{"id":"https://openalex.org/W4403537536","doi":"https://doi.org/10.1016/j.esmoop.2024.103899","title":"161P Early phase cancer clinical trials: A viable treatment option for patients?","display_name":"161P Early phase cancer clinical trials: A viable treatment option for patients?","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403537536","doi":"https://doi.org/10.1016/j.esmoop.2024.103899"},"language":"en","primary_location":{"id":"doi:10.1016/j.esmoop.2024.103899","doi":"https://doi.org/10.1016/j.esmoop.2024.103899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103899","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.esmoop.2024.103899","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112362131","display_name":"R.C. Dawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R.C. Dawson","raw_affiliation_strings":["Experimental Cancer Medicine Department, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Cancer Medicine Department, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Yan","raw_affiliation_strings":["Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109582328","display_name":"Ereny Samwel Poles Saad","orcid":"https://orcid.org/0000-0001-6725-8557","observed_orcids":["https://orcid.org/0000-0001-6725-8557"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E.S. Poles Saad","raw_affiliation_strings":["Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048550515","display_name":"Hitesh B. Mistry","orcid":"https://orcid.org/0000-0002-9683-1903","observed_orcids":["https://orcid.org/0000-0002-9683-1903"]},"institutions":[{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. Mistry","raw_affiliation_strings":["The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059528777","display_name":"Julio Herrero Colomina","orcid":"https://orcid.org/0009-0005-4243-0724","observed_orcids":["https://orcid.org/0009-0005-4243-0724"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Herrero Colomina","raw_affiliation_strings":["Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Christodoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Christodoulou","raw_affiliation_strings":["ECMT, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ECMT, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073681825","display_name":"Lydia Sutherland","orcid":"https://orcid.org/0009-0008-1079-9940","observed_orcids":["https://orcid.org/0009-0008-1079-9940"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Sutherland","raw_affiliation_strings":["Pharmacy, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049575537","display_name":"Ik Shin Chin","orcid":"https://orcid.org/0000-0002-7659-8753","observed_orcids":["https://orcid.org/0000-0002-7659-8753"]},"institutions":[{"id":"https://openalex.org/I2801674322","display_name":"University Hospital Coventry","ror":"https://ror.org/025821s54","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801674322","https://openalex.org/I2802705189"]},{"id":"https://openalex.org/I2802705189","display_name":"University Hospitals Coventry and Warwickshire NHS Trust","ror":"https://ror.org/025n38288","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802705189"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I.S. Chin","raw_affiliation_strings":["Oncology Department, University Hospital Coventry - University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, University Hospital Coventry - University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK","institution_ids":["https://openalex.org/I2801674322","https://openalex.org/I2802705189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070242435","display_name":"Natalie Cook","orcid":"https://orcid.org/0000-0003-2606-1082","observed_orcids":["https://orcid.org/0000-0003-2606-1082"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Cook","raw_affiliation_strings":["Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080991347","display_name":"Matthew Krebs","orcid":"https://orcid.org/0000-0001-7540-3064","observed_orcids":["https://orcid.org/0000-0001-7540-3064"]},"institutions":[{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M.G. Krebs","raw_affiliation_strings":["Experimental Cancer Medicine Department, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Cancer Medicine Department, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020696914","display_name":"Fiona C. Thistlethwaite","orcid":"https://orcid.org/0000-0002-4832-7008","observed_orcids":["https://orcid.org/0000-0002-4832-7008"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. Thistlethwaite","raw_affiliation_strings":["Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022848214","display_name":"Donna M. Graham","orcid":"https://orcid.org/0000-0001-6500-8140","observed_orcids":["https://orcid.org/0000-0001-6500-8140"]},"institutions":[{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.M. Graham","raw_affiliation_strings":["Experimental Cancer Medicine Department, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Cancer Medicine Department, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033090749","display_name":"Louise Carter","orcid":"https://orcid.org/0000-0002-9854-2304","observed_orcids":["https://orcid.org/0000-0002-9854-2304"]},"institutions":[{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Carter","raw_affiliation_strings":["Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":{"value":3730,"currency":"USD","value_usd":3730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"103899","last_page":"103899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.2782999873161316,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-clinical-trials","display_name":"cancer clinical trials","score":0.7839999794960022},{"id":"https://openalex.org/keywords/clinical-trial-eligibility-criteria","display_name":"inclusion and exclusion criteria","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6131003499031067},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5670723915100098},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45136335492134094},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44050052762031555},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4320603609085083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39271867275238037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.esmoop.2024.103899","doi":"https://doi.org/10.1016/j.esmoop.2024.103899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103899","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.esmoop.2024.103899","doi":"https://doi.org/10.1016/j.esmoop.2024.103899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103899","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7028236881","https://openalex.org/W4323570075","https://openalex.org/W4353101362","https://openalex.org/W7167082592","https://openalex.org/W4254295055","https://openalex.org/W4408220561","https://openalex.org/W2060967049","https://openalex.org/W4408220377","https://openalex.org/W2137402221","https://openalex.org/W7137828474"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-10-19T00:00:00"}