{"id":"https://openalex.org/W4403714191","doi":"https://doi.org/10.1038/s41598-024-76674-6","title":"Optimized partial freezing protocol enables 10-day storage of rat livers","display_name":"Optimized partial freezing protocol enables 10-day storage of rat livers","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403714191","doi":"https://doi.org/10.1038/s41598-024-76674-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/39011100"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-76674-6","doi":"https://doi.org/10.1038/s41598-024-76674-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-76674-6","pdf_url":"https://www.nature.com/articles/s41598-024-76674-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-024-76674-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086728549","display_name":"Ozge Sila Ozgur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ozge Sila Ozgur","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087476292","display_name":"McLean S. Taggart","orcid":"https://orcid.org/0000-0003-3889-3513","observed_orcids":["https://orcid.org/0000-0003-3889-3513"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mclean Taggart","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113279040","display_name":"Mohammedreza Mojoudi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammedreza Mojoudi","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035289950","display_name":"Casie A. Pendexter","orcid":"https://orcid.org/0000-0003-0484-6997","observed_orcids":["https://orcid.org/0000-0003-0484-6997"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casie Pendexter","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069979579","display_name":"Irina Filz von Reiterdank","orcid":"https://orcid.org/0000-0002-0234-2704","observed_orcids":["https://orcid.org/0000-0002-0234-2704"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Filz von Reiterdank","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092766910","display_name":"Anil Kharga","orcid":"https://orcid.org/0009-0008-6887-6224","observed_orcids":["https://orcid.org/0009-0008-6887-6224"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Kharga","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009785468","display_name":"Heidi Yeh","orcid":"https://orcid.org/0000-0002-7379-0600","observed_orcids":["https://orcid.org/0000-0002-7379-0600"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi Yeh","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075867487","display_name":"Mehmet Toner","orcid":"https://orcid.org/0000-0002-3647-3665","observed_orcids":["https://orcid.org/0000-0002-3647-3665"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Toner","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034721456","display_name":"Alban Longchamp","orcid":"https://orcid.org/0000-0002-1743-4935","observed_orcids":["https://orcid.org/0000-0002-1743-4935"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alban Longchamp","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA","Shriners Hospitals for Children, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084682391","display_name":"Shannon N. Tessier","orcid":"https://orcid.org/0000-0003-2373-232X","observed_orcids":["https://orcid.org/0000-0003-2373-232X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shannon N. Tessier","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. SNTESSIER@mgh.harvard.edu","Shriners Hospitals for Children, Boston, MA, USA. SNTESSIER@mgh.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. SNTESSIER@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA. SNTESSIER@mgh.harvard.edu","institution_ids":["https://openalex.org/I4210115081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042296246","display_name":"Korkut Uygun","orcid":"https://orcid.org/0000-0003-2088-7860","observed_orcids":["https://orcid.org/0000-0003-2088-7860"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210115081","display_name":"Shriners Hospitals for Children - Boston","ror":"https://ror.org/02g397b52","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115081","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Korkut Uygun","raw_affiliation_strings":["Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. KUYGUN@mgh.harvard.edu","Shriners Hospitals for Children, Boston, MA, USA. KUYGUN@mgh.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. KUYGUN@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Boston, MA, USA. KUYGUN@mgh.harvard.edu","institution_ids":["https://openalex.org/I4210115081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042296246","https://openalex.org/A5084682391"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210115081"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":6.4936,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.9766721,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"25260","last_page":"25260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/partial-freezing","display_name":"partial freezing","score":0.9639999866485596},{"id":"https://openalex.org/keywords/organ-cryopreservation","display_name":"organ cryopreservation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/liver-preservation","display_name":"liver preservation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/subzero-storage","display_name":"subzero storage","score":0.781000018119812},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ice-nucleation","display_name":"ice nucleation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/vascular-resistance","display_name":"vascular resistance","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tissue-edema","display_name":"tissue edema","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.6679999828338623},{"id":"https://openalex.org/keywords/static-cold-storage","display_name":"static cold storage","score":0.6990000009536743},{"id":"https://openalex.org/keywords/organ-transplantation","display_name":"organ transplantation","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C68528507","wikidata":"https://www.wikidata.org/wiki/Q692267","display_name":"Cryoprotectant","level":4,"score":0.899161696434021},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.734923243522644},{"id":"https://openalex.org/C2988529969","wikidata":"https://www.wikidata.org/wiki/Q5142478","display_name":"Cold storage","level":2,"score":0.6691465377807617},{"id":"https://openalex.org/C95053279","wikidata":"https://www.wikidata.org/wiki/Q672832","display_name":"Cryobiology","level":4,"score":0.4675281047821045},{"id":"https://openalex.org/C2908988968","wikidata":"https://www.wikidata.org/wiki/Q763244","display_name":"Blood preservation","level":2,"score":0.43967896699905396},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.4314810335636139},{"id":"https://openalex.org/C168529131","wikidata":"https://www.wikidata.org/wiki/Q13656562","display_name":"Osmotic shock","level":3,"score":0.4220028221607208},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3929818272590637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3463648855686188},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3439885973930359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2701862156391144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21825110912322998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2056778073310852},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-024-76674-6","doi":"https://doi.org/10.1038/s41598-024-76674-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-76674-6","pdf_url":"https://www.nature.com/articles/s41598-024-76674-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4584242/v1","doi":"https://doi.org/10.21203/rs.3.rs-4584242/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-4584242/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:39011100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39011100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmid:39448774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39448774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11502795","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11502795","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11502795/pdf/41598_2024_Article_76674.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11247935","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11247935","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0a44f97abddf4e259e421489770299b9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0a44f97abddf4e259e421489770299b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-76674-6","doi":"https://doi.org/10.1038/s41598-024-76674-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-76674-6","pdf_url":"https://www.nature.com/articles/s41598-024-76674-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1656549027","display_name":null,"funder_award_id":"R01HL157803","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1772008459","display_name":null,"funder_award_id":"R01DK114506","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2010549676","display_name":null,"funder_award_id":"EEC 1941543","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2426309849","display_name":null,"funder_award_id":"R01 DK114506","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2432075724","display_name":"High subzero preservation of liver for transplantation","funder_award_id":"3r01dk114506-07s1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2631201405","display_name":null,"funder_award_id":"R01DK096075","funder_id":"https://openalex.org/F4320313002","funder_display_name":"Shriners Hospitals for Children"},{"id":"https://openalex.org/G2699583584","display_name":null,"funder_award_id":"R01 DK096075","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G353039596","display_name":null,"funder_award_id":"R01DK114506","funder_id":"https://openalex.org/F4320313002","funder_display_name":"Shriners Hospitals for Children"},{"id":"https://openalex.org/G5535173492","display_name":null,"funder_award_id":"R01EB028782","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6628441132","display_name":null,"funder_award_id":"K99/R00 HL1431149","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G738160294","display_name":null,"funder_award_id":"K99-R00","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7960091169","display_name":"NSF Engineering Research Center for Advanced Technologies for Preservation of Biological Systems (ATP-Bio)","funder_award_id":"1941543","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8181044754","display_name":"Role of endogenous hydrogen sulfide in the control of vascular aging","funder_award_id":"185927","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G9000042905","display_name":null,"funder_award_id":"R01EB028782","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000078997","display_name":null,"funder_award_id":"R01HL157803","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000100809","display_name":null,"funder_award_id":"R01DK096075","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000174082","display_name":null,"funder_award_id":"R24OD034189","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000194663","display_name":null,"funder_award_id":"R01DK114506","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000898729","display_name":"A quantitative viability metric for liver transplantation using Resonance Raman Spectroscopy","funder_award_id":"R01DK134590","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320313002","display_name":"Shriners Hospitals for Children","ror":"https://ror.org/03e8tm275"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403714191.pdf","grobid_xml":"https://content.openalex.org/works/W4403714191.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1592290913","https://openalex.org/W1656145083","https://openalex.org/W1965120035","https://openalex.org/W1981622038","https://openalex.org/W1995195785","https://openalex.org/W2001748786","https://openalex.org/W2010911756","https://openalex.org/W2014380192","https://openalex.org/W2021829052","https://openalex.org/W2022541258","https://openalex.org/W2023506360","https://openalex.org/W2029078848","https://openalex.org/W2030485704","https://openalex.org/W2032983989","https://openalex.org/W2044347649","https://openalex.org/W2073057280","https://openalex.org/W2094592516","https://openalex.org/W2098252463","https://openalex.org/W2114109537","https://openalex.org/W2128354723","https://openalex.org/W2167623723","https://openalex.org/W2290531317","https://openalex.org/W2325372602","https://openalex.org/W2366586089","https://openalex.org/W2491410206","https://openalex.org/W2592436647","https://openalex.org/W2592581276","https://openalex.org/W2621460803","https://openalex.org/W2781832454","https://openalex.org/W3000332038","https://openalex.org/W3081635159","https://openalex.org/W3113731465","https://openalex.org/W3137808688","https://openalex.org/W4220902067","https://openalex.org/W4229442342","https://openalex.org/W4285593015","https://openalex.org/W4298616574","https://openalex.org/W4312187092","https://openalex.org/W4321791315","https://openalex.org/W4322489648","https://openalex.org/W4376651090","https://openalex.org/W4380051241","https://openalex.org/W4385637317","https://openalex.org/W4401558346","https://openalex.org/W6656375244","https://openalex.org/W6772662403"],"related_works":["https://openalex.org/W2475406839","https://openalex.org/W2103885090","https://openalex.org/W2018201699","https://openalex.org/W1967974915","https://openalex.org/W2009793436","https://openalex.org/W4311762970","https://openalex.org/W12371713","https://openalex.org/W585089950","https://openalex.org/W1591913692","https://openalex.org/W1520531555"],"abstract_inverted_index":{"Preserving":[0],"organs":[1],"at":[2,35],"subzero":[3],"temperatures":[4],"with":[5,77,109,157],"halted":[6],"metabolic":[7],"activity":[8],"holds":[9],"the":[10,17,116,147,168,176],"potential":[11],"to":[12,65,86,164],"prolong":[13],"preservation":[14,119,192],"and":[15,50,57,90,120,126,140,161,193],"expand":[16],"donor":[18],"organ":[19,188],"pool":[20],"for":[21,63,154],"transplant.":[22],"Our":[23],"group":[24],"recently":[25],"introduced":[26],"partial":[27,74],"freezing,":[28],"a":[29,61,183],"novel":[30],"approach":[31],"in":[32,97,186],"high-subzero":[33],"storage":[34,40],"-15\u00b0C,":[36],"enabling":[37],"5":[38,165],"days":[39,156],"of":[41,83,170],"rodent":[42],"livers":[43,150,174],"through":[44,94,190],"precise":[45],"control":[46],"over":[47],"ice":[48,88],"nucleation":[49],"unfrozen":[51],"fraction.":[52],"However,":[53],"increased":[54,81,134],"vascular":[55,138,159],"resistance":[56,139,160],"tissue":[58],"edema":[59],"suggested":[60],"need":[62],"improvements":[64],"extend":[66],"viable":[67],"preservation.":[68,129],"Here,":[69],"we":[70,143],"describe":[71],"an":[72,95,110],"optimized":[73,148],"freezing":[75],"protocol":[76],"key":[78],"optimizations":[79],"including":[80],"concentration":[82],"propylene":[84],"glycol":[85],"reduce":[87],"recrystallization":[89],"maintained":[91],"osmotic":[92],"balance":[93],"increase":[96],"bovine":[98],"serum":[99],"albumin,":[100],"all":[101],"while":[102],"minimizing":[103],"sheer":[104],"stress":[105],"during":[106,118],"cryoprotectant":[107],"unloading":[108],"acclimation":[111],"period.":[112],"These":[113],"approaches":[114],"ensured":[115],"viability":[117,169],"recovery":[121],"processes,":[122],"promoting":[123],"liver":[124],"function":[125],"ensuring":[127],"optimal":[128],"This":[130,180],"was":[131],"evidenced":[132],"by":[133],"oxygen":[135],"consumption,":[136],"decreased":[137],"edema.":[141],"Ultimately,":[142],"show":[144],"that":[145],"using":[146],"protocol,":[149],"can":[151],"be":[152],"stored":[153,173],"10":[155],"comparable":[158],"lactate":[162],"levels":[163],"days,":[166],"outperforming":[167],"time-matched":[171],"cold":[172],"as":[175],"current":[177],"gold":[178],"standard.":[179],"study":[181],"represents":[182],"significant":[184],"advancement":[185],"expanding":[187],"availability":[189],"prolonged":[191],"thereby":[194],"revolutionizing":[195],"transplant":[196],"medicine.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
