{"id":"https://openalex.org/W4403436769","doi":"https://doi.org/10.1158/1078-0432.c.7494063","title":"Data from HER2 Antibody\u2013Drug Conjugates Are Active against Desmoplastic Small Round Cell Tumor","display_name":"Data from HER2 Antibody\u2013Drug Conjugates Are Active against Desmoplastic Small Round Cell Tumor","publication_year":2024,"publication_date":"2024-10-15","ids":{"openalex":"https://openalex.org/W4403436769","doi":"https://doi.org/10.1158/1078-0432.c.7494063"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.7494063","doi":"https://doi.org/10.1158/1078-0432.c.7494063","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7494063","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.7494063","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015491983","display_name":"Tom Zhang","orcid":"https://orcid.org/0009-0007-0979-9719","observed_orcids":["https://orcid.org/0009-0007-0979-9719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-0979-9719","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109455203","display_name":"Christopher A. Febres\u2010Aldana","orcid":"https://orcid.org/0000-0002-4754-1344","observed_orcids":["https://orcid.org/0000-0002-4754-1344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher A. Febres-Aldana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4754-1344","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004567240","display_name":"Zebing Liu","orcid":"https://orcid.org/0000-0003-4682-1253","observed_orcids":["https://orcid.org/0000-0003-4682-1253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zebing Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4682-1253","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014777471","display_name":"Jenna-Marie Dix","orcid":"https://orcid.org/0000-0001-8822-4049","observed_orcids":["https://orcid.org/0000-0001-8822-4049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenna-Marie Dix","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8822-4049","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080665412","display_name":"Ryan Cheng","orcid":"https://orcid.org/0000-0002-7154-5353","observed_orcids":["https://orcid.org/0000-0002-7154-5353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan Cheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7154-5353","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000623233","display_name":"Raymond G. Dematteo","orcid":"https://orcid.org/0009-0002-9081-1837","observed_orcids":["https://orcid.org/0009-0002-9081-1837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond G. Dematteo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-9081-1837","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083515254","display_name":"Allan J.W. Lui","orcid":"https://orcid.org/0000-0001-7624-3437","observed_orcids":["https://orcid.org/0000-0001-7624-3437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan J.W. Lui","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7624-3437","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004437156","display_name":"Inna Khodos","orcid":"https://orcid.org/0009-0004-1378-9562","observed_orcids":["https://orcid.org/0009-0004-1378-9562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Inna Khodos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-1378-9562","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106368090","display_name":"Leo Gili","orcid":"https://orcid.org/0009-0007-5648-2722","observed_orcids":["https://orcid.org/0009-0007-5648-2722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leo Gili","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-5648-2722","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053843638","display_name":"Marissa S. Mattar","orcid":"https://orcid.org/0000-0002-2846-9914","observed_orcids":["https://orcid.org/0000-0002-2846-9914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marissa S. Mattar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2846-9914","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094358943","display_name":"Jeanine Lisanti","orcid":"https://orcid.org/0009-0008-1378-7662","observed_orcids":["https://orcid.org/0009-0008-1378-7662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeanine Lisanti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1378-7662","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084398509","display_name":"Charlene Kwong","orcid":"https://orcid.org/0009-0008-1499-0996","observed_orcids":["https://orcid.org/0009-0008-1499-0996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlene Kwong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1499-0996","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068098277","display_name":"Irina Linkov","orcid":"https://orcid.org/0000-0001-7520-5359","observed_orcids":["https://orcid.org/0000-0001-7520-5359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina Linkov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7520-5359","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048134641","display_name":"Murray J. Tipping","orcid":"https://orcid.org/0000-0001-5262-2723","observed_orcids":["https://orcid.org/0000-0001-5262-2723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murray J. Tipping","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5262-2723","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004111432","display_name":"Elisa de Stanchina","orcid":"https://orcid.org/0000-0002-3873-315X","observed_orcids":["https://orcid.org/0000-0002-3873-315X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa de Stanchina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3873-315X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016138736","display_name":"Igor Odintsov","orcid":"https://orcid.org/0000-0001-8073-8803","observed_orcids":["https://orcid.org/0000-0001-8073-8803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Odintsov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8073-8803","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046345178","display_name":"Marc Ladanyi","orcid":"https://orcid.org/0000-0001-9055-7213","observed_orcids":["https://orcid.org/0000-0001-9055-7213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Ladanyi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9055-7213","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030479930","display_name":"Romel Somwar","orcid":"https://orcid.org/0000-0002-5282-6889","observed_orcids":["https://orcid.org/0000-0002-5282-6889"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romel Somwar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5282-6889","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/desmoplastic-small-round-cell-tumor","display_name":"desmoplastic small round cell tumor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.8460000157356262},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9919999837875366},{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/trastuzumab-emtansine","display_name":"trastuzumab emtansine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ewsr1-wt1-fusion","display_name":"EWSR1-WT1 fusion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6629999876022339},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.828000009059906},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.7680000066757202},{"id":"https://openalex.org/keywords/drug-internalization","display_name":"drug internalization","score":0.6890000104904175},{"id":"https://openalex.org/keywords/p53-dependent-apoptosis","display_name":"p53-dependent apoptosis","score":0.871999979019165},{"id":"https://openalex.org/keywords/bystander-effect","display_name":"bystander effect","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.662740170955658},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6316974759101868},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.6249439716339111},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5433507561683655},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34635668992996216},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33550286293029785},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31155431270599365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2760447561740875},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.1743355691432953},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.167639821767807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15433964133262634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.7494063","doi":"https://doi.org/10.1158/1078-0432.c.7494063","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7494063","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.7494063","doi":"https://doi.org/10.1158/1078-0432.c.7494063","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7494063","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2143004018","https://openalex.org/W2330362314","https://openalex.org/W2435669318","https://openalex.org/W1995639836","https://openalex.org/W2103568534","https://openalex.org/W2057862416","https://openalex.org/W2754988198","https://openalex.org/W1543576583","https://openalex.org/W2893386726","https://openalex.org/W4214766446"],"abstract_inverted_index":{"AbstractPurpose:":[0],"Desmoplastic":[1],"small":[2],"round":[3],"cell":[4,110,160],"tumor":[5,172,209],"(DSRCT)":[6],"is":[7,218],"a":[8,47,66,87,219],"rare":[9],"but":[10],"highly":[11],"aggressive":[12,234],"soft":[13],"tissue":[14],"sarcoma":[15],"that":[16],"arises":[17],"in":[18,63,75,107,136,171,179,222],"the":[19,26,32],"abdominopelvic":[20],"cavity":[21],"of":[22,28,34,49,156],"young":[23],"males.":[24],"Since":[25],"discovery":[27],"EWSR1::WT1":[29],"fusion":[30],"as":[31,65],"driver":[33],"DSRCT,":[35],"no":[36],"actionable":[37],"genomic":[38],"alterations":[39],"have":[40],"been":[41],"identified,":[42],"limiting":[43],"disease":[44],"management":[45],"to":[46,96,213],"combination":[48],"surgery,":[50],"chemotherapy,":[51],"and":[52,78,86,103,112,128,141,148,162,182,191,196,240],"radiation,":[53],"with":[54,143,165,203],"very":[55],"poor":[56],"outcomes.":[57],"Herein,":[58],"we":[59],"evaluated":[60,106,124],"ERBB2/HER2":[61,71,133,217],"expression":[62,72],"DSRCT":[64,108,137,158],"therapeutic":[67,175,220],"target.":[68],"Experimental":[69],"Design:":[70],"was":[73,117,123,134,177,183,201],"assessed":[74],"clinical":[76,247],"samples":[77,138],"patient-derived":[79],"xenografts":[80,181],"(PDX)":[81],"using":[82,152],"RNA":[83,146],"sequencing,":[84],"RT-qPCR,":[85],"newly":[88],"developed":[89],"HER2":[90,97,187,214,224],"IHC":[91,150],"assay":[92],"(clone":[93],"29D8).":[94],"Responses":[95],"antibody\u2013drug":[98],"conjugates":[99],"(ADC)\u2014trastuzumab":[100],"deruxtecan":[101],"(T-DXd)":[102],"trastuzumab":[104,168],"emtansine\u2014were":[105],"PDX,":[109,159],"line,":[111,161],"organoid":[113,163],"models.":[114],"Drug":[115],"internalization":[116,190],"demonstrated":[118],"by":[119,125,185],"live":[120],"microscopy.":[121],"Apoptosis":[122],"Western":[126],"blotting":[127],"caspase":[129],"activity":[130],"assays.":[131],"Results:":[132],"detectable":[135],"from":[139],"patients":[140],"PDXs,":[142],"higher":[144],"sensitivity":[145],"assays":[147],"improved":[149],"detectability":[151],"clone":[153],"29D8.":[154],"Treatment":[155],"ERBB2/HER2-expressing":[157],"models":[164],"T-DXd":[166],"or":[167],"emtansine":[169],"resulted":[170],"regression.":[173],"This":[174],"response":[176],"long-lasting":[178],"T-DXd\u2013treated":[180],"mediated":[184],"rapid":[186],"ADC":[188],"complex":[189],"cytotoxicity,":[192],"triggering":[193,207],"p53-mediated":[194],"apoptosis":[195],"growth":[197],"arrest.":[198],"Xenograft":[199],"regression":[200],"associated":[202],"bystander":[204],"payload":[205],"effects":[206],"global":[208],"niche":[210],"responses":[211],"proportional":[212],"status.":[215],"Conclusions:":[216],"target":[221],"DSRCT.":[223],"ADCs":[225],"may":[226],"represent":[227],"novel":[228],"options":[229],"for":[230,244],"managing":[231],"this":[232],"exceptionally":[233],"sarcoma,":[235],"possibly":[236],"fulfilling":[237],"an":[238],"urgent":[239],"historically":[241],"unmet":[242],"need":[243],"more":[245],"effective":[246],"therapy.":[248]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}