{"id":"https://openalex.org/W4403487403","doi":"https://doi.org/10.1021/acsanm.4c05295","title":"Oxygen Nanobubbles Halt Tumor Aggression and Metastasis by Inhibiting Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Lung and Mammary Adenocarcinoma","display_name":"Oxygen Nanobubbles Halt Tumor Aggression and Metastasis by Inhibiting Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Lung and Mammary Adenocarcinoma","publication_year":2024,"publication_date":"2024-10-17","ids":{"openalex":"https://openalex.org/W4403487403","doi":"https://doi.org/10.1021/acsanm.4c05295"},"language":"en","primary_location":{"id":"doi:10.1021/acsanm.4c05295","doi":"https://doi.org/10.1021/acsanm.4c05295","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsanm.4c05295","pdf_url":null,"source":{"id":"https://openalex.org/S4210191493","display_name":"ACS Applied Nano Materials","issn_l":"2574-0970","issn":["2574-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Nano Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104247656","display_name":"Kumari Bhavya","orcid":"https://orcid.org/0000-0003-1751-1854","observed_orcids":["https://orcid.org/0000-0003-1751-1854"]},"institutions":[{"id":"https://openalex.org/I119241673","display_name":"Indian Institute of Technology Ropar","ror":"https://ror.org/02qkhhn56","country_code":"IN","type":"education","lineage":["https://openalex.org/I119241673"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kumari Bhavya","raw_affiliation_strings":["Department of Biomedical Engineering","Indian Institute of Technology Ropar","Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0003-1751-1854","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology Ropar","institution_ids":["https://openalex.org/I119241673"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India","institution_ids":["https://openalex.org/I119241673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009054242","display_name":"Kalyani Agarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119241673","display_name":"Indian Institute of Technology Ropar","ror":"https://ror.org/02qkhhn56","country_code":"IN","type":"education","lineage":["https://openalex.org/I119241673"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kalyani Agarwal","raw_affiliation_strings":["Department of Chemical Engineering","Indian Institute of Technology Ropar","Department of Chemical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology Ropar","institution_ids":["https://openalex.org/I119241673"]},{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India","institution_ids":["https://openalex.org/I119241673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091929235","display_name":"Deepa Negi","orcid":"https://orcid.org/0000-0002-8092-8065","observed_orcids":["https://orcid.org/0000-0002-8092-8065"]},"institutions":[{"id":"https://openalex.org/I119241673","display_name":"Indian Institute of Technology Ropar","ror":"https://ror.org/02qkhhn56","country_code":"IN","type":"education","lineage":["https://openalex.org/I119241673"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepa Negi","raw_affiliation_strings":["Department of Biomedical Engineering","Indian Institute of Technology Ropar","Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0002-8092-8065","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology Ropar","institution_ids":["https://openalex.org/I119241673"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India","institution_ids":["https://openalex.org/I119241673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091615527","display_name":"Karishma Niveria","orcid":"https://orcid.org/0000-0003-2707-7545","observed_orcids":["https://orcid.org/0000-0003-2707-7545"]},"institutions":[{"id":"https://openalex.org/I110166357","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Karishma Niveria","raw_affiliation_strings":["Nanobiotech Laboratory, Department of Zoology, Kirori Mal College","University of Delhi","Nanobiotech Laboratory, Department of Zoology, Kirori Mal College, University of Delhi, Delhi 110007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanobiotech Laboratory, Department of Zoology, Kirori Mal College","institution_ids":[]},{"raw_affiliation_string":"University of Delhi","institution_ids":["https://openalex.org/I110166357"]},{"raw_affiliation_string":"Nanobiotech Laboratory, Department of Zoology, Kirori Mal College, University of Delhi, Delhi 110007, India","institution_ids":["https://openalex.org/I110166357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049714716","display_name":"Yashveer Singh","orcid":"https://orcid.org/0000-0003-1625-8156","observed_orcids":["https://orcid.org/0000-0003-1625-8156"]},"institutions":[{"id":"https://openalex.org/I119241673","display_name":"Indian Institute of Technology Ropar","ror":"https://ror.org/02qkhhn56","country_code":"IN","type":"education","lineage":["https://openalex.org/I119241673"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yashveer Singh","raw_affiliation_strings":["Department of Chemistry","Indian Institute of Technology Ropar","Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0003-1625-8156","affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology Ropar","institution_ids":["https://openalex.org/I119241673"]},{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India","institution_ids":["https://openalex.org/I119241673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080857013","display_name":"Anita  Kamra Verma","orcid":"https://orcid.org/0000-0001-6341-5930","observed_orcids":["https://orcid.org/0000-0001-6341-5930"]},"institutions":[{"id":"https://openalex.org/I110166357","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213","country_code":"IN","type":"education","lineage":["https://openalex.org/I110166357"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anita Kamra Verma","raw_affiliation_strings":["Fellow, Delhi School of Public Health, Institution of Eminence","Nanobiotech Laboratory, Department of Zoology, Kirori Mal College","University of Delhi","Fellow, Delhi School of Public Health, Institution of Eminence, University of Delhi, Delhi 110007, India","Nanobiotech Laboratory, Department of Zoology, Kirori Mal College, University of Delhi, Delhi 110007, India"],"raw_orcid":"https://orcid.org/0000-0001-6341-5930","affiliations":[{"raw_affiliation_string":"Fellow, Delhi School of Public Health, Institution of Eminence","institution_ids":[]},{"raw_affiliation_string":"Nanobiotech Laboratory, Department of Zoology, Kirori Mal College","institution_ids":[]},{"raw_affiliation_string":"University of Delhi","institution_ids":["https://openalex.org/I110166357"]},{"raw_affiliation_string":"Fellow, Delhi School of Public Health, Institution of Eminence, University of Delhi, Delhi 110007, India","institution_ids":["https://openalex.org/I110166357"]},{"raw_affiliation_string":"Nanobiotech Laboratory, Department of Zoology, Kirori Mal College, University of Delhi, Delhi 110007, India","institution_ids":["https://openalex.org/I110166357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067387483","display_name":"Suman Dasgupta","orcid":"https://orcid.org/0000-0003-2599-2299","observed_orcids":["https://orcid.org/0000-0003-2599-2299"]},"institutions":[{"id":"https://openalex.org/I126601174","display_name":"Tezpur University","ror":"https://ror.org/005x56091","country_code":"IN","type":"education","lineage":["https://openalex.org/I126601174"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suman Dasgupta","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology","Tezpur University","Department of Molecular Biology and Biotechnology, Tezpur University, Napaam 784 028, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"Tezpur University","institution_ids":["https://openalex.org/I126601174"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Tezpur University, Napaam 784 028, India","institution_ids":["https://openalex.org/I126601174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037916171","display_name":"Neelkanth Nirmalkar","orcid":"https://orcid.org/0000-0002-1602-3843","observed_orcids":["https://orcid.org/0000-0002-1602-3843"]},"institutions":[{"id":"https://openalex.org/I119241673","display_name":"Indian Institute of Technology Ropar","ror":"https://ror.org/02qkhhn56","country_code":"IN","type":"education","lineage":["https://openalex.org/I119241673"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Neelkanth Nirmalkar","raw_affiliation_strings":["Department of Chemical Engineering","Indian Institute of Technology Ropar","Department of Chemical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0002-1602-3843","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology Ropar","institution_ids":["https://openalex.org/I119241673"]},{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India","institution_ids":["https://openalex.org/I119241673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049303231","display_name":"Durba Pal","orcid":"https://orcid.org/0000-0001-7672-3529","observed_orcids":["https://orcid.org/0000-0001-7672-3529"]},"institutions":[{"id":"https://openalex.org/I119241673","display_name":"Indian Institute of Technology Ropar","ror":"https://ror.org/02qkhhn56","country_code":"IN","type":"education","lineage":["https://openalex.org/I119241673"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Durba Pal","raw_affiliation_strings":["Department of Biomedical Engineering","Indian Institute of Technology Ropar","Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India"],"raw_orcid":"https://orcid.org/0000-0001-7672-3529","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology Ropar","institution_ids":["https://openalex.org/I119241673"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, 140001 Punjab, India","institution_ids":["https://openalex.org/I119241673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037916171","https://openalex.org/A5049303231"],"corresponding_institution_ids":["https://openalex.org/I119241673"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6558,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.56655429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"7","issue":"21","first_page":"25198","last_page":"25211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.2037000060081482,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.1307000070810318,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen-nanobubbles","display_name":"oxygen nanobubbles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.996999979019165},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mammary-adenocarcinoma","display_name":"mammary adenocarcinoma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/prolyl-hydroxylation","display_name":"prolyl hydroxylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8539999723434448},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8299999833106995},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.9350000023841858},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6050000190734863},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.49000000953674316},{"id":"https://openalex.org/keywords/enhanced-permeability-and-retention-effect","display_name":"enhanced permeability and retention effect","score":0.6489999890327454},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.8137377500534058},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7696166634559631},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6739943027496338},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.599071741104126},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.522089421749115},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5001239776611328},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4749106168746948},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44026950001716614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3545736074447632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3233222961425781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2267620861530304},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.149166077375412},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06465554237365723},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsanm.4c05295","doi":"https://doi.org/10.1021/acsanm.4c05295","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsanm.4c05295","pdf_url":null,"source":{"id":"https://openalex.org/S4210191493","display_name":"ACS Applied Nano Materials","issn_l":"2574-0970","issn":["2574-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Nano Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G10883452","display_name":null,"funder_award_id":"# BT/PR40669/MED/32/761/2020","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G4879308690","display_name":null,"funder_award_id":"DST/INSPIRE/04/2016/001163","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6433042951","display_name":null,"funder_award_id":"SB/WEA-02/2017","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320330156","display_name":"Indian Institute of Technology Ropar","ror":"https://ror.org/02qkhhn56"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W628038580","https://openalex.org/W1493048246","https://openalex.org/W1751833946","https://openalex.org/W1958345783","https://openalex.org/W1964365939","https://openalex.org/W1988742771","https://openalex.org/W1990099735","https://openalex.org/W1995205984","https://openalex.org/W2014245338","https://openalex.org/W2021381932","https://openalex.org/W2055130200","https://openalex.org/W2081753042","https://openalex.org/W2082978870","https://openalex.org/W2084863590","https://openalex.org/W2107689216","https://openalex.org/W2113638068","https://openalex.org/W2117692326","https://openalex.org/W2125257427","https://openalex.org/W2130522035","https://openalex.org/W2139369439","https://openalex.org/W2144625075","https://openalex.org/W2154553709","https://openalex.org/W2154563468","https://openalex.org/W2157000380","https://openalex.org/W2171427413","https://openalex.org/W2204695292","https://openalex.org/W2361876374","https://openalex.org/W2414236267","https://openalex.org/W2501239489","https://openalex.org/W2560447818","https://openalex.org/W2592596559","https://openalex.org/W2739854791","https://openalex.org/W2748806740","https://openalex.org/W2770519390","https://openalex.org/W2770758857","https://openalex.org/W2781664750","https://openalex.org/W2884319649","https://openalex.org/W2888667841","https://openalex.org/W2890988943","https://openalex.org/W2896774678","https://openalex.org/W2900496893","https://openalex.org/W2909893490","https://openalex.org/W2911336091","https://openalex.org/W2937347338","https://openalex.org/W2943446742","https://openalex.org/W2973126765","https://openalex.org/W2987284967","https://openalex.org/W2990325874","https://openalex.org/W2999304663","https://openalex.org/W3012596266","https://openalex.org/W3015018360","https://openalex.org/W3015714049","https://openalex.org/W3033436161","https://openalex.org/W3033878161","https://openalex.org/W3042468003","https://openalex.org/W3047043366","https://openalex.org/W3132408337","https://openalex.org/W3137219943","https://openalex.org/W3137916819","https://openalex.org/W3146146685","https://openalex.org/W3164894153","https://openalex.org/W3171867299","https://openalex.org/W4206282718","https://openalex.org/W4226070970","https://openalex.org/W4281655119","https://openalex.org/W4283653090","https://openalex.org/W4319827025","https://openalex.org/W4388837399"],"related_works":["https://openalex.org/W4387812203","https://openalex.org/W2748806740","https://openalex.org/W2527386946","https://openalex.org/W2884319649","https://openalex.org/W7126098523","https://openalex.org/W2568562949","https://openalex.org/W2975041122","https://openalex.org/W2886168501","https://openalex.org/W2943446742","https://openalex.org/W2911336091"],"abstract_inverted_index":{"The":[0],"rapid":[1],"proliferation":[2],"of":[3,69,94,110,125,132],"cancer":[4],"cells":[5],"creates":[6],"a":[7,142,172],"hypoxic":[8],"microenvironment":[9],"in":[10,122,145],"solid":[11,178],"tumors,":[12],"driving":[13],"aggressiveness":[14,93],"through":[15],"epithelial-to-mesenchymal":[16],"transition":[17],"(EMT),":[18],"invasion,":[19],"and":[20,55,65,74,86,96,129,138,149],"migration,":[21],"often":[22],"leading":[23,114],"to":[24,26,32,78,82,115],"resistance":[25],"conventional":[27],"chemotherapies.":[28],"Delivering":[29],"oxygen":[30,45,57],"directly":[31],"the":[33,62,83,92,102,123,130,158],"tumor":[34,79,166],"site":[35],"can":[36],"address":[37],"these":[38],"challenges.":[39],"Herein,":[40],"we":[41],"fabricated":[42],"liposomal":[43],"encapsulated":[44],"nanobubbles":[46,100],"(L-ONBs)":[47],"with":[48,141],"nanoscale":[49],"size":[50],"that":[51,61],"exhibit":[52],"enhanced":[53,84],"stability":[54,64],"efficient":[56],"release.":[58],"Characterization":[59],"revealed":[60],"robust":[63],"negative":[66],"surface":[67],"charge":[68],"L-ONB":[70],"particles":[71],"prevent":[72],"aggregation":[73],"facilitate":[75],"passive":[76],"targeting":[77],"tissues":[80],"due":[81],"permeability":[85],"retention":[87],"effect,":[88],"thereby":[89],"significantly":[90],"reducing":[91],"lung":[95],"breast":[97],"tumors.":[98,179],"Oxygen":[99],"countered":[101],"hypoxia-induced":[103,165],"EMT":[104],"pathway":[105],"by":[106,161],"facilitating":[107],"prolyl":[108],"hydroxylation":[109],"hypoxia-inducible":[111],"factor":[112],"1\u03b1,":[113],"its":[116],"proteasomal":[117],"degradation.":[118],"This":[119],"process":[120],"resulted":[121],"upregulation":[124],"epithelial":[126],"marker":[127],"E-cadherin":[128],"downregulation":[131],"mesenchymal":[133],"markers":[134],"such":[135],"as":[136,171],"N-cadherin":[137],"vimentin,":[139],"along":[140],"significant":[143],"decrease":[144],"transforming":[146],"growth":[147,152],"factor-\u03b2":[148],"vascular":[150],"endothelial":[151],"factor-A.":[153],"Overall,":[154],"our":[155],"study":[156],"elucidates":[157],"cellular":[159],"mechanisms":[160],"which":[162],"L-ONBs":[163],"inhibit":[164],"aggressiveness,":[167],"highlighting":[168],"their":[169],"potential":[170],"promising":[173],"therapeutic":[174],"option":[175],"for":[176],"managing":[177]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-18T00:00:00"}