{"id":"https://openalex.org/W4403727368","doi":"https://doi.org/10.14309/01.ajg.0001034384.17840.f4","title":"S1254 Head-to-Head Comparison Between Adalimumab and Infliximab in Perianal Crohn\u2019s Disease: A Systematic Review and Meta-Analysis","display_name":"S1254 Head-to-Head Comparison Between Adalimumab and Infliximab in Perianal Crohn\u2019s Disease: A Systematic Review and Meta-Analysis","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403727368","doi":"https://doi.org/10.14309/01.ajg.0001034384.17840.f4"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0001034384.17840.f4","doi":"https://doi.org/10.14309/01.ajg.0001034384.17840.f4","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001034384.17840.f4","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057582041","display_name":"Tarek Aboursheid","orcid":"https://orcid.org/0009-0009-5060-2855","observed_orcids":["https://orcid.org/0009-0009-5060-2855"]},"institutions":[{"id":"https://openalex.org/I1320343167","display_name":"Ascension","ror":"https://ror.org/00s1szh94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320343167"]},{"id":"https://openalex.org/I4210104042","display_name":"St. Francis Hospital","ror":"https://ror.org/01ed3w678","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104042","https://openalex.org/I4210121601"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tarek Aboursheid","raw_affiliation_strings":["Ascension Saint Francis Hospital, Evanston, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ascension Saint Francis Hospital, Evanston, IL;","institution_ids":["https://openalex.org/I1320343167","https://openalex.org/I4210104042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039696256","display_name":"Azizullah Beran","orcid":"https://orcid.org/0000-0002-4161-942X","observed_orcids":["https://orcid.org/0000-0002-4161-942X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azizullah Beran","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN;","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014551592","display_name":"Mohamad Hijazi","orcid":"https://orcid.org/0000-0001-5812-2375","observed_orcids":["https://orcid.org/0000-0001-5812-2375"]},"institutions":[{"id":"https://openalex.org/I4210150191","display_name":"TriHealth","ror":"https://ror.org/04jpa5e08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamad Hijazi","raw_affiliation_strings":["TriHealth Corporation, Cincinnati, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriHealth Corporation, Cincinnati, OH;","institution_ids":["https://openalex.org/I4210150191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049540259","display_name":"Mhd Kutaiba Albuni","orcid":"https://orcid.org/0000-0002-1417-8817","observed_orcids":["https://orcid.org/0000-0002-1417-8817"]},"institutions":[{"id":"https://openalex.org/I4210150191","display_name":"TriHealth","ror":"https://ror.org/04jpa5e08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mhd K. Albuni","raw_affiliation_strings":["TriHealth Corporation, Cincinnati, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriHealth Corporation, Cincinnati, OH;","institution_ids":["https://openalex.org/I4210150191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063856237","display_name":"Bisher Sawaf","orcid":"https://orcid.org/0000-0001-6751-619X","observed_orcids":["https://orcid.org/0000-0001-6751-619X"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bisher Sawaf","raw_affiliation_strings":["University of Toledo Health Sciences Campus, Toledo, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo Health Sciences Campus, Toledo, OH;","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020058923","display_name":"Khaled H. Abdeljawad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khaled Abdeljawad","raw_affiliation_strings":["Indiana University, Indianapolis, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University, Indianapolis, IN;","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113303493","display_name":"M Kenan Rahima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312636312","display_name":"Good Samaritan Hospital","ror":"https://ror.org/03rj2a342","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312636312","https://openalex.org/I4210150191"]},{"id":"https://openalex.org/I4210150191","display_name":"TriHealth","ror":"https://ror.org/04jpa5e08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Kenan Rahima","raw_affiliation_strings":["TriHealth Good Samaritan Hospital, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriHealth Good Samaritan Hospital, Cincinnati, OH","institution_ids":["https://openalex.org/I1312636312","https://openalex.org/I4210150191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5057582041"],"corresponding_institution_ids":["https://openalex.org/I1320343167","https://openalex.org/I4210104042"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"119","issue":"10S","first_page":"S893","last_page":"S893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perianal-fistulizing-crohn-s-disease","display_name":"perianal fistulizing Crohn's disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":0.9860000014305115},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":1.0},{"id":"https://openalex.org/keywords/anti-tnf-therapy","display_name":"anti-TNF therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/fistula-healing","display_name":"fistula healing","score":0.9660000205039978},{"id":"https://openalex.org/keywords/radiological-healing","display_name":"radiological healing","score":0.8510000109672546},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.6869999766349792},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.7749999761581421},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.7960000038146973},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7609999775886536},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.4950000047683716},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.47999998927116394},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.41100001335144043},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9679062366485596},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.8531606197357178},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.7945173978805542},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.547805666923523},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5239370465278625},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.48450252413749695},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43037551641464233},{"id":"https://openalex.org/C2780312720","wikidata":"https://www.wikidata.org/wiki/Q5689100","display_name":"Head (geology)","level":2,"score":0.4299287796020508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3005777597427368},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C114793014","wikidata":"https://www.wikidata.org/wiki/Q52109","display_name":"Geomorphology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0001034384.17840.f4","doi":"https://doi.org/10.14309/01.ajg.0001034384.17840.f4","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001034384.17840.f4","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410233052","https://openalex.org/W4385564241","https://openalex.org/W2031882359","https://openalex.org/W2020597287","https://openalex.org/W4406698710","https://openalex.org/W2611564874","https://openalex.org/W2611795730","https://openalex.org/W2792112423","https://openalex.org/W2977332840","https://openalex.org/W2936145716"],"abstract_inverted_index":{"Introduction:":[0],"Perianal":[1,383],"Fistulizing":[2],"Crohn's":[3],"disease":[4,385,399],"(PF-CD)":[5],"can":[6],"have":[7],"a":[8,80,83,135,184,328],"significant":[9,218,261],"deleterious":[10],"impact":[11],"on":[12,160,254,332,391],"the":[13,30,69,87,104,131,169,221,255,292,298,318,333,343,392],"quality":[14],"of":[15,32,35,71,86,97,106,112,171,186,200,300,321,324,345,394,396],"life,":[16],"and":[17,73,82,95,168,206,230,242,265,302],"its":[18],"management":[19,34],"presents":[20],"notable":[21],"clinical":[22,151],"challenges.":[23],"Anti-tumor":[24],"necrosis":[25],"factor":[26],"(TNF)":[27],"has":[28],"been":[29],"mainstay":[31],"medical":[33],"PF-CD,":[36,77],"especially":[37],"with":[38,108,122,183,189],"infliximab":[39],"(IFX),":[40],"but":[41],"other":[42],"Anti-TNF":[43],"medications":[44],"are":[45,371],"commonly":[46],"used":[47,233],"such":[48],"as":[49,148],"Adalimumab":[50],"(ADA).":[51],"Published":[52],"studies":[53,101,115,182,216,225,232],"primarily":[54],"evaluate":[55],"individual":[56],"treatments":[57],"rather":[58],"than":[59],"direct":[60],"comparisons":[61],"between":[62,203,220,240,263],"them.":[63],"In":[64],"order":[65],"to":[66,75,295,312,340,362,373],"directly":[67,296],"compare":[68,297],"efficacy":[70,105,299],"IFX":[72,109,243,266,303,313,341,363],"ADA":[74,107,241,264,301,309,337,356],"treat":[76],"we":[78,326],"conducted":[79],"met-analysis":[81],"systematic":[84],"review":[85],"current":[88],"literature.":[89],"Methods:":[90],"We":[91,306],"searched":[92],"PubMed,":[93],"Embase,":[94],"Web":[96],"Science":[98],"databases":[99],"for":[100,110,364],"that":[102,308,355],"compared":[103],"treatment":[111,201],"PF-CD.":[113,305,316,365],"Single-arm":[114],"were":[116,128,196],"excluded.":[117],"Pooled":[118],"risk":[119],"ratios":[120],"(RR)":[121],"corresponding":[123],"95%":[124,246,274,283],"confidence":[125],"intervals":[126],"(CIs)":[127],"calculated":[129],"by":[130,150],"Mantel-Haenszel":[132],"method":[133,164,258,393],"within":[134],"random-effect":[136],"model.":[137],"The":[138,198],"primary":[139],"outcome":[140],"was":[141,146,157,212,238,269,310,347],"overall":[142],"PF-CD":[143,161,236],"healing,":[144,325],"which":[145],"defined":[147],"healing":[149,162,173,228,237,256,334,346],"or":[152,279,350],"radiological":[153,172,177,322],"assessment.":[154],"Subgroup":[155,251,388],"analysis":[156,252,330,389],"performed":[158,270,327],"based":[159,253,390],"assessment":[163,257,268,323,335,344,395],"(clinical":[165],"vs":[166,175],"radiological)":[167],"degree":[170],"(partial":[174],"complete":[176],"healing).":[178],"Results:":[179],"Six":[180],"observational":[181],"total":[185],"590":[187],"patients":[188],"perianal":[190,397],"CD":[191],"(ADA":[192],"=216,":[193],"IFX=":[194],"374)":[195],"included.":[197],"duration":[199],"ranged":[202],"1":[204],"year":[205],"3.8":[207],"years.":[208],"Combined":[209],"immunomodulator":[210],"use":[211],"reported":[213],"in":[214,304,314],"3":[215],"without":[217],"difference":[219,262],"2":[222,231],"groups.":[223],"Four":[224],"evaluated":[226],"fistula":[227],"clinically":[229,271,349],"MRI.":[234],"Overall":[235,382],"comparable":[239],"(RR":[244,272,281],"0.90,":[245,273],"CI":[247,275,284],"0.76-1.06,":[248],"P":[249,277,286],"=0.20).":[250],"showed":[259],"no":[260],"whether":[267,342],"0.67-1.21,":[276],"=0.49)":[278],"radiologically":[280],"0.91,":[282],"0.74-1.13,":[285],"=0.40).":[287],"Conclusion:":[288],"Our":[289,352],"study":[290],"is":[291],"first":[293],"meta-analysis":[294],"found":[307],"non-inferior":[311,339],"treating":[315],"Considering":[317],"superior":[319],"accuracy":[320],"subgroup":[329],"focusing":[331],"method.":[336],"remained":[338],"done":[348],"radiologically.":[351],"findings":[353],"suggest":[354],"may":[357],"be":[358],"an":[359],"acceptable":[360],"alternative":[361],"Large-scale":[366],"head-to-head":[367],"randomized":[368],"controlled":[369],"trials":[370],"necessary":[372],"validate":[374],"our":[375],"results":[376],"(see":[377],"Figure":[378],"1).Figure":[379],"1.:":[380],"A)":[381],"Crohn\u2019s":[384,398],"healing.":[386,400],"B)":[387]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-10-25T00:00:00"}