{"id":"https://openalex.org/W4403520166","doi":"https://doi.org/10.1158/2326-6074.tumimm24-a016","title":"Abstract A016: Bitter taste receptor T2R5 regulates cell viability and apoptosis in head and neck squamous cell carcinoma","display_name":"Abstract A016: Bitter taste receptor T2R5 regulates cell viability and apoptosis in head and neck squamous cell carcinoma","publication_year":2024,"publication_date":"2024-10-18","ids":{"openalex":"https://openalex.org/W4403520166","doi":"https://doi.org/10.1158/2326-6074.tumimm24-a016"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6074.tumimm24-a016","doi":"https://doi.org/10.1158/2326-6074.tumimm24-a016","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm24-a016","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092552546","display_name":"Sarah M. Sywanycz","orcid":"https://orcid.org/0009-0005-7853-3696","observed_orcids":["https://orcid.org/0009-0005-7853-3696"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M Sywanycz","raw_affiliation_strings":["University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brianna L Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brianna L Hill","raw_affiliation_strings":["University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019182795","display_name":"Zoey A. Miller","orcid":"https://orcid.org/0000-0002-1955-4033","observed_orcids":["https://orcid.org/0000-0002-1955-4033"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoey A Miller","raw_affiliation_strings":["University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040022220","display_name":"Robert J. Lee","orcid":"https://orcid.org/0000-0001-5826-6686","observed_orcids":["https://orcid.org/0000-0001-5826-6686"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J Lee","raw_affiliation_strings":["University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061187034","display_name":"Ryan M. Carey","orcid":"https://orcid.org/0000-0002-0186-2265","observed_orcids":["https://orcid.org/0000-0002-0186-2265"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan M Carey","raw_affiliation_strings":["University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA. 1","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"10_Supplement","first_page":"A016","last_page":"A016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/phenanthroline","display_name":"phenanthroline","score":0.9449999928474426},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.734000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/caspase-3-7","display_name":"caspase 3/7","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cisplatin-sensitization","display_name":"cisplatin sensitization","score":0.9359999895095825},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6539999842643738},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gpcr-agonists","display_name":"GPCR agonists","score":0.5809999704360962},{"id":"https://openalex.org/keywords/gpcr-antagonists","display_name":"GPCR antagonists","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6601011157035828},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.639642596244812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6024622917175293},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.594062864780426},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.5531472563743591},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5047134160995483},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.4970739185810089},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48976588249206543},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.443990021944046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3575131893157959},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.28597700595855713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25807684659957886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22978761792182922},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0852954089641571},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08205956220626831},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06318008899688721}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6074.tumimm24-a016","doi":"https://doi.org/10.1158/2326-6074.tumimm24-a016","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm24-a016","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4248622074","https://openalex.org/W1977661140","https://openalex.org/W4252618551","https://openalex.org/W2358619800","https://openalex.org/W1590660384","https://openalex.org/W2375620929","https://openalex.org/W2387778373","https://openalex.org/W2383208797","https://openalex.org/W3135732811","https://openalex.org/W2094885988"],"abstract_inverted_index":{"Abstract":[0],"Bitter":[1,61,383],"taste":[2,62,384],"receptors":[3,12],"(T2Rs)":[4],"are":[5],"a":[6,44,67,94,122,159,193,207,243,276,279],"large":[7],"family":[8],"of":[9,233,283,291,332,349,402],"G-protein":[10],"coupled":[11],"(GPCRs)":[13],"first":[14],"identified":[15],"for":[16,71,89,103,175,303],"their":[17],"role":[18,277,315],"in":[19,30,79,117,316,334,351,359,392,407],"detecting":[20],"bitter":[21],"stimuli.":[22],"T2Rs":[23,54],"have":[24],"been":[25],"shown":[26],"to":[27,56,74,83,100,120,149,164,231,256,266,343],"be":[28,101,329],"expressed":[29,115],"benign":[31],"and":[32,38,49,59,86,129,190,322,347,353,390,394,412],"malignant":[33],"extra-oral":[34],"tissue,":[35],"including":[36],"head":[37,393],"neck":[39,395],"squamous":[40,396],"cell":[41,127,139,178,211,263,388,397],"carcinomas":[42],"(HNSCC),":[43],"cancer":[45,317],"with":[46,185,199,204,237,253,258,286,361],"high":[47,87,95,287,305,324],"morbidity":[48],"mortality.":[50],"In":[51,319],"HNSCC,":[52],"certain":[53],"appear":[55],"regulate":[57],"proliferation":[58],"apoptosis.":[60,133],"receptor,":[63],"T2R5,":[64],"may":[65,274,328],"pose":[66],"novel":[68],"therapeutic":[69],"target":[70],"HNSCC":[72,118,138,284,335,352],"due":[73],"its":[75,323],"higher":[76],"relative":[77],"expression":[78,290,308],"cancerous":[80],"tissue":[81,85],"compared":[82,265],"normal":[84],"specificity":[88],"agonists.":[90],"1,10-phenanthroline-5,6-dione":[91],"(phenanthroline)":[92],"is":[93],"potency":[96,325],"T2R5":[97,116,147,234,292,321,350,386],"agonist":[98,326],"yet":[99],"studied":[102],"potential":[104,354],"anti-cancer":[105],"effects.":[106],"We":[107,134],"hypothesized":[108],"that":[109,136],"phenanthroline":[110,165,205,238,254,327],"will":[111,341],"act":[112],"on":[113,210],"endogenously":[114],"lines":[119,140],"stimulate":[121],"GPCR-mediated":[123],"calcium":[124,162,168,196],"response,":[125],"decrease":[126,209],"viability,":[128],"increase":[130],"caspase":[131,244],"3/7-mediated":[132],"found":[135],"three":[137,177],"(SCC":[141],"47,":[142],"RPMI":[143],"2650,":[144],"FaDu)":[145],"express":[146],"but":[148],"varying":[150],"degrees":[151],"measured":[152,166,216,241],"by":[153,167,217,242],"qPCR":[154],"(n=":[155],"6).":[156],"There":[157],"was":[158],"significant":[160],"dose-dependent":[161,208],"response":[163,197],"fluorescent":[169],"indicator":[170],"dye,":[171],"Fluo-":[172],"4":[173],"AM,":[174],"all":[176],"lines.":[179],"Calcium":[180],"responses":[181],"were":[182,227],"significantly":[183],"dampened":[184],"G\u03b1":[186],"protein":[187],"inhibitors,":[188],"YM254890":[189],"FR900359,":[191],"suggesting":[192],"GPCR":[194],"mediated":[195],"consistent":[198],"established":[200],"T2R":[201],"functionality.":[202],"Treatment":[203],"showed":[206,260,298],"viability":[212,264,389],"at":[213,249],"24":[214,250],"hours":[215],"crystal":[218,225],"violet":[219,226],"assay.":[220],"Individual":[221],"IC50":[222],"values":[223],"from":[224],"roughly":[228],"inversely":[229],"correlated":[230],"level":[232],"expression.":[235],"Stimulation":[236],"increased":[239],"apoptosis":[240,333,391],"3/7":[245],"activity":[246],"dye":[247],"(CellEvent)":[248],"hours.":[251],"Pretreatment":[252],"prior":[255],"treatment":[257,268],"cisplatin":[259],"decreased":[261],"overall":[262,301],"each":[267],"alone":[269],"(p":[270],"=":[271],"0.0062),":[272],"which":[273],"suggest":[275],"as":[278],"sensitizing":[280],"agent.":[281],"Comparison":[282],"patients":[285],"or":[288],"low":[289,307],"using":[293],"The":[294],"Cancer":[295,408,422],"Genome":[296],"Atlas":[297],"greater":[299],"long-term":[300],"survival":[302],"the":[304,345,403],"versus":[306],"group":[309],"(p=":[310],"0.04),":[311],"possibly":[312],"supporting":[313],"T2R5\u2019s":[314],"regulation.":[318],"summary,":[320],"important":[330],"regulators":[331],"warranting":[336],"further":[337],"exploration.":[338],"Future":[339],"direction":[340],"continue":[342],"explore":[344],"mechanisms":[346],"roles":[348],"sensitization":[355],"effects":[356],"when":[357],"used":[358],"combination":[360],"other":[362],"agents":[363],"like":[364],"cisplatin.":[365],"Citation":[366],"Format:":[367],"Sarah":[368],"M":[369,381],"Sywanycz,":[370],"Brianna":[371],"L":[372],"Hill,":[373],"Zoey":[374],"A":[375],"Miller,":[376],"Robert":[377],"J":[378],"Lee,":[379],"Ryan":[380],"Carey.":[382],"receptor":[385],"regulates":[387],"carcinoma":[398],"[abstract].":[399],"In:":[400],"Proceedings":[401],"AACR":[404],"Special":[405],"Conference":[406],"Research:":[409],"Tumor":[410],"Immunology":[411],"Immunotherapy;":[413],"2024":[414],"Oct":[415],"18-21;":[416],"Boston,":[417],"MA.":[418],"Philadelphia":[419],"(PA):":[420],"AACR;":[421],"Immunol":[423],"Res":[424],"2024;12(10":[425],"Suppl):Abstract":[426],"nr":[427],"A016.":[428]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}