{"id":"https://openalex.org/W4403474752","doi":"https://doi.org/10.29271/jcpsp.2024.10.1267","title":"Advanced Oesophageal Cancer: A Step Forward in Chemotherapy-Free Treatment","display_name":"Advanced Oesophageal Cancer: A Step Forward in Chemotherapy-Free Treatment","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403474752","doi":"https://doi.org/10.29271/jcpsp.2024.10.1267","pmid":"https://pubmed.ncbi.nlm.nih.gov/39410704"},"language":"en","primary_location":{"id":"doi:10.29271/jcpsp.2024.10.1267","doi":"https://doi.org/10.29271/jcpsp.2024.10.1267","is_oa":true,"landing_page_url":"https://doi.org/10.29271/jcpsp.2024.10.1267","pdf_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=S3JhNDhkQW9WTENTdEhvNUlIamRtdz09","source":{"id":"https://openalex.org/S4210202897","display_name":"Journal of College of Physicians And Surgeons Pakistan","issn_l":"1022-386X","issn":["1022-386X","1681-7168"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697874","host_organization_name":"College of Physicians and Surgeons Pakistan","host_organization_lineage":["https://openalex.org/P4322697874"],"host_organization_lineage_names":["College of Physicians and Surgeons Pakistan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons Pakistan","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=S3JhNDhkQW9WTENTdEhvNUlIamRtdz09","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110869796","display_name":"Maham Zaman","orcid":"https://orcid.org/0009-0002-3551-0046","observed_orcids":["https://orcid.org/0009-0002-3551-0046"]},"institutions":[{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Maham Zaman","raw_affiliation_strings":["Department of Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I4405273397"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Efrah Ashraf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Efrah Ashraf","raw_affiliation_strings":["Department of Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I4405273397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090917555","display_name":"Vikash Kumar Karmani","orcid":"https://orcid.org/0000-0001-8622-0300","observed_orcids":["https://orcid.org/0000-0001-8622-0300"]},"institutions":[{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Vikash Kumar Karmani","raw_affiliation_strings":["Department of Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, Pakistan","institution_ids":["https://openalex.org/I4405273397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405273397"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"10","first_page":"1267","last_page":"1267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy-free-treatment","display_name":"chemotherapy-free treatment","score":0.8389999866485596},{"id":"https://openalex.org/keywords/toripalimab","display_name":"toripalimab","score":0.972000002861023},{"id":"https://openalex.org/keywords/surufatinib","display_name":"surufatinib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gastroesophageal-junction-cancer","display_name":"gastroesophageal junction cancer","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6385945081710815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.61967533826828},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5901085734367371},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45569342374801636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43274426460266113},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35566627979278564}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.29271/jcpsp.2024.10.1267","doi":"https://doi.org/10.29271/jcpsp.2024.10.1267","is_oa":true,"landing_page_url":"https://doi.org/10.29271/jcpsp.2024.10.1267","pdf_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=S3JhNDhkQW9WTENTdEhvNUlIamRtdz09","source":{"id":"https://openalex.org/S4210202897","display_name":"Journal of College of Physicians And Surgeons Pakistan","issn_l":"1022-386X","issn":["1022-386X","1681-7168"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697874","host_organization_name":"College of Physicians and Surgeons Pakistan","host_organization_lineage":["https://openalex.org/P4322697874"],"host_organization_lineage_names":["College of Physicians and Surgeons Pakistan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons Pakistan","raw_type":"journal-article"},{"id":"pmid:39410704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39410704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.29271/jcpsp.2024.10.1267","doi":"https://doi.org/10.29271/jcpsp.2024.10.1267","is_oa":true,"landing_page_url":"https://doi.org/10.29271/jcpsp.2024.10.1267","pdf_url":"https://www.jcpsp.pk/oas/mpdf/generate_pdf.php?string=S3JhNDhkQW9WTENTdEhvNUlIamRtdz09","source":{"id":"https://openalex.org/S4210202897","display_name":"Journal of College of Physicians And Surgeons Pakistan","issn_l":"1022-386X","issn":["1022-386X","1681-7168"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322697874","host_organization_name":"College of Physicians and Surgeons Pakistan","host_organization_lineage":["https://openalex.org/P4322697874"],"host_organization_lineage_names":["College of Physicians and Surgeons Pakistan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the College of Physicians and Surgeons Pakistan","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403474752.pdf","grobid_xml":"https://content.openalex.org/works/W4403474752.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W4214915284","https://openalex.org/W4324134612","https://openalex.org/W4386764738","https://openalex.org/W4396696566"],"related_works":["https://openalex.org/W1979537265","https://openalex.org/W4223556450","https://openalex.org/W4361026116","https://openalex.org/W7116958194","https://openalex.org/W4402909448","https://openalex.org/W4387095868","https://openalex.org/W4401248294","https://openalex.org/W4401728224","https://openalex.org/W4409205141","https://openalex.org/W4390501304"],"abstract_inverted_index":{"Oesophageal":[0],"cancer":[1,213],"(EC)":[2],"is":[3,49,77,103,137],"a":[4,28,66,112,165,174,179],"major":[5],"global":[6,46],"health":[7],"issue,":[8],"ranking":[9],"seventh":[10],"in":[11,22,31,55,70,161,199],"incidence":[12,33],"and":[13,34,59,143,151,206,217,239,252,269],"the":[14,32,45,78,90,200,229],"sixth":[15],"foremost":[16],"cause":[17],"of":[18,36,44,89,131,169,194],"cancer-associated":[19],"mortality":[20,35],"worldwide":[21],"2020.":[23],"1":[24],"Recent":[25],"data":[26],"show":[27],"concerning":[29],"increase":[30,48],"EC,":[37],"with":[38,57,72,96,106,123,177,211,220,257],"Asia":[39],"contributing":[40],"to":[41,139,153],"nearly":[42],"80%":[43],"cases.This":[47],"significantly":[50],"straining":[51],"healthcare":[52],"systems,":[53],"especially":[54],"nations":[56],"lower":[58],"moderate":[60],"incomes.2":[61],"Cytotoxic":[62],"chemotherapy,":[63],"either":[64],"as":[65],"standalone":[67],"treatment":[68,145],"or":[69,84],"conjunction":[71],"immune":[73],"checkpoint":[74],"inhibitors":[75],"(ICIs),":[76],"preferred":[79],"initial":[80],"therapy":[81],"for":[82,235,248,255,265,272],"advanced":[83,97,124],"metastatic":[85],"unresectable":[86],"solid":[87],"tumours":[88],"gastrointestinal":[91],"(GI)":[92],"tract.3":[93],"For":[94],"individuals":[95],"gastroesophageal":[98],"junction":[99],"cancers":[100],"(GEJCs),":[101],"chemotherapy":[102],"often":[104],"ineffective":[105],"most":[107],"patients":[108,122,196],"surviving":[109],"less":[110],"than":[111],"year":[113],"after":[114],"treatment.Additionally,":[115],"they":[116],"must":[117],"endure":[118],"severe":[119],"side":[120,191],"effects.Japanese":[121],"EC":[125],"typically":[126],"have":[127],"an":[128],"average":[129],"survival":[130,244,260],"only":[132],"8.1":[133],"months":[134,247,254,264,271],"following":[135],"chemotherapy.It":[136],"crucial":[138],"find":[140],"more":[141,149],"effective":[142,150],"tolerable":[144],"options":[146],"that":[147],"are":[148],"easier":[152],"tolerate.4":[154],"A":[155],"recent":[156],"clinical":[157],"trial":[158],"conducted":[159],"solely":[160],"China":[162],"has":[163],"introduced":[164],"revolutionary":[166],"regimen":[167],"devoid":[168],"chemotherapy.3":[170],"It":[171],"combines":[172],"toripalimab,":[173],"PD-1":[175],"inhibitor,":[176],"surufatinib,":[178],"multi-targeted":[180],"tyrosine":[181],"kinase":[182],"inhibitor":[183],"(TKI),":[184],"demonstrating":[185],"significant":[186],"anti-tumour":[187],"effects":[188],"alongside":[189],"manageable":[190],"effects.A":[192],"total":[193],"60":[195],"were":[197,233],"included":[198],"study":[201],"between":[202],"17":[203],"December":[204],"2019,":[205],"29":[207],"January":[208],"2021:":[209],"20":[210,219],"gastric":[212],"(GC)":[214],"/":[215,237,250,267],"GEJCs":[216,238,251,268],"another":[218],"oesophageal":[221],"squamous":[222],"cell":[223],"carcinomas":[224],"(ESCCs).By":[225],"28":[226],"February":[227],"2023,":[228],"objective":[230],"response":[231],"rates":[232],"31.6%":[234],"GC":[236,249,266],"30.0%for":[240],"ESCCs.The":[241],"median":[242,258],"progression-free":[243],"was":[245],"4.1":[246],"2.7":[253],"ESCCs,":[256],"overall":[259],"recorded":[261],"at":[262],"13.7":[263],"10.4":[270],"ESCCs.":[273]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-17T00:00:00"}
