{"id":"https://openalex.org/W4403598381","doi":"https://doi.org/10.3390/app14209605","title":"Immobilization of Levocetirizine on Mesoporous Silica for Antiallergenic Gel Formulation","display_name":"Immobilization of Levocetirizine on Mesoporous Silica for Antiallergenic Gel Formulation","publication_year":2024,"publication_date":"2024-10-21","ids":{"openalex":"https://openalex.org/W4403598381","doi":"https://doi.org/10.3390/app14209605"},"language":"en","primary_location":{"id":"doi:10.3390/app14209605","doi":"https://doi.org/10.3390/app14209605","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app14209605","pdf_url":"https://www.mdpi.com/2076-3417/14/20/9605/pdf?version=1729515543","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3417/14/20/9605/pdf?version=1729515543","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023854793","display_name":"Kl\u00e1ra Szentmih\u00e1lyi","orcid":"https://orcid.org/0000-0002-3618-8151","observed_orcids":["https://orcid.org/0000-0002-3618-8151"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Kl\u00e1ra Szentmih\u00e1lyi","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-3618-8151","affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064928088","display_name":"Szilvia Kl\u00e9bert","orcid":"https://orcid.org/0000-0002-3107-3371","observed_orcids":["https://orcid.org/0000-0002-3107-3371"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Szilvia Kl\u00e9bert","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-3107-3371","affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077158690","display_name":"Krisztina M\u00f3ricz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096237","display_name":"Egis Pharmaceuticals (Hungary)","ror":"https://ror.org/00qzn0672","country_code":"HU","type":"company","lineage":["https://openalex.org/I4210096237"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Krisztina M\u00f3ricz","raw_affiliation_strings":["EGIS Pharmaceuticals PLC, Kereszt\u00fari \u00fat 30-38, H-1106 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EGIS Pharmaceuticals PLC, Kereszt\u00fari \u00fat 30-38, H-1106 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067288984","display_name":"Antal Bal\u00e1zs Szenes-Nagy","orcid":"https://orcid.org/0000-0003-4623-0875","observed_orcids":["https://orcid.org/0000-0003-4623-0875"]},"institutions":[{"id":"https://openalex.org/I4210096237","display_name":"Egis Pharmaceuticals (Hungary)","ror":"https://ror.org/00qzn0672","country_code":"HU","type":"company","lineage":["https://openalex.org/I4210096237"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Antal Bal\u00e1zs Szenes-Nagy","raw_affiliation_strings":["EGIS Pharmaceuticals PLC, Kereszt\u00fari \u00fat 30-38, H-1106 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0003-4623-0875","affiliations":[{"raw_affiliation_string":"EGIS Pharmaceuticals PLC, Kereszt\u00fari \u00fat 30-38, H-1106 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032347985","display_name":"Zolt\u00e1n May","orcid":"https://orcid.org/0000-0002-6493-5425","observed_orcids":["https://orcid.org/0000-0002-6493-5425"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n May","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030479737","display_name":"Eszter B\u00f3dis","orcid":"https://orcid.org/0000-0002-5794-5641","observed_orcids":["https://orcid.org/0000-0002-5794-5641"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Eszter B\u00f3dis","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-5794-5641","affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039224904","display_name":"M. Mohai","orcid":"https://orcid.org/0000-0002-5162-1590","observed_orcids":["https://orcid.org/0000-0002-5162-1590"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Mikl\u00f3s Mohai","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-5162-1590","affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012554784","display_name":"L\u00e1szl\u00f3 Trif","orcid":"https://orcid.org/0000-0002-3960-1829","observed_orcids":["https://orcid.org/0000-0002-3960-1829"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"L\u00e1szl\u00f3 Trif","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-3960-1829","affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039035966","display_name":"Mirella Mirank\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Mirella Mirank\u00f3","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052020174","display_name":"Tivadar Feczk\u00f3","orcid":"https://orcid.org/0000-0002-6119-7922","observed_orcids":["https://orcid.org/0000-0002-6119-7922"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tivadar Feczk\u00f3","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029301101","display_name":"Zolt\u00e1n K\u00e1roly","orcid":"https://orcid.org/0000-0002-7701-1539","observed_orcids":["https://orcid.org/0000-0002-7701-1539"]},"institutions":[{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n K\u00e1roly","raw_affiliation_strings":["Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-7701-1539","affiliations":[{"raw_affiliation_string":"Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tud\u00f3sok K\u00f6r\u00fatja 2, H-1117 Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064928088"],"corresponding_institution_ids":["https://openalex.org/I4210096417","https://openalex.org/I80251312"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2728},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2728},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10875306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"20","first_page":"9605","last_page":"9605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.43700000643730164,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.43700000643730164,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10735","display_name":"Mesoporous Materials and Catalysis","score":0.20970000326633453,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levocetirizine","display_name":"levocetirizine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mesoporous-silica","display_name":"mesoporous silica","score":0.8999999761581421},{"id":"https://openalex.org/keywords/drug-immobilization","display_name":"drug immobilization","score":0.9750000238418579},{"id":"https://openalex.org/keywords/topical-gel-formulation","display_name":"topical gel formulation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antiallergic-drugs","display_name":"antiallergic drugs","score":0.7850000262260437},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ear-edema","display_name":"ear edema","score":0.8600000143051147},{"id":"https://openalex.org/keywords/croton-oil","display_name":"croton oil","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5225034356117249},{"id":"https://openalex.org/C2780920841","wikidata":"https://www.wikidata.org/wiki/Q421091","display_name":"Levocetirizine","level":2,"score":0.42347806692123413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3496667742729187},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19947317242622375}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/app14209605","doi":"https://doi.org/10.3390/app14209605","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app14209605","pdf_url":"https://www.mdpi.com/2076-3417/14/20/9605/pdf?version=1729515543","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a8b4a9558459434c8cc8439afa2a2674","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a8b4a9558459434c8cc8439afa2a2674","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Sciences, Vol 14, Iss 20, p 9605 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/app14209605","doi":"https://doi.org/10.3390/app14209605","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app14209605","pdf_url":"https://www.mdpi.com/2076-3417/14/20/9605/pdf?version=1729515543","source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9057000279426575}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403598381.pdf","grobid_xml":"https://content.openalex.org/works/W4403598381.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1966500444","https://openalex.org/W1966834540","https://openalex.org/W1996984925","https://openalex.org/W2000016376","https://openalex.org/W2000366249","https://openalex.org/W2001754064","https://openalex.org/W2004513240","https://openalex.org/W2011254969","https://openalex.org/W2011853196","https://openalex.org/W2012268383","https://openalex.org/W2017578953","https://openalex.org/W2027197256","https://openalex.org/W2032174676","https://openalex.org/W2046142803","https://openalex.org/W2053071175","https://openalex.org/W2054345064","https://openalex.org/W2054616259","https://openalex.org/W2076759023","https://openalex.org/W2080279782","https://openalex.org/W2093390887","https://openalex.org/W2114841760","https://openalex.org/W2125746450","https://openalex.org/W2206617507","https://openalex.org/W2739931821","https://openalex.org/W2773607015","https://openalex.org/W2788014396","https://openalex.org/W2793555126","https://openalex.org/W2898479620","https://openalex.org/W2914866862","https://openalex.org/W2999765484","https://openalex.org/W3071594890","https://openalex.org/W3090227268","https://openalex.org/W4220782584","https://openalex.org/W4308122685","https://openalex.org/W4309845644","https://openalex.org/W4377138633","https://openalex.org/W4400870362"],"related_works":["https://openalex.org/W4309845644","https://openalex.org/W4320149668","https://openalex.org/W6922505041","https://openalex.org/W2605618359","https://openalex.org/W2057025619","https://openalex.org/W3142018684","https://openalex.org/W4317206873","https://openalex.org/W3039014572","https://openalex.org/W3141699392","https://openalex.org/W2898479620"],"abstract_inverted_index":{"Levocetirizine":[0],"dihydrochloride":[1,52,97],"is":[2,28,128,140,163],"an":[3],"effective":[4],"antiallergenic":[5],"drug":[6],"applied":[7],"mostly":[8],"orally;":[9],"however,":[10],"developing":[11],"a":[12,24,63,74,79,85,181,191,201,211,222],"topical":[13],"formulation":[14,26,216,232],"for":[15,104,179],"localized":[16],"treatment":[17],"could":[18],"be":[19,132,177],"beneficial.":[20],"To":[21],"achieve":[22],"this,":[23],"modified":[25],"technique":[27],"necessary":[29],"to":[30,131,142,210,225],"enhance":[31],"bioavailability":[32],"efficiency":[33],"and":[34,54,117,184],"minimize":[35],"possible":[36],"side":[37],"effects.":[38],"Therefore,":[39],"levocetirizine":[40,59,72,110,150,193,218],"particles":[41],"were":[42,60],"prepared":[43],"by":[44,82,113],"immobilization":[45,94],"on":[46,62,78],"mesoporous":[47],"silica":[48],"material.":[49],"Both":[50],"the":[51,69,96,124,134,137,143,154,157,161,166,169,214,230],"form":[53,77,98,125],"its":[55],"free":[56,75,138,194,219],"base":[57,76,139,195,220],"of":[58,68,109,126,156,168],"fixed":[61],"silica-type":[64],"Syloid":[65,80,162],"support.":[66],"Immobilization":[67],"active":[70,121,158,171],"ingredient":[71,122,159,172],"in":[73,84,95,99,123,133,145,198,200],"support":[81],"mixing":[83],"dichloromethane":[86],"solution":[87],"provides":[88],"better":[89],"surface":[90,144],"coverage":[91],"(65.5%)":[92],"than":[93,165],"water":[100],"or":[101],"methanol":[102],"(24.5%":[103],"both).":[105],"The":[106,120,148],"successful":[107],"binding":[108],"was":[111,196],"confirmed":[112],"X-ray":[114],"photoelectron":[115],"spectroscopy":[116],"infrared":[118],"measurements.":[119],"hydrochloride":[127],"more":[129,182],"likely":[130],"pores,":[135],"while":[136],"bound":[141],"larger":[146],"quantities.":[147],"time-dependent":[149],"release":[151],"showed":[152],"that":[153,229],"liberation":[155],"from":[160],"slower":[164],"dissolution":[167],"starting":[170],"itself,":[173],"so":[174],"it":[175],"may":[176,233],"suitable":[178],"exerting":[180],"reliable":[183],"prolonged":[185],"local":[186],"effect.":[187],"A":[188],"gel":[189],"containing":[190,217],"Syloid-fixed":[192],"tested":[197],"vivo":[199],"croton":[202],"oil-induced":[203],"ear":[204],"edema":[205],"mouse":[206],"model.":[207],"When":[208],"compared":[209],"reference":[212],"gel,":[213,227],"half-dose":[215],"demonstrated":[221],"similar":[223],"efficacy":[224],"Fenistil":[226],"indicating":[228],"new":[231],"offer":[234],"superior":[235],"effectiveness":[236],"at":[237],"lower":[238],"doses.":[239]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2024-10-22T00:00:00"}