{"id":"https://openalex.org/W4403714167","doi":"https://doi.org/10.1142/s1793984424300085","title":"A Review Hydrogel Nanoparticle in Drug Delivery: Properties and Applications","display_name":"A Review Hydrogel Nanoparticle in Drug Delivery: Properties and Applications","publication_year":2024,"publication_date":"2024-10-25","ids":{"openalex":"https://openalex.org/W4403714167","doi":"https://doi.org/10.1142/s1793984424300085"},"language":"en","primary_location":{"id":"doi:10.1142/s1793984424300085","doi":"https://doi.org/10.1142/s1793984424300085","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s1793984424300085","pdf_url":null,"source":{"id":"https://openalex.org/S4210174734","display_name":"Nano LIFE","issn_l":"1793-9844","issn":["1793-9844","1793-9852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano LIFE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Aliaa Ahmed Jasim","orcid":"https://orcid.org/0009-0003-2718-3812","observed_orcids":["https://orcid.org/0009-0003-2718-3812"]},"institutions":[{"id":"https://openalex.org/I4387153874","display_name":"Al-Zahraa University for Women","ror":"https://ror.org/05c2btq38","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4387153874"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Aliaa Ahmed Jasim","raw_affiliation_strings":["Collage of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq"],"raw_orcid":"https://orcid.org/0009-0003-2718-3812","affiliations":[{"raw_affiliation_string":"Collage of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq","institution_ids":["https://openalex.org/I4387153874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114389526","display_name":"Jameel M. Dhabab","orcid":"https://orcid.org/0009-0002-2610-3107","observed_orcids":["https://orcid.org/0009-0002-2610-3107"]},"institutions":[{"id":"https://openalex.org/I4405255115","display_name":"Alnukhba University College","ror":"https://ror.org/02mvf8z51","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405255115"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Jameel M. Dhabab","raw_affiliation_strings":["Chemistry Department, Al-Nukhba University College, Baghdad, Iraq"],"raw_orcid":"https://orcid.org/0009-0002-2610-3107","affiliations":[{"raw_affiliation_string":"Chemistry Department, Al-Nukhba University College, Baghdad, Iraq","institution_ids":["https://openalex.org/I4405255115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079316536","display_name":"Ahmed Mahdi Rheima","orcid":"https://orcid.org/0000-0003-3533-3393","observed_orcids":["https://orcid.org/0000-0003-3533-3393"]},"institutions":[{"id":"https://openalex.org/I15873915","display_name":"Mustansiriyah University","ror":"https://ror.org/05s04wy35","country_code":"IQ","type":"education","lineage":["https://openalex.org/I15873915"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ahmed Mahdi Rheima","raw_affiliation_strings":["College of Science, Chemistry Department, Mustansiriyah University, Baghdad, Iraq"],"raw_orcid":"https://orcid.org/0000-0003-3533-3393","affiliations":[{"raw_affiliation_string":"College of Science, Chemistry Department, Mustansiriyah University, Baghdad, Iraq","institution_ids":["https://openalex.org/I15873915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024854983","display_name":"Haider Kamil Zaidan","orcid":"https://orcid.org/0000-0003-4060-2092","observed_orcids":["https://orcid.org/0000-0003-4060-2092"]},"institutions":[{"id":"https://openalex.org/I4400573189","display_name":"Al-Mustaqbal University","ror":"https://ror.org/023a3xe97","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4400573189"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Haider Kamil Zaidan","raw_affiliation_strings":["College of Nursing, Al-Mustaqbal University, 51001 Babylon, Iraq"],"raw_orcid":"https://orcid.org/0000-0003-4060-2092","affiliations":[{"raw_affiliation_string":"College of Nursing, Al-Mustaqbal University, 51001 Babylon, Iraq","institution_ids":["https://openalex.org/I4400573189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072834607","display_name":"Zainab Talib Al-Sharify","orcid":"https://orcid.org/0000-0002-3870-3815","observed_orcids":["https://orcid.org/0000-0002-3870-3815"]},"institutions":[{"id":"https://openalex.org/I4405270746","display_name":"Al-Hikma University College","ror":"https://ror.org/018gk6662","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405270746"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB","IQ"],"is_corresponding":false,"raw_author_name":"Zainab T. Al-Sharify","raw_affiliation_strings":["Chemistry Department, Al Hikma University College, Baghdad, Iraq","School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT, Birmingham, UK"],"raw_orcid":"https://orcid.org/0000-0002-3870-3815","affiliations":[{"raw_affiliation_string":"Chemistry Department, Al Hikma University College, Baghdad, Iraq","institution_ids":["https://openalex.org/I4405270746"]},{"raw_affiliation_string":"School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT, Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100499717","display_name":"Duaa Mohammed Athair","orcid":"https://orcid.org/0009-0000-1630-6715","observed_orcids":["https://orcid.org/0009-0000-1630-6715"]},"institutions":[{"id":"https://openalex.org/I15873915","display_name":"Mustansiriyah University","ror":"https://ror.org/05s04wy35","country_code":"IQ","type":"education","lineage":["https://openalex.org/I15873915"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Duaa Mohammed Athair","raw_affiliation_strings":["Office of the Scientific Assistant, Technology Incubator Division, Mustansiriyah University, Baghdad, Iraq"],"raw_orcid":"https://orcid.org/0009-0000-1630-6715","affiliations":[{"raw_affiliation_string":"Office of the Scientific Assistant, Technology Incubator Division, Mustansiriyah University, Baghdad, Iraq","institution_ids":["https://openalex.org/I15873915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068474193","display_name":"Ehsan Kianfar","orcid":"https://orcid.org/0000-0002-7213-3772","observed_orcids":["https://orcid.org/0000-0002-7213-3772"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I4210093963","display_name":"Islamic Azad University of Gachsaran","ror":"https://ror.org/00nt0xf41","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210093963"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ehsan Kianfar","raw_affiliation_strings":["Young Researchers and Elite Club, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-7213-3772","affiliations":[{"raw_affiliation_string":"Young Researchers and Elite Club, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I4210093963"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3282,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.34132383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12642","display_name":"Polymer-Based Agricultural Enhancements","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":1.0},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7379999756813049},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hydrogel-synthesis","display_name":"hydrogel synthesis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/natural-polymers","display_name":"natural polymers","score":0.8100000023841858},{"id":"https://openalex.org/keywords/synthetic-polymers","display_name":"synthetic polymers","score":1.0},{"id":"https://openalex.org/keywords/hybrid-hydrogels","display_name":"hybrid hydrogels","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bioprinting","display_name":"bioprinting","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.9670000076293945},{"id":"https://openalex.org/keywords/stimuli-responsive-hydrogels","display_name":"stimuli-responsive hydrogels","score":0.8389999866485596},{"id":"https://openalex.org/keywords/self-healing-hydrogels","display_name":"self-healing hydrogels","score":1.0},{"id":"https://openalex.org/keywords/bioactive-hydrogels","display_name":"bioactive hydrogels","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hydrogel-degradation","display_name":"hydrogel degradation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.7009999752044678},{"id":"https://openalex.org/keywords/extracellular-matrix-mimicry","display_name":"extracellular matrix mimicry","score":0.7419999837875366},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.752774715423584},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6497285962104797},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5474697351455688},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49625450372695923},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4000437259674072},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3694368302822113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15896162390708923},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.121609628200531}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s1793984424300085","doi":"https://doi.org/10.1142/s1793984424300085","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s1793984424300085","pdf_url":null,"source":{"id":"https://openalex.org/S4210174734","display_name":"Nano LIFE","issn_l":"1793-9844","issn":["1793-9844","1793-9852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano LIFE","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W1509573995","https://openalex.org/W1969330428","https://openalex.org/W1983775646","https://openalex.org/W1985117263","https://openalex.org/W1998261124","https://openalex.org/W2005474600","https://openalex.org/W2010064799","https://openalex.org/W2010475149","https://openalex.org/W2011175537","https://openalex.org/W2018689329","https://openalex.org/W2025057010","https://openalex.org/W2031502774","https://openalex.org/W2032104553","https://openalex.org/W2032180171","https://openalex.org/W2041505150","https://openalex.org/W2041660207","https://openalex.org/W2041780028","https://openalex.org/W2044512869","https://openalex.org/W2049060647","https://openalex.org/W2057802677","https://openalex.org/W2070884273","https://openalex.org/W2073192711","https://openalex.org/W2076921592","https://openalex.org/W2079975322","https://openalex.org/W2080064071","https://openalex.org/W2096669060","https://openalex.org/W2099769176","https://openalex.org/W2146087334","https://openalex.org/W2150493503","https://openalex.org/W2152753864","https://openalex.org/W2334861488","https://openalex.org/W2567464684","https://openalex.org/W2586637063","https://openalex.org/W2621076372","https://openalex.org/W2621103819","https://openalex.org/W2732517296","https://openalex.org/W2738360456","https://openalex.org/W2751188329","https://openalex.org/W2798113757","https://openalex.org/W2810354999","https://openalex.org/W2887267168","https://openalex.org/W2895298053","https://openalex.org/W2896165996","https://openalex.org/W2896823263","https://openalex.org/W2898287703","https://openalex.org/W2952567755","https://openalex.org/W2959708895","https://openalex.org/W2967070597","https://openalex.org/W2983143476","https://openalex.org/W2990712642","https://openalex.org/W3000527856","https://openalex.org/W3002592311","https://openalex.org/W3002764058","https://openalex.org/W3005031804","https://openalex.org/W3005813900","https://openalex.org/W3009046733","https://openalex.org/W3015717458","https://openalex.org/W3033402837","https://openalex.org/W3092732291","https://openalex.org/W3093310226","https://openalex.org/W3114806059","https://openalex.org/W3136294944","https://openalex.org/W3137728161","https://openalex.org/W3137770255","https://openalex.org/W3154892358","https://openalex.org/W3157057024","https://openalex.org/W3165516549","https://openalex.org/W3165548789","https://openalex.org/W3175659141","https://openalex.org/W3198509218","https://openalex.org/W3210844808","https://openalex.org/W4200064246","https://openalex.org/W4206609275","https://openalex.org/W4206774656","https://openalex.org/W4220848199","https://openalex.org/W4221118272","https://openalex.org/W4225263260","https://openalex.org/W4286504570","https://openalex.org/W4289927311","https://openalex.org/W4293403421","https://openalex.org/W4294613106","https://openalex.org/W4296004327","https://openalex.org/W4304807065","https://openalex.org/W4317401413","https://openalex.org/W4318393759","https://openalex.org/W4318776579","https://openalex.org/W4321163528","https://openalex.org/W4323255589","https://openalex.org/W4323569006","https://openalex.org/W4360999809","https://openalex.org/W4366687138","https://openalex.org/W4380729919","https://openalex.org/W4381046516","https://openalex.org/W4382790583","https://openalex.org/W4385696837","https://openalex.org/W4386423654","https://openalex.org/W4386529239","https://openalex.org/W4386896189","https://openalex.org/W4387360182","https://openalex.org/W4387783605","https://openalex.org/W4388153897","https://openalex.org/W4388989656","https://openalex.org/W4390349533","https://openalex.org/W4390498921","https://openalex.org/W4390764931","https://openalex.org/W4390975248","https://openalex.org/W4391096973","https://openalex.org/W4391134034","https://openalex.org/W4391151059","https://openalex.org/W4391340020","https://openalex.org/W4391445762","https://openalex.org/W4391581772","https://openalex.org/W4391613383","https://openalex.org/W4391774678","https://openalex.org/W4391990891","https://openalex.org/W4392017060","https://openalex.org/W4392385318","https://openalex.org/W4392627046","https://openalex.org/W4392745475","https://openalex.org/W4392764977","https://openalex.org/W4393010368","https://openalex.org/W4393029190","https://openalex.org/W4393041574","https://openalex.org/W4394714638","https://openalex.org/W4394732647","https://openalex.org/W4395478645","https://openalex.org/W4395679527","https://openalex.org/W4399035873","https://openalex.org/W4399229505","https://openalex.org/W4400038974","https://openalex.org/W4400309039","https://openalex.org/W4400381521","https://openalex.org/W4400473360"],"related_works":["https://openalex.org/W4393029190","https://openalex.org/W7154513787","https://openalex.org/W4415932533","https://openalex.org/W7140676649","https://openalex.org/W4416025662","https://openalex.org/W7160028180","https://openalex.org/W2941945771","https://openalex.org/W4221118272","https://openalex.org/W4392885637","https://openalex.org/W2123155732"],"abstract_inverted_index":{"As":[0],"customizable":[1],"biomaterials,":[2],"hydrogels":[3,116,173,202],"have":[4],"attracted":[5],"great":[6],"promise":[7,178],"in":[8,100,112,166,181],"several":[9],"industries,":[10],"including":[11,82,136,169],"drug":[12,105],"delivery,":[13],"tissue":[14,54,120,222],"engineering,":[15],"biosensing":[16],"and":[17,35,38,49,53,74,87,95,141,174,203,216,221],"regenerative":[18],"medicine.":[19],"Three-dimensional":[20],"networks":[21],"of":[22,65,79,150,188,201,205],"these":[23],"hydrophilic":[24],"polymers":[25,86],"exhibit":[26],"special":[27],"properties,":[28,138],"such":[29],"as":[30],"increased":[31],"water":[32],"content,":[33],"soft":[34],"flexible":[36],"texture":[37],"biocompatibility,":[39],"making":[40,209],"them":[41,210],"excellent":[42,123],"candidates":[43],"to":[44,117,193],"simulate":[45],"the":[46,69,148,182,186,195],"extracellular":[47],"matrix":[48],"promote":[50],"cell":[51],"development":[52],"regeneration.":[55],"In":[56,184],"this":[57,189],"review":[58,158,190],"paper,":[59],"we":[60],"provide":[61,194],"a":[62,198,211],"comprehensive":[63],"overview":[64],"hydrogels,":[66,89,171,176],"focusing":[67],"on":[68,147,219],"design":[70],"concepts,":[71],"synthesis":[72],"processes":[73,114],"characterization":[75],"techniques.":[76],"Different":[77],"types":[78],"hydrogel":[80,152,167],"materials,":[81],"natural":[83],"polymers,":[84],"synthetic":[85],"hybrid":[88],"along":[90],"with":[91,122,144,197],"their":[92,206],"unique":[93],"properties":[94],"applications":[96],"are":[97,107,126],"discussed.":[98],"Improvements":[99],"hydrogel-based":[101],"platforms":[102],"for":[103,154,214],"controlled":[104],"delivery":[106],"being":[108],"investigated.":[109],"Recent":[110],"advances":[111,180],"bioprinting":[113],"using":[115],"create":[118],"complex":[119],"constructs":[121],"spatial":[124],"control":[125],"also":[127,160],"explored.":[128],"Hydrogel":[129],"performance":[130],"is":[131,192],"examined":[132],"across":[133],"multiple":[134],"variables,":[135],"mechanical":[137],"degradation":[139],"behavior":[140],"biological":[142],"interactions,":[143],"an":[145],"emphasis":[146],"importance":[149],"tailoring":[151],"qualities":[153],"specific":[155],"applications.":[156],"This":[157],"paper":[159,191],"provides":[161],"insights":[162],"into":[163],"future":[164],"directions":[165],"research,":[168],"stimuli-sensitive":[170],"self-healing":[172],"bioactive":[175],"which":[177],"promising":[179],"field.":[183],"general,":[185],"aim":[187],"reader":[196],"detailed":[199],"understanding":[200],"all":[204],"potential":[207],"applications,":[208],"valuable":[212],"tool":[213],"scientists":[215],"researchers":[217],"working":[218],"biomaterials":[220],"engineering.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-10-25T00:00:00"}