{"id":"https://openalex.org/W4403687239","doi":"https://doi.org/10.4314/tjpr.v23i9.5","title":"Adipose-derived mesenchymal stem cells mitigate doxorubicin-induced cardiomyopathy in rats","display_name":"Adipose-derived mesenchymal stem cells mitigate doxorubicin-induced cardiomyopathy in rats","publication_year":2024,"publication_date":"2024-10-08","ids":{"openalex":"https://openalex.org/W4403687239","doi":"https://doi.org/10.4314/tjpr.v23i9.5"},"language":"en","primary_location":{"id":"doi:10.4314/tjpr.v23i9.5","doi":"https://doi.org/10.4314/tjpr.v23i9.5","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v23i9.5","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/280145/264237","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-9827","issn":["1596-9827","1596-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ajol.info/index.php/tjpr/article/download/280145/264237","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049098332","display_name":"Demet Erciyes","orcid":"https://orcid.org/0000-0003-1331-8221","observed_orcids":["https://orcid.org/0000-0003-1331-8221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Demet Erciyes","raw_affiliation_strings":["Department of Cardiology , Faculty of Medicine , Demiro\u011flu Bilim University , Istanbul ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology , Faculty of Medicine , Demiro\u011flu Bilim University , Istanbul ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029550968","display_name":"Ejder Saylav Bora","orcid":"https://orcid.org/0000-0002-2448-2337","observed_orcids":["https://orcid.org/0000-0002-2448-2337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ejder Saylav Bora","raw_affiliation_strings":["Department of Emergency Medicine ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020236390","display_name":"Mustafa Ag\u00e2h Tekindal","orcid":"https://orcid.org/0000-0002-4060-7048","observed_orcids":["https://orcid.org/0000-0002-4060-7048"]},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Agah Tekindal","raw_affiliation_strings":["Department of Basic Medical Sciences \u0130zmir Katip \u00c7elebi Un\u0131versity , Faculty of Medicine , Izmir ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences \u0130zmir Katip \u00c7elebi Un\u0131versity , Faculty of Medicine , Izmir ,","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060613447","display_name":"Duygu Burcu Arda","orcid":"https://orcid.org/0000-0002-4384-1323","observed_orcids":["https://orcid.org/0000-0002-4384-1323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duygu Burcu Arda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014161241","display_name":"Oytun Erba\u015f","orcid":"https://orcid.org/0000-0001-5427-8428","observed_orcids":["https://orcid.org/0000-0001-5427-8428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oytun Erbas","raw_affiliation_strings":["Department of Physiology , Faculty of Medicine , Demiro\u011flu Bilim University , Istanbul , Tu\u0308rkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology , Faculty of Medicine , Demiro\u011flu Bilim University , Istanbul , Tu\u0308rkiye","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"9","first_page":"1433","last_page":"1440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":1.0},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.875},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9340000152587891},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7950000166893005},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/gdf15","display_name":"GDF15","score":0.8809999823570251},{"id":"https://openalex.org/keywords/probnp","display_name":"proBNP","score":0.6230000257492065},{"id":"https://openalex.org/keywords/troponin","display_name":"troponin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.843999981880188},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cardiac-histopathology","display_name":"cardiac histopathology","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8495083451271057},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6540035605430603},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5687695145606995},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5272252559661865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4625370502471924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4229021370410919},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3334667682647705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27123361825942993},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.19159668684005737},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18392950296401978},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08609139919281006}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4314/tjpr.v23i9.5","doi":"https://doi.org/10.4314/tjpr.v23i9.5","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v23i9.5","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/280145/264237","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-9827","issn":["1596-9827","1596-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4314/tjpr.v23i9.5","doi":"https://doi.org/10.4314/tjpr.v23i9.5","is_oa":true,"landing_page_url":"https://doi.org/10.4314/tjpr.v23i9.5","pdf_url":"https://www.ajol.info/index.php/tjpr/article/download/280145/264237","source":{"id":"https://openalex.org/S174262287","display_name":"Tropical Journal of Pharmaceutical Research","issn_l":"1596-9827","issn":["1596-9827","1596-5996"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jpps-1","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311017","host_organization_name":"Pharmacotherapy Group, University of Benin, Benin City","host_organization_lineage":["https://openalex.org/P4310311017"],"host_organization_lineage_names":["Pharmacotherapy Group, University of Benin, Benin City"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical Journal of Pharmaceutical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403687239.pdf","grobid_xml":"https://content.openalex.org/works/W4403687239.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7163699623","https://openalex.org/W2125759277","https://openalex.org/W1827349666","https://openalex.org/W4406287554","https://openalex.org/W2617738697","https://openalex.org/W2959304846","https://openalex.org/W4401544614","https://openalex.org/W2940279430","https://openalex.org/W2994548186","https://openalex.org/W7136158313"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"investigate":[2],"the":[3,44,167,217],"effect":[4],"of":[5,20,58,87,99,169,222],"adipose-derived":[6],"mesenchymal":[7,191],"stem":[8,192],"cells":[9,193],"(ADMSCs)":[10,194],"on":[11],"doxorubicin":[12],"(DOX)-induced":[13],"cardiomyopathy":[14],"in":[15,113,150,175,225],"rats.":[16],"Methods:":[17],"A":[18],"total":[19],"30":[21],"male":[22],"Sprague-Dawley":[23],"rats":[24],"were":[25,119,147],"randomized":[26],"into":[27,67],"control":[28],"(n":[29,35],"=":[30,36],"10)":[31],"and":[32,110,115,166,201,209,220],"study":[33,45,63],"groups":[34],"20).":[37],"Control":[38],"group":[39,46,64,71,91,158,179,185],"received":[40,47,72,92],"no":[41],"intervention":[42],"while":[43],"DOX":[48,73,93,155,176,182],"administered":[49],"intraperitoneally":[50,104],"(i.p.)":[51],"six":[52],"times":[53],"daily":[54],"at":[55,84,96],"a":[56,85,97,106],"dose":[57,86,98],"2.5":[59],"mg/kg/":[60],"day.":[61],"The":[62],"was":[65],"divided":[66],"2":[68],"groups.":[69,122],"One":[70],"+":[74,94,156,177,183],"normal":[75],"saline":[76,157,184],"(0.9":[77],"%w/v)":[78],"sodium":[79],"chloride":[80],"(NaCl)":[81],"solution":[82],"ntraperitoneally":[83],"1":[88],"mL/kg/day.":[89],"Another":[90],"ADMSC":[95,152,178],"2.0":[100],"x":[101],"106":[102],"cells/kg":[103],"twice":[105],"week.":[107],"Biochemical":[108],"parameters":[109],"histopathological":[111],"changes":[112],"blood":[114],"heart":[116,142],"tissue":[117],"samples":[118],"compared":[120,153,180],"among":[121],"Results:":[123],"Caspase-3":[124],"immuno-expression,":[125],"plasma":[126],"malondialdehyde":[127],"(MDA),":[128],"tumor":[129],"necrosis":[130],"factor-\u03b1":[131],"(TNF-\u03b1),":[132],"growth":[133,144],"differentiation":[134],"factor-15":[135],"(GDF-15),":[136],"pro-brain":[137],"natriuretic":[138],"peptide":[139],"(Pro-BNP),":[140],"troponin,":[141],"transforming":[143],"factor\u2013\u03b2":[145],"(TGF-\u03b2)":[146],"significantly":[148,173],"lower":[149],"DOX+":[151],"to":[154,181,215],"(p":[159,186],"<":[160,187],"0.05).":[161,188],"However,":[162],"caspase-3":[163,196],"immune":[164],"expression":[165],"number":[168],"regularly":[170],"arranged":[171],"cardiomyocytes":[172],"decreased":[174],"Conclusion:":[189],"Adipose-derived":[190],"reduce":[195],"immunoexpression,":[197],"restore":[198],"cardiac":[199,205,226],"histology,":[200],"ameliorate":[202],"DOX-":[203],"induced":[204],"injury.":[206,227],"Further":[207],"investigation":[208],"clinical":[210],"trials":[211],"are":[212],"recommended,":[213],"especially":[214],"determine":[216],"continued":[218],"safety":[219],"efficacy":[221],"AD-MSC-based":[223],"therapy":[224]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-10-24T00:00:00"}
