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bi Ning Zhang","raw_affiliation_strings":["1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","2School of Ophthalmology, Shandong First Medical University, Qingdao, China","3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"],"raw_orcid":"https://orcid.org/0000-0002-4308-3729","affiliations":[{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"2School of Ophthalmology, Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108325919","display_name":"Lixin Xie","orcid":"https://orcid.org/0000-0003-2747-3361","observed_orcids":["https://orcid.org/0000-0003-2747-3361"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lixin Xie","raw_affiliation_strings":["1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","2School of Ophthalmology, Shandong First Medical University, Qingdao, China","3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"],"raw_orcid":"https://orcid.org/0000-0003-2747-3361","affiliations":[{"raw_affiliation_string":"1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"2School of Ophthalmology, Shandong First Medical University, Qingdao, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"3State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5108325919"],"corresponding_institution_ids":["https://openalex.org/I4210163399"],"apc_list":null,"apc_paid":null,"fwci":5.5683,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.96459557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"74","issue":"1","first_page":"22","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.42579999566078186,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.42579999566078186,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.15780000388622284,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-keratopathy","display_name":"diabetic keratopathy","score":1.0},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/corneal-nerve-regeneration","display_name":"corneal nerve regeneration","score":0.9509999752044678},{"id":"https://openalex.org/keywords/trigeminal-ganglion","display_name":"trigeminal ganglion","score":0.7850000262260437},{"id":"https://openalex.org/keywords/retrograde-transport","display_name":"retrograde transport","score":0.8529999852180481},{"id":"https://openalex.org/keywords/corneal-edema","display_name":"corneal edema","score":0.6800000071525574},{"id":"https://openalex.org/keywords/ocular-surface-disease","display_name":"ocular surface disease","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.7402907609939575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7369505763053894},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.49931836128234863},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.4455578029155731},{"id":"https://openalex.org/C2909399601","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Corneal Diseases","level":3,"score":0.4408688545227051},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.4343518614768982},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.4257518947124481},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.4125220775604248},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.34677714109420776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30671989917755127},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3049444556236267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17492210865020752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1609569489955902},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.12286809086799622},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11316460371017456},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07534053921699524}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003316","descriptor_name":"Corneal Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003316","descriptor_name":"Corneal Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/db24-0393","doi":"https://doi.org/10.2337/db24-0393","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db24-0393","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11664026","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11664026","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmid:39446568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39446568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11664026","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11664026","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1968783003","display_name":null,"funder_award_id":"2019ZL001","funder_id":"https://openalex.org/F4320328999","funder_display_name":"Shandong First Medical University"},{"id":"https://openalex.org/G3324988064","display_name":null,"funder_award_id":"82101091","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5242952536","display_name":null,"funder_award_id":"2019RC008","funder_id":"https://openalex.org/F4320328999","funder_display_name":"Shandong First Medical University"},{"id":"https://openalex.org/G7317256109","display_name":null,"funder_award_id":"82271059","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328999","display_name":"Shandong First Medical University","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W265142245","https://openalex.org/W1596048577","https://openalex.org/W1985765032","https://openalex.org/W2048638072","https://openalex.org/W2126822372","https://openalex.org/W2147141118","https://openalex.org/W2318073942","https://openalex.org/W2321265334","https://openalex.org/W2417032300","https://openalex.org/W2527694273","https://openalex.org/W2737725878","https://openalex.org/W2737787547","https://openalex.org/W2738165667","https://openalex.org/W2766739672","https://openalex.org/W2797357911","https://openalex.org/W2804017581","https://openalex.org/W2920682232","https://openalex.org/W2970312470","https://openalex.org/W3023680900","https://openalex.org/W3085242377","https://openalex.org/W3087196284","https://openalex.org/W3092913715","https://openalex.org/W3111331330","https://openalex.org/W3111962636","https://openalex.org/W3112352736","https://openalex.org/W3158593362","https://openalex.org/W3159422802","https://openalex.org/W3190178590","https://openalex.org/W3205252098","https://openalex.org/W4206147286","https://openalex.org/W4212942249","https://openalex.org/W4214882774","https://openalex.org/W4220715697","https://openalex.org/W4291164838","https://openalex.org/W4291710759","https://openalex.org/W4302028035","https://openalex.org/W4306956964","https://openalex.org/W4385897546","https://openalex.org/W4400913931"],"related_works":["https://openalex.org/W4403006596","https://openalex.org/W3023680900","https://openalex.org/W4212942249","https://openalex.org/W4401321394","https://openalex.org/W4385758442","https://openalex.org/W1896650885","https://openalex.org/W2564740711","https://openalex.org/W4410277369","https://openalex.org/W7125476333","https://openalex.org/W4387953146"],"abstract_inverted_index":{"Diabetic":[0],"keratopathy":[1],"(DK)":[2],"is":[3,190],"a":[4,34,54,67,129,150,154,176],"common":[5],"chronic":[6],"metabolic":[7],"disorder":[8],"that":[9,62],"causes":[10],"ocular":[11],"surface":[12],"complications.":[13],"Among":[14],"various":[15],"therapeutic":[16,36,178,188],"approaches,":[17],"local":[18],"delivery":[19,44,60],"of":[20,30,100,157,184],"nerve":[21,139,147,167],"growth":[22],"factor":[23],"(NGF)":[24],"remains":[25],"the":[26,41,72,134,143,160],"most":[27],"effective":[28,182],"treatment":[29,183],"DK.":[31],"However,":[32],"achieving":[33],"sustained":[35],"effect":[37],"with":[38],"NGF":[39,59,120],"and":[40,82,93,145,186],"frequent":[42],"drug":[43],"burden":[45],"remain":[46],"challenging":[47],"during":[48],"clinical":[49],"practice.":[50],"Here,":[51],"we":[52,174],"developed":[53],"novel":[55,177],"adeno-associated":[56],"virus":[57],"(AAV)-based":[58],"system":[61],"achieved":[63],"1-year-long-lasting":[64],"effects":[65],"by":[66],"single":[68,155],"injection.":[69],"We":[70],"refined":[71],"corneal":[73,80,96,116,138,146,161,166],"stromal":[74],"injection":[75,156],"technique,":[76],"resulting":[77],"in":[78,125],"reduced":[79],"edema":[81],"improved":[83],"AAV":[84,87],"distribution":[85],"homogeneity.":[86],"serotype":[88],"AAV.rh10":[89],"exhibited":[90],"high":[91],"tropism":[92],"specificity":[94],"to":[95,108,164,192],"nerves.":[97],"A":[98],"dose":[99],"2":[101],"\u00d7":[102],"109":[103],"vector":[104],"genomes":[105],"was":[106,122],"determined":[107],"achieve":[109],"efficient":[110],"Ngf":[111],"gene":[112],"expression":[113],"without":[114],"inducing":[115],"immune":[117],"responses.":[118],"Moreover,":[119],"protein":[121],"highly":[123],"expressed":[124],"trigeminal":[126],"ganglion":[127],"through":[128],"retrograde":[130],"transport":[131],"mechanism,":[132],"indicating":[133],"capacity":[135],"for":[136,169,180],"repairing":[137],"damage":[140],"at":[141],"both":[142],"root":[144],"endings.":[148],"In":[149],"mouse":[151],"DK":[152,194],"model,":[153],"AAV-Ngf":[158],"into":[159],"stroma":[162],"led":[163],"marked":[165],"regeneration":[168],"over":[170],"5":[171],"months.":[172],"Together,":[173],"provide":[175],"paradigm":[179],"long-term":[181],"DK,":[185],"this":[187],"approach":[189],"superior":[191],"current":[193],"therapies.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-10-25T00:00:00"}