{"id":"https://openalex.org/W4403727610","doi":"https://doi.org/10.1021/acs.oprd.4c00293","title":"Continuous Sonocrystallization Process for Controlling the Polymorphs and Particle Size of Perampanel","display_name":"Continuous Sonocrystallization Process for Controlling the Polymorphs and Particle Size of Perampanel","publication_year":2024,"publication_date":"2024-10-23","ids":{"openalex":"https://openalex.org/W4403727610","doi":"https://doi.org/10.1021/acs.oprd.4c00293"},"language":"en","primary_location":{"id":"doi:10.1021/acs.oprd.4c00293","doi":"https://doi.org/10.1021/acs.oprd.4c00293","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.oprd.4c00293","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research &amp; Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019811375","display_name":"Koji Machida","orcid":"https://orcid.org/0009-0008-2286-3567","observed_orcids":["https://orcid.org/0009-0008-2286-3567"]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]},{"id":"https://openalex.org/I4387152983","display_name":"Osaka Metropolitan University","ror":"https://ror.org/01hvx5h04","country_code":"JP","type":"education","lineage":["https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koji Machida","raw_affiliation_strings":["Department of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka 558-8585, Japan","Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan"],"raw_orcid":"https://orcid.org/0009-0008-2286-3567","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka 558-8585, Japan","institution_ids":["https://openalex.org/I4387152983"]},{"raw_affiliation_string":"Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101648261","display_name":"Koichi Igarashi","orcid":"https://orcid.org/0000-0002-8789-3723","observed_orcids":["https://orcid.org/0000-0002-8789-3723"]},"institutions":[{"id":"https://openalex.org/I4387152983","display_name":"Osaka Metropolitan University","ror":"https://ror.org/01hvx5h04","country_code":"JP","type":"education","lineage":["https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Igarashi","raw_affiliation_strings":["Department of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka 558-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka 558-8585, Japan","institution_ids":["https://openalex.org/I4387152983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064236505","display_name":"Hideo Kawachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Kawachi","raw_affiliation_strings":["Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mai Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mai Okamoto","raw_affiliation_strings":["Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shumpei Yonezawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shumpei Yonezawa","raw_affiliation_strings":["Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuka Morishige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Morishige","raw_affiliation_strings":["Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077883017","display_name":"Masayuki Azuma","orcid":"https://orcid.org/0000-0002-1443-0728","observed_orcids":["https://orcid.org/0000-0002-1443-0728"]},"institutions":[{"id":"https://openalex.org/I4387152983","display_name":"Osaka Metropolitan University","ror":"https://ror.org/01hvx5h04","country_code":"JP","type":"education","lineage":["https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Azuma","raw_affiliation_strings":["Department of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka 558-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka 558-8585, Japan","institution_ids":["https://openalex.org/I4387152983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049861668","display_name":"Akira Nishiyama","orcid":"https://orcid.org/0000-0001-5971-820X","observed_orcids":["https://orcid.org/0000-0001-5971-820X"]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Nishiyama","raw_affiliation_strings":["Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma & Supplemental Nutrition Solutions Vehicle, Pharma Business Division, Kaneka Corporation, 1-8, Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019811375"],"corresponding_institution_ids":["https://openalex.org/I4210131637","https://openalex.org/I4387152983"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2624,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.32293735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"28","issue":"11","first_page":"4003","last_page":"4010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11842","display_name":"Ultrasound and Cavitation Phenomena","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3102","display_name":"Acoustics and Ultrasonics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10402","display_name":"Phase Equilibria and Thermodynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sonocrystallization","display_name":"sonocrystallization","score":0.9819999933242798},{"id":"https://openalex.org/keywords/perampanel","display_name":"perampanel","score":0.9520000219345093},{"id":"https://openalex.org/keywords/continuous-crystallization","display_name":"continuous crystallization","score":0.7870000004768372},{"id":"https://openalex.org/keywords/polymorph-control","display_name":"polymorphism control","score":0.6370000243186951},{"id":"https://openalex.org/keywords/particle-size-control","display_name":"particle size control","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ultrasound","display_name":"ultrasound","score":0.5120000243186951},{"id":"https://openalex.org/keywords/msmpr-crystallizer","display_name":"MSMPR crystallizer","score":0.843999981880188},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pharmaceutical-crystallization","display_name":"pharmaceutical crystallization","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2780836401","wikidata":"https://www.wikidata.org/wiki/Q868658","display_name":"Perampanel","level":3,"score":0.6110354661941528},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5137323141098022},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5099004507064819},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.41951116919517517},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41013461351394653},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.33572638034820557},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24133378267288208},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22530940175056458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10970211029052734},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.10331946611404419},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07903844118118286},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0709523856639862},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.06096714735031128},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.oprd.4c00293","doi":"https://doi.org/10.1021/acs.oprd.4c00293","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.oprd.4c00293","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research &amp; Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1195955210","https://openalex.org/W1457414945","https://openalex.org/W1963885647","https://openalex.org/W1972157024","https://openalex.org/W1983162648","https://openalex.org/W2007345870","https://openalex.org/W2012197565","https://openalex.org/W2030821447","https://openalex.org/W2055172914","https://openalex.org/W2058199900","https://openalex.org/W2066530594","https://openalex.org/W2086999377","https://openalex.org/W2091280284","https://openalex.org/W2093316728","https://openalex.org/W2094614178","https://openalex.org/W2142720002","https://openalex.org/W2266425951","https://openalex.org/W2298439093","https://openalex.org/W2302481426","https://openalex.org/W2316099892","https://openalex.org/W2322156480","https://openalex.org/W2334592091","https://openalex.org/W2626499280","https://openalex.org/W2895333491","https://openalex.org/W2921034967","https://openalex.org/W2921484436","https://openalex.org/W2944350700","https://openalex.org/W3036305772","https://openalex.org/W3037947492","https://openalex.org/W3094089747","https://openalex.org/W3114767549","https://openalex.org/W3162024937","https://openalex.org/W3187971951","https://openalex.org/W3197356082","https://openalex.org/W3208029770","https://openalex.org/W4387091604","https://openalex.org/W4390738900","https://openalex.org/W4391486005","https://openalex.org/W4391777606"],"related_works":["https://openalex.org/W7155175620","https://openalex.org/W2302481426","https://openalex.org/W2030821447","https://openalex.org/W2933652471","https://openalex.org/W2969926512","https://openalex.org/W3036305772","https://openalex.org/W2738697670","https://openalex.org/W2278771383","https://openalex.org/W2008257378","https://openalex.org/W4403633168"],"abstract_inverted_index":{"Sonocrystallization":[0],"is":[1],"a":[2,73,107,118],"promising":[3],"technology":[4,81],"for":[5,26,40,120],"improving":[6],"the":[7,12,17,36,60,85,90,98,121,124],"reproducibility":[8],"and":[9,30,49,79,94],"productivity":[10],"of":[11,16,21,38,87,92,113,123],"crystallization":[13,41,71,86],"process":[14,101],"because":[15],"unique":[18],"cavitation":[19],"effect":[20],"ultrasound":[22,39,66,93,115],"as":[23,25],"well":[24],"controlling":[27],"crystal":[28],"polymorphs":[29],"particle":[31],"size.":[32],"Despite":[33],"these":[34],"advantages,":[35],"use":[37],"has":[42,50],"typically":[43],"been":[44,52],"limited":[45],"to":[46,84],"laboratory":[47],"studies":[48],"not":[51],"widely":[53],"adopted":[54],"on":[55],"an":[56],"industrial":[57],"scale":[58],"by":[59],"pharmaceutical":[61],"industry.":[62],"In":[63],"this":[64,80],"study,":[65],"was":[67,82,102],"combined":[68],"with":[69],"continuous":[70,99,125],"using":[72,106],"mixed-suspension,":[74],"mixed-product":[75],"removal":[76],"(MSMPR)":[77],"crystallizer,":[78],"applied":[83],"perampanel,":[88],"demonstrating":[89],"effects":[91],"its":[95],"practicality.":[96],"Finally,":[97],"sonocrystallization":[100,126],"successfully":[103],"scaled":[104],"up":[105],"10":[108],"L":[109],"ultrasonic":[110],"crystallizer":[111],"capable":[112],"direct":[114],"irradiation,":[116],"providing":[117],"methodology":[119],"scale-up":[122],"process.":[127]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-10-25T00:00:00"}
