{"id":"https://openalex.org/W4403548764","doi":"https://doi.org/10.1016/j.kint.2024.08.024","title":"ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease","display_name":"ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease","publication_year":2024,"publication_date":"2024-10-18","ids":{"openalex":"https://openalex.org/W4403548764","doi":"https://doi.org/10.1016/j.kint.2024.08.024","pmid":"https://pubmed.ncbi.nlm.nih.gov/39428173"},"language":"en","primary_location":{"id":"doi:10.1016/j.kint.2024.08.024","doi":"https://doi.org/10.1016/j.kint.2024.08.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.kint.2024.08.024","pdf_url":"https://www.kidney-international.org/article/S0085-2538(24)00630-6/pdf","source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.kidney-international.org/article/S0085-2538(24)00630-6/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055485962","display_name":"Tomoki Yanagi","orcid":"https://orcid.org/0000-0003-1808-2932","observed_orcids":["https://orcid.org/0000-0003-1808-2932"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoki Yanagi","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1808-2932","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroaki Kikuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroaki Kikuchi","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: hiroaki.k1114@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: hiroaki.k1114@gmail.com","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021174309","display_name":"Koh Takeuchi","orcid":"https://orcid.org/0000-0002-6227-4627","observed_orcids":["https://orcid.org/0000-0002-6227-4627"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koh Takeuchi","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081692861","display_name":"Koichiro Susa","orcid":"https://orcid.org/0000-0002-0100-4527","observed_orcids":["https://orcid.org/0000-0002-0100-4527"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichiro Susa","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021087086","display_name":"Takayasu Mori","orcid":"https://orcid.org/0000-0002-9308-7787","observed_orcids":["https://orcid.org/0000-0002-9308-7787"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayasu Mori","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9308-7787","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079660078","display_name":"Motoko Chiga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoko Chiga","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063353884","display_name":"Kouhei Yamamoto","orcid":"https://orcid.org/0000-0003-3883-4353","observed_orcids":["https://orcid.org/0000-0003-3883-4353"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouhei Yamamoto","raw_affiliation_strings":["Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008349629","display_name":"Asuka Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asuka Furukawa","raw_affiliation_strings":["Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111287538","display_name":"Takumi Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Kanazawa","raw_affiliation_strings":["Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085946915","display_name":"Yuki Kato","orcid":"https://orcid.org/0000-0002-1526-2754","observed_orcids":["https://orcid.org/0000-0002-1526-2754"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Kato","raw_affiliation_strings":["Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043688993","display_name":"Naohiro Takahashi","orcid":"https://orcid.org/0000-0001-9431-9036","observed_orcids":["https://orcid.org/0000-0001-9431-9036"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohiro Takahashi","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023791078","display_name":"Takefumi Suzuki","orcid":"https://orcid.org/0000-0002-5147-1684","observed_orcids":["https://orcid.org/0000-0002-5147-1684"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takefumi Suzuki","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033817054","display_name":"Yutaro Mori","orcid":"https://orcid.org/0000-0002-8499-5636","observed_orcids":["https://orcid.org/0000-0002-8499-5636"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaro Mori","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018367057","display_name":"Benjamin C. Carter","orcid":"https://orcid.org/0000-0001-6530-9568","observed_orcids":["https://orcid.org/0000-0001-6530-9568"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin C. Carter","raw_affiliation_strings":["Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037481712","display_name":"Makiko Mori","orcid":"https://orcid.org/0000-0003-3427-2461","observed_orcids":["https://orcid.org/0000-0003-3427-2461"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makiko Mori","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034290232","display_name":"Yuta Nakano","orcid":"https://orcid.org/0000-0002-6069-066X","observed_orcids":["https://orcid.org/0000-0002-6069-066X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Nakano","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028964887","display_name":"Tamami Fujiki","orcid":"https://orcid.org/0000-0002-6697-5930","observed_orcids":["https://orcid.org/0000-0002-6697-5930"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamami Fujiki","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Hara","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786321","display_name":"Soichiro Suzuki","orcid":"https://orcid.org/0009-0006-4118-0222","observed_orcids":["https://orcid.org/0009-0006-4118-0222"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Soichiro Suzuki","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042068623","display_name":"Fumiaki Ando","orcid":"https://orcid.org/0000-0002-8401-1705","observed_orcids":["https://orcid.org/0000-0002-8401-1705"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiaki Ando","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037416725","display_name":"Shintaro Mandai","orcid":"https://orcid.org/0000-0001-6709-306X","observed_orcids":["https://orcid.org/0000-0001-6709-306X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shintaro Mandai","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6709-306X","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057001276","display_name":"Shinya Honda","orcid":"https://orcid.org/0000-0003-3443-044X","observed_orcids":["https://orcid.org/0000-0003-3443-044X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Honda","raw_affiliation_strings":["Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053173877","display_name":"Satoru Torii","orcid":"https://orcid.org/0000-0003-4841-7131","observed_orcids":["https://orcid.org/0000-0003-4841-7131"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Torii","raw_affiliation_strings":["Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006956477","display_name":"Shigeomi Shimizu","orcid":"https://orcid.org/0000-0002-8437-0791","observed_orcids":["https://orcid.org/0000-0002-8437-0791"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeomi Shimizu","raw_affiliation_strings":["Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048923727","display_name":"Hajime Tanaka","orcid":"https://orcid.org/0000-0003-3632-2901","observed_orcids":["https://orcid.org/0000-0003-3632-2901"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Tanaka","raw_affiliation_strings":["Department of Urology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuhisa Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhisa Fujii","raw_affiliation_strings":["Department of Urology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079359671","display_name":"Tatemitsu Rai","orcid":"https://orcid.org/0000-0001-7695-778X","observed_orcids":["https://orcid.org/0000-0001-7695-778X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatemitsu Rai","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Department of Nephrology and Hypertension, Dokkyo Medical University, Tochigi, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7695-778X","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Department of Nephrology and Hypertension, Dokkyo Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I125602781","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112002848","display_name":"Shinichi Uchida","orcid":"https://orcid.org/0000-0003-1491-6071","observed_orcids":["https://orcid.org/0000-0003-1491-6071"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Uchida","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016613844","display_name":"Eisei Sohara","orcid":"https://orcid.org/0000-0003-1668-8308","observed_orcids":["https://orcid.org/0000-0003-1668-8308"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Eisei Sohara","raw_affiliation_strings":["Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: esohara.kid@tmd.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: esohara.kid@tmd.ac.jp","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016613844"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.6114,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.84121049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"106","issue":"5","first_page":"887","last_page":"906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ulk1","display_name":"ULK1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9020000100135803},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/amp-atp-ratio","display_name":"AMP/ATP ratio","score":0.8899999856948853},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.852776288986206},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7151429653167725},{"id":"https://openalex.org/C71680706","wikidata":"https://www.wikidata.org/wiki/Q18032908","display_name":"ULK1","level":5,"score":0.706572949886322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5652450919151306},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47952914237976074},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.44731056690216064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3485628366470337},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.21877336502075195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18286845088005066},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17279773950576782},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.11505496501922607}],"mesh":[{"descriptor_ui":"D000071189","descriptor_name":"Autophagy-Related Protein-1 Homolog","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000071189","descriptor_name":"Autophagy-Related Protein-1 Homolog","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011753","descriptor_name":"Pyrones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.kint.2024.08.024","doi":"https://doi.org/10.1016/j.kint.2024.08.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.kint.2024.08.024","pdf_url":"https://www.kidney-international.org/article/S0085-2538(24)00630-6/pdf","source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"doi:10.1101/2023.08.09.552390","doi":"https://doi.org/10.1101/2023.08.09.552390","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.08.09.552390","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/08/09/2023.08.09.552390.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39428173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39428173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.kint.2024.08.024","doi":"https://doi.org/10.1016/j.kint.2024.08.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.kint.2024.08.024","pdf_url":"https://www.kidney-international.org/article/S0085-2538(24)00630-6/pdf","source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1024629771","display_name":"\u814e\u81d3\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3092\u7528\u3044\u305f\u814e\u7dda\u7dad\u5316\u4fee\u98fe\u907a\u4f1d\u5b50\u306e\u63a2\u7d22","funder_award_id":"23ek0310018h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G1201347580","display_name":"Investigation of the regulatory mechanism of renal fibrosis using forward genetics with renal organoids","funder_award_id":"22K19518","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1838581054","display_name":"Investigation of aggravating factors for renal fibrosis using kidney organoids","funder_award_id":"21K08223","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G258542238","display_name":"Novel therapies for chemotherapy-induced fluid disorders via targeting water channels","funder_award_id":"24K11434","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2728665030","display_name":"\u7dda\u7dad\u5316\u30ec\u30dd\u30fc\u30bf\u30fc\u814e\u81d3\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u306b\u3088\u308bCKD\u5897\u60aa\u56e0\u5b50\u306e\u65b0\u898f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0","funder_award_id":"24K11426","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4204990518","display_name":"Non-canonical beta-catenin phosphorylation and regulation of gene expression in chronic kidney disease","funder_award_id":"23K19610","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4571843634","display_name":null,"funder_award_id":"JP21ek0310018","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4804279708","display_name":"Elucidation of physiological functions of Ulk1 phosphorylation which acts as a molecular switch leading to alternative autophagy","funder_award_id":"23K05748","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4882170996","display_name":null,"funder_award_id":"JP23ek0310018","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4890024836","display_name":null,"funder_award_id":"24ek0310023h0001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4917899021","display_name":"\u30a8\u30cd\u30eb\u30ae\u30fc\u611f\u77e5\u6a5f\u69cb\u306e\u7834\u7dbb\u306b\u3088\u308b\u6162\u6027\u814e\u81d3\u75c5\u306e\u7dda\u7dad\u5316\u9032\u884c\u6a5f\u5e8f\u89e3\u660e\u3068\u6cbb\u7642\u6cd5\u958b\u767a","funder_award_id":"24K02465","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4957674109","display_name":"Dissecting Pathogenic PKA Signaling Pathways and Advancing Targeted Therapeutic Strategies","funder_award_id":"23K24346","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5556861516","display_name":"Elucidation of molecular pathogenesis and development of novel therapeutic strategy of energy-sensing failure of AMPK in chronic kidney disease","funder_award_id":"19H03672","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5912327695","display_name":null,"funder_award_id":"21ek0109554h0001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6332709248","display_name":null,"funder_award_id":"22ek0109554h0002","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6337595204","display_name":"Application of AKAPs-PKA disruptors in the treatment of PKA-related diseases","funder_award_id":"19H01049","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6441411564","display_name":null,"funder_award_id":"JP22ek0310018","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G651366840","display_name":"Elucidating the mechanism of blood-brain barrier breakdown and cognitive dysfunction in chronic kidney disease","funder_award_id":"24K22093","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6567422089","display_name":null,"funder_award_id":"19ek0109304h0002","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6991679601","display_name":"Non-canonical beta-catenin phosphorylation and regulation of gene expression in polycystic kidney disease","funder_award_id":"24K19143","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7095872534","display_name":"\u907a\u4f1d\u6027\u814e\u7dda\u7dad\u5316\u75c7\u30cd\u30d5\u30ed\u30f3\u7646\u306e\u75c5\u614b\u89e3\u660e\u3068\u65b0\u898f\u6cbb\u7642\u6cd5\u958b\u767a","funder_award_id":"23ek0109554h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G7214193964","display_name":null,"funder_award_id":"23H04773","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G769247701","display_name":null,"funder_award_id":"JP21ek0310018","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G833514557","display_name":null,"funder_award_id":"JP22ek0310018","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320311436","display_name":"Salt Science Research Foundation","ror":"https://ror.org/05th9sq46"},{"id":"https://openalex.org/F4320317302","display_name":"Boehringer Ingelheim Japan","ror":"https://ror.org/02r1d7x68"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403548764.pdf","grobid_xml":"https://content.openalex.org/works/W4403548764.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1911315538","https://openalex.org/W1970041220","https://openalex.org/W1978763812","https://openalex.org/W1990278643","https://openalex.org/W2009263255","https://openalex.org/W2023825886","https://openalex.org/W2028048674","https://openalex.org/W2031315554","https://openalex.org/W2033497590","https://openalex.org/W2050622384","https://openalex.org/W2057218469","https://openalex.org/W2060438440","https://openalex.org/W2065582101","https://openalex.org/W2065592028","https://openalex.org/W2069207582","https://openalex.org/W2070910260","https://openalex.org/W2074894911","https://openalex.org/W2080107084","https://openalex.org/W2080481362","https://openalex.org/W2081347564","https://openalex.org/W2081920342","https://openalex.org/W2083655799","https://openalex.org/W2094780189","https://openalex.org/W2096250721","https://openalex.org/W2103659405","https://openalex.org/W2103851013","https://openalex.org/W2107227663","https://openalex.org/W2125908568","https://openalex.org/W2131188896","https://openalex.org/W2158809211","https://openalex.org/W2165945094","https://openalex.org/W2166714586","https://openalex.org/W2462514513","https://openalex.org/W2524370053","https://openalex.org/W2620374183","https://openalex.org/W2624957646","https://openalex.org/W2625887862","https://openalex.org/W2735200095","https://openalex.org/W2737775216","https://openalex.org/W2738534974","https://openalex.org/W2755578884","https://openalex.org/W2789860667","https://openalex.org/W2899521984","https://openalex.org/W2901291807","https://openalex.org/W2950572743","https://openalex.org/W2965495200","https://openalex.org/W3004978237","https://openalex.org/W3023583175","https://openalex.org/W3094017947","https://openalex.org/W3115958767","https://openalex.org/W3133726630","https://openalex.org/W3155656876","https://openalex.org/W4307842788","https://openalex.org/W4380987956"],"related_works":["https://openalex.org/W4397046216","https://openalex.org/W4307842788","https://openalex.org/W2901291807","https://openalex.org/W2158809211","https://openalex.org/W7133467977","https://openalex.org/W3202103309","https://openalex.org/W2778975235","https://openalex.org/W2624957646","https://openalex.org/W3096834656","https://openalex.org/W2368221029"],"abstract_inverted_index":{"Adenosine":[0],"monophosphate":[1],"(AMP)-activated":[2],"protein":[3],"kinase":[4,9,79],"(AMPK)":[5],"is":[6,39,63,109,142],"a":[7,132,139,166],"central":[8],"involved":[10],"in":[11,19,41,44,52,65,76,98,112,128,161,170],"energy":[12,74],"homeostasis.":[13],"Increased":[14],"intracellular":[15],"AMP":[16,26,61,88,95,117,145],"levels":[17],"result":[18],"AMPK":[20,37,92,124,127],"activation":[21,38,93],"through":[22],"the":[23,28,42,53,57,129,156],"binding":[24],"of":[25,30,73,83,90,131,144,158],"to":[27,116],"\u03b3-subunit":[29],"AMPK.":[31,91],"Recently,":[32],"we":[33,70],"reported":[34],"that":[35,141,151],"AMP-induced":[36],"impaired":[40,97],"kidneys":[43,130],"chronic":[45],"kidney":[46,159],"disease":[47],"(CKD)":[48],"despite":[49,102],"an":[50,103,122],"increase":[51],"AMP/ATP":[54,105],"ratio.":[55,106],"However,":[56],"mechanisms":[58,72],"by":[59,94],"which":[60,77],"sensing":[62,118],"disrupted":[64],"CKD":[66,113,133,162,171],"are":[67],"unclear.":[68],"Here,":[69],"identified":[71],"homeostasis":[75],"Unc-51-like":[78],"1":[80],"(ULK1)-dependent":[81],"phosphorylation":[82],"AMPK\u03b31":[84],"at":[85],"Ser260/Thr262":[86],"promoting":[87],"sensitivity":[89],"was":[96],"Ulk1":[99],"knockout":[100],"mice":[101],"increased":[104],"ULK1":[107],"expression":[108],"markedly":[110],"downregulated":[111],"kidneys,":[114],"leading":[115],"failure.":[119],"Additionally,":[120],"MK8722,":[121],"allosteric":[123],"activator,":[125],"stimulated":[126],"mouse":[134],"model":[135],"(5/6th":[136],"nephrectomy)":[137],"via":[138],"pathway":[140],"independent":[143],"sensing.":[146],"Thus,":[147],"our":[148],"study":[149],"shows":[150],"MK8722":[152],"treatment":[153],"significantly":[154],"attenuates":[155],"deterioration":[157],"function":[160],"and":[163],"may":[164],"be":[165],"potential":[167],"therapeutic":[168],"option":[169],"therapeutics.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-10-19T00:00:00"}
