{"id":"https://openalex.org/W4409572266","doi":"https://doi.org/10.1016/j.ijbiomac.2025.143325","title":"Mapping dihydropteroate synthase evolvability through identification of a novel evolutionarily critical substructure","display_name":"Mapping dihydropteroate synthase evolvability through identification of a novel evolutionarily critical substructure","publication_year":2025,"publication_date":"2025-04-18","ids":{"openalex":"https://openalex.org/W4409572266","doi":"https://doi.org/10.1016/j.ijbiomac.2025.143325","pmid":"https://pubmed.ncbi.nlm.nih.gov/40254194"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2025.143325","doi":"https://doi.org/10.1016/j.ijbiomac.2025.143325","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2025.143325","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2024/10/18/2024.10.16.618629.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005181308","display_name":"Dwipanjan Sanyal","orcid":"https://orcid.org/0009-0007-5452-5071","observed_orcids":["https://orcid.org/0009-0007-5452-5071"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dwipanjan Sanyal","raw_affiliation_strings":["Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008029787","display_name":"Arti Shivram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. Shivram","raw_affiliation_strings":["Department of Computer Science and Information Systems, Birla Institute of Technology and Science-Pilani, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Systems, Birla Institute of Technology and Science-Pilani, Hyderabad, India","institution_ids":["https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Deeptanshu Pandey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deeptanshu Pandey","raw_affiliation_strings":["Department of Biological Sciences, Birla Institute of Technology and Science-Pilani, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Birla Institute of Technology and Science-Pilani, Hyderabad, India","institution_ids":["https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068460811","display_name":"Suharto Banerjee","orcid":"https://orcid.org/0000-0002-3747-8425","observed_orcids":["https://orcid.org/0000-0002-3747-8425"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Suharto Banerjee","raw_affiliation_strings":["Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I2613432","https://openalex.org/I4210140006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Vladimir N. Uversky","raw_affiliation_strings":["USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA","Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210140006"]},{"raw_affiliation_string":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I2613432","https://openalex.org/I4210140006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106115285","display_name":"Danny Muzata","orcid":"https://orcid.org/0000-0003-0023-9233","observed_orcids":["https://orcid.org/0000-0003-0023-9233"]},"institutions":[{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Danny Muzata","raw_affiliation_strings":["Department of Computer Science and Information Systems, Birla Institute of Technology and Science-Pilani, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Systems, Birla Institute of Technology and Science-Pilani, Hyderabad, India","institution_ids":["https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043498106","display_name":"Aneesh Sreevallabh Chivukula","orcid":"https://orcid.org/0000-0002-0445-4435","observed_orcids":["https://orcid.org/0000-0002-0445-4435"]},"institutions":[{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aneesh Sreevallabh Chivukula","raw_affiliation_strings":["Department of Computer Science and Information Systems, Birla Institute of Technology and Science-Pilani, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Systems, Birla Institute of Technology and Science-Pilani, Hyderabad, India","institution_ids":["https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050918282","display_name":"Ravi Jasuja","orcid":"https://orcid.org/0000-0002-3422-2395","observed_orcids":["https://orcid.org/0000-0002-3422-2395"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Jasuja","raw_affiliation_strings":["Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052537544","display_name":"Krishnananda Chattopadhyay","orcid":"https://orcid.org/0000-0002-1449-8909","observed_orcids":["https://orcid.org/0000-0002-1449-8909"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Krishnananda Chattopadhyay","raw_affiliation_strings":["Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India. Electronic address: krish@iicb.res.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India. Electronic address: krish@iicb.res.in","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101925543","display_name":"Sourav Chowdhury","orcid":"https://orcid.org/0000-0002-1148-2995","observed_orcids":["https://orcid.org/0000-0002-1148-2995"]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sourav Chowdhury","raw_affiliation_strings":["Department of Biological Sciences, Birla Institute of Technology and Science-Pilani, Hyderabad, India. Electronic address: sourav.chowdhury@hyderabad.bits-pilani.ac.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Birla Institute of Technology and Science-Pilani, Hyderabad, India. Electronic address: sourav.chowdhury@hyderabad.bits-pilani.ac.in","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5052537544","https://openalex.org/A5101925543"],"corresponding_institution_ids":["https://openalex.org/I160344538","https://openalex.org/I4210101034","https://openalex.org/I74796645"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.0873,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.85766019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"311","issue":"Pt 2","first_page":"143325","last_page":"143325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.75,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.75,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.09759999811649323,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydropteroate-synthase","display_name":"dihydropteroate synthase","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7670000195503235},{"id":"https://openalex.org/keywords/sulfonamide-resistance","display_name":"sulfonamide resistance","score":0.9229999780654907},{"id":"https://openalex.org/keywords/escape-mutations","display_name":"escape mutations","score":0.5299999713897705},{"id":"https://openalex.org/keywords/deep-mutational-scanning","display_name":"deep mutational scanning","score":0.6930000185966492},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/adaptive-walks","display_name":"adaptive walks","score":0.8259999752044678},{"id":"https://openalex.org/keywords/evolutionary-constraints","display_name":"evolutionary constraints","score":0.5920000076293945},{"id":"https://openalex.org/keywords/folate-pathway","display_name":"folate pathway","score":0.8370000123977661},{"id":"https://openalex.org/keywords/druggability","display_name":"druggability","score":0.6359999775886536},{"id":"https://openalex.org/keywords/network-topology","display_name":"network topology","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2777234095","wikidata":"https://www.wikidata.org/wiki/Q5276443","display_name":"Dihydropteroate synthase","level":5,"score":0.8417118787765503},{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.7472796440124512},{"id":"https://openalex.org/C99679407","wikidata":"https://www.wikidata.org/wiki/Q56761637","display_name":"Substructure","level":2,"score":0.7238113284111023},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5759649276733398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4799661636352539},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4743579626083374},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3898178040981293},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2756607234477997},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0967751145362854},{"id":"https://openalex.org/C2777035104","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Pyrimethamine","level":4,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004094","descriptor_name":"Dihydropteroate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004094","descriptor_name":"Dihydropteroate Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004094","descriptor_name":"Dihydropteroate Synthase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ijbiomac.2025.143325","doi":"https://doi.org/10.1016/j.ijbiomac.2025.143325","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2025.143325","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"doi:10.1101/2024.10.16.618629","doi":"https://doi.org/10.1101/2024.10.16.618629","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.16.618629","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/10/18/2024.10.16.618629.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40254194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40254194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:25300","doi":null,"is_oa":false,"landing_page_url":"https://orcid.org/0000-0002-3747-8425","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1101/2024.10.16.618629","doi":"https://doi.org/10.1101/2024.10.16.618629","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.16.618629","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/10/18/2024.10.16.618629.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323889","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28"},{"id":"https://openalex.org/F4320335835","display_name":"CSIR \u2013 Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409572266.pdf","grobid_xml":"https://content.openalex.org/works/W4409572266.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W192243001","https://openalex.org/W1503398984","https://openalex.org/W1865100759","https://openalex.org/W2002559872","https://openalex.org/W2014776147","https://openalex.org/W2021252825","https://openalex.org/W2032735940","https://openalex.org/W2034549041","https://openalex.org/W2055043387","https://openalex.org/W2061808233","https://openalex.org/W2067424615","https://openalex.org/W2070701334","https://openalex.org/W2070815578","https://openalex.org/W2074948884","https://openalex.org/W2081629200","https://openalex.org/W2089493613","https://openalex.org/W2099449559","https://openalex.org/W2106590971","https://openalex.org/W2108638835","https://openalex.org/W2127322768","https://openalex.org/W2133791017","https://openalex.org/W2134967712","https://openalex.org/W2146891463","https://openalex.org/W2151595894","https://openalex.org/W2164088236","https://openalex.org/W2166806184","https://openalex.org/W2167482691","https://openalex.org/W2169966677","https://openalex.org/W2171641243","https://openalex.org/W2176516200","https://openalex.org/W2319149979","https://openalex.org/W2495313893","https://openalex.org/W2750791471","https://openalex.org/W2793369199","https://openalex.org/W2804523481","https://openalex.org/W2902371088","https://openalex.org/W2992355302","https://openalex.org/W3080903272","https://openalex.org/W3087907330","https://openalex.org/W3125138074","https://openalex.org/W3136442199","https://openalex.org/W3140414188","https://openalex.org/W3147791891","https://openalex.org/W3183301495","https://openalex.org/W3205657162","https://openalex.org/W3209603403","https://openalex.org/W4246270606","https://openalex.org/W4255677297","https://openalex.org/W4285097748","https://openalex.org/W4285800624","https://openalex.org/W4308256044","https://openalex.org/W4403600184"],"related_works":["https://openalex.org/W4403545204","https://openalex.org/W4246270606","https://openalex.org/W2133791017","https://openalex.org/W7171471390","https://openalex.org/W2307373173","https://openalex.org/W2095087880","https://openalex.org/W2149701011","https://openalex.org/W7221360692","https://openalex.org/W2143705904","https://openalex.org/W2075791969"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-04-18T00:00:00"}
