{"id":"https://openalex.org/W4403621664","doi":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211","title":"M\u00e9todos alternativos para avalia\u00e7\u00e3o de endotoxinas: desafios e tend\u00eancias internacionais visando \u00e0 seguran\u00e7a de pacientes","display_name":"M\u00e9todos alternativos para avalia\u00e7\u00e3o de endotoxinas: desafios e tend\u00eancias internacionais visando \u00e0 seguran\u00e7a de pacientes","publication_year":2024,"publication_date":"2024-08-26","ids":{"openalex":"https://openalex.org/W4403621664","doi":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211"},"language":"pt","primary_location":{"id":"doi:10.11606/t.9.2024.tde-10102024-093211","doi":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211","pdf_url":"http://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-093211/publico/Ellen_Gameiro_Hilinski_DO_Original.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-093211/publico/Ellen_Gameiro_Hilinski_DO_Original.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033705022","display_name":"Ellen Gameiro Hilinski","orcid":"https://orcid.org/0000-0003-0045-2739","observed_orcids":["https://orcid.org/0000-0003-0045-2739"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ellen Gameiro Hilinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033705022"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxin-detection","display_name":"endotoxin detection","score":0.8009999990463257},{"id":"https://openalex.org/keywords/fluorogenic-substrates","display_name":"fluorogenic substrates","score":0.5509999990463257},{"id":"https://openalex.org/keywords/hyperimmune-sera","display_name":"hyperimmune sera","score":0.652999997138977},{"id":"https://openalex.org/keywords/tetanus-antitoxin","display_name":"tetanus antitoxin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/0-9-sodium-chloride-solution","display_name":"0.9% sodium chloride solution","score":0.7519999742507935},{"id":"https://openalex.org/keywords/method-performance-evaluation","display_name":"method performance evaluation","score":0.621999979019165},{"id":"https://openalex.org/keywords/robustness","display_name":"robustness","score":0.5299999713897705},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3306778073310852}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.11606/t.9.2024.tde-10102024-093211","doi":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211","pdf_url":"http://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-093211/publico/Ellen_Gameiro_Hilinski_DO_Original.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},{"id":"pmh:oai:teses.usp.br:tde-10102024-093211","doi":null,"is_oa":false,"landing_page_url":"https://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-093211/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.11606/t.9.2024.tde-10102024-093211","doi":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.9.2024.tde-10102024-093211","pdf_url":"http://www.teses.usp.br/teses/disponiveis/9/9139/tde-10102024-093211/publico/Ellen_Gameiro_Hilinski_DO_Original.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403621664.pdf","grobid_xml":"https://content.openalex.org/works/W4403621664.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1797316113","https://openalex.org/W1964809885","https://openalex.org/W1968132547","https://openalex.org/W1968334024","https://openalex.org/W1968378295","https://openalex.org/W1975215292","https://openalex.org/W1981893392","https://openalex.org/W2003684755","https://openalex.org/W2015358274","https://openalex.org/W2025291641","https://openalex.org/W2027216673","https://openalex.org/W2034670853","https://openalex.org/W2043189848","https://openalex.org/W2058335181","https://openalex.org/W2095222286","https://openalex.org/W2104243768","https://openalex.org/W2122934056","https://openalex.org/W2285231993","https://openalex.org/W2473548561","https://openalex.org/W2476120410","https://openalex.org/W2618335231","https://openalex.org/W2734797035","https://openalex.org/W2738102896","https://openalex.org/W2783199919","https://openalex.org/W2790590804","https://openalex.org/W2801885288","https://openalex.org/W2801906762","https://openalex.org/W3011124008","https://openalex.org/W3046824205","https://openalex.org/W3049523465","https://openalex.org/W3118846685","https://openalex.org/W3158077973","https://openalex.org/W4232915931","https://openalex.org/W4236134101","https://openalex.org/W4239122927","https://openalex.org/W4255100787","https://openalex.org/W4385816346"],"related_works":["https://openalex.org/W7120573923","https://openalex.org/W4320165817","https://openalex.org/W3194799605","https://openalex.org/W2186926212","https://openalex.org/W3022558822","https://openalex.org/W2409945491","https://openalex.org/W2406038373","https://openalex.org/W3185015651","https://openalex.org/W6926952881","https://openalex.org/W3118846685"],"abstract_inverted_index":{"A":[0],"implementa\u00e7\u00e3o":[1],"de":[2,11,14,27,41,54,57,72,77,79,81,88,97,112,122,146,154,170,180,185,192,200,220,228,243,248,272],"m\u00e9todos":[3,100,133],"alternativos":[4,134],"in":[5],"vitro":[6],"que":[7,50,188,236],"permitam":[8],"a":[9,22,25,69,177,218,231,241,251,259,264],"quantifica\u00e7\u00e3o":[10,173],"n\u00edveis":[12,111],"reduzidos":[13],"endotoxinas":[15,73,229,244],"bacterianas":[16,74],"possui":[17],"grande":[18],"relev\u00e2ncia":[19],"para":[20,30,68,84,151,176,217,240,250,258],"garantir":[21],"seguran\u00e7a":[23],"e":[24,48,87,93,141,149,158,161,164,172,197,254,263],"qualidade":[26],"produtos":[28],"farmac\u00eauticos":[29],"uso":[31,85],"parenteral.":[32],"O":[33],"trabalho":[34,155],"teve":[35],"por":[36,101],"objetivo":[37],"avaliar":[38],"o":[39,52,207],"desempenho":[40,98],"dois":[42],"kits":[43,137],"comerciais":[44],"(Endozyme\u00ae":[45],"II":[46,139],"Go":[47,140],"EndoLISA\u00ae)":[49],"utilizam":[51],"receptor":[53],"uma":[55,215,246],"endotoxina":[56],"s\u00edntese":[58],"(fator":[59],"C":[60,103],"recombinante)":[61],"em":[62,75],"combina\u00e7\u00e3o":[63],"com":[64,124],"um":[65],"substrato":[66,195],"fluorog\u00eanico,":[67],"determina\u00e7\u00e3o":[70],"quantitativa":[71],"amostras":[76],"solu\u00e7\u00e3o":[78],"Cloreto":[80],"S\u00f3dio":[82],"0,9%":[83],"parenteral":[86],"soros":[89,221],"hiperimunes":[90,222],"(antirr\u00e1bico,":[91],"antibotr\u00f3pico":[92],"antitet\u00e2nico).":[94],"As":[95],"avalia\u00e7\u00f5es":[96],"dos":[99,130,261,268],"fator":[102],"recombinante":[104],"foram":[105,120,174],"realizadas":[106],"para,":[107],"no":[108],"m\u00ednimo,":[109],"5":[110,165,232],"concentra\u00e7\u00f5es,":[113],"contemplando":[114],"seis":[115],"par\u00e2metros":[116],"farmacopeicos.":[117],"Os":[118,132,168,183],"ensaios":[119,184],"conduzidos":[121],"acordo":[123],"as":[125,152],"metodologias":[126],"recomendadas":[127],"pelo":[128],"fabricante":[129],"kits.":[131],"empregando":[135],"os":[136,204,237],"Endozyme\u00ae":[138],"EndoLISA\u00ae":[142,209],"atenderam":[143],"aos":[144],"crit\u00e9rios":[145],"exatid\u00e3o,":[147],"precis\u00e3o":[148],"linearidade":[150],"faixas":[153],"entre":[156],"0,005":[157],"10":[159],"UE/mL,":[160,166],"0,05":[162],"UE/mL":[163],"respectivamente.":[167],"limites":[169],"detec\u00e7\u00e3o":[171,242],"definidos":[175],"menor":[178],"concentra\u00e7\u00e3o":[179],"cada":[181],"faixa.":[182],"robustez":[186],"demonstraram":[187],"desvios":[189],"nos":[190,198,223],"tempos":[191,199],"adi\u00e7\u00e3o":[193],"do":[194],"enzim\u00e1tico":[196],"liga\u00e7\u00e3o":[201],"n\u00e3o":[202,210],"impactaram":[203],"resultados.":[205],"Entretanto,":[206],"kit":[208],"deve":[211],"ser":[212],"considerado":[213],"como":[214],"op\u00e7\u00e3o":[216],"avalia\u00e7\u00e3o":[219],"quais":[224],"s\u00e3o":[225],"esperadas":[226],"concentra\u00e7\u00f5es":[227],"superiores":[230],"UE/mL.":[233],"Conclui-se,":[234],"portanto,":[235],"reagentes":[238],"recombinantes":[239],"oferecem":[245],"oportunidade":[247],"moderniza\u00e7\u00e3o":[249],"\u00e1rea":[252],"farmac\u00eautica":[253],"podem":[255],"contribuir":[256],"significativamente":[257],"conserva\u00e7\u00e3o":[260],"caranguejos-ferradura":[262],"redu\u00e7\u00e3o":[265],"da":[266],"utiliza\u00e7\u00e3o":[267],"coelhos":[269],"na":[270],"realiza\u00e7\u00e3o":[271],"ensaios.":[273]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-10-22T00:00:00"}
