{"id":"https://openalex.org/W4403554241","doi":"https://doi.org/10.1016/j.htct.2024.09.1009","title":"RESULTADOS DO CAPLACIZUMABE NA P\u00daRPURA TROMBOCITOP\u00caNICA TROMB\u00d3TICA: UMA REVIS\u00c3O SISTEM\u00c1TICA E META-AN\u00c1LISE","display_name":"RESULTADOS DO CAPLACIZUMABE NA P\u00daRPURA TROMBOCITOP\u00caNICA TROMB\u00d3TICA: UMA REVIS\u00c3O SISTEM\u00c1TICA E META-AN\u00c1LISE","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403554241","doi":"https://doi.org/10.1016/j.htct.2024.09.1009"},"language":"pt","primary_location":{"id":"doi:10.1016/j.htct.2024.09.1009","doi":"https://doi.org/10.1016/j.htct.2024.09.1009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2024.09.1009","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2024.09.1009","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114327830","display_name":"T Stabach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136792","display_name":"Universidade do Contestado","ror":"https://ror.org/03qbgfe05","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210136792"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T Stabach","raw_affiliation_strings":["Universidade do Contestado (UnC), Mafra, SC, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade do Contestado (UnC), Mafra, SC, Brasil","institution_ids":["https://openalex.org/I4210136792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114327831","display_name":"CRPES Antocheski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136792","display_name":"Universidade do Contestado","ror":"https://ror.org/03qbgfe05","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210136792"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"CRPES Antocheski","raw_affiliation_strings":["Universidade do Contestado (UnC), Mafra, SC, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade do Contestado (UnC), Mafra, SC, Brasil","institution_ids":["https://openalex.org/I4210136792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114327832","display_name":"DG Dums","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136792","display_name":"Universidade do Contestado","ror":"https://ror.org/03qbgfe05","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210136792"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"DG Dums","raw_affiliation_strings":["Universidade do Contestado (UnC), Mafra, SC, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade do Contestado (UnC), Mafra, SC, Brasil","institution_ids":["https://openalex.org/I4210136792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114327833","display_name":"AFV Carazzai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136792","display_name":"Universidade do Contestado","ror":"https://ror.org/03qbgfe05","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210136792"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"AFV Carazzai","raw_affiliation_strings":["Universidade do Contestado (UnC), Mafra, SC, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade do Contestado (UnC), Mafra, SC, Brasil","institution_ids":["https://openalex.org/I4210136792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060840542","display_name":"Fernando Tureck","orcid":"https://orcid.org/0000-0001-5583-1088","observed_orcids":["https://orcid.org/0000-0001-5583-1088"]},"institutions":[{"id":"https://openalex.org/I4210136792","display_name":"Universidade do Contestado","ror":"https://ror.org/03qbgfe05","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210136792"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F Tureck","raw_affiliation_strings":["Universidade do Contestado (UnC), Mafra, SC, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade do Contestado (UnC), Mafra, SC, Brasil","institution_ids":["https://openalex.org/I4210136792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210136792"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":null,"first_page":"S601","last_page":"S601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caplacizumab","display_name":"caplacizumab","score":0.9110000133514404},{"id":"https://openalex.org/keywords/thrombotic-thrombocytopenic-purpura","display_name":"thrombotic thrombocytopenic purpura","score":0.9860000014305115},{"id":"https://openalex.org/keywords/monoclonal-antibody-therapy","display_name":"monoclonal antibody therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7789999842643738},{"id":"https://openalex.org/keywords/refractoriness","display_name":"refractoriness","score":0.8149999976158142},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bleeding-events","display_name":"bleeding events","score":0.9079999923706055},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.5680000185966492},{"id":"https://openalex.org/keywords/platelet-count-normalization","display_name":"platelet count normalization","score":0.8510000109672546},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.753000020980835},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.703000009059906},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.4020000100135803},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7704570293426514},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.32833972573280334},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.09702029824256897}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2024.09.1009","doi":"https://doi.org/10.1016/j.htct.2024.09.1009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2024.09.1009","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:58c4a1fc161e42eda0a7e305b4dc173f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/58c4a1fc161e42eda0a7e305b4dc173f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S601- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2024.09.1009","doi":"https://doi.org/10.1016/j.htct.2024.09.1009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2024.09.1009","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7222739340","https://openalex.org/W6890025433","https://openalex.org/W6958071856","https://openalex.org/W7124545044","https://openalex.org/W4285143783","https://openalex.org/W4281621786","https://openalex.org/W6891556006","https://openalex.org/W2946387366","https://openalex.org/W4294300890","https://openalex.org/W4387731708"],"abstract_inverted_index":{"Atrav\u00e9s":[0],"de":[1,4,42,58,102,121,141,152,160,165,175,182,185,190,240,258,263,282,308,317,331,347,358,419,428],"dois":[2],"estudos":[3,218,349,420],"fase":[5],"II":[6],"e":[7,62,128,146,163,178,188,213,221,248,367,372,382,386,399,421],"III,":[8],"o":[9,27,133,195,259,292,302,305,397,400],"caplacizumabe,":[10,198,324],"um":[11,279,298,333],"anticorpo":[12],"monoclonal,":[13],"foi":[14,66,83,97,192,296,373],"aprovado":[15],"como":[16,105],"parte":[17],"da":[18,88,180,236,269,287,294,300,310,336,339,402,437],"terapia":[19,237,295],"na":[20,39,267,360],"P\u00farpura":[21],"Trombocitop\u00eanica":[22],"Tromb\u00f3tica":[23],"(PTT).":[24],"Desta":[25],"forma,":[26],"objetivo":[28],"deste":[29],"trabalho":[30],"\u00e9":[31,215,278,327],"analisar":[32],"os":[33,205,352],"resultados":[34,395],"do":[35,37,69,86,197,246,250,252,323],"uso":[36,196,251,309],"caplacizumabe":[38,134,260,363],"PTT.":[40],"Trata-se":[41],"uma":[43,100,433],"revis\u00e3o":[44,96,220],"sistem\u00e1tica":[45],"com":[46,138,149,194,223,291,378],"meta-an\u00e1lise":[47,82,120],"que":[48,132,229,274,303,388],"pesquisou":[49],"artigos":[50,109],"publicados":[51],"nos":[52,217],"\u00faltimos":[53],"15":[54],"anos":[55],"nas":[56],"bases":[57],"dados:":[59],"LILACS,":[60],"PubMed":[61],"SciELO.":[63],"A":[64,81],"pesquisa":[65],"refinada":[67],"atrav\u00e9s":[68,85],"acr\u00f4nimo":[70],"PICO.":[71],"Os":[72],"dados":[73,103],"obtidos":[74],"foram":[75,202],"relatados":[76],"conforme":[77],"a":[78,111,119,136,147,224,256,275,325,345,365,368,409],"diretriz":[79],"PRISMA.":[80],"realizada":[84],"software":[87],"Cochrane":[89],"Review":[90],"Manager":[91],"5.4.":[92],"O":[93,362],"protocolo":[94],"desta":[95,219],"registrado":[98],"em":[99,227,272,426],"base":[101],"conhecida":[104],"PROSPERO":[106],"(#CRD42023454800).":[107],"8":[108],"compuseram":[110],"amostra":[112],"final,":[113],"totalizando":[114],"691":[115],"pacientes,":[116],"sendo":[117],"feito":[118],"4":[122],"desfechos:":[123],"mortalidade,":[124,270],"refratariedade,":[125],"eventos":[126,129,161,166,314,353,384],"hemorr\u00e1gicos":[127,385],"tromboemb\u00f3licos.":[130],"Demonstrou-se":[131],"reduziu":[135],"mortalidade":[137,212],"Odds":[139,150],"Ratio":[140,151],"0.24":[142],"(95%":[143,154],"IC":[144,155],"0.10\u20120.61)":[145],"refratariedade":[148,214,369],"0.22":[153],"0.10\u20120.50).":[156],"Tamb\u00e9m":[157],"houve":[158],"redu\u00e7\u00e3o":[159,184,268,288],"tromboemb\u00f3licos":[162,354,387],"aumento":[164,299],"hemorr\u00e1gicos,":[167,315],"mas":[168],"sem":[169],"signific\u00e2ncia":[170,391],"estat\u00edstica.":[171,392],"Um":[172],"menor":[173],"tempo":[174,306],"interna\u00e7\u00e3o":[176],"hospitalar":[177],"normaliza\u00e7\u00e3o":[179],"contagem":[181],"plaquetas,":[183],"exacerba\u00e7\u00f5es,":[186,290],"n\u00famero":[187,418],"volume":[189],"plasmaf\u00e9rese":[191],"observado":[193,297],"enquanto":[199],"as":[200],"recidivas":[201,381],"divergentes":[203],"entre":[204,211],"estudos.":[206],"Uma":[207],"rela\u00e7\u00e3o":[208],"diretamente":[209],"proporcional":[210],"observada":[216],"condiz":[222],"literatura,":[225],"tendo":[226,271],"vista":[228,273],"quase":[230],"metade":[231],"dos":[232,370,383,394],"\u00f3bitos":[233],"no":[234,321],"grupo":[235,322],"padr\u00e3o":[238],"decorreram":[239],"doen\u00e7a":[241],"refrat\u00e1ria":[242,265,277],"devido":[243,355,415],"ao":[244,416],"atraso":[245],"diagn\u00f3stico":[247],"in\u00edcio":[249],"caplacizumabe.":[253],"Sendo":[254],"assim,":[255],"capacidade":[257],"evitar":[261],"epis\u00f3dios":[262],"PTT":[264,276],"impactou":[266],"importante":[280],"indicador":[281],"mau":[283],"progn\u00f3stico.":[284],"Ademais,":[285],"apesar":[286,316],"das":[289,380],"t\u00e9rmino":[293],"recidiva,":[301],"questiona":[304],"ideal":[307],"medica\u00e7\u00e3o.":[311,438],"Referente":[312],"aos":[313],"serem":[318],"mais":[319,348,435],"evidentes":[320],"avalia\u00e7\u00e3o":[326,434],"limitada":[328],"pela":[329],"dificuldade":[330],"diferenciar":[332],"sangramento":[334],"decorrente":[335],"medica\u00e7\u00e3o":[337,403],"ou":[338],"doen\u00e7a.":[340],"Por":[341],"fim,":[342],"an\u00e1lises":[343],"pontuam":[344],"necessidade":[346],"para":[350,375,432],"avaliar":[351],"\u00e0":[356],"falta":[357],"padroniza\u00e7\u00e3o":[359],"avalia\u00e7\u00e3o.":[361],"melhorou":[364],"sobrevida":[366],"pacientes":[371],"favor\u00e1vel":[374],"outros":[376],"desfechos,":[377],"exce\u00e7\u00e3o":[379],"n\u00e3o":[389],"demonstraram":[390],"Apesar":[393],"promissores,":[396],"acesso":[398],"custo":[401],"ainda":[404],"s\u00e3o":[405,430],"problemas":[406],"enfrentados,":[407],"dificultando":[408],"implanta\u00e7\u00e3o":[410],"dessa":[411],"terap\u00eautica.":[412],"Al\u00e9m":[413],"disso,":[414],"baixo":[417],"amostras":[422],"populacionais,":[423],"outras":[424],"experi\u00eancias":[425],"centros":[427],"sa\u00fade":[429],"necess\u00e1rias":[431],"detalhada":[436]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2024-10-19T00:00:00"}
