{"id":"https://openalex.org/W4403419795","doi":"https://doi.org/10.1016/j.jtho.2024.09.440","title":"P2.10A.05 Ipat-Lung: A Multi-Center Phase 2 Study of Ipatasertib Plus Docetaxel in NSCLC Patients who Have Failed or Are Intolerant to 1st Line Immunotherapy","display_name":"P2.10A.05 Ipat-Lung: A Multi-Center Phase 2 Study of Ipatasertib Plus Docetaxel in NSCLC Patients who Have Failed or Are Intolerant to 1st Line Immunotherapy","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403419795","doi":"https://doi.org/10.1016/j.jtho.2024.09.440"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtho.2024.09.440","doi":"https://doi.org/10.1016/j.jtho.2024.09.440","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2024.09.440","pdf_url":"https://www.jto.org/article/S1556-0864(24)01314-5/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jto.org/article/S1556-0864(24)01314-5/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Zhang","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103428067","display_name":"Chen Huang","orcid":"https://orcid.org/0009-0004-7721-3298","observed_orcids":["https://orcid.org/0009-0004-7721-3298"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.H. Huang","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015345962","display_name":"P. Neupane","orcid":"https://orcid.org/0000-0002-4637-9509","observed_orcids":["https://orcid.org/0000-0002-4637-9509"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.C. Neupane","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008657694","display_name":"Ravi Reddy Chuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Chuda","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088458994","display_name":"Richard J. McKittrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.J. McKittrick","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M.R. Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.R. Allen","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102998238","display_name":"Qiangqiang Dai","orcid":"https://orcid.org/0009-0009-3977-1738","observed_orcids":["https://orcid.org/0009-0009-3977-1738"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q. Dai","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073499519","display_name":"Zachary S. Collins","orcid":"https://orcid.org/0000-0003-2641-7990","observed_orcids":["https://orcid.org/0000-0003-2641-7990"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Collins","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026965633","display_name":"Rashna Madan","orcid":"https://orcid.org/0009-0004-6492-4584","observed_orcids":["https://orcid.org/0009-0004-6492-4584"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Madan","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074901638","display_name":"Milind A. Phadnis","orcid":"https://orcid.org/0000-0001-6472-9325","observed_orcids":["https://orcid.org/0000-0001-6472-9325"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A. Phadnis","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City/KS/USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101982219","display_name":"Cheng Zhong","orcid":"https://orcid.org/0000-0002-5422-3766","observed_orcids":["https://orcid.org/0000-0002-5422-3766"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Zhong","raw_affiliation_strings":["University of Kansas, Lawrence/KS/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas, Lawrence/KS/USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083477114","display_name":"Muhammad Furqan","orcid":"https://orcid.org/0000-0003-3137-2053","observed_orcids":["https://orcid.org/0000-0003-3137-2053"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Furqan","raw_affiliation_strings":["University of Iowa Carver College of Medicine, Iowa City/IA/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa Carver College of Medicine, Iowa City/IA/USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071987481","display_name":"Zhonglin Hao","orcid":"https://orcid.org/0000-0003-4638-0814","observed_orcids":["https://orcid.org/0000-0003-4638-0814"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2802239656","display_name":"Markey Cancer Center","ror":"https://ror.org/01dhvva97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2802239656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Hao","raw_affiliation_strings":["University of Kentucky Markey Cancer Center, Lexington/KY/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky Markey Cancer Center, Lexington/KY/USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2802239656"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.5806,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69396159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"19","issue":"10","first_page":"S245","last_page":"S245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ipatasertib","display_name":"ipatasertib","score":0.984000027179718},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/acquired-resistance","display_name":"acquired resistance","score":0.5},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9688214063644409},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.8836063146591187},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5979520678520203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5881607532501221},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.47769907116889954},{"id":"https://openalex.org/C2779177807","wikidata":"https://www.wikidata.org/wiki/Q3658562","display_name":"non-small cell lung cancer (NSCLC)","level":4,"score":0.473037451505661},{"id":"https://openalex.org/C3019258254","wikidata":"https://www.wikidata.org/wiki/Q1423317","display_name":"Second line","level":3,"score":0.4451938569545746},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.3449018597602844},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.33918946981430054},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.15092888474464417},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jtho.2024.09.440","doi":"https://doi.org/10.1016/j.jtho.2024.09.440","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2024.09.440","pdf_url":"https://www.jto.org/article/S1556-0864(24)01314-5/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jtho.2024.09.440","doi":"https://doi.org/10.1016/j.jtho.2024.09.440","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2024.09.440","pdf_url":"https://www.jto.org/article/S1556-0864(24)01314-5/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403419795.pdf","grobid_xml":"https://content.openalex.org/works/W4403419795.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388575789","https://openalex.org/W4403465235","https://openalex.org/W3195812440","https://openalex.org/W304662101","https://openalex.org/W2611197613","https://openalex.org/W4243951005","https://openalex.org/W4307583713","https://openalex.org/W7212171902","https://openalex.org/W3101025619","https://openalex.org/W4415519189"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-10-16T00:00:00"}