{"id":"https://openalex.org/W4403540140","doi":"https://doi.org/10.1056/aioa2400468","title":"AI-Based Anomaly Detection for Clinical-Grade Histopathological Diagnostics","display_name":"AI-Based Anomaly Detection for Clinical-Grade Histopathological Diagnostics","publication_year":2024,"publication_date":"2024-10-18","ids":{"openalex":"https://openalex.org/W4403540140","doi":"https://doi.org/10.1056/aioa2400468","pmid":"https://pubmed.ncbi.nlm.nih.gov/42932761"},"language":"en","primary_location":{"id":"doi:10.1056/aioa2400468","doi":"https://doi.org/10.1056/aioa2400468","is_oa":false,"landing_page_url":"https://doi.org/10.1056/aioa2400468","pdf_url":null,"source":{"id":"https://openalex.org/S4389157821","display_name":"NEJM AI","issn_l":"2836-9386","issn":["2836-9386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NEJM AI","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2406.14866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028665299","display_name":"Jonas Dippel","orcid":"https://orcid.org/0000-0002-0552-8977","observed_orcids":["https://orcid.org/0000-0002-0552-8977"]},"institutions":[{"id":"https://openalex.org/I4401727010","display_name":"Berlin Institute for the Foundations of Learning and Data","ror":"https://ror.org/05dsfb086","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4401727010","https://openalex.org/I4577782","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jonas Dippel","raw_affiliation_strings":["Berlin Institute for the Foundations of Learning and Data, Berlin","Machine Learning Group, Technical University of Berlin, Berlin"],"raw_orcid":"https://orcid.org/0000-0002-0552-8977","affiliations":[{"raw_affiliation_string":"Berlin Institute for the Foundations of Learning and Data, Berlin","institution_ids":["https://openalex.org/I4401727010"]},{"raw_affiliation_string":"Machine Learning Group, Technical University of Berlin, Berlin","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006159231","display_name":"Niklas Preni\u00dfl","orcid":"https://orcid.org/0000-0003-4619-558X","observed_orcids":["https://orcid.org/0000-0003-4619-558X"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niklas Preni\u00dfl","raw_affiliation_strings":["Biomedical Innovation Academy and Charit\u00e9 Junior Digital Clinician Scientist Program, Berlin Institute of Health, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin"],"raw_orcid":"https://orcid.org/0000-0003-4619-558X","affiliations":[{"raw_affiliation_string":"Biomedical Innovation Academy and Charit\u00e9 Junior Digital Clinician Scientist Program, Berlin Institute of Health, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084914129","display_name":"Julius Hense","orcid":"https://orcid.org/0009-0007-1160-1636","observed_orcids":["https://orcid.org/0009-0007-1160-1636"]},"institutions":[{"id":"https://openalex.org/I4401727010","display_name":"Berlin Institute for the Foundations of Learning and Data","ror":"https://ror.org/05dsfb086","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4401727010","https://openalex.org/I4577782","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julius Hense","raw_affiliation_strings":["Berlin Institute for the Foundations of Learning and Data, Berlin","Machine Learning Group, Technical University of Berlin, Berlin"],"raw_orcid":"https://orcid.org/0009-0007-1160-1636","affiliations":[{"raw_affiliation_string":"Berlin Institute for the Foundations of Learning and Data, Berlin","institution_ids":["https://openalex.org/I4401727010"]},{"raw_affiliation_string":"Machine Learning Group, Technical University of Berlin, Berlin","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072159507","display_name":"Philipp Liznerski","orcid":"https://orcid.org/0009-0000-9067-8672","observed_orcids":["https://orcid.org/0009-0000-9067-8672"]},"institutions":[{"id":"https://openalex.org/I4387152675","display_name":"Rheinland-Pf\u00e4lzische Technische Universit\u00e4t Kaiserslautern-Landau","ror":"https://ror.org/01qrts582","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387152675"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Liznerski","raw_affiliation_strings":["University of Kaiserslautern-Landau, Kaiserslautern, Germany"],"raw_orcid":"https://orcid.org/0009-0000-9067-8672","affiliations":[{"raw_affiliation_string":"University of Kaiserslautern-Landau, Kaiserslautern, Germany","institution_ids":["https://openalex.org/I4387152675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046586273","display_name":"Tobias Winterhoff","orcid":"https://orcid.org/0000-0002-4609-2268","observed_orcids":["https://orcid.org/0000-0002-4609-2268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Winterhoff","raw_affiliation_strings":["Aignostics GmbH, Berlin"],"raw_orcid":"https://orcid.org/0000-0002-4609-2268","affiliations":[{"raw_affiliation_string":"Aignostics GmbH, Berlin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054151444","display_name":"Simon Schallenberg","orcid":"https://orcid.org/0000-0002-7897-7116","observed_orcids":["https://orcid.org/0000-0002-7897-7116"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simon Schallenberg","raw_affiliation_strings":["Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin"],"raw_orcid":"https://orcid.org/0000-0002-7897-7116","affiliations":[{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091841504","display_name":"Marius Kloft","orcid":"https://orcid.org/0000-0001-6829-3725","observed_orcids":["https://orcid.org/0000-0001-6829-3725"]},"institutions":[{"id":"https://openalex.org/I4387152675","display_name":"Rheinland-Pf\u00e4lzische Technische Universit\u00e4t Kaiserslautern-Landau","ror":"https://ror.org/01qrts582","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387152675"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marius Kloft","raw_affiliation_strings":["University of Kaiserslautern-Landau, Kaiserslautern, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6829-3725","affiliations":[{"raw_affiliation_string":"University of Kaiserslautern-Landau, Kaiserslautern, Germany","institution_ids":["https://openalex.org/I4387152675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093111939","display_name":"Oliver Buchstab","orcid":"https://orcid.org/0009-0001-6003-3918","observed_orcids":["https://orcid.org/0009-0001-6003-3918"]},"institutions":[{"id":"https://openalex.org/I4405259543","display_name":"Pathologisches Institut","ror":"https://ror.org/02cqe8q68","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Buchstab","raw_affiliation_strings":["Institute of Pathology, Ludwig Maximilian University, Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0001-6003-3918","affiliations":[{"raw_affiliation_string":"Institute of Pathology, Ludwig Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070494503","display_name":"David A. Horst","orcid":"https://orcid.org/0000-0003-4755-5743","observed_orcids":["https://orcid.org/0000-0003-4755-5743"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Horst","raw_affiliation_strings":["German Cancer Research Center, Heidelberg, and German Cancer Consortium, Munich, Germany","Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin"],"raw_orcid":"https://orcid.org/0000-0003-4755-5743","affiliations":[{"raw_affiliation_string":"German Cancer Research Center, Heidelberg, and German Cancer Consortium, Munich, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012826628","display_name":"Maximilian Alber","orcid":"https://orcid.org/0009-0006-2162-6477","observed_orcids":["https://orcid.org/0009-0006-2162-6477","https://orcid.org/0000-0002-4614-6297"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Alber","raw_affiliation_strings":["Aignostics GmbH, Berlin","Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin"],"raw_orcid":"https://orcid.org/0009-0006-2162-6477","affiliations":[{"raw_affiliation_string":"Aignostics GmbH, Berlin","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016979661","display_name":"Lukas Ruff","orcid":"https://orcid.org/0000-0002-9707-297X","observed_orcids":["https://orcid.org/0000-0002-9707-297X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukas Ruff","raw_affiliation_strings":["Aignostics GmbH, Berlin"],"raw_orcid":"https://orcid.org/0000-0002-9707-297X","affiliations":[{"raw_affiliation_string":"Aignostics GmbH, Berlin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107838719","display_name":"Klaus\u2010Robert M\u00fcller","orcid":"https://orcid.org/0000-0002-3861-7685","observed_orcids":["https://orcid.org/0000-0002-3861-7685"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]},{"id":"https://openalex.org/I4401727010","display_name":"Berlin Institute for the Foundations of Learning and Data","ror":"https://ror.org/05dsfb086","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4401727010","https://openalex.org/I4577782","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE","KR"],"is_corresponding":false,"raw_author_name":"Klaus-Robert M\u00fcller","raw_affiliation_strings":["Berlin Institute for the Foundations of Learning and Data, Berlin","Department of Artificial Intelligence, Korea University, Seoul, Korea","Machine Learning Group, Technical University of Berlin, Berlin","Max-Planck Institute for Informatics, Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3861-7685","affiliations":[{"raw_affiliation_string":"Berlin Institute for the Foundations of Learning and Data, Berlin","institution_ids":["https://openalex.org/I4401727010"]},{"raw_affiliation_string":"Department of Artificial Intelligence, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Machine Learning Group, Technical University of Berlin, Berlin","institution_ids":["https://openalex.org/I4577782"]},{"raw_affiliation_string":"Max-Planck Institute for Informatics, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058109622","display_name":"Frederick Klauschen","orcid":"https://orcid.org/0000-0002-9131-2389","observed_orcids":["https://orcid.org/0000-0002-9131-2389"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4401727010","display_name":"Berlin Institute for the Foundations of Learning and Data","ror":"https://ror.org/05dsfb086","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4401727010","https://openalex.org/I4577782","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4405259543","display_name":"Pathologisches Institut","ror":"https://ror.org/02cqe8q68","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frederick Klauschen","raw_affiliation_strings":["Bavarian Cancer Research Center, Munich, Germany","Berlin Institute for the Foundations of Learning and Data, Berlin","German Cancer Research Center, Heidelberg, and German Cancer Consortium, Munich, Germany","Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","Institute of Pathology, Ludwig Maximilian University, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9131-2389","affiliations":[{"raw_affiliation_string":"Bavarian Cancer Research Center, Munich, Germany","institution_ids":[]},{"raw_affiliation_string":"Berlin Institute for the Foundations of Learning and Data, Berlin","institution_ids":["https://openalex.org/I4401727010"]},{"raw_affiliation_string":"German Cancer Research Center, Heidelberg, and German Cancer Consortium, Munich, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9 \u2014 Berlin University Medicine, Berlin","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Pathology, Ludwig Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I4405259543","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5961,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.9130773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"1","issue":"11","first_page":"AIoa2400468","last_page":"AIoa2400468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11512","display_name":"Anomaly Detection Techniques and Applications","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anomaly-detection","display_name":"anomaly detection","score":0.8939999938011169},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.7590000033378601},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.9300000071525574},{"id":"https://openalex.org/keywords/clinical-diagnostics","display_name":"clinical diagnostics","score":0.6029999852180481},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"digital pathology","score":0.574999988079071},{"id":"https://openalex.org/keywords/computer-aided-diagnosis","display_name":"computer-aided diagnosis","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C739882","wikidata":"https://www.wikidata.org/wiki/Q3560506","display_name":"Anomaly detection","level":2,"score":0.6336159706115723},{"id":"https://openalex.org/C12997251","wikidata":"https://www.wikidata.org/wiki/Q567560","display_name":"Anomaly (physics)","level":2,"score":0.5285312533378601},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38626596331596375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3338683545589447},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.33025452494621277},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.319736510515213},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14520496129989624},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1056/aioa2400468","doi":"https://doi.org/10.1056/aioa2400468","is_oa":false,"landing_page_url":"https://doi.org/10.1056/aioa2400468","pdf_url":null,"source":{"id":"https://openalex.org/S4389157821","display_name":"NEJM AI","issn_l":"2836-9386","issn":["2836-9386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NEJM AI","raw_type":"journal-article"},{"id":"pmid:42932761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42932761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NEJM AI","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:2406.14866","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2406.14866","pdf_url":"https://arxiv.org/pdf/2406.14866","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2406.14866","doi":"https://doi.org/10.48550/arxiv.2406.14866","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2406.14866","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2406.14866","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2406.14866","pdf_url":"https://arxiv.org/pdf/2406.14866","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403540140.pdf","grobid_xml":"https://content.openalex.org/works/W4403540140.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1499008677","https://openalex.org/W1787224781","https://openalex.org/W2129112648","https://openalex.org/W2129439022","https://openalex.org/W2792433889","https://openalex.org/W2921802966","https://openalex.org/W2956228567","https://openalex.org/W2999399991","https://openalex.org/W3035937807","https://openalex.org/W3037083567","https://openalex.org/W3037492894","https://openalex.org/W3044996171","https://openalex.org/W3084873959","https://openalex.org/W3089028909","https://openalex.org/W3118929067","https://openalex.org/W3127694486","https://openalex.org/W3128646645","https://openalex.org/W3132191748","https://openalex.org/W3135345798","https://openalex.org/W3139079932","https://openalex.org/W3142659855","https://openalex.org/W3157224024","https://openalex.org/W3160261825","https://openalex.org/W3195516695","https://openalex.org/W4281481864","https://openalex.org/W4281562763","https://openalex.org/W4288725068","https://openalex.org/W4288809219","https://openalex.org/W4291021272","https://openalex.org/W4387619082","https://openalex.org/W4387873179","https://openalex.org/W4388295203","https://openalex.org/W4390024648","https://openalex.org/W4390880024","https://openalex.org/W4391849646","https://openalex.org/W4392847531"],"related_works":["https://openalex.org/W4281562763","https://openalex.org/W7077169065","https://openalex.org/W7171571837","https://openalex.org/W7164939446","https://openalex.org/W296380546","https://openalex.org/W4403103868","https://openalex.org/W4390024648","https://openalex.org/W4393574639","https://openalex.org/W4387933377","https://openalex.org/W4389944144"],"abstract_inverted_index":{"BACKGROUND:":[0],"While":[1],"previous":[2],"studies":[3],"of":[4,29,44,67,77,84,97,161,222,236,289,298],"artificial":[5],"intelligence":[6],"(AI)":[7],"have":[8],"shown":[9],"its":[10],"potential":[11],"for":[12,35,63,94,119,150,257],"diagnosing":[13],"diseases":[14,45,138],"using":[15],"imaging":[16],"data,":[17],"clinical":[18,39,220],"implementation":[19],"lags":[20],"behind.":[21],"AI":[22,51,285,299,305],"models":[23,52,300],"require":[24],"training":[25,120,134,149],"with":[26,165,191],"large":[27,74],"numbers":[28],"examples,":[30],"which":[31,81],"are":[32,46,82],"only":[33,132],"available":[34],"common":[36,91,137],"diseases.":[37,145],"In":[38,212],"reality,":[40],"however,":[41],"the":[42,64,85,88,100,151,173,208,217,296],"majority":[43],"less":[47,143],"frequent,":[48],"and":[49,121,168,179,186,194,203,227,250,307,312],"current":[50],"overlook":[53],"or":[54,273],"misclassify":[55],"them.":[56],"An":[57],"effective,":[58],"comprehensive":[59],"technique":[60],"is":[61,287],"needed":[62],"full":[65],"spectrum":[66,160],"real-world":[68,75,234],"diagnoses.":[69],"METHODS:":[70],"We":[71,123],"collected":[72],"two":[73],"datasets":[76],"gastrointestinal":[78],"(GI)":[79],"biopsies,":[80],"prototypical":[83],"problem.":[86],"Herein,":[87],"10":[89],"most":[90],"findings":[92],"accounted":[93],"approximately":[95],"90%":[96],"cases,":[98,246],"whereas":[99],"remaining":[101],"10%":[102],"contained":[103],"56":[104],"disease":[105],"entities,":[106],"including":[107,270],"many":[108],"cancers.":[109],"Seventeen":[110],"million":[111],"histological":[112],"images":[113],"from":[114,136],"5423":[115],"cases":[116],"were":[117,189],"used":[118],"evaluation.":[122],"propose":[124],"a":[125,158,232],"deep":[126],"anomaly":[127],"detection":[128],"(AD)":[129],"approach":[130],"that":[131],"requires":[133],"data":[135],"to":[139,182,265],"also":[140],"detect":[141,266],"all":[142],"frequent":[144],"RESULTS:":[146],"Without":[147],"specific":[148],"diseases,":[152],"our":[153,280],"best-performing":[154],"model":[155],"reliably":[156,199],"detected":[157,190],"broad":[159],"infrequent":[162],"(\"anomalous\")":[163],"pathologies":[164],"95.0%":[166],"(stomach)":[167,193],"91.0%":[169],"(colon)":[170,196],"area":[171],"under":[172],"receiver":[174],"operating":[175],"characteristic":[176],"curve":[177],"(AUROC)":[178],"was":[180],"able":[181],"generalize":[183],"between":[184],"scanners":[185],"hospitals.":[187],"Cancers":[188],"97.7%":[192],"96.9%":[195],"AUROC.":[197],"Heatmaps":[198],"highlighted":[200],"anomalous":[201,245],"areas":[202],"can":[204,243,262],"guide":[205],"pathologists":[206],"during":[207],"diagnostic":[209],"process.":[210],"CONCLUSIONS:":[211],"this":[213],"study,":[214],"we":[215],"establish":[216],"first":[218],"effective":[219],"application":[221],"AI-based":[223],"AD":[224,242,293],"in":[225,276,301,309],"histopathology":[226],"demonstrate":[228],"high":[229],"performance":[230],"on":[231],"unique":[233],"collection":[235],"GI":[237,277],"biopsies.":[238,278],"The":[239],"proposed":[240],"novel":[241],"flag":[244],"facilitate":[247],"case":[248],"prioritization,":[249],"reduce":[251],"missed":[252],"diagnoses,":[253],"providing":[254],"critical":[255],"support":[256],"pathologists.":[258],"By":[259],"design,":[260],"it":[261],"be":[263],"expected":[264],"any":[267],"pathological":[268],"alteration":[269],"rare":[271],"primary":[272],"metastatic":[274],"cancers":[275],"To":[279],"knowledge,":[281],"no":[282],"other":[283],"published":[284],"tool":[286],"capable":[288],"zero-shot":[290],"pan-cancer":[291],"detection.":[292],"may":[294],"enhance":[295],"safety":[297],"histopathology,":[302],"thereby":[303],"driving":[304],"adoption":[306],"automation":[308],"routine":[310],"diagnostics":[311],"beyond.":[313]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-19T00:00:00"}