{"id":"https://openalex.org/W4403528396","doi":"https://doi.org/10.12669/pjms.40.10.10292","title":"Identification of genetic risk variants for Type-2 Diabetes mellitus in Pakistani Pashtun population: A case-control association study","display_name":"Identification of genetic risk variants for Type-2 Diabetes mellitus in Pakistani Pashtun population: A case-control association study","publication_year":2024,"publication_date":"2024-10-18","ids":{"openalex":"https://openalex.org/W4403528396","doi":"https://doi.org/10.12669/pjms.40.10.10292","pmid":"https://pubmed.ncbi.nlm.nih.gov/39554687","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11568737"},"language":"en","primary_location":{"id":"doi:10.12669/pjms.40.10.10292","doi":"https://doi.org/10.12669/pjms.40.10.10292","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.40.10.10292","pdf_url":null,"source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.12669/pjms.40.10.10292","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025055705","display_name":"Asif Jan","orcid":"https://orcid.org/0000-0003-3880-5579","observed_orcids":["https://orcid.org/0000-0003-3880-5579"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Asif Jan","raw_affiliation_strings":["Asif Jan, District Headquarter Hospital (DHQH) Charsadda, Charsadda 24430, Pakistan. Department of Pharmacy, University of Peshawar, Peshawar 25000, Pakistan","District Hospital Charsadda KP"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asif Jan, District Headquarter Hospital (DHQH) Charsadda, Charsadda 24430, Pakistan. Department of Pharmacy, University of Peshawar, Peshawar 25000, Pakistan","institution_ids":["https://openalex.org/I36001604"]},{"raw_affiliation_string":"District Hospital Charsadda KP","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073027745","display_name":"Ramzi A. Mothana","orcid":"https://orcid.org/0000-0003-4220-7854","observed_orcids":["https://orcid.org/0000-0003-4220-7854"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ramzi A. Mothana","raw_affiliation_strings":["Ramzi A. Mothana, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 1151, Saudi Arabia","Department of Pharmacognosy,College of Pharmacy, King Saud University, Riyadh  1151,  Saudia Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ramzi A. Mothana, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 1151, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Department of Pharmacognosy,College of Pharmacy, King Saud University, Riyadh  1151,  Saudia Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048841145","display_name":"Jun-Ya Kaimori","orcid":"https://orcid.org/0000-0001-6892-3942","observed_orcids":["https://orcid.org/0000-0001-6892-3942"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Jun-Ya Kaimori","raw_affiliation_strings":["Jun-Ya Kaimori, Department of Nephrology, Osaka University Graduate School of Medicine, Suita, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Institute of Medical Science, University of Toronto, Toronto 43964, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jun-Ya Kaimori, Department of Nephrology, Osaka University Graduate School of Medicine, Suita, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Institute of Medical Science, University of Toronto, Toronto 43964, ON, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026186505","display_name":"Tahir Muhammad","orcid":"https://orcid.org/0000-0001-5819-1397","observed_orcids":["https://orcid.org/0000-0001-5819-1397"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I4405280014","display_name":"Campbell Family Mental Health Research Institute","ror":"https://ror.org/02ab2j218","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1338135719","https://openalex.org/I4405280014"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tahir Muhammad","raw_affiliation_strings":["Tahir Muhammad, Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health, Research Institute, Centre for Addiction & Mental Health, Toronto 43964, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tahir Muhammad, Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health, Research Institute, Centre for Addiction & Mental Health, Toronto 43964, ON, Canada","institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I4405280014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103851204","display_name":"Mehtab Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154799132","display_name":"Universit\u00e9 de Moncton","ror":"https://ror.org/029tnqt29","country_code":"CA","type":"education","lineage":["https://openalex.org/I154799132"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mehtab Khan","raw_affiliation_strings":["Mehtab Khan, Department of Biology, Faculty of Science, University of Moncton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mehtab Khan, Department of Biology, Faculty of Science, University of Moncton, Canada","institution_ids":["https://openalex.org/I154799132"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Syed Shaukat Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68649149","display_name":"University of Malakand","ror":"https://ror.org/012xdha97","country_code":"PK","type":"education","lineage":["https://openalex.org/I68649149"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Syed Shaukat Ali","raw_affiliation_strings":["Syed Shaukat Ali, Department of Pharmacy, University of Malakand, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syed Shaukat Ali, Department of Pharmacy, University of Malakand, Pakistan","institution_ids":["https://openalex.org/I68649149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101476691","display_name":"Naveed Rahman","orcid":"https://orcid.org/0009-0007-0640-4320","observed_orcids":["https://orcid.org/0009-0007-0640-4320"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Naveed Rahman","raw_affiliation_strings":["Naveed Rahman, Department of Pharmacy, University of Peshawar, Peshawar 25000, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naveed Rahman, Department of Pharmacy, University of Peshawar, Peshawar 25000, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063575575","display_name":"Abdullah R. Alanzi","orcid":"https://orcid.org/0009-0000-2565-6573","observed_orcids":["https://orcid.org/0009-0000-2565-6573"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah R. Alanzi","raw_affiliation_strings":["Abdullah R. Alanzi, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 1151, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abdullah R. Alanzi, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 1151, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025055705"],"corresponding_institution_ids":["https://openalex.org/I36001604"],"apc_list":{"value":400,"currency":"USD","value_usd":400},"apc_paid":{"value":400,"currency":"USD","value_usd":400},"fwci":0.2093,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46548595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"40","issue":"10","first_page":"2336","last_page":"2343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/genetic-risk-variants","display_name":"genetic risk variants","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pashtun-population","display_name":"Pashtun population","score":0.8289999961853027},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9509999752044678},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.46299999952316284},{"id":"https://openalex.org/keywords/khyber-pakhtunkhwa","display_name":"Khyber Pakhtunkhwa","score":0.8769999742507935},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.7590000033378601},{"id":"https://openalex.org/keywords/south-asian-populations","display_name":"South Asian populations","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8294188976287842},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.6270551085472107},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5903369188308716},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5199095606803894},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5128695964813232},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.46906566619873047},{"id":"https://openalex.org/C3020075751","wikidata":"https://www.wikidata.org/wiki/Q183314","display_name":"Khyber pakhtunkhwa","level":2,"score":0.4482802748680115},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4461914002895355},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4330092966556549},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.41225701570510864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40797221660614014},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27660369873046875},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.23879921436309814},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.13860315084457397},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13268479704856873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1157776415348053},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.058771759271621704},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C45355965","wikidata":"https://www.wikidata.org/wiki/Q1643441","display_name":"Socioeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.12669/pjms.40.10.10292","doi":"https://doi.org/10.12669/pjms.40.10.10292","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.40.10.10292","pdf_url":null,"source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11568737","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11568737","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11568737/pdf/PJMS-40-2336.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pak J Med Sci","raw_type":"Text"},{"id":"pmid:39554687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39554687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.12669/pjms.40.10.10292","doi":"https://doi.org/10.12669/pjms.40.10.10292","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.40.10.10292","pdf_url":null,"source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2120667610","display_name":null,"funder_award_id":"RSP2024R119","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"}],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403528396.pdf","grobid_xml":"https://content.openalex.org/works/W4403528396.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W8631552","https://openalex.org/W1809679152","https://openalex.org/W1976735484","https://openalex.org/W1984068087","https://openalex.org/W2003353039","https://openalex.org/W2023307378","https://openalex.org/W2023962370","https://openalex.org/W2028281706","https://openalex.org/W2030614447","https://openalex.org/W2060730208","https://openalex.org/W2108234281","https://openalex.org/W2119180969","https://openalex.org/W2120041117","https://openalex.org/W2131271579","https://openalex.org/W2159422401","https://openalex.org/W2466943507","https://openalex.org/W2468561246","https://openalex.org/W2753990837","https://openalex.org/W2884798826","https://openalex.org/W2981594637","https://openalex.org/W3168441927","https://openalex.org/W3207618018","https://openalex.org/W4205709148","https://openalex.org/W4283032265","https://openalex.org/W4301392395","https://openalex.org/W4319063510"],"related_works":["https://openalex.org/W4319063510","https://openalex.org/W4283032265","https://openalex.org/W4283009992","https://openalex.org/W2005887705","https://openalex.org/W3134150391","https://openalex.org/W2147168627","https://openalex.org/W1978706496","https://openalex.org/W2922062000","https://openalex.org/W2161261572","https://openalex.org/W2525917034"],"abstract_inverted_index":{"Background":[0],"and":[1,27,48,51,111,130,139,182,291],"Objective:":[2],"Pakistan,":[3],"a":[4,11],"South":[5],"Asian":[6],"developing":[7],"country,":[8],"is":[9,270,300],"experiencing":[10],"rapid":[12],"increase":[13],"in":[14,24,144,210,222,254,293],"number":[15],"of":[16,22,29,83,220,246,279],"diabetes":[17,23],"cases.":[18],"High":[19],"prevalence":[20],"ratio":[21],"Pakistani":[25,43,255],"population":[26,45,106,212],"lack":[28],"genetic":[30,114,142,205,218,247],"research":[31],"studies":[32],"prompted":[33],"us":[34],"to":[35,94,228],"design":[36],"this":[37,223],"study.":[38,261],"This":[39,61,201,269],"present":[40],"study":[41,70,88,146,202],"investigated":[42],"Pashtun":[44,211,256],"for":[46,109,124,155,166,208,250],"(known":[47],"novel":[49,112],"SNPs)":[50],"its":[52],"possible":[53],"correlation":[54],"with":[55,76,187,198],"Type-2":[56,251],"Diabetes":[57,252],"Mellitus":[58],"(T2DM).":[59],"Methods:":[60],"two":[62],"stage":[63,100],"(discovery":[64],"&":[65,78],"validation":[66,118],"stage),":[67],"case-control":[68,259],"association":[69,126,131,195,260],"included":[71],"one":[72],"thousand":[73],"individuals":[74],"(Patients":[75],"T2DM=500":[77],"controls=500)":[79],"from":[80,91],"eight":[81],"districts":[82],"Khyber":[84],"Pakhtunkhwa":[85],"Pakistan.":[86],"The":[87],"duration/period":[89],"was":[90,107],"March":[92],"2018":[93],"January":[95],"2020.":[96],"In":[97,116],"the":[98,104,117,145,153,159,167,217,277,280,297],"first":[99],"(the":[101],"discovery":[102],"stage)":[103],"target":[105],"screened":[108],"known":[110,138,154],"T2DM-associated":[113],"markers.":[115],"stage,":[119],"identified":[120,160],"variants":[121,149,161,191,207,249],"were":[122,150,164],"confirmed":[123,165],"T2DM":[125,209,221],"using":[127],"MassARRAY":[128],"genotyping":[129],"analysis.":[132],"Results:":[133],"Exome":[134],"sequencing":[135],"detected":[136],"eleven":[137],"four":[140],"novel/new":[141],"markers":[143],"population.":[147],"Novel":[148],"preferred":[151],"over":[152],"follow-up":[156],"analysis/validation.":[157],"Among":[158],"strong":[162],"associations":[163],"following":[168],"variants;":[169],"rs1781133/ANKRD65":[170],"(OR=2.10,":[171],"95%Cl=1.06\u20133.08,":[172],"P=0.003)":[173],"rs2274791/TTLL10":[174],"(OR=1.97,":[175],"95%Cl=1.36-2.62,":[176],"P=0.025),":[177],"rs71628928/RNF223":[178],"(OR=1.82,":[179],"95%Cl=0.97-1.92,":[180],"P=0.041),":[181],"rs609805/SCNN1D":[183],"(OR=2.21,":[184],"95%Cl=1.92-3.09,":[185],"P=0.001)":[186],"T2DM;":[188],"other":[189],"reported":[190],"showed":[192],"no":[193],"noticeable":[194],"(having":[196],"P>0.05)":[197],"T2DM.":[199],"Conclusion:":[200],"reports":[203],"new":[204],"risk":[206,248],"providing":[213],"valuable":[214],"insights":[215],"into":[216],"basis":[219],"group.":[224],"doi:":[225,267],"https://doi.org/10.12669/pjms.40.10.10292":[226,268],"How":[227],"cite":[229],"this:":[230],"Jan":[231],"A,":[232],"Mothana":[233],"RA,":[234],"Kaimori":[235],"JY,":[236],"Muhammad":[237],"T,":[238],"Khan":[239],"M,":[240],"Ali":[241],"SS,":[242],"et":[243],"al.":[244],"Identification":[245],"mellitus":[253],"population:":[257],"A":[258],"Pak":[262],"J":[263],"Med":[264],"Sci.":[265],"2024;40(10):2336-2343.":[266],"an":[271],"Open":[272],"Access":[273],"article":[274],"distributed":[275],"under":[276],"terms":[278],"Creative":[281],"Commons":[282],"Attribution":[283],"License":[284],"(http://creativecommons.org/licenses/by/3.0),":[285],"which":[286],"permits":[287],"unrestricted":[288],"use,":[289],"distribution,":[290],"reproduction":[292],"any":[294],"medium,":[295],"provided":[296],"original":[298],"work":[299],"properly":[301],"cited.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-19T00:00:00"}