{"id":"https://openalex.org/W4403725701","doi":"https://doi.org/10.14309/01.ajg.0001041928.94767.70","title":"S3140 Isolated Rectal Neurofibroma: A Case Report","display_name":"S3140 Isolated Rectal Neurofibroma: A Case Report","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403725701","doi":"https://doi.org/10.14309/01.ajg.0001041928.94767.70"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0001041928.94767.70","doi":"https://doi.org/10.14309/01.ajg.0001041928.94767.70","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001041928.94767.70","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113270194","display_name":"Zhexiang He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhexiang He","raw_affiliation_strings":["Presenter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Presenter","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109739735","display_name":"Shuja Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100184","display_name":"Conway Regional Health System","ror":"https://ror.org/019n7yz73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuja Khan","raw_affiliation_strings":["Conway Regional Health System, Conway, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conway Regional Health System, Conway, AR","institution_ids":["https://openalex.org/I4210100184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099644031","display_name":"Arthur Slaton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100184","display_name":"Conway Regional Health System","ror":"https://ror.org/019n7yz73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Slaton","raw_affiliation_strings":["Conway Regional Health System, Conway, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conway Regional Health System, Conway, AR","institution_ids":["https://openalex.org/I4210100184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073962795","display_name":"Owen Maat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100184","display_name":"Conway Regional Health System","ror":"https://ror.org/019n7yz73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Owen Maat","raw_affiliation_strings":["Conway Regional Health System, Conway, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Conway Regional Health System, Conway, AR","institution_ids":["https://openalex.org/I4210100184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113270194"],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"119","issue":"10S","first_page":"S2126","last_page":"S2127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11991","display_name":"Soft tissue tumor case studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-nerve-sheath-tumor","display_name":"peripheral nerve sheath tumor","score":0.8709999918937683},{"id":"https://openalex.org/keywords/rectal-bleeding","display_name":"rectal bleeding","score":0.6779999732971191},{"id":"https://openalex.org/keywords/malignant-peripheral-nerve-sheath-tumor","display_name":"malignant peripheral nerve sheath tumor","score":0.6539999842643738},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.953000009059906},{"id":"https://openalex.org/keywords/polypectomy","display_name":"polypectomy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/malignant-transformation-risk","display_name":"malignant transformation risk","score":0.5580000281333923},{"id":"https://openalex.org/keywords/surveillance-colonoscopy","display_name":"surveillance colonoscopy","score":0.546999990940094},{"id":"https://openalex.org/keywords/internal-hemorrhoids","display_name":"internal hemorrhoids","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9801486730575562},{"id":"https://openalex.org/C2777831590","wikidata":"https://www.wikidata.org/wiki/Q1418735","display_name":"Neurofibroma","level":3,"score":0.7621828317642212},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.42049315571784973},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3511291742324829},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2106601893901825},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.12199938297271729}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0001041928.94767.70","doi":"https://doi.org/10.14309/01.ajg.0001041928.94767.70","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001041928.94767.70","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400137527","https://openalex.org/W3029092029","https://openalex.org/W3208928506","https://openalex.org/W7161297158","https://openalex.org/W2978159754","https://openalex.org/W7155369896","https://openalex.org/W76343947","https://openalex.org/W2893454571","https://openalex.org/W1979689390","https://openalex.org/W4280515304"],"abstract_inverted_index":{"Introduction:":[0],"Neurofibromas":[1,258],"are":[2,17,38,278,288],"considered":[3],"benign":[4,196,260],"peripheral":[5,264,302],"nerve":[6,265,303],"sheath":[7,266,304],"tumors":[8,261,305],"containing":[9],"Schwann":[10,269],"cells,":[11,270],"fibroblasts,":[12,271],"and":[13,41,122,134,159,248,272,354],"perineurial":[14,273],"cells.":[15,274],"They":[16,209],"commonly":[18,279],"associated":[19,100,280],"with":[20,76,84,101,119,132,183,234,281,379,409,741],"familial":[21],"disorders,":[22],"such":[23],"as":[24],"neurofibromatosis":[25,353],"type":[26],"1,":[27,365],"NF2-related":[28],"schwannomatosis,":[29],"germline":[30],"PDGFRA-mutant":[31],"syndrome,":[32,283],"etc.":[33],"However,":[34],"isolated":[35,65,284,311,325,376],"colonic":[36,66,312,326,377],"neurofibromas":[37,233,277,285,293,313,327,378],"very":[39],"rare,":[40],"only":[42],"a":[43,61,73,77,85,108,129,213,218,251],"few":[44],"cases":[45],"were":[46,176,207,210,232],"reported":[47],"in":[48,178,199,228,254,584,608],"the":[49,52,93,149,179,189,226,229,295,307,318,337,350,358],"literature":[50],"during":[51],"last":[53],"several":[54],"decades.":[55],"In":[56,188],"this":[57,125],"report,":[58],"we":[59],"present":[60],"rare":[62,410],"case":[63],"of":[64,80,195,297,320,324,352,360,422,697],"neurofibroma.":[67],"Case":[68],"Description/Methods:":[69],"The":[70,110,140,221],"patient":[71,111,245],"is":[72,161,328,345],"55-year-old":[74],"woman":[75],"medical":[78],"history":[79],"coronary":[81],"artery":[82],"disease":[83,700],"stent":[86],"on":[87],"Plavix.":[88],"She":[89,151,167],"was":[90,246],"referred":[91],"to":[92,97,148,204,317,330,334,347],"gastroenterology":[94],"clinic":[95],"due":[96,316,333],"abdominal":[98,117,559,636],"pain":[99,118,469,740],"bleeding":[102,442,570,742],"that":[103,153,225],"had":[104,128],"been":[105],"occurring":[106],"for":[107,250,310],"week.":[109],"described":[112],"experiencing":[113],"left":[114,585,634],"lower":[115],"quadrant":[116],"severe":[120],"cramping":[121],"constipation.":[123],"During":[124],"period,":[126],"she":[127,160],"bowel":[130,165],"movement":[131],"blood":[133,649],"pus,":[135],"which":[136,170,175],"alleviated":[137],"her":[138,146,154],"pain.":[139],"episode":[141],"occurred":[142],"2":[143],"months":[144],"before":[145],"visit":[147],"clinic.":[150],"mentioned":[152],"symptoms":[155],"have":[156],"now":[157],"resolved,":[158],"having":[162],"regular":[163],"daily":[164],"movements.":[166],"underwent":[168],"colonoscopy":[169,253,501,513,540,667,685],"revealed":[171,224],"multiple":[172,276],"nonbleeding":[173],"diverticula":[174],"found":[177],"sigmoid":[180],"colon,":[181],"along":[182],"grade/stage":[184],"II":[185],"internal":[186],"hemorrhoids.":[187],"distal":[190,230],"rectum,":[191],"three":[192],"sentinel":[193],"polyps":[194,227],"appearance,":[197],"ranging":[198],"size":[200],"from":[201,263,670],"4":[202],"mm":[203],"10":[205,711],"mm,":[206],"discovered.":[208],"removed":[211],"through":[212],"single":[214],"piece":[215],"polypectomy":[216],"using":[217],"hot":[219],"snare.":[220],"pathology":[222,380],"report":[223],"rectum":[231],"SOX10":[235],"+,":[236,517,544,573,592,613,653,674,705,707,709,712,748],"desmin":[237,576,620,659,721],"\u2013,":[238,240,242,475,477,479,520,547,550,594,598,615,617,619,621,624,655,658,722,724,729,751,753],"CD117":[239,518,614,723,750],"DOG1":[241,752],"CD34":[243,480,593,616,654,713,754],"\u2013.The":[244],"contacted":[247],"scheduled":[249],"follow-up":[252],"6":[255],"months.":[256],"Discussion:":[257],"represent":[259],"emerging":[262],"components,":[267],"comprising":[268],"While":[275,291],"hereditary":[282],"exist":[286],"but":[287],"not":[289],"well-described.":[290],"NF1-associated":[292],"harbor":[294],"risk":[296,359],"malignant":[298,301,361],"transformation":[299,362],"into":[300],"(MPNSTs),":[306],"malignancy":[308],"potential":[309],"remains":[314,341],"uncertain":[315],"lack":[319],"data.The":[321],"clinical":[322],"significance":[323],"yet":[329],"be":[331,355],"established":[332],"its":[335],"rarity;":[336],"optimal":[338],"management":[339],"strategy":[340],"uncertain.":[342],"Close":[343],"monitoring":[344],"advocated":[346],"both":[348],"exclude":[349],"possibility":[351],"vigilant":[356],"about":[357],"(see":[363],"Figure":[364],"Table":[366,372],"1).Figure":[367],"1.:":[368],"Distal":[369,743],"Rectal":[370,441,453,569,744],"Polyp.":[371],"1.":[373],"-":[374,461],"All":[375],"reports":[381],"Reference":[382],"Age":[383],"Sex":[384],"Presentation":[385],"Location":[386],"Pathology":[387],"Keith":[388],"(1937)":[389],"[7]":[390],"50":[391],"Female":[392,416,452,466,486,510,538,557,568,605,645,683,738],"Pain":[393,489,528,583],"Rectum":[394,405,420,431,571],"Benign":[395],"spindle":[396],"cell":[397,407],"lesion":[398,408],"Woolf":[399],"(1938)":[400],"[8]":[401],"70":[402,509],"Male":[403,440,499,527,632,665,694],"Asymptomatic":[404],"Spindle":[406],"mitoses":[411],"Butler":[412],"(1959)":[413],"[9]":[414],"45":[415,728],"Pain,":[417,606],"bleeding,":[418,454],"tenesmus":[419,455],"Features":[421],"plexiform":[423],"neurofibroma":[424],"Geboes":[425],"(1978)":[426],"[10]":[427],"N/A":[428,429],"NA":[430],"Diagnosis":[432],"confirmed":[433],"by":[434],"electron":[435],"microscopy":[436],"Abramson(1997)":[437],"[11]":[438],"53":[439],"Transverse":[443,502,561],"colon":[444,471,492,515,531,542,562,590,687],"Neurofibroma":[445,563,640,703],"S100":[446,706],"+":[447,459,494,505,533,689,714,717],"Bononi":[448],"(2000)":[449],"[12]":[450],"68":[451],"Diffuse":[456],"involvement":[457],"NeurofibromaS100":[458,493,504,516,532,543,572,591,612,652,673,688],"SMA":[460,476,551],"Panteris":[462],"(2005)":[463],"[13]":[464],"65":[465],"Bloody":[467],"diarrheaAbdominal":[468],"Descending":[470],"NeurofibromaS100+,":[472],"Vimentin+,":[473],"Desmin":[474,521,599],"c-kit":[478,656],"\u2013":[481,522,552,577,600,660,732,755],"Carter":[482],"(2008)":[483],"[14]":[484],"52":[485,526],"Non-bloody":[487],"diarrhea,":[488],"Rectum,":[490],"transverse":[491],"Hindy":[495],"(2012)":[496],"[15]":[497],"59":[498],"Screening":[500,512,539,666,684],"Colon":[503,745],"Chelimilla":[506],"(2013)":[507],"[16]":[508],"Asymptomatic,":[511],"Ascending":[514,686],"\u2013SMA":[519],"Bilal":[523],"(2016)":[524,535,554,565],"[17]":[525],"Proximal":[529],"descending":[530],"Ahn":[534],"[18]":[536],"26":[537],"Sigmoid":[541,589],"CD34+,c-Kit":[545],"(CD117)":[546,597,657],"DOG":[548,622,730],"1":[549,623,731],"Kassi":[553],"[19]":[555],"37":[556],"Painful":[558],"mass":[560,637],"Parmar":[564],"[20]":[566],"13":[567],"c-Kit":[574],"(CD117)\u2013,":[575],"Adioui":[578],"(2018)":[579,602,629],"[21]":[580],"29":[581],"Fenale":[582],"iliac":[586],"fossa,":[587],"Fatigue":[588],"C-":[595],"Kit":[596],"Miao":[601],"[22]":[603],"24":[604],"Mass":[607],"stool":[609],"Ileocecal":[610],"valve":[611],"Actin":[618],"Low":[625,675],"Ki":[626,676],"67":[627,677],"Olakayode":[628],"[23]":[630],"12":[631],"Painless":[633],"hypochondrial":[635],"Splenic":[638],"flexure":[639,651],"Imagami":[641],"(2020)":[642,662,680],"[24]":[643],"81":[644],"Positive":[646],"fecal":[647],"occult":[648],"Hepatic":[650],"Ghoneim":[661],"[25]":[663],"51":[664],"15":[668],"cm":[669],"anal":[671],"verge":[672],"index":[678],"Sun":[679],"[26]":[681],"33":[682],"Tinguria":[690],"(2022)":[691],"[27]":[692],"76":[693],"Anemia":[695],"Symptoms":[696],"gastroesophageal":[698],"reflux":[699],"(GERD)":[701],"SigmoidColon":[702],"Vimentin":[704],"EMA":[708],"SOX":[710],"(Patchy),":[715],"Neurofilament":[716],"(in":[718],"axonal":[719],"elements),":[720],"Pan-cytokeratin":[725],"(AE1/AE3)\u2013,":[726],"HMB":[727],"He":[733],"(2024)":[734],"Current":[735],"study":[736],"55":[737],"Abdominal":[739],"Spindled":[746],"neurofibromaSOX10":[747],"desmin\u2013,":[749]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-25T00:00:00"}