{"id":"https://openalex.org/W4403525239","doi":"https://doi.org/10.1016/j.esmoop.2024.103736","title":"Androgen receptor pathway inhibitors and drug\u2013drug interactions in prostate cancer","display_name":"Androgen receptor pathway inhibitors and drug\u2013drug interactions in prostate cancer","publication_year":2024,"publication_date":"2024-10-18","ids":{"openalex":"https://openalex.org/W4403525239","doi":"https://doi.org/10.1016/j.esmoop.2024.103736","pmid":"https://pubmed.ncbi.nlm.nih.gov/39426080","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11533040"},"language":"en","primary_location":{"id":"doi:10.1016/j.esmoop.2024.103736","doi":"https://doi.org/10.1016/j.esmoop.2024.103736","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103736","pdf_url":"https://www.esmoopen.com/article/S2059-7029(24)01506-0/pdf","source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.esmoopen.com/article/S2059-7029(24)01506-0/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028522949","display_name":"Hatice B\u00f6lek","orcid":"https://orcid.org/0000-0001-8659-7327","observed_orcids":["https://orcid.org/0000-0001-8659-7327"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H. Bolek","raw_affiliation_strings":["Department of Medical Oncology, Ankara University School of Medicine, Ankara; Ankara University Cancer Research Institute, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8659-7327","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Ankara University School of Medicine, Ankara; Ankara University Cancer Research Institute, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010059818","display_name":"Sat\u0131 Co\u015fkun Yazgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S.C. Yazgan","raw_affiliation_strings":["Department of Medical Oncology, Ankara University School of Medicine, Ankara; Ankara University Cancer Research Institute, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Ankara University School of Medicine, Ankara; Ankara University Cancer Research Institute, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083927273","display_name":"Emre Yeked\u00fcz","orcid":"https://orcid.org/0000-0001-6819-5930","observed_orcids":["https://orcid.org/0000-0001-6819-5930"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Yeked\u00fcz","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019688174","display_name":"Marina Dusevic Kaymakcalan","orcid":"https://orcid.org/0000-0003-4956-9129","observed_orcids":["https://orcid.org/0000-0003-4956-9129"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.D. Kaymakcalan","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058325420","display_name":"Rana R. McKay","orcid":"https://orcid.org/0000-0002-0581-7963","observed_orcids":["https://orcid.org/0000-0002-0581-7963"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.R. McKay","raw_affiliation_strings":["Moores Cancer Center, University of California San Diego, La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009101766","display_name":"Silke Gillessen","orcid":"https://orcid.org/0000-0001-5746-6555","observed_orcids":["https://orcid.org/0000-0001-5746-6555"]},"institutions":[{"id":"https://openalex.org/I4210095212","display_name":"Ente Ospedaliero Cantonale","ror":"https://ror.org/00sh19a92","country_code":"CH","type":"other","lineage":["https://openalex.org/I4210095212"]},{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S. Gillessen","raw_affiliation_strings":["Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), Bellinzona; Faculty of Biomedical Sciences, USI, Lugano, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5746-6555","affiliations":[{"raw_affiliation_string":"Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), Bellinzona; Faculty of Biomedical Sciences, USI, Lugano, Switzerland","institution_ids":["https://openalex.org/I4210095212","https://openalex.org/I4404532900","https://openalex.org/I57201433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067436525","display_name":"Y\u00fcksel \u00dcr\u00fcn","orcid":"https://orcid.org/0000-0002-9152-9887","observed_orcids":["https://orcid.org/0000-0002-9152-9887"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Y. \u00dcr\u00fcn","raw_affiliation_strings":["Department of Medical Oncology, Ankara University School of Medicine, Ankara; Ankara University Cancer Research Institute, Ankara, Turkey. Electronic address: yuksel.urun@ankara.edu.tr"],"raw_orcid":"https://orcid.org/0000-0002-9152-9887","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Ankara University School of Medicine, Ankara; Ankara University Cancer Research Institute, Ankara, Turkey. Electronic address: yuksel.urun@ankara.edu.tr","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5067436525"],"corresponding_institution_ids":["https://openalex.org/I149218525"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":{"value":3730,"currency":"USD","value_usd":3730},"fwci":2.9645,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.94422311,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"9","issue":"11","first_page":"103736","last_page":"103736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8519999980926514},{"id":"https://openalex.org/keywords/androgen-receptor-pathway-inhibitors","display_name":"androgen receptor pathway inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.984000027179718},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/apalutamide","display_name":"apalutamide","score":1.0},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cyp2d6-inhibition","display_name":"CYP2D6 inhibition","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cyp3a4-induction","display_name":"CYP3A4 induction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5339999794960022},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7957334518432617},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.788131594657898},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7016887068748474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48476308584213257},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4492378532886505},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3136611580848694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27161359786987305}],"mesh":[{"descriptor_ui":"D000069501","descriptor_name":"Abiraterone Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000069501","descriptor_name":"Abiraterone Acetate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000736","descriptor_name":"Androstenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010669","descriptor_name":"Phenylthiohydantoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010669","descriptor_name":"Phenylthiohydantoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013867","descriptor_name":"Thiohydantoins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013867","descriptor_name":"Thiohydantoins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.esmoop.2024.103736","doi":"https://doi.org/10.1016/j.esmoop.2024.103736","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103736","pdf_url":"https://www.esmoopen.com/article/S2059-7029(24)01506-0/pdf","source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11533040","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11533040","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11533040/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"Text"},{"id":"pmid:39426080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39426080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO open","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.esmoop.2024.103736","doi":"https://doi.org/10.1016/j.esmoop.2024.103736","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103736","pdf_url":"https://www.esmoopen.com/article/S2059-7029(24)01506-0/pdf","source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307771","display_name":"Bayer","ror":"https://ror.org/04hmn8g73"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320308982","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421"},{"id":"https://openalex.org/F4320312140","display_name":"Exelixis","ror":"https://ror.org/01e3jga91"},{"id":"https://openalex.org/F4320319264","display_name":"MacroGenics","ror":"https://ror.org/01hcd4187"},{"id":"https://openalex.org/F4320319515","display_name":"Seagen","ror":null},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324142","display_name":"European Society for Medical Oncology","ror":"https://ror.org/03xtz2n86"},{"id":"https://openalex.org/F4320327373","display_name":"Schweizerische Arbeitsgemeinschaft f\u00fcr Klinische Krebsforschung","ror":"https://ror.org/04rtrpb08"},{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403525239.pdf","grobid_xml":"https://content.openalex.org/works/W4403525239.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W1524135277","https://openalex.org/W1561231235","https://openalex.org/W1594637841","https://openalex.org/W1655166217","https://openalex.org/W1783939843","https://openalex.org/W1793340070","https://openalex.org/W1829552734","https://openalex.org/W1968073258","https://openalex.org/W1973558234","https://openalex.org/W1978945460","https://openalex.org/W1985580668","https://openalex.org/W1987791292","https://openalex.org/W2001554352","https://openalex.org/W2002050650","https://openalex.org/W2002175782","https://openalex.org/W2004561313","https://openalex.org/W2006095434","https://openalex.org/W2012272000","https://openalex.org/W2015014216","https://openalex.org/W2015642559","https://openalex.org/W2018126221","https://openalex.org/W2025409217","https://openalex.org/W2026375486","https://openalex.org/W2039613248","https://openalex.org/W2043023257","https://openalex.org/W2045111884","https://openalex.org/W2047207059","https://openalex.org/W2050994261","https://openalex.org/W2055346449","https://openalex.org/W2059248961","https://openalex.org/W2064851427","https://openalex.org/W2068691394","https://openalex.org/W2078105435","https://openalex.org/W2084637523","https://openalex.org/W2113569308","https://openalex.org/W2114143292","https://openalex.org/W2119504728","https://openalex.org/W2123808537","https://openalex.org/W2133489902","https://openalex.org/W2137467802","https://openalex.org/W2139976767","https://openalex.org/W2141569270","https://openalex.org/W2148643283","https://openalex.org/W2148659963","https://openalex.org/W2156532554","https://openalex.org/W2166918329","https://openalex.org/W2168018544","https://openalex.org/W2168108459","https://openalex.org/W2186659228","https://openalex.org/W2256020981","https://openalex.org/W2261870911","https://openalex.org/W2264105361","https://openalex.org/W2330871695","https://openalex.org/W2396891752","https://openalex.org/W2489425084","https://openalex.org/W2507923735","https://openalex.org/W2509022872","https://openalex.org/W2517095380","https://openalex.org/W2518805078","https://openalex.org/W2620746860","https://openalex.org/W2620798309","https://openalex.org/W2787698975","https://openalex.org/W2792086148","https://openalex.org/W2797645683","https://openalex.org/W2810806599","https://openalex.org/W2891937783","https://openalex.org/W2913767564","https://openalex.org/W2917593000","https://openalex.org/W2938589827","https://openalex.org/W2947014957","https://openalex.org/W2947893479","https://openalex.org/W2963794755","https://openalex.org/W2969575782","https://openalex.org/W2977338802","https://openalex.org/W2978713040","https://openalex.org/W3017468178","https://openalex.org/W3018908320","https://openalex.org/W3024133569","https://openalex.org/W3026527927","https://openalex.org/W3031020438","https://openalex.org/W3040922014","https://openalex.org/W3047208147","https://openalex.org/W3083310601","https://openalex.org/W3084238852","https://openalex.org/W3128646645","https://openalex.org/W3133770459","https://openalex.org/W3146922707","https://openalex.org/W3157532249","https://openalex.org/W3158318954","https://openalex.org/W3176349057","https://openalex.org/W3184597490","https://openalex.org/W3207280939","https://openalex.org/W3216238012","https://openalex.org/W4210371991","https://openalex.org/W4211231869","https://openalex.org/W4213140514","https://openalex.org/W4223437636","https://openalex.org/W4286218443","https://openalex.org/W4288178076","https://openalex.org/W4303961775","https://openalex.org/W4306907107","https://openalex.org/W4313470793","https://openalex.org/W4321018302","https://openalex.org/W4324136676","https://openalex.org/W4361026527","https://openalex.org/W4367601567","https://openalex.org/W4376121167","https://openalex.org/W4379285544","https://openalex.org/W4381550549","https://openalex.org/W4385242205","https://openalex.org/W4390946922","https://openalex.org/W4392880669","https://openalex.org/W6712198050","https://openalex.org/W6716986801"],"related_works":["https://openalex.org/W4408428886","https://openalex.org/W4399094862","https://openalex.org/W4413302702","https://openalex.org/W7161261238","https://openalex.org/W4399071477","https://openalex.org/W4206232885","https://openalex.org/W4317625849","https://openalex.org/W4412521312","https://openalex.org/W4416093535","https://openalex.org/W7130330700"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,22,40,68,133],"represents":[2],"a":[3,90,111],"major":[4],"global":[5],"health":[6],"challenge,":[7],"necessitating":[8],"efficacious":[9],"therapeutic":[10,116],"strategies.":[11],"Androgen":[12],"receptor":[13,49],"pathway":[14],"inhibitors":[15],"(ARPIs)":[16],"have":[17],"become":[18],"central":[19],"to":[20,114,125,149],"prostate":[21,67,132],"treatment,":[23],"demonstrating":[24],"significant":[25],"effectiveness":[26],"in":[27,69,131],"both":[28],"metastatic":[29],"and":[30,103,108,118,135],"non-metastatic":[31],"contexts.":[32],"Abiraterone":[33],"acetate,":[34],"by":[35,55,101,106],"inhibiting":[36],"androgen":[37,48],"synthesis,":[38],"deprives":[39],"cells":[41],"androgens":[42],"necessary":[43],"for":[44,84],"growth,":[45],"while":[46],"second-generation":[47],"(AR)":[50],"antagonists":[51],"disrupt":[52],"AR":[53,57],"signaling":[54],"blocking":[56],"binding,":[58],"thereby":[59],"impeding":[60],"tumor":[61],"progression.":[62],"Given":[63],"the":[64,70,82,127,143],"predominance":[65],"of":[66,129,145],"elderly,":[71],"who":[72],"often":[73],"present":[74],"with":[75,87,139],"multiple":[76],"comorbidities":[77],"requiring":[78],"complex":[79],"pharmacological":[80],"regimens,":[81],"potential":[83],"drug-drug":[85],"interactions":[86],"ARPIs":[88,130],"is":[89],"critical":[91],"concern.":[92],"These":[93],"interactions,":[94],"particularly":[95],"through":[96],"pathways":[97],"like":[98],"CYP2D6":[99],"inhibition":[100],"abiraterone":[102],"CYP3A4":[104],"induction":[105],"enzalutamide":[107],"apalutamide,":[109],"necessitate":[110],"thorough":[112],"understanding":[113],"optimize":[115,150],"outcomes":[117],"minimize":[119],"adverse":[120],"effects.":[121],"This":[122],"review":[123],"aims":[124],"delineate":[126],"efficacy":[128],"management":[134,148],"elucidate":[136],"their":[137],"interaction":[138],"common":[140],"medications,":[141],"highlighting":[142],"importance":[144],"vigilant":[146],"drug":[147],"patient":[151],"care.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-10-19T00:00:00"}
