{"id":"https://openalex.org/W4403719933","doi":"https://doi.org/10.14309/01.ajg.0001038632.31477.af","title":"S2316 Appropriate Use of PPIs in the Outpatient Setting and the Consequences of their Long-term Use","display_name":"S2316 Appropriate Use of PPIs in the Outpatient Setting and the Consequences of their Long-term Use","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403719933","doi":"https://doi.org/10.14309/01.ajg.0001038632.31477.af"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0001038632.31477.af","doi":"https://doi.org/10.14309/01.ajg.0001038632.31477.af","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001038632.31477.af","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093087761","display_name":"Ramy Sekla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ramy Sekla","raw_affiliation_strings":["Presenter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Presenter","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113886565","display_name":"Mena Tawfik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151507","display_name":"Parkview Medical Center","ror":"https://ror.org/04r3w0y76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mena Tawfik","raw_affiliation_strings":["Parkview Medical Center, Pueblo, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parkview Medical Center, Pueblo, CO","institution_ids":["https://openalex.org/I4210151507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068937472","display_name":"Aleena Sammar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151507","display_name":"Parkview Medical Center","ror":"https://ror.org/04r3w0y76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleena Sammar","raw_affiliation_strings":["Parkview Medical Center, Pueblo, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parkview Medical Center, Pueblo, CO","institution_ids":["https://openalex.org/I4210151507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064117516","display_name":"Kourtney Aylor-Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151507","display_name":"Parkview Medical Center","ror":"https://ror.org/04r3w0y76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kourtney Aylor-Lee","raw_affiliation_strings":["Parkview Medical Center, Pueblo, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parkview Medical Center, Pueblo, CO","institution_ids":["https://openalex.org/I4210151507"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5093087761"],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"119","issue":"10S","first_page":"S1662","last_page":"S1663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.15710000693798065,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/long-term-ppi-use","display_name":"long-term PPI use","score":0.7900000214576721},{"id":"https://openalex.org/keywords/appropriate-prescribing","display_name":"appropriate prescribing","score":0.5830000042915344},{"id":"https://openalex.org/keywords/hypomagnesemia","display_name":"hypomagnesemia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.5889999866485596},{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.6930000185966492},{"id":"https://openalex.org/keywords/reflux-esophagitis","display_name":"reflux esophagitis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/overprescribing","display_name":"overprescribing","score":0.6499999761581421},{"id":"https://openalex.org/keywords/outpatient-care","display_name":"outpatient care","score":0.4009999930858612},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.49900001287460327},{"id":"https://openalex.org/keywords/quality-improvement","display_name":"quality improvement","score":0.5820000171661377},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9770044088363647},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6896949410438538},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48575571179389954},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0001038632.31477.af","doi":"https://doi.org/10.14309/01.ajg.0001038632.31477.af","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001038632.31477.af","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7114811088","https://openalex.org/W4416030516","https://openalex.org/W4403726697","https://openalex.org/W4416030737","https://openalex.org/W2625321173","https://openalex.org/W3140623768","https://openalex.org/W2921126231","https://openalex.org/W4313248739","https://openalex.org/W2911622735","https://openalex.org/W2885286595"],"abstract_inverted_index":{"Introduction:":[0],"Gastroesophageal":[1],"(GERD)is":[2],"one":[3],"of":[4,34,56,80,191,230,247,268,279,322,375,380],"the":[5,22,78,92,160,280,313,376],"most":[6,377],"common":[7,378],"diseases":[8],"encountered":[9],"by":[10],"primary":[11,72],"care":[12],"physicians":[13],"(PCPs)":[14],"and":[15,88,116,144,255,271,277,319,354],"gastroenterologists.":[16],"Proton":[17],"pump":[18],"inhibitors":[19],"(PPIs)":[20],"remain":[21],"mainstay":[23],"treatment;":[24],"however,":[25],"multiple":[26],"studies":[27],"raised":[28],"questions":[29],"about":[30,41],"adverse":[31,102,387],"events,":[32],"safety":[33],"long-term":[35,100,203,349,367],"use":[36,311],"in":[37,60,312],"addition":[38],"to":[39,68,76,90,98,152,316,338,372,383],"concerns":[40],"overprescribing":[42],"PPIs.":[43],"Methods:":[44],"We":[45],"conducted":[46],"a":[47,300,335],"quality":[48],"improvement,":[49],"prospective,":[50],"single":[51],"center":[52],"study":[53],"including":[54,104],"patients":[55,81,132,158,164,281,361],"UCHealth":[57],"Parkview":[58],"Clinic":[59],"Pueblo,":[61],"CO,":[62],"receiving":[63,82,142],"PPIs":[64],"from":[65],"February":[66,69],"2023":[67],"2024.":[70],"The":[71],"end":[73],"point":[74],"was":[75,97],"assess":[77,99],"percentage":[79],"PPI":[83,123,143,174,183,310,332,345,381],"for":[84,147,182,202,206,284],"an":[85,199],"appropriate":[86,200],"indication":[87,201,337],"attempt":[89],"wean":[91],"rest.":[93],"A":[94,288],"secondary":[95],"endpoint":[96],"potential":[101,386],"events":[103],"chronic":[105],"kidney":[106],"disease":[107],"(CKD)":[108],"progression,":[109],"hypomagnesemia,":[110,238],"osteoporosis,":[111],"fractures,":[112],"dementia,":[113],"Clostridioides":[114],"difficile,":[115],"pneumonia.":[117],"Patients":[118,235],"with":[119,134,150,223,244,258,265,305,343,365],"GERD":[120],"symptoms":[121,318],"on":[122,340,357],"during":[124],"that":[125,193],"period":[126],"were":[127,131,166,214,327],"included.":[128],"Exclusion":[129],"criteria":[130],"managed":[133],"lifestyle":[135],"modifications":[136],"or":[137,218,224,227,333],"H2":[138],"blockers":[139],"but":[140,243,264],"not":[141],"those":[145,192,385],"lost":[146],"follow":[148],"up":[149],"inability":[151],"extract":[153],"their":[154,248,269],"data.":[155],"Results:":[156],"Eighty-six":[157],"met":[159],"inclusion":[161],"criteria;":[162],"25":[163],"(29%)":[165],"successfully":[167,329],"weaned":[168,330],"off":[169,331],"PPI;":[170],"61":[171],"(71%)":[172],"continued":[173,194],"after":[175],"1":[176],"year,":[177],"despite":[178],"our":[179,344],"best":[180],"efforts":[181],"deprescribing,":[184],"when":[185],"clinically":[186],"indicated":[187],"(Figure":[188],"1).":[189],"Out":[190],"PPI,":[195,210],"16":[196],"(26.22%)":[197],"had":[198,237,241,253,262,274,334],"use.":[204,368],"Indications":[205],"long":[207],"term":[208],"maintenance":[209,341],"per":[211],"ACG":[212],"guidelines,":[213],"LA":[215],"grade":[216],"C":[217],"D":[219],"esophagitis,":[220],"Barrett\u2019s":[221],"esophagus":[222],"without":[225],"dysplasia,":[226],"documented":[228],"history":[229],"bleeding":[231],"GI":[232],"ulcers.":[233],"Seventeen":[234],"(19.76%)":[236],"9":[239],"(10.4%)":[240],"CKD":[242,249],"no":[245,266],"progression":[246,267],"stage;":[250],"21":[251],"(24.4%)":[252],"osteoporosis":[254],"11":[256],"(12.79%)":[257],"osteopenia.":[259],"Four":[260],"(4.6%)":[261],"dementia":[263],"symptoms,":[270],"8":[272],"(9.3%)":[273],"bacterial":[275],"pneumonia":[276],"none":[278],"tested":[282],"positive":[283],"C.":[285],"difficile.":[286],"Conclusion:":[287],"large":[289],"US":[290],"retrospective":[291],"database":[292],"study,":[293],"evaluating":[294],"more":[295,360],"than":[296],"50,000":[297],"patients,":[298],"demonstrated":[299],"substantial":[301],"annual":[302],"cost":[303],"burden":[304],"GERD.":[306],"Current":[307],"guidelines":[308],"recommend":[309],"lowest":[314],"dose":[315],"control":[317],"maintain":[320],"healing":[321],"reflux":[323],"esophagitis.":[324],"Forty-onepatients":[325],"(47.6%)":[326],"either":[328],"clinical":[336],"be":[339,373],"therapy":[342],"deprescribing":[346,382],"approach.":[347],"While":[348],"side":[350],"effects":[351],"are":[352,362],"uncommon":[353],"mainly":[355],"based":[356],"observational":[358],"studies,":[359],"at":[363],"risk":[364],"increased":[366],"It":[369],"is":[370],"prudent":[371],"aware":[374],"approaches":[379],"avoid":[384],"events.Figure":[388],"1.:":[389],"Graphs.":[390]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2024-10-25T00:00:00"}