{"id":"https://openalex.org/W4403552882","doi":"https://doi.org/10.3389/fphys.2024.1508133","title":"Editorial: Functional modifications of ion channels in arrhythmogenesis","display_name":"Editorial: Functional modifications of ion channels in arrhythmogenesis","publication_year":2024,"publication_date":"2024-10-18","ids":{"openalex":"https://openalex.org/W4403552882","doi":"https://doi.org/10.3389/fphys.2024.1508133","pmid":"https://pubmed.ncbi.nlm.nih.gov/39493865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11527714"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2024.1508133","doi":"https://doi.org/10.3389/fphys.2024.1508133","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2024.1508133","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1508133/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1508133/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065702246","display_name":"Drew M. Nassal","orcid":"https://orcid.org/0000-0002-8018-3913","observed_orcids":["https://orcid.org/0000-0002-8018-3913"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Drew Nassal","raw_affiliation_strings":["Department of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","Frick Center for Heart Failure and Arrhythmia Research, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]},{"raw_affiliation_string":"Frick Center for Heart Failure and Arrhythmia Research, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079314197","display_name":"David R. Van Wagoner","orcid":"https://orcid.org/0000-0001-8250-9828","observed_orcids":["https://orcid.org/0000-0001-8250-9828"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David R. Van Wagoner","raw_affiliation_strings":["Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, United States","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051430483","display_name":"Mona El Refaey","orcid":"https://orcid.org/0000-0003-3989-0920","observed_orcids":["https://orcid.org/0000-0003-3989-0920"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mona El Refaey","raw_affiliation_strings":["Division of Cardiac Surgery, Department of Surgery, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","Frick Center for Heart Failure and Arrhythmia Research, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiac Surgery, Department of Surgery, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]},{"raw_affiliation_string":"Frick Center for Heart Failure and Arrhythmia Research, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051430483","https://openalex.org/A5065702246","https://openalex.org/A5079314197"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I2802841970","https://openalex.org/I52357470"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":null,"first_page":"1508133","last_page":"1508133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.8849999904632568},{"id":"https://openalex.org/keywords/arrhythmogenesis","display_name":"arrhythmogenesis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cardiac-ion-channels","display_name":"cardiac ion channels","score":0.9110000133514404},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.8629999756813049},{"id":"https://openalex.org/keywords/internal-translation","display_name":"internal translation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/beta-adrenergic-receptor-desensitization","display_name":"beta-adrenergic receptor desensitization","score":0.9380000233650208},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9980000257492065},{"id":"https://openalex.org/keywords/remdesivir","display_name":"remdesivir","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sinoatrial-node","display_name":"sinoatrial node","score":0.8970000147819519},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/action-potential-propagation","display_name":"action potential propagation","score":0.5440000295639038},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.6521635055541992},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4018787741661072},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4013882875442505},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.34851133823394775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23713436722755432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21042433381080627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16391253471374512},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphys.2024.1508133","doi":"https://doi.org/10.3389/fphys.2024.1508133","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2024.1508133","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1508133/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11527714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11527714","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11527714/pdf/fphys-15-1508133.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:39493865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39493865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:8a8059f279b449da9f8ca5faca4e9e21","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8a8059f279b449da9f8ca5faca4e9e21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2024.1508133","doi":"https://doi.org/10.3389/fphys.2024.1508133","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2024.1508133","pdf_url":"https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1508133/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3791825247","display_name":"Defining new pathways for cardiac automaticity","funder_award_id":"R00HL146969","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000878821","display_name":"Regulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophy","funder_award_id":"R00HL157684","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000899634","display_name":"Atrial Fibrillation Post-GWAS: Mechanisms to Treatment","funder_award_id":"P01HL158502","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000915941","display_name":"Novel Roles of Protein phosphatase 2A in Cardiac Arrhythmia","funder_award_id":"R01HL175380","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403552882.pdf","grobid_xml":"https://content.openalex.org/works/W4403552882.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2809442687","https://openalex.org/W2891288279","https://openalex.org/W4206215027","https://openalex.org/W4385564760"],"related_works":["https://openalex.org/W2803679205","https://openalex.org/W4392470906","https://openalex.org/W3095036989","https://openalex.org/W3200695675","https://openalex.org/W2295752291","https://openalex.org/W2885659271","https://openalex.org/W3166072758","https://openalex.org/W2090617427","https://openalex.org/W2131718975","https://openalex.org/W1984852056"],"abstract_inverted_index":{"Arrhythmias":[0],"are":[1],"a":[2,8,43,173,202,241,557,678,905],"major":[3,9],"public":[4],"health":[5],"burden":[6],"and":[7,13,16,91,96,110,121,161,207,210,248,262,302,337,346,351,359,364,375,380,433,483,491,507,519,526,539,552,572,587,604,629,666,743,767,819,840,866,909],"cause":[10],"of":[11,46,71,79,88,106,113,152,179,199,266,279,285,300,305,320,333,372,377,389,397,426,438,455,465,481,488,512,547,624,644,653,698,710,728,763,770,781,791,806,811,821,830,845,855,885,890,900],"morbidity":[12],"mortality":[14],"(Srinivasan":[15],"Schilling,":[17],"2018).":[18,147],"Pharmacologic":[19],"anti-arrhythmic":[20],"agents":[21],"targeting":[22,50],"ion":[23,52,132,316,322,330,334,338,404],"channel":[24,133,335,339,405,794],"activity":[25],"have":[26],"often":[27],"triggered":[28],"pro-arrhythmic":[29,292],"outcomes":[30],"(Saljic":[31],"et":[32,145,224,254,383,542,704,833],"al.,":[33,146,225,384],"2023).":[34],"To":[35,746],"address":[36],"this":[37,163,267,447,554,573,891],"paradox,":[38],"we":[39],"sought":[40],"to":[41,76,138,141,270,406,422,429,470,485,499,504,529,564,601,681,730,789,824],"provide":[42,240],"comprehensive":[44],"overview":[45],"the":[47,58,69,86,104,111,126,130,150,177,257,264,276,298,318,344,386,400,424,430,435,478,486,509,545,566,579,607,645,651,683,707,726,748,771,776,779,792,800,826,843,853,886,897,901],"functional":[48,84],"modifications":[49,67,336],"cardiac":[51,219,259,271,325,360,442,517,538,584,588,625,663,668,849],"channels.":[53],"We":[54,148],"were":[55,186],"interested":[56],"in":[57,124,157,309,324,440,446,468,502,536,550,617,636,648,650,695,718,754,842],"molecular":[59],"interventions":[60],"and/or":[61],"therapies":[62],"aimed":[63],"at":[64],"inducing/inhibiting":[65],"these":[66,80,367],"for":[68,245,415,533,802,847,869,878,907],"treatment":[70],"arrhythmia.":[72],"Our":[73,116],"scope":[74],"was":[75,419,787],"highlight":[77],"some":[78],"modifications,":[81],"evaluate":[82],"their":[83,92,894],"impact,":[85],"regulation":[87,454,487,555],"upstream":[89,356],"pathways":[90],"interaction":[93],"with":[94],"physiologic":[95,368],"pathologic":[97],"signaling":[98,647],"pathways.":[99,919],"These":[100,797],"insights":[101,191],"may":[102,915],"facilitate":[103],"identification":[105,376],"novel":[107,114,378],"physiological":[108],"targets":[109,358],"development":[112,820],"therapeutics.":[115],"topic":[117,229],"includes":[118,461],"connexin-43":[119],"(Cx-43)":[120],"its":[122,193,393,416],"role":[123,299,388,437],"maintaining":[125],"electrical":[127,286,443,456],"rhythm":[128,260,518],"as":[129,167,859,904],"only":[131,401],"that":[134,673],"has":[135,612],"been":[136,614],"reported":[137],"be":[139,289,500,677],"subject":[140],"internal":[142,398],"translation":[143],"(Kotini":[144],"include":[149,916],"impact":[151,511,780],"\u03b2-adrenergic":[153],"receptor":[154,627],"(\u03b2-AR)":[155],"desensitization":[156,603,611,675],"heart":[158,685],"failure":[159],"(HF),":[160],"how":[162,231,263,282,641],"downregulation":[164,605],"can":[165,239,288,676],"serve":[166],"an":[168,311,713,753,836],"adaptive":[169],"process":[170,268,680],"rather":[171],"than":[172],"detrimental":[174,510,560,616],"process.":[175,561],"Further,":[176],"effects":[178,464,709,829],"Remdesivir":[180],"(RDV)":[181],"on":[182,275,392,515,606,783,815,838],"sinoatrial":[183,740],"nodal":[184],"cells":[185],"studied,":[187],"providing":[188],"foundational":[189],"mechanistic":[190],"into":[192,366],"future":[194,527],"clinical":[195,732,761],"use.":[196],"Finally,":[197,341],"modeling":[198,848],"arrhythmia":[200,246,872,912],"is":[201,556,570,575,594],"barrier":[203],"towards":[204],"new":[205],"discoveries":[206],"traditional":[208],"animal":[209],"cell":[211,608,880],"culture":[212,861],"models":[213],"do":[214],"not":[215],"truly":[216],"reflect":[217],"human":[218],"electro-pathophysiology":[220],"(van":[221],"der":[222],"Velden":[223],"2022).":[226],"Therefore,":[227,670],"our":[228,251],"discusses":[230],"patient-specific":[232],"induced":[233],"pluripotent":[234],"stem":[235],"cells-derived":[236],"cardiomyocytes":[237],"(iPSC-CMs)":[238],"better":[242],"personalized":[243],"platform":[244],"monitoring":[247,805],"drug":[249,715],"screening.In":[250],"topic,":[252],"Lei":[253],"al.":[255,543,705,834],"reviewed":[256,315,385,876],"normal":[258,283],"propagation":[261,284],"breakdown":[265],"leads":[269,600],"arrhythmias.":[272,850],"They":[273,295,314,473,521,851,874],"focused":[274,804],"electrophysiological":[277],"basis":[278],"arrhythmogenesis,":[280],"highlighting":[281],"activation":[287,574,582,593,599,643],"disrupted":[290],"by":[291,458,523,578],"triggering":[293],"events.":[294],"also":[296,634,875],"described":[297,496,706],"spatial":[301],"temporal":[303],"instability":[304],"propagated":[306],"AP":[307],"waves":[308],"creating":[310],"arrhythmic":[312,373,689],"substrate.":[313],"channels,":[317,331],"roles":[319,452],"different":[321],"channels":[323],"action":[326,480],"potentials,":[327],"interactions":[328],"between":[329,348],"mechanisms":[332],"modulation.":[340],"they":[342,449,495,671,751],"discussed":[343,508,544,640],"feedforward":[345],"feedback":[347],"excitation-contraction":[349],"coupling":[350,457],"surface":[352],"membrane":[353],"processes,":[354],"including":[355,738],"modulatory":[357],"remodeling.":[361],"Further":[362],"analysis":[363],"insight":[365],"processes":[369],"enhances":[370,583],"understanding":[371],"events":[374,690],"investigational":[379],"immunotherapeutic":[381],"approaches.Whisenant":[382],"expanding":[387],"Cx-43,":[390],"focusing":[391],"unique":[394],"protein":[395],"modification":[396],"translation,":[399],"currently":[402],"identified":[403,421,768],"undergo":[407],"such":[408,858],"regulation.":[409],"The":[410,638],"resulting":[411],"protein,":[412],"labeled":[413],"GJA1-20k":[414,482,497,513,531],"truncated":[417],"length,":[418],"initially":[420],"promote":[423],"trafficking":[425,490],"full-length":[427],"Cx-43":[428,484],"intercalated":[431],"discs":[432],"enhance":[434],"canonical":[436],"connexins":[439],"supporting":[441],"coupling.":[444],"However,":[445],"review,":[448],"emphasized":[450],"additional":[451],"beyond":[453],"GJA1-20k,":[459],"which":[460,476,759,786,882,914],"promoting":[462,700],"cardioprotective":[463],"ischemic":[466,505],"preconditioning":[467],"response":[469,503,563],"ischemia/reperfusion":[471],"injury.":[472],"highlighted":[474,852],"studies":[475],"attribute":[477],"therapeutic":[479,534],"mitochondrial":[489],"fusion/fission":[492],"balance.":[493],"Physiologically,":[494],"expression":[498,532],"regulated":[501],"stress":[506],"ablation":[514],"both":[516,537],"metabolism.":[520],"concluded":[522,672],"emphasizing":[524],"existing":[525],"pursuits":[528],"harness":[530],"opportunities":[535,839],"non-cardiac":[540],"applications.Mahmood":[541],"controversy":[546],"\u03b2-AR":[548,602,610,646,674],"desensitization/downregulation":[549],"HF":[551,618,649],"whether":[553],"self-preserving":[558,679],"or":[559],"In":[562],"HF,":[565],"sympathetic":[567,592,598,693],"nervous":[568],"system":[569],"activated,":[571],"mediated":[576],"mainly":[577],"\u03b21-AR.":[580],"Receptor":[581],"contractility,":[585],"relaxation":[586],"output.":[589],"While":[590],"short-term":[591],"beneficial,":[595],"long":[596],"term":[597],"membrane.":[609],"traditionally":[613],"considered":[615],"progression.":[619],"Abnormal":[620],"Ca":[621,631,660],"2+":[622,632,661],"handling":[623],"ryanodine":[626],"(RyR2)":[628],"diastolic":[630],"leak":[633],"occur":[635],"HF.":[637],"authors":[639],"further":[642,657],"presence":[652],"RyR2":[654],"dysfunction":[655,766],"would":[656],"aggravate":[658],"abnormal":[659],"handling,":[662],"dysfunction,":[664],"arrhythmogenesis":[665],"sudden":[667],"death.":[669],"protect":[682],"failing":[684],"from":[686],"developing":[687,910],"lethal":[688],"under":[691],"sustained":[692],"stimulation":[694],"HF.In":[696],"consideration":[697],"therapeutics":[699],"proarrhythmic":[701],"behavior,":[702],"Li":[703],"electrophysiologic":[708,827],"remdesivir":[711],"(RDV),":[712],"antiviral":[714],"widely":[716],"used":[717],"COVID-19":[719],"treatment.":[720],"Their":[721],"study":[722,777],"addresses":[723],"concerns":[724],"about":[725],"potential":[727],"RDV":[729,782,812],"induce":[731],"symptoms":[733],"resembling":[734],"sick":[735],"sinus":[736,744,764],"syndrome":[737],"bradycardia,":[739],"conduction":[741],"block,":[742],"arrest.":[745],"investigate":[747],"underlying":[749],"mechanisms,":[750],"employed":[752],"vivo":[755],"guinea":[756],"pig":[757],"model":[758],"recapitulated":[760],"findings":[762,798],"node":[765],"suppression":[769],"pacemaker":[772],"current,":[773],"If.":[774],"Furthermore,":[775],"uncovered":[778],"QT":[784],"prolongation,":[785],"attributed":[788],"inhibition":[790],"hERG":[793],"current":[795],"(IKr).":[796],"emphasize":[799],"need":[801],"more":[803,887],"patients":[807],"receiving":[808],"RDV,":[809],"stratification":[810],"use":[813],"based":[814],"patient":[816],"risk":[817],"factors,":[818],"supplemental":[822],"strategies":[823],"counteract":[825],"side":[828],"RDV.Lastly,":[831],"Joshi":[832],"provides":[835],"update":[837],"challenges":[841],"application":[844],"iPSC-CMs":[846],"power":[854],"combined":[856],"technologies":[857],"3D":[860],"models,":[862],"CRISPR":[863],"gene":[864],"editing,":[865],"optical":[867],"platforms":[868],"enhancing":[870],"iPSC-CM":[871,902],"research.":[873],"approaches":[877],"improving":[879],"maturation,":[881],"remains":[883],"one":[884],"pronounced":[888],"limitations":[889],"platform.":[892],"Collectively,":[893],"review":[895],"underlines":[896],"continued":[898],"significance":[899],"technology":[903],"resource":[906],"identifying":[908],"translational":[911],"interventions,":[913],"posttranslational":[917],"regulatory":[918]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-10-19T00:00:00"}