{"id":"https://openalex.org/W4403538543","doi":"https://doi.org/10.1016/j.heliyon.2024.e39471","title":"From inflammation to immune regulation: The dual nature of dietary lectins in health and disease","display_name":"From inflammation to immune regulation: The dual nature of dietary lectins in health and disease","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403538543","doi":"https://doi.org/10.1016/j.heliyon.2024.e39471","pmid":"https://pubmed.ncbi.nlm.nih.gov/39502251","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11535980"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e39471","doi":"https://doi.org/10.1016/j.heliyon.2024.e39471","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e39471","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2024.e39471","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022243900","display_name":"Emadeldin Hassan E. Konozy","orcid":"https://orcid.org/0000-0001-9478-8633","observed_orcids":["https://orcid.org/0000-0001-9478-8633"]},"institutions":[{"id":"https://openalex.org/I133771110","display_name":"University of Cape Coast","ror":"https://ror.org/0492nfe34","country_code":"GH","type":"education","lineage":["https://openalex.org/I133771110"]},{"id":"https://openalex.org/I64838667","display_name":"Karary University","ror":"https://ror.org/03ws81249","country_code":"SD","type":"education","lineage":["https://openalex.org/I64838667"]}],"countries":["GH","SD"],"is_corresponding":true,"raw_author_name":"Emadeldin H.E. Konozy","raw_affiliation_strings":["Biomedical and Clinical Research Centre (BCRC), College of Health and Allied Sciences (CoHAS), University of Cape Coast, Cape Coast, Ghana","Biotechnology Department, Africa City of Technology, Khartoum, Sudan","Pharmaceutical Research and Development Centre, Faculty of Pharmacy, Karary University Omdurman, Khartoum State, Sudan"],"raw_orcid":"https://orcid.org/0000-0001-9478-8633","affiliations":[{"raw_affiliation_string":"Biomedical and Clinical Research Centre (BCRC), College of Health and Allied Sciences (CoHAS), University of Cape Coast, Cape Coast, Ghana","institution_ids":["https://openalex.org/I133771110"]},{"raw_affiliation_string":"Biotechnology Department, Africa City of Technology, Khartoum, Sudan","institution_ids":[]},{"raw_affiliation_string":"Pharmaceutical Research and Development Centre, Faculty of Pharmacy, Karary University Omdurman, Khartoum State, Sudan","institution_ids":["https://openalex.org/I64838667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013847522","display_name":"Makarim Elfadil M. Osman","orcid":"https://orcid.org/0000-0001-6619-6999","observed_orcids":["https://orcid.org/0000-0001-6619-6999"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Makarim Elfadil M. Osman","raw_affiliation_strings":["Biotechnology Department, Africa City of Technology, Khartoum, Sudan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Department, Africa City of Technology, Khartoum, Sudan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013847522","https://openalex.org/A5022243900"],"corresponding_institution_ids":["https://openalex.org/I133771110","https://openalex.org/I64838667"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":1.4444,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.83361368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"10","issue":"20","first_page":"e39471","last_page":"e39471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-lectins","display_name":"dietary lectins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9179999828338623},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mushroom-lectin","display_name":"mushroom lectin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nutrient-absorption","display_name":"nutrient absorption","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7969040870666504},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7071136236190796},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.601243793964386},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.4619064927101135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4078070819377899},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39064812660217285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36231520771980286},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1681595742702484},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.09944918751716614},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e39471","doi":"https://doi.org/10.1016/j.heliyon.2024.e39471","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e39471","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11535980","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11535980","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11535980/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:39502251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39502251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e4a1cbdda2614d38bd74a966ea2e5e8c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e4a1cbdda2614d38bd74a966ea2e5e8c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 20, Pp e39471- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e39471","doi":"https://doi.org/10.1016/j.heliyon.2024.e39471","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e39471","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403538543.pdf","grobid_xml":"https://content.openalex.org/works/W4403538543.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W61553088","https://openalex.org/W101256121","https://openalex.org/W1797072623","https://openalex.org/W1916989212","https://openalex.org/W1922160377","https://openalex.org/W1971499778","https://openalex.org/W1977000116","https://openalex.org/W1978745043","https://openalex.org/W1979886186","https://openalex.org/W1985273618","https://openalex.org/W1985316729","https://openalex.org/W1990034676","https://openalex.org/W1992139355","https://openalex.org/W2007029082","https://openalex.org/W2009839094","https://openalex.org/W2011168733","https://openalex.org/W2013246540","https://openalex.org/W2016043102","https://openalex.org/W2016846290","https://openalex.org/W2018723556","https://openalex.org/W2019222925","https://openalex.org/W2020087765","https://openalex.org/W2032972007","https://openalex.org/W2036294559","https://openalex.org/W2036938579","https://openalex.org/W2054408326","https://openalex.org/W2058469304","https://openalex.org/W2060138100","https://openalex.org/W2064106041","https://openalex.org/W2068122784","https://openalex.org/W2070286548","https://openalex.org/W2079800833","https://openalex.org/W2082853052","https://openalex.org/W2082914105","https://openalex.org/W2093550570","https://openalex.org/W2099170840","https://openalex.org/W2101367530","https://openalex.org/W2112652702","https://openalex.org/W2118810921","https://openalex.org/W2134747757","https://openalex.org/W2137425841","https://openalex.org/W2138659131","https://openalex.org/W2146086072","https://openalex.org/W2146114339","https://openalex.org/W2150677483","https://openalex.org/W2156448586","https://openalex.org/W2162113510","https://openalex.org/W2167559046","https://openalex.org/W2316960414","https://openalex.org/W2328701270","https://openalex.org/W2329730748","https://openalex.org/W2331407944","https://openalex.org/W2333291780","https://openalex.org/W2336926927","https://openalex.org/W2465409678","https://openalex.org/W2466633242","https://openalex.org/W2543744498","https://openalex.org/W2566956920","https://openalex.org/W2607815597","https://openalex.org/W2625976727","https://openalex.org/W2728005117","https://openalex.org/W2734838604","https://openalex.org/W2741220547","https://openalex.org/W2750174063","https://openalex.org/W2753247050","https://openalex.org/W2782959446","https://openalex.org/W2802917777","https://openalex.org/W2883216230","https://openalex.org/W2895785422","https://openalex.org/W2899058738","https://openalex.org/W2907490195","https://openalex.org/W2915526534","https://openalex.org/W2929731516","https://openalex.org/W2937088153","https://openalex.org/W3000038593","https://openalex.org/W3005658988","https://openalex.org/W3013522609","https://openalex.org/W3024109494","https://openalex.org/W3042009432","https://openalex.org/W3049693933","https://openalex.org/W3088262499","https://openalex.org/W3092339924","https://openalex.org/W3092481426","https://openalex.org/W3092711845","https://openalex.org/W3118400948","https://openalex.org/W3134184621","https://openalex.org/W3157245446","https://openalex.org/W3169038641","https://openalex.org/W3194187969","https://openalex.org/W4220814523","https://openalex.org/W4224211841","https://openalex.org/W4231878812","https://openalex.org/W4250792373","https://openalex.org/W4254780622","https://openalex.org/W4281780066","https://openalex.org/W4290703691","https://openalex.org/W4295073546","https://openalex.org/W4296613236","https://openalex.org/W4309711106","https://openalex.org/W4316664297","https://openalex.org/W4320913507","https://openalex.org/W4328051247","https://openalex.org/W4361298358","https://openalex.org/W4388869360","https://openalex.org/W6849453353"],"related_works":["https://openalex.org/W4408683541","https://openalex.org/W1451821793","https://openalex.org/W7081633724","https://openalex.org/W3048396433","https://openalex.org/W101256121","https://openalex.org/W2155740757","https://openalex.org/W1973586530","https://openalex.org/W1999551112","https://openalex.org/W2165150149","https://openalex.org/W4226482998"],"abstract_inverted_index":{"Beans,":[0],"vegetables,":[1],"fruits,":[2],"and":[3,11,26,47,56,66,89,130,149,163,193],"mushrooms":[4],"offer":[5],"a":[6],"delightful":[7],"array":[8],"of":[9,14,132,143,158,170,182],"fragrances":[10],"an":[12],"abundance":[13],"nutrients,":[15],"including":[16],"essential":[17],"vitamins,":[18],"minerals,":[19],"protein":[20],"rich":[21],"in":[22,101,124,146],"vital":[23],"amino":[24],"acids,":[25],"omega-3":[27],"fatty":[28],"acids.":[29],"However,":[30],"they":[31],"may":[32],"also":[33],"contain":[34],"lectins,":[35,79,106],"carbohydrate-binding":[36],"proteins":[37],"with":[38,86,113],"potential":[39,99,120,176],"health":[40],"risks.":[41],"While":[42,77],"some":[43,78],"lectins":[44,145,160,184],"exhibit":[45,110],"stability":[46],"resistance":[48],"to":[49,53,138,175],"digestion,":[50],"posing":[51],"threats":[52],"gastrointestinal":[54],"integrity":[55],"immune":[57,75,116,147],"function,":[58],"others,":[59,92],"such":[60,80,93],"as":[61,81,94],"those":[62],"from":[63,161],"butterfly":[64],"peas":[65],"pink":[67],"bauhinia,":[68],"show":[69],"immunomodulatory":[70,111,156],"properties":[71,112],"that":[72],"could":[73],"bolster":[74],"responses.":[76],"phytohemagglutinin,":[82],"have":[83,97,185],"been":[84,186],"associated":[85],"inflammatory":[87],"responses":[88],"autoimmune":[90,150,177],"disorders,":[91],"wheat":[95],"lectin,":[96],"shown":[98],"benefits":[100],"nutrient":[102],"absorption.":[103],"Additionally,":[104],"mushroom":[105],"while":[107],"generally":[108],"nontoxic,":[109],"implications":[114],"for":[115,190],"health.":[117],"Despite":[118],"their":[119,168],"benefits,":[121],"challenges":[122],"remain":[123],"understanding":[125],"lectin":[126],"dosages,":[127],"administration":[128],"routes,":[129],"mechanisms":[131,169],"action.":[133,171],"Further":[134],"research":[135],"is":[136],"needed":[137],"elucidate":[139],"the":[140,155,179],"intricate":[141],"roles":[142,181],"dietary":[144,159,183],"function":[148],"disorders.":[151],"This":[152],"review":[153],"surveys":[154],"effects":[157],"plants":[162],"mushrooms,":[164],"shedding":[165],"light":[166],"on":[167],"From":[172],"inflammation":[173],"modulation":[174],"implications,":[178],"diverse":[180],"explored,":[187],"highlighting":[188],"avenues":[189],"future":[191],"investigations":[192],"therapeutic":[194],"exploration.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-10-19T00:00:00"}
