{"id":"https://openalex.org/W4403667535","doi":"https://doi.org/10.1016/j.bbrc.2024.150894","title":"Triple-regulated conditionally replicating adenovirus for effective and safer treatment of peritoneal carcinomatosis","display_name":"Triple-regulated conditionally replicating adenovirus for effective and safer treatment of peritoneal carcinomatosis","publication_year":2024,"publication_date":"2024-10-24","ids":{"openalex":"https://openalex.org/W4403667535","doi":"https://doi.org/10.1016/j.bbrc.2024.150894","pmid":"https://pubmed.ncbi.nlm.nih.gov/39481189"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2024.150894","doi":"https://doi.org/10.1016/j.bbrc.2024.150894","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150894","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbrc.2024.150894","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086736989","display_name":"Junichi Kamizono","orcid":"https://orcid.org/0009-0003-6476-486X","observed_orcids":["https://orcid.org/0009-0003-6476-486X"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]},{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Kamizono","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Department of Orthopaedic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Department of Orthopaedic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan","institution_ids":["https://openalex.org/I105296287","https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063798308","display_name":"Yuya Nishikawaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuya Nishikawaji","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043000480","display_name":"Satoshi Nagano","orcid":"https://orcid.org/0000-0003-2015-1730","observed_orcids":["https://orcid.org/0000-0003-2015-1730"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Nagano","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Innovative Therapy Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; South Kyushu Center for Innovative Medical Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Department of Clinical Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2015-1730","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Innovative Therapy Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; South Kyushu Center for Innovative Medical Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Department of Clinical Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Minako Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minako Ikeda","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshiharu Horikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiharu Horikawa","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Department of Orthopaedic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Department of Orthopaedic Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063473277","display_name":"Taro Kamisasanuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taro Kamisasanuki","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051371660","display_name":"Kaoru Mitsui","orcid":"https://orcid.org/0000-0003-0534-9845","observed_orcids":["https://orcid.org/0000-0003-0534-9845"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Mitsui","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Innovative Therapy Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; South Kyushu Center for Innovative Medical Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0534-9845","affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Innovative Therapy Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; South Kyushu Center for Innovative Medical Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113518406","display_name":"Eriko Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eriko Matsuda","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110052726","display_name":"Ken-ichiro Kosai","orcid":"https://orcid.org/0009-0006-2327-0486","observed_orcids":["https://orcid.org/0009-0006-2327-0486"]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]},{"id":"https://openalex.org/I4210119230","display_name":"Kagoshima University Hospital","ror":"https://ror.org/02dkdym27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210119230"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ken-ichiro Kosai","raw_affiliation_strings":["Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Innovative Therapy Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; South Kyushu Center for Innovative Medical Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Clinical and Translational Research, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan. Electronic address: kosai@m2.kufm.kagoshima-u.ac.jp"],"raw_orcid":"https://orcid.org/0009-0006-2327-0486","affiliations":[{"raw_affiliation_string":"Department of Gene Therapy and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Innovative Therapy Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; South Kyushu Center for Innovative Medical Research and Application, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Center for Clinical and Translational Research, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; Division of Gene Therapy and Regenerative Medicine, Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, 830-0011, Japan. Electronic address: kosai@m2.kufm.kagoshima-u.ac.jp","institution_ids":["https://openalex.org/I107139324","https://openalex.org/I4210119230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110052726"],"corresponding_institution_ids":["https://openalex.org/I107139324","https://openalex.org/I4210119230"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":{"value":2880,"currency":"USD","value_usd":2880},"fwci":0.2012,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.38632615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"737","issue":null,"first_page":"150894","last_page":"150894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conditionally-replicating-adenovirus","display_name":"conditionally replicating adenovirus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.843999981880188},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mkn45-cells","display_name":"MKN45 cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/gene-therapy-safety","display_name":"gene therapy safety","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2991818862","wikidata":"https://www.wikidata.org/wiki/Q2071182","display_name":"Peritoneal carcinomatosis","level":4,"score":0.8668911457061768},{"id":"https://openalex.org/C2776654903","wikidata":"https://www.wikidata.org/wiki/Q2601463","display_name":"SAFER","level":2,"score":0.7941263914108276},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.572832465171814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3877190947532654},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35359275341033936},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2560844123363495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2488219439983368},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11876413226127625},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2024.150894","doi":"https://doi.org/10.1016/j.bbrc.2024.150894","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150894","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:39481189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39481189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrc.2024.150894","doi":"https://doi.org/10.1016/j.bbrc.2024.150894","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150894","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5240396458","display_name":"Development of innovative gene therapy of conditionally regulating adenovirus for treating pediatric solid cancer","funder_award_id":"19390286","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6108565076","display_name":"Relationship between cancer locomotive syndrome and physical activity","funder_award_id":"21K09327","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1530089119","https://openalex.org/W1544229812","https://openalex.org/W1968592882","https://openalex.org/W1983644508","https://openalex.org/W1984254868","https://openalex.org/W1992550581","https://openalex.org/W1993657698","https://openalex.org/W2007629275","https://openalex.org/W2008996723","https://openalex.org/W2018893865","https://openalex.org/W2028988293","https://openalex.org/W2034903741","https://openalex.org/W2043564987","https://openalex.org/W2048878179","https://openalex.org/W2053176259","https://openalex.org/W2057611916","https://openalex.org/W2066416111","https://openalex.org/W2089230473","https://openalex.org/W2095615635","https://openalex.org/W2106636191","https://openalex.org/W2109721404","https://openalex.org/W2119819168","https://openalex.org/W2151246565","https://openalex.org/W2395618179","https://openalex.org/W2413800984","https://openalex.org/W2473091182","https://openalex.org/W2503957764","https://openalex.org/W2596442933","https://openalex.org/W2945416434","https://openalex.org/W2963564623","https://openalex.org/W3016401999","https://openalex.org/W3119110836","https://openalex.org/W3120711435","https://openalex.org/W3122585400","https://openalex.org/W4200069910","https://openalex.org/W4362723216","https://openalex.org/W4390192002","https://openalex.org/W4393935425","https://openalex.org/W4400269162"],"related_works":["https://openalex.org/W2089230473","https://openalex.org/W2057611916","https://openalex.org/W1978706589","https://openalex.org/W2114389217","https://openalex.org/W2567349194","https://openalex.org/W2025811898","https://openalex.org/W2571667415","https://openalex.org/W3095328542","https://openalex.org/W2886692282","https://openalex.org/W2162289198"],"abstract_inverted_index":{"There":[0],"is":[1],"no":[2],"effective":[3,234],"therapy":[4],"for":[5,30,212,232],"peritoneal":[6,33,173,217],"carcinomatosis":[7,174],"derived":[8],"from":[9],"gastric":[10,31,97,117,215],"cancer.":[11],"An":[12],"ideal":[13],"conditionally":[14],"replicating":[15],"adenovirus":[16],"(CRA)":[17],"that":[18,158],"selectively":[19],"replicates":[20],"in":[21,95,115,128,144],"and":[22,42,57,67,81,92,100,111,119,124,135,170,192,235],"kills":[23],"cancer":[24,98,118,202],"cells":[25,99,143,152,165,187],"has":[26],"not":[27,126],"been":[28],"developed":[29],"cancer-derived":[32,216],"carcinomatosis.":[34,218],"Using":[35],"our":[36],"platform":[37],"technology":[38],"of":[39,53,60,63,73,163,172,224,229,238,241],"CRA":[40,225],"regulated":[41],"treating":[43],"tumors":[44],"with":[45],"multiple":[46],"factors":[47],"(m-CRA),":[48],"we":[49],"generated":[50],"two":[51,96],"types":[52],"survivin-responsive":[54],"m-CRAs,":[55],"Surv.m-CRA-CMVp":[56,136],"Surv.m-CRA-CEAp,":[58],"consisting":[59],"E1A":[61],"downstream":[62,72],"the":[64,68,74,198,208,227,233],"survivin":[65],"promoter,":[66,84],"mutated":[69],"E1B":[70,221],"gene":[71,79],"human":[75],"cytomegalovirus":[76],"immediate":[77],"early":[78],"enhancer/promoter":[80],"carcinoembryonic":[82,213],"antigen":[83,106],"respectively.":[85,104],"Survivin":[86],"mRNA":[87],"was":[88,107,125],"expressed":[89,108],"at":[90,109],"high":[91,110],"undetectable":[93],"levels":[94,114],"eleven":[101],"normal":[102,120,151],"cells,":[103,122],"Carcinoembryonic":[105],"very":[112],"low":[113],"MKN-45":[116,142,164,186],"PrEC":[121],"respectively,":[123],"detected":[127],"other":[129],"cell":[130],"types.":[131],"While":[132],"both":[133],"Surv.m-CRA-CEAp":[134,146,183,200],"exhibited":[137],"potent":[138,209],"cytotoxic":[139],"effects":[140],"on":[141],"vitro,":[145],"significantly":[147],"reduced":[148],"cytotoxicity":[149],"to":[150,154],"compared":[153],"Surv.m-CRA-CMVp.":[155],"Control":[156],"mice":[157,181],"received":[159],"an":[160],"intraperitoneal":[161],"injection":[162],"gradually":[166],"lost":[167],"body":[168,190],"weight":[169,191],"died":[171],"within":[175],"98":[176],"days.":[177,195],"In":[178,196],"contrast,":[179],"all":[180],"receiving":[182],"or":[184],"Surv.m-CRA-CMVp-infected":[185],"increased":[188],"their":[189],"survived":[193],"120":[194],"conclusion,":[197],"triple-regulated":[199],"enhances":[201],"specificity":[203],"(i.e.,":[204],"safety)":[205],"without":[206],"reducing":[207],"therapeutic":[210],"effect":[211],"antigen-positive":[214],"The":[219],"modified":[220],"promoter":[222],"strategy":[223],"facilitates":[226],"development":[228],"novel":[230],"CRAs":[231],"safe":[236],"treatment":[237],"a":[239],"variety":[240],"refractory":[242],"cancers.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-24T00:00:00"}