{"id":"https://openalex.org/W4403465262","doi":"https://doi.org/10.1016/bs.pmbts.2024.08.006","title":"The Huntington\u2019s disease drug pipeline: a review of small molecules and their therapeutic targets","display_name":"The Huntington\u2019s disease drug pipeline: a review of small molecules and their therapeutic targets","publication_year":2024,"publication_date":"2024-10-16","ids":{"openalex":"https://openalex.org/W4403465262","doi":"https://doi.org/10.1016/bs.pmbts.2024.08.006","pmid":"https://pubmed.ncbi.nlm.nih.gov/39947748"},"language":"en","primary_location":{"id":"doi:10.1016/bs.pmbts.2024.08.006","doi":"https://doi.org/10.1016/bs.pmbts.2024.08.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.pmbts.2024.08.006","pdf_url":null,"source":{"id":"https://openalex.org/S2506244597","display_name":"Progress in molecular biology and translational science","issn_l":"1877-1173","issn":["1877-1173","1878-0814"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Molecular Biology and Translational Science","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105783381","display_name":"Sameera Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sameera Khan","raw_affiliation_strings":["Department of Zoology, Aligarh Muslim University, Aligarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Aligarh Muslim University, Aligarh, India","institution_ids":["https://openalex.org/I171210897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113398608","display_name":"Nargis Bano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nargis Bano","raw_affiliation_strings":["Department of Zoology, Aligarh Muslim University, Aligarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Aligarh Muslim University, Aligarh, India","institution_ids":["https://openalex.org/I171210897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir N. Uversky","raw_affiliation_strings":["Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210140006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024174818","display_name":"Shakir Ahamad","orcid":"https://orcid.org/0000-0002-9873-7806","observed_orcids":["https://orcid.org/0000-0002-9873-7806"]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shakir Ahamad","raw_affiliation_strings":["Department of Chemistry, Aligarh Muslim University, Aligarh, India. Electronic address: shakirzaheer111@gmail.com"],"raw_orcid":"https://orcid.org/0000-0002-9873-7806","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Aligarh Muslim University, Aligarh, India. Electronic address: shakirzaheer111@gmail.com","institution_ids":["https://openalex.org/I171210897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052861994","display_name":"Shahnawaz Ali Bhat","orcid":"https://orcid.org/0000-0003-4098-8810","observed_orcids":["https://orcid.org/0000-0003-4098-8810"]},"institutions":[{"id":"https://openalex.org/I171210897","display_name":"Aligarh Muslim University","ror":"https://ror.org/03kw9gc02","country_code":"IN","type":"education","lineage":["https://openalex.org/I171210897"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shahnawaz Ali Bhat","raw_affiliation_strings":["Department of Zoology, Aligarh Muslim University, Aligarh, India. Electronic address: shahnawazalibhat@gmail.com"],"raw_orcid":"https://orcid.org/0000-0003-4098-8810","affiliations":[{"raw_affiliation_string":"Department of Zoology, Aligarh Muslim University, Aligarh, India. Electronic address: shahnawazalibhat@gmail.com","institution_ids":["https://openalex.org/I171210897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024174818","https://openalex.org/A5052861994"],"corresponding_institution_ids":["https://openalex.org/I171210897"],"apc_list":null,"apc_paid":null,"fwci":3.7943,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.93724967,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"211","issue":null,"first_page":"169","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/small-molecule-drugs","display_name":"small molecule drugs","score":0.9070000052452087},{"id":"https://openalex.org/keywords/drug-pipeline","display_name":"drug development pipeline","score":0.8669999837875366},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6800000071525574},{"id":"https://openalex.org/keywords/tetrabenazine","display_name":"tetrabenazine","score":0.875},{"id":"https://openalex.org/keywords/deutetrabenazine","display_name":"deutetrabenazine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chorea","display_name":"chorea","score":0.906000018119812},{"id":"https://openalex.org/keywords/cag-repeat-expansion","display_name":"CAG repeat expansion","score":0.8730000257492065},{"id":"https://openalex.org/keywords/huntingtin-gene","display_name":"huntingtin gene","score":0.8100000023841858},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.578000009059906},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7047591209411621},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6110148429870605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4842498004436493},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.4293123185634613},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3974379301071167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18329104781150818},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1685314178466797},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013747","descriptor_name":"Tetrabenazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013747","descriptor_name":"Tetrabenazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/bs.pmbts.2024.08.006","doi":"https://doi.org/10.1016/bs.pmbts.2024.08.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.pmbts.2024.08.006","pdf_url":null,"source":{"id":"https://openalex.org/S2506244597","display_name":"Progress in molecular biology and translational science","issn_l":"1877-1173","issn":["1877-1173","1878-0814"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Molecular Biology and Translational Science","raw_type":"book-chapter"},{"id":"pmid:39947748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39947748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in molecular biology and translational science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5012211838","display_name":null,"funder_award_id":"30\\u2013564/2021","funder_id":"https://openalex.org/F4320320767","funder_display_name":"University Grants Commission"},{"id":"https://openalex.org/G6816968026","display_name":null,"funder_award_id":"5/4\\u20135/3/13/Neuro/2022-NCD-I","funder_id":"https://openalex.org/F4320320720","funder_display_name":"Indian Council of Medical Research"}],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":212,"referenced_works":["https://openalex.org/W856574645","https://openalex.org/W1181462150","https://openalex.org/W1482169712","https://openalex.org/W1502625668","https://openalex.org/W1509721882","https://openalex.org/W1539087030","https://openalex.org/W1554445829","https://openalex.org/W1814590669","https://openalex.org/W1874118197","https://openalex.org/W1896472383","https://openalex.org/W1966906920","https://openalex.org/W1967744692","https://openalex.org/W1969083180","https://openalex.org/W1969175290","https://openalex.org/W1970986383","https://openalex.org/W1971591376","https://openalex.org/W1973523024","https://openalex.org/W1979286873","https://openalex.org/W1982138826","https://openalex.org/W1983866386","https://openalex.org/W1985723850","https://openalex.org/W1988845402","https://openalex.org/W1992519312","https://openalex.org/W1995970444","https://openalex.org/W1998122246","https://openalex.org/W2000486056","https://openalex.org/W2002311914","https://openalex.org/W2005895876","https://openalex.org/W2007796463","https://openalex.org/W2007945544","https://openalex.org/W2014311428","https://openalex.org/W2014520750","https://openalex.org/W2018830049","https://openalex.org/W2018928754","https://openalex.org/W2020096302","https://openalex.org/W2022317515","https://openalex.org/W2029984090","https://openalex.org/W2031280902","https://openalex.org/W2031758006","https://openalex.org/W2032730097","https://openalex.org/W2037206353","https://openalex.org/W2039237464","https://openalex.org/W2041626049","https://openalex.org/W2042521416","https://openalex.org/W2043899474","https://openalex.org/W2044218944","https://openalex.org/W2044882250","https://openalex.org/W2048277695","https://openalex.org/W2049007928","https://openalex.org/W2050347556","https://openalex.org/W2051840700","https://openalex.org/W2052864139","https://openalex.org/W2052970339","https://openalex.org/W2054811059","https://openalex.org/W2058182560","https://openalex.org/W2058634928","https://openalex.org/W2062059213","https://openalex.org/W2063690295","https://openalex.org/W2064886170","https://openalex.org/W2065154065","https://openalex.org/W2068230856","https://openalex.org/W2069676793","https://openalex.org/W2071161130","https://openalex.org/W2076546188","https://openalex.org/W2077138840","https://openalex.org/W2079726930","https://openalex.org/W2080713345","https://openalex.org/W2083967784","https://openalex.org/W2087453865","https://openalex.org/W2088781652","https://openalex.org/W2090786642","https://openalex.org/W2091492780","https://openalex.org/W2094890154","https://openalex.org/W2098670658","https://openalex.org/W2100103422","https://openalex.org/W2102952096","https://openalex.org/W2106148598","https://openalex.org/W2106575578","https://openalex.org/W2107972568","https://openalex.org/W2110461159","https://openalex.org/W2111149100","https://openalex.org/W2111444310","https://openalex.org/W2112516420","https://openalex.org/W2113917457","https://openalex.org/W2114311651","https://openalex.org/W2114377748","https://openalex.org/W2115211381","https://openalex.org/W2115995998","https://openalex.org/W2116449089","https://openalex.org/W2118638591","https://openalex.org/W2119191573","https://openalex.org/W2120935292","https://openalex.org/W2124573815","https://openalex.org/W2125393554","https://openalex.org/W2128517811","https://openalex.org/W2129447571","https://openalex.org/W2133775329","https://openalex.org/W2134573022","https://openalex.org/W2137288609","https://openalex.org/W2137580576","https://openalex.org/W2144333171","https://openalex.org/W2145442021","https://openalex.org/W2147297400","https://openalex.org/W2147983580","https://openalex.org/W2149313534","https://openalex.org/W2154019575","https://openalex.org/W2155488504","https://openalex.org/W2158201442","https://openalex.org/W2164598632","https://openalex.org/W2164962997","https://openalex.org/W2170563234","https://openalex.org/W2171577843","https://openalex.org/W2211836478","https://openalex.org/W2214139931","https://openalex.org/W2253321251","https://openalex.org/W2291779372","https://openalex.org/W2313095031","https://openalex.org/W2318414036","https://openalex.org/W2318803223","https://openalex.org/W2321362142","https://openalex.org/W2334352839","https://openalex.org/W2398540841","https://openalex.org/W2411284065","https://openalex.org/W2438672867","https://openalex.org/W2507516362","https://openalex.org/W2518987298","https://openalex.org/W2522941116","https://openalex.org/W2554167534","https://openalex.org/W2555247063","https://openalex.org/W2557765283","https://openalex.org/W2559839541","https://openalex.org/W2587575254","https://openalex.org/W2589384063","https://openalex.org/W2607293164","https://openalex.org/W2607710022","https://openalex.org/W2609055977","https://openalex.org/W2617139971","https://openalex.org/W2625794193","https://openalex.org/W2728628113","https://openalex.org/W2752628236","https://openalex.org/W2762830304","https://openalex.org/W2765989831","https://openalex.org/W2767248511","https://openalex.org/W2785441464","https://openalex.org/W2790491367","https://openalex.org/W2800788078","https://openalex.org/W2806723183","https://openalex.org/W2809481807","https://openalex.org/W2894059953","https://openalex.org/W2905256099","https://openalex.org/W2907074026","https://openalex.org/W2913970828","https://openalex.org/W2914387374","https://openalex.org/W2922394471","https://openalex.org/W2946190357","https://openalex.org/W2957618800","https://openalex.org/W2957683864","https://openalex.org/W2970649733","https://openalex.org/W2975999621","https://openalex.org/W2979935062","https://openalex.org/W2982548291","https://openalex.org/W2999291880","https://openalex.org/W3000136226","https://openalex.org/W3000473074","https://openalex.org/W3005905327","https://openalex.org/W3007261124","https://openalex.org/W3008306561","https://openalex.org/W3009683915","https://openalex.org/W3014286388","https://openalex.org/W3028143627","https://openalex.org/W3042763822","https://openalex.org/W3049633837","https://openalex.org/W3087469413","https://openalex.org/W3088023295","https://openalex.org/W3103080220","https://openalex.org/W3121712239","https://openalex.org/W3123015207","https://openalex.org/W3123102387","https://openalex.org/W3127297964","https://openalex.org/W3128854579","https://openalex.org/W3135637142","https://openalex.org/W3155551674","https://openalex.org/W3186892847","https://openalex.org/W3187326368","https://openalex.org/W3193814024","https://openalex.org/W3205233248","https://openalex.org/W4205141635","https://openalex.org/W4210641545","https://openalex.org/W4210641858","https://openalex.org/W4212959738","https://openalex.org/W4213195620","https://openalex.org/W4220831067","https://openalex.org/W4221019154","https://openalex.org/W4223554306","https://openalex.org/W4225007813","https://openalex.org/W4229445814","https://openalex.org/W4233823505","https://openalex.org/W4255568361","https://openalex.org/W4255716481","https://openalex.org/W4281485069","https://openalex.org/W4282972828","https://openalex.org/W4285164848","https://openalex.org/W4308256044","https://openalex.org/W4311083213","https://openalex.org/W4311282980","https://openalex.org/W4312032637","https://openalex.org/W4319215699","https://openalex.org/W4321172613","https://openalex.org/W6646126081","https://openalex.org/W6685036246","https://openalex.org/W6702672725","https://openalex.org/W6740308643"],"related_works":["https://openalex.org/W4312032637","https://openalex.org/W7203636646","https://openalex.org/W4414167095","https://openalex.org/W4210641858","https://openalex.org/W4413791213","https://openalex.org/W4398177891","https://openalex.org/W4397291031","https://openalex.org/W2807641408","https://openalex.org/W4295259866","https://openalex.org/W1966721340"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-17T00:00:00"}