{"id":"https://openalex.org/W4403520121","doi":"https://doi.org/10.1158/2326-6074.tumimm24-b037","title":"Abstract B037: AB-2100, a PSMA-inducible CA9-specific CAR T cell product intended for the treatment of ccRCC provides long-term tumor responses in preclinical mouse model","display_name":"Abstract B037: AB-2100, a PSMA-inducible CA9-specific CAR T cell product intended for the treatment of ccRCC provides long-term tumor responses in preclinical mouse model","publication_year":2024,"publication_date":"2024-10-18","ids":{"openalex":"https://openalex.org/W4403520121","doi":"https://doi.org/10.1158/2326-6074.tumimm24-b037"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6074.tumimm24-b037","doi":"https://doi.org/10.1158/2326-6074.tumimm24-b037","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm24-b037","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091514863","display_name":"Suchismita Mohanty","orcid":"https://orcid.org/0000-0001-6182-6533","observed_orcids":["https://orcid.org/0000-0001-6182-6533"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suchismita Mohanty","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065954491","display_name":"Jeremy Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Chen","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007176590","display_name":"Alma Gomez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alma Gomez","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012990902","display_name":"Angela C. Boroughs","orcid":"https://orcid.org/0000-0002-9701-9538","observed_orcids":["https://orcid.org/0000-0002-9701-9538"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Boroughs","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029335246","display_name":"Irene Scarf\u00f2","orcid":"https://orcid.org/0000-0002-5545-3248","observed_orcids":["https://orcid.org/0000-0002-5545-3248"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Scarfo","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078921018","display_name":"Laura Lim","orcid":"https://orcid.org/0009-0002-6848-7102","observed_orcids":["https://orcid.org/0009-0002-6848-7102"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Lim","raw_affiliation_strings":["University of Colorado Anschutz Medical Campus., Aurora, CO, 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus., Aurora, CO, 2","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101967257","display_name":"Kevin H. Dang","orcid":"https://orcid.org/0000-0001-5695-926X","observed_orcids":["https://orcid.org/0000-0001-5695-926X"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Dang","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019765983","display_name":"Marvin Chew","orcid":"https://orcid.org/0000-0002-4688-5807","observed_orcids":["https://orcid.org/0000-0002-4688-5807"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marvin Chew","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078553534","display_name":"Rakesh Sudhakar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh Sudhakar","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074254926","display_name":"Michelle Ly Thai Nguyen","orcid":"https://orcid.org/0009-0007-2594-4904","observed_orcids":["https://orcid.org/0009-0007-2594-4904"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Nguyen","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078431783","display_name":"Thomas J. Gardner","orcid":"https://orcid.org/0000-0003-0838-8751","observed_orcids":["https://orcid.org/0000-0003-0838-8751"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Gardner","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077376500","display_name":"Beatriz Millare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatriz Millare","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021671895","display_name":"James Zhang","orcid":"https://orcid.org/0000-0002-6251-0474","observed_orcids":["https://orcid.org/0000-0002-6251-0474"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Zhang","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068123180","display_name":"Darrian Moskowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrian Moskowitz","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008640262","display_name":"Stanley Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley Zhou","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102634242","display_name":"Neroli H. Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neroli H. Xie","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079556448","display_name":"Nickolas Attanasio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nickolas Attanasio","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016002551","display_name":"Amanda Fearon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Fearon","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ivan Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Chan","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038074721","display_name":"Vibhavari Sail","orcid":"https://orcid.org/0000-0002-6716-1672","observed_orcids":["https://orcid.org/0000-0002-6716-1672"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vibhavari Sail","raw_affiliation_strings":["Arsenal bio, South San Francisco, CA, 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal bio, South San Francisco, CA, 3","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088479952","display_name":"Vince Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vince Thomas","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104263267","display_name":"Jennesa Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennesa Smith","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027511315","display_name":"Jennifer McDevitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer McDevitt","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070171264","display_name":"Levi J. Rupp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levi Gray-Rupp","raw_affiliation_strings":["Arsenal Bio, South San Francisco, 4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, 4","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101490682","display_name":"Alba Gonzalez","orcid":"https://orcid.org/0000-0002-6232-6001","observed_orcids":["https://orcid.org/0000-0002-6232-6001"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alba Gonzalez","raw_affiliation_strings":["Arsenal Bio, South San Fransisco, CA. 5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Fransisco, CA. 5","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048253446","display_name":"Christopher L. Murriel","orcid":"https://orcid.org/0000-0002-8161-6848","observed_orcids":["https://orcid.org/0000-0002-8161-6848"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Murriel","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043992139","display_name":"W. Nicholas Haining","orcid":"https://orcid.org/0000-0001-7871-3762","observed_orcids":["https://orcid.org/0000-0001-7871-3762"]},"institutions":[{"id":"https://openalex.org/I4210154375","display_name":"Arsenal Biosciences (United States)","ror":"https://ror.org/053344077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Nicholas Haining","raw_affiliation_strings":["Arsenal Bio, South San Francisco, CA, 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arsenal Bio, South San Francisco, CA, 1","institution_ids":["https://openalex.org/I4210154375"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"10_Supplement","first_page":"B037","last_page":"B037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.8809999823570251},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ix","display_name":"carbonic anhydrase IX","score":0.9539999961853027},{"id":"https://openalex.org/keywords/crispr-knock-in","display_name":"CRISPR knock-in","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-vasculature-targeting","display_name":"tumor vasculature targeting","score":0.6480000019073486},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5405979752540588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5334722399711609},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4410938620567322},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30986887216567993},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19343838095664978}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6074.tumimm24-b037","doi":"https://doi.org/10.1158/2326-6074.tumimm24-b037","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm24-b037","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393094872","https://openalex.org/W4388042622","https://openalex.org/W4391302088","https://openalex.org/W4362593520","https://openalex.org/W4365511810","https://openalex.org/W4415899026","https://openalex.org/W4415899116","https://openalex.org/W2953983891","https://openalex.org/W4362541463","https://openalex.org/W7133240052"],"abstract_inverted_index":{"Abstract":[0],"Common":[1],"challenges":[2],"of":[3,38,91,110,168,177,185,193,203,217,228,246,254,286,291,366,379],"CAR-T":[4],"cell":[5,13,15,32,130,163,360],"therapies":[6],"in":[7,123,128,196,208,219,232,235,276,372,384],"solid":[8],"tumors,":[9],"such":[10],"as":[11],"clear":[12],"renal":[14],"carcinoma":[16],"(ccRCC),":[17],"include":[18,132],"insufficient":[19],"therapeutic":[20],"potency":[21],"and":[22,63,115,138,147,159,165,181,268,270,389],"tumor":[23,76,93,143,187,278,370],"specificity.":[24],"AB-2100":[25,46,111,173,198,218,262,287],"is":[26,71,103],"an":[27,64],"autologous":[28],"integrated":[29],"circuit":[30],"T":[31,129,162,359],"product":[33,361],"generated":[34],"via":[35],"CRISPR-mediated":[36],"knock-in":[37],"a":[39,43,48,56,148,211,239,355],"single":[40],"transgene":[41],"into":[42],"safe-harbor":[44],"locus.":[45],"encodes":[47],"transcriptionally":[49],"regulated":[50],"sequential":[51,79],"AND":[52,80],"gate":[53,102],"that":[54,113,172,226,244,261],"comprises":[55],"priming":[57,89],"receptor":[58],"(PrimeR)":[59],"specific":[60],"for":[61,288,363],"PSMA":[62,114,267],"inducible":[65],"CAR":[66,98,358],"targeting":[67],"CA9":[68,97,116,186],"antigen,":[69],"which":[70],"widely":[72],"expressed":[73],"on":[74],"ccRCC":[75,194,367],"cells.":[77],"AB-2100\u2019s":[78],"logic-gate":[81],"design":[82],"aims":[83],"to":[84,95,105,119,141,154,160,190],"confer":[85],"tumor-specific":[86,183],"activity":[87],"by":[88],"off":[90,176],"PSMA-expressing":[92,178],"vasculature":[94],"induce":[96,182],"expression.":[99],"The":[100],"logic":[101],"intended":[104,362],"increase":[106,234],"the":[107,191,220,229,249,277,283,289,364,380],"safety":[108],"profile":[109],"given":[112],"are":[117],"predicted":[118],"have":[120],"limited":[121],"co-expression":[122],"normal":[124],"tissues.":[125],"Additional":[126],"enhancements":[127],"functionality":[131],"short-hairpin":[133],"RNAs":[134],"(shRNA)":[135],"against":[136],"Fas":[137],"TGFBR2":[139],"designed":[140,153],"prevent":[142],"microenvironment":[144],"(TME)-mediated":[145],"suppression,":[146],"synthetic":[149],"pathway":[150],"activator":[151],"(SPA)":[152],"drive":[155],"constitutive":[156],"STAT3":[157],"signaling":[158],"enhance":[161],"expansion":[164],"antitumor":[166,236],"activityMechanism":[167],"action":[169],"studies":[170],"demonstrate":[171,260],"can":[174,271],"prime":[175],"endothelial":[179],"cells":[180],"killing":[184,202],"cells,":[188],"leading":[189],"eradication":[192],"targets":[195,264],"vitro.":[197],"also":[199],"exhibited":[200],"selective":[201],"dual":[204],"antigen":[205],"expressing":[206],"tumors":[207,265],"vivo":[209],"using":[210],"dual-flank":[212],"subcutaneous":[213,221],"xenograft":[214,223,241],"model.":[215],"Evaluation":[216],"A498":[222],"model":[224,242,375],"demonstrated":[225,243],"inclusion":[227],"SPA":[230,247],"resulted":[231],"significant":[233],"efficacy.":[237],"Furthermore,":[238],"rechallenge":[240],"presence":[245],"increased":[248],"long":[250],"term":[251],"functional":[252],"persistence":[253],"AB-2100.":[255],"In":[256],"summary,":[257],"preclinical":[258,373],"data":[259],"selectively":[263],"co-expressing":[266],"CA9,":[269],"overcome":[272],"multiple":[273],"suppressive":[274],"mechanisms":[275],"microenvironment.":[279],"These":[280],"results":[281],"support":[282],"ongoing":[284],"evaluation":[285],"treatment":[290,365],"advanced":[292],"or":[293],"metastatic":[294],"ccRCC.":[295],"Citation":[296],"Format:":[297],"Suchismita":[298],"Mohanty,":[299],"Jeremy":[300],"Chen,":[301],"Alma":[302],"Gomez,":[303],"Angela":[304],"Boroughs,":[305],"Irene":[306],"Scarfo,":[307],"Laura":[308],"Lim,":[309],"Kevin":[310],"Dang,":[311],"Marvin":[312],"Chew,":[313],"Rakesh":[314],"Sudhakar,":[315],"Michelle":[316],"Nguyen,":[317],"Thomas":[318],"Gardner,":[319],"Beatriz":[320],"Millare,":[321],"James":[322],"Zhang,":[323],"Darrian":[324],"Moskowitz,":[325],"Stanley":[326],"Zhou,":[327],"Neroli":[328],"H.":[329],"Xie,":[330],"Nickolas":[331],"Attanasio,":[332],"Amanda":[333],"Fearon,":[334],"Ivan":[335],"Chan,":[336],"Vibhavari":[337],"Sail,":[338],"Vince":[339],"Thomas,":[340],"Jennesa":[341],"Smith,":[342],"Jennifer":[343],"McDevitt,":[344],"Levi":[345],"Gray-Rupp,":[346],"Alba":[347],"Gonzalez,":[348],"Christopher":[349],"Murriel,":[350],"W.":[351],"Nicholas":[352],"Haining.":[353],"AB-2100,":[354],"PSMA-inducible":[356],"CA9-specific":[357],"provides":[368],"long-term":[369],"responses":[371],"mouse":[374],"[abstract].":[376],"In:":[377],"Proceedings":[378],"AACR":[381],"Special":[382],"Conference":[383],"Cancer":[385,399],"Research:":[386],"Tumor":[387],"Immunology":[388],"Immunotherapy;":[390],"2024":[391],"Oct":[392],"18-21;":[393],"Boston,":[394],"MA.":[395],"Philadelphia":[396],"(PA):":[397],"AACR;":[398],"Immunol":[400],"Res":[401],"2024;12(10":[402],"Suppl):Abstract":[403],"nr":[404],"B037.":[405]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-18T00:00:00"}