{"id":"https://openalex.org/W4403668060","doi":"https://doi.org/10.1016/j.ijbiomac.2024.136883","title":"Withanolides-enriched leaf extract of Withania somnifera exert anti-obesity effects by inducing brown adipocyte-like phenotype via tuning MAP-kinase signaling axis","display_name":"Withanolides-enriched leaf extract of Withania somnifera exert anti-obesity effects by inducing brown adipocyte-like phenotype via tuning MAP-kinase signaling axis","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403668060","doi":"https://doi.org/10.1016/j.ijbiomac.2024.136883","pmid":"https://pubmed.ncbi.nlm.nih.gov/39454897"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2024.136883","doi":"https://doi.org/10.1016/j.ijbiomac.2024.136883","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.136883","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052860136","display_name":"Acharya Balkrishna","orcid":"https://orcid.org/0000-0003-4749-6317","observed_orcids":["https://orcid.org/0000-0003-4749-6317"]},"institutions":[{"id":"https://openalex.org/I4210145585","display_name":"Patanjali Research Foundation","ror":"https://ror.org/04f68cb23","country_code":"IN","type":"other","lineage":["https://openalex.org/I4210145585"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Acharya Balkrishna","raw_affiliation_strings":["Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India; Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Roorkee-Haridwar Road, Haridwar 249405, Uttarakhand, India; Patanjali Yog Peeth (UK) Trust, 40 Lambhill Street, Kinning Park, Glasgow G41 1AU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India; Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Roorkee-Haridwar Road, Haridwar 249405, Uttarakhand, India; Patanjali Yog Peeth (UK) Trust, 40 Lambhill Street, Kinning Park, Glasgow G41 1AU, UK","institution_ids":["https://openalex.org/I4210145585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101540702","display_name":"Priya Kumari","orcid":"https://orcid.org/0000-0002-1802-5412","observed_orcids":["https://orcid.org/0000-0002-1802-5412"]},"institutions":[{"id":"https://openalex.org/I4210145585","display_name":"Patanjali Research Foundation","ror":"https://ror.org/04f68cb23","country_code":"IN","type":"other","lineage":["https://openalex.org/I4210145585"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priya Kumari","raw_affiliation_strings":["Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India","institution_ids":["https://openalex.org/I4210145585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pratibha Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145585","display_name":"Patanjali Research Foundation","ror":"https://ror.org/04f68cb23","country_code":"IN","type":"other","lineage":["https://openalex.org/I4210145585"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pratibha Singh","raw_affiliation_strings":["Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India","institution_ids":["https://openalex.org/I4210145585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052966308","display_name":"Nishit Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145585","display_name":"Patanjali Research Foundation","ror":"https://ror.org/04f68cb23","country_code":"IN","type":"other","lineage":["https://openalex.org/I4210145585"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nishit Pathak","raw_affiliation_strings":["Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India","institution_ids":["https://openalex.org/I4210145585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109518531","display_name":"Sudeep Verma","orcid":"https://orcid.org/0009-0006-6892-5976","observed_orcids":["https://orcid.org/0009-0006-6892-5976"]},"institutions":[{"id":"https://openalex.org/I4210145585","display_name":"Patanjali Research Foundation","ror":"https://ror.org/04f68cb23","country_code":"IN","type":"other","lineage":["https://openalex.org/I4210145585"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudeep Verma","raw_affiliation_strings":["Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India","institution_ids":["https://openalex.org/I4210145585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044506124","display_name":"Rishabh Dev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145585","display_name":"Patanjali Research Foundation","ror":"https://ror.org/04f68cb23","country_code":"IN","type":"other","lineage":["https://openalex.org/I4210145585"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rishabh Dev","raw_affiliation_strings":["Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India","institution_ids":["https://openalex.org/I4210145585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051628387","display_name":"Anurag Varshney","orcid":"https://orcid.org/0000-0001-8509-0882","observed_orcids":["https://orcid.org/0000-0001-8509-0882"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]},{"id":"https://openalex.org/I4210145585","display_name":"Patanjali Research Foundation","ror":"https://ror.org/04f68cb23","country_code":"IN","type":"other","lineage":["https://openalex.org/I4210145585"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anurag Varshney","raw_affiliation_strings":["Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India; Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Roorkee-Haridwar Road, Haridwar 249405, Uttarakhand, India; Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address: anurag@patanjali.res.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Division, Patanjali Research Foundation (Trust), NH-58, Haridwar 249405, Uttarakhand, India; Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Roorkee-Haridwar Road, Haridwar 249405, Uttarakhand, India; Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address: anurag@patanjali.res.in","institution_ids":["https://openalex.org/I152429107","https://openalex.org/I4210145585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051628387"],"corresponding_institution_ids":["https://openalex.org/I152429107","https://openalex.org/I4210145585"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":2.1142,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.84578979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"282","issue":"Pt 2","first_page":"136883","last_page":"136883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ashwagandha","display_name":"Withania somnifera","score":0.996999979019165},{"id":"https://openalex.org/keywords/withanolides","display_name":"withanolides","score":0.8820000290870667},{"id":"https://openalex.org/keywords/anti-obesity-effect","display_name":"anti-obesity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.7310000061988831},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.968999981880188},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.9860000014305115},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.7239999771118164},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8709999918937683},{"id":"https://openalex.org/keywords/fat-deposition","display_name":"fat deposition","score":0.7229999899864197},{"id":"https://openalex.org/keywords/phytochemical-profiling","display_name":"phytochemical profiling","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2780069950","wikidata":"https://www.wikidata.org/wiki/Q852660","display_name":"Withania somnifera","level":3,"score":0.9377801418304443},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6823903918266296},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.6617892384529114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46945351362228394},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44092434644699097},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.4276929199695587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3727083206176758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.279316246509552},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.25974240899086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1890266239643097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1817588210105896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032341","descriptor_name":"Withania","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052437","descriptor_name":"Adipocytes, Brown","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D052437","descriptor_name":"Adipocytes, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054358","descriptor_name":"Withanolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054358","descriptor_name":"Withanolides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijbiomac.2024.136883","doi":"https://doi.org/10.1016/j.ijbiomac.2024.136883","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2024.136883","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"pmid:39454897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39454897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1966832357","https://openalex.org/W1967648469","https://openalex.org/W1967923229","https://openalex.org/W1970692155","https://openalex.org/W1988213849","https://openalex.org/W2009829588","https://openalex.org/W2025401975","https://openalex.org/W2039082172","https://openalex.org/W2089257130","https://openalex.org/W2098635194","https://openalex.org/W2108763926","https://openalex.org/W2111645882","https://openalex.org/W2121921343","https://openalex.org/W2125419487","https://openalex.org/W2132162317","https://openalex.org/W2158103150","https://openalex.org/W2160677035","https://openalex.org/W2162186867","https://openalex.org/W2164045012","https://openalex.org/W2174595423","https://openalex.org/W2189359567","https://openalex.org/W2304296579","https://openalex.org/W2336833178","https://openalex.org/W2346565415","https://openalex.org/W2523961905","https://openalex.org/W2554533390","https://openalex.org/W2727205166","https://openalex.org/W2768528423","https://openalex.org/W2769191713","https://openalex.org/W2809162043","https://openalex.org/W2894769619","https://openalex.org/W2901467308","https://openalex.org/W2901758642","https://openalex.org/W2902121131","https://openalex.org/W2913539314","https://openalex.org/W2939495270","https://openalex.org/W2944286475","https://openalex.org/W3004812565","https://openalex.org/W3005439514","https://openalex.org/W3011747422","https://openalex.org/W3022233400","https://openalex.org/W3115953384","https://openalex.org/W3117514348","https://openalex.org/W3120744005","https://openalex.org/W3132189451","https://openalex.org/W3154407415","https://openalex.org/W3172649413","https://openalex.org/W3204772254","https://openalex.org/W3217337816","https://openalex.org/W4200364245","https://openalex.org/W4205354356","https://openalex.org/W4225149338","https://openalex.org/W4226188769","https://openalex.org/W4283764385","https://openalex.org/W4297489959","https://openalex.org/W4318318019","https://openalex.org/W4366988345","https://openalex.org/W4367610508","https://openalex.org/W4378639322","https://openalex.org/W4378745393","https://openalex.org/W4385704511","https://openalex.org/W4387849379","https://openalex.org/W6855546767"],"related_works":["https://openalex.org/W3115953384","https://openalex.org/W7127955292","https://openalex.org/W4295007525","https://openalex.org/W3004812565","https://openalex.org/W2095954547","https://openalex.org/W4401229363","https://openalex.org/W3149979423","https://openalex.org/W4413763666","https://openalex.org/W3097239146","https://openalex.org/W3017385763"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-10-24T00:00:00"}
