{"id":"https://openalex.org/W4403622011","doi":"https://doi.org/10.1039/d4ra05694a","title":"The significance of chirality in contemporary drug discovery-a mini review","display_name":"The significance of chirality in contemporary drug discovery-a mini review","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4403622011","doi":"https://doi.org/10.1039/d4ra05694a","pmid":"https://pubmed.ncbi.nlm.nih.gov/39439836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11495282"},"language":"en","primary_location":{"id":"doi:10.1039/d4ra05694a","doi":"https://doi.org/10.1039/d4ra05694a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4ra05694a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra05694a","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4403622011"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra05694a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138904421","display_name":"Narmatha Senkuttuvan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175691731","display_name":"Pondicherry University","ror":"https://ror.org/01a3mef16","country_code":"IN","type":"education","lineage":["https://openalex.org/I175691731"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narmatha Senkuttuvan","raw_affiliation_strings":["Department of Chemistry, Pondicherry University, Puducherry \u2013 605 014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Pondicherry University, Puducherry \u2013 605 014, India","institution_ids":["https://openalex.org/I175691731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092827703","display_name":"Boopathi Komarasamy","orcid":"https://orcid.org/0009-0007-8418-3623","observed_orcids":["https://orcid.org/0009-0007-8418-3623"]},"institutions":[{"id":"https://openalex.org/I175691731","display_name":"Pondicherry University","ror":"https://ror.org/01a3mef16","country_code":"IN","type":"education","lineage":["https://openalex.org/I175691731"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Boopathi Komarasamy","raw_affiliation_strings":["Department of Chemistry, Pondicherry University, Puducherry \u2013 605 014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Pondicherry University, Puducherry \u2013 605 014, India","institution_ids":["https://openalex.org/I175691731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002036164","display_name":"Rajavenkatesh Krishnamoorthy","orcid":"https://orcid.org/0000-0001-7613-955X","observed_orcids":["https://orcid.org/0000-0001-7613-955X"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajavenkatesh Krishnamoorthy","raw_affiliation_strings":["Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, Karnataka, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuvajyoti Sarkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106542073","display_name":"University of Calcutta","ror":"https://ror.org/01e7v7w47","country_code":"IN","type":"education","lineage":["https://openalex.org/I106542073"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shuvajyoti Sarkar","raw_affiliation_strings":["Department of Chemistry, Rajabazar Science College, University of Calcutta, College Street, Kolkata-700009, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rajabazar Science College, University of Calcutta, College Street, Kolkata-700009, India","institution_ids":["https://openalex.org/I106542073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071785907","display_name":"Sivasankaran Dhanasekaran","orcid":"https://orcid.org/0000-0003-2726-1545","observed_orcids":["https://orcid.org/0000-0003-2726-1545"]},"institutions":[{"id":"https://openalex.org/I94948490","display_name":"B.S. Abdur Rahman Crescent Institute of Science & Technology","ror":"https://ror.org/01fqhas03","country_code":"IN","type":"education","lineage":["https://openalex.org/I94948490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sivasankaran Dhanasekaran","raw_affiliation_strings":["Department of Chemistry, B. S. Abdur Rahman Crescent Institute of Science & Technology, Chennai, Tamilnadu, 600 048, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, B. S. Abdur Rahman Crescent Institute of Science & Technology, Chennai, Tamilnadu, 600 048, India","institution_ids":["https://openalex.org/I94948490"]}]},{"author_position":"last","author":{"id":null,"display_name":"Parthiban Anaikutti","orcid":"https://orcid.org/0000-0001-7836-3205","observed_orcids":["https://orcid.org/0000-0001-7836-3205"]},"institutions":[{"id":"https://openalex.org/I85461943","display_name":"Saveetha University","ror":"https://ror.org/0034me914","country_code":"IN","type":"education","lineage":["https://openalex.org/I85461943"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Parthiban Anaikutti","raw_affiliation_strings":["Medicinal Chemistry Laboratory, Department of General Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India"],"raw_orcid":"https://orcid.org/0000-0001-7836-3205","affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Laboratory, Department of General Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I85461943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I85461943"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":4.0868,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.96916812,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":"45","first_page":"33429","last_page":"33448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12527","display_name":"Chemistry and Stereochemistry Studies","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chirality","display_name":"chirality","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chiral-drugs","display_name":"chiral drugs","score":0.8579999804496765},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.875},{"id":"https://openalex.org/keywords/chiral-induction","display_name":"chiral induction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/enantiomeric-excess","display_name":"enantiomeric excess","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fda-approved-drugs","display_name":"FDA-approved drugs","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C124668440","wikidata":"https://www.wikidata.org/wiki/Q2305173","display_name":"Chirality (physics)","level":5,"score":0.5732032060623169},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.5594555139541626},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4321773648262024},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42894062399864197},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40581753849983215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38138607144355774},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35604315996170044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3175771236419678},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2840927839279175},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2635560929775238},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2273010015487671},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.07980906963348389},{"id":"https://openalex.org/C7602139","wikidata":"https://www.wikidata.org/wiki/Q6718","display_name":"Quark","level":2,"score":0.0},{"id":"https://openalex.org/C52703039","wikidata":"https://www.wikidata.org/wiki/Q5101837","display_name":"Chiral symmetry breaking","level":3,"score":0.0},{"id":"https://openalex.org/C20621625","wikidata":"https://www.wikidata.org/wiki/Q6961432","display_name":"Nambu\u2013Jona-Lasinio model","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d4ra05694a","doi":"https://doi.org/10.1039/d4ra05694a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4ra05694a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra05694a","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11495282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11495282","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11495282/pdf/RA-014-D4RA05694A.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:39439836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39439836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d4ra05694a","doi":"https://doi.org/10.1039/d4ra05694a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4ra05694a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra05694a","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330981","display_name":"National Institute of Pharmaceutical Education and Research, Raebareli","ror":"https://ror.org/025qtp564"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403622011.pdf","grobid_xml":"https://content.openalex.org/works/W4403622011.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W965780359","https://openalex.org/W1982272424","https://openalex.org/W1999197232","https://openalex.org/W2063189260","https://openalex.org/W2091601323","https://openalex.org/W2096095251","https://openalex.org/W2112180572","https://openalex.org/W2117497402","https://openalex.org/W2120033951","https://openalex.org/W2162201817","https://openalex.org/W2174399815","https://openalex.org/W2540499968","https://openalex.org/W2584919896","https://openalex.org/W2734647920","https://openalex.org/W2749370327","https://openalex.org/W2761652334","https://openalex.org/W2786849322","https://openalex.org/W2916172020","https://openalex.org/W2951887320","https://openalex.org/W2987117261","https://openalex.org/W3001216252","https://openalex.org/W3014245175","https://openalex.org/W3014882016","https://openalex.org/W3110081665","https://openalex.org/W3183930479","https://openalex.org/W3191740793","https://openalex.org/W3204486370","https://openalex.org/W4200094957","https://openalex.org/W4220658953","https://openalex.org/W4223595357","https://openalex.org/W4224999452","https://openalex.org/W4255287828","https://openalex.org/W4283032142","https://openalex.org/W4284884112","https://openalex.org/W4285289811","https://openalex.org/W4295088440","https://openalex.org/W4308188970","https://openalex.org/W4310117868","https://openalex.org/W4317033653","https://openalex.org/W4319769524","https://openalex.org/W4319826818","https://openalex.org/W4321601696","https://openalex.org/W4323572378","https://openalex.org/W4361256073","https://openalex.org/W4365444049","https://openalex.org/W4365811136","https://openalex.org/W4376604801","https://openalex.org/W4376641767","https://openalex.org/W4378172917","https://openalex.org/W4378783031","https://openalex.org/W4380301705","https://openalex.org/W4384625903","https://openalex.org/W4385406392","https://openalex.org/W4385684525","https://openalex.org/W4386399078","https://openalex.org/W4390049991","https://openalex.org/W4390532091","https://openalex.org/W4391752837"],"related_works":["https://openalex.org/W4321601696","https://openalex.org/W7164994159","https://openalex.org/W2013417542","https://openalex.org/W1539028102","https://openalex.org/W4552020","https://openalex.org/W4233657182","https://openalex.org/W606289839","https://openalex.org/W2491386550","https://openalex.org/W4386782476","https://openalex.org/W2387482993"],"abstract_inverted_index":{"Advancements":[0],"in":[1,4,12,41],"asymmetric":[2],"synthesis":[3,52],"recent":[5],"years":[6,43],"have":[7],"led":[8],"to":[9,31],"considerable":[10],"interest":[11],"the":[13,39,42],"development":[14],"of":[15,18,34],"single":[16],"enantiomers":[17],"chiral":[19,35,57],"drug":[20],"molecules":[21],"for":[22],"medicinal":[23],"chemistry":[24],"settings.":[25],"In":[26],"this":[27],"review,":[28],"we":[29],"want":[30],"compile":[32],"examples":[33],"medicines":[36],"approved":[37],"by":[38],"FDA":[40],"2022":[44],"and":[45],"2023":[46],"with":[47,54],"an":[48],"emphasis":[49],"on":[50,56],"their":[51],"along":[53],"information":[55],"induction":[58],"as":[59,61],"well":[60],"enantiomeric":[62],"excess.":[63]},"counts_by_year":[{"year":2026,"cited_by_count":64},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-10-22T00:00:00"}