{"id":"https://openalex.org/W4403418951","doi":"https://doi.org/10.1101/2024.10.14.24315487","title":"A novel prediction model for immunotherapy induced pneumonitis prediction based on Chest CT and electronic health record","display_name":"A novel prediction model for immunotherapy induced pneumonitis prediction based on Chest CT and electronic health record","publication_year":2024,"publication_date":"2024-10-15","ids":{"openalex":"https://openalex.org/W4403418951","doi":"https://doi.org/10.1101/2024.10.14.24315487"},"language":"en","primary_location":{"id":"doi:10.1101/2024.10.14.24315487","doi":"https://doi.org/10.1101/2024.10.14.24315487","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.14.24315487","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/10/15/2024.10.14.24315487.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2024/10/15/2024.10.14.24315487.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057851690","display_name":"Qing Lyu","orcid":"https://orcid.org/0000-0002-9824-0170","observed_orcids":["https://orcid.org/0000-0002-9824-0170"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qing Lyu","raw_affiliation_strings":["Wake Forest University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-9824-0170","affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109607267","display_name":"Hongyu Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyu Yuan","raw_affiliation_strings":["Wake Forest University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103235807","display_name":"Zhen Lin","orcid":"https://orcid.org/0000-0002-6181-5532","observed_orcids":["https://orcid.org/0000-0002-6181-5532","https://orcid.org/0000-0003-0765-5432"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Lin","raw_affiliation_strings":["Wake Forest University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017205474","display_name":"Janardhana Ponnatapura","orcid":"https://orcid.org/0000-0002-7459-0854","observed_orcids":["https://orcid.org/0000-0002-7459-0854"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janardhana Ponnatapura","raw_affiliation_strings":["Wake Forest University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000092822","display_name":"Christopher T. Whitlow","orcid":"https://orcid.org/0000-0003-2392-8293","observed_orcids":["https://orcid.org/0000-0003-2392-8293"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher T Whitlow","raw_affiliation_strings":["Wake Forest University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057851690"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-pneumonitis","display_name":"immune checkpoint inhibitor pneumonitis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immunotherapy-adverse-events","display_name":"immunotherapy adverse events","score":0.6890000104904175},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/chest-ct","display_name":"chest CT","score":0.5120000243186951},{"id":"https://openalex.org/keywords/radiomics","display_name":"radiomics","score":0.6800000071525574},{"id":"https://openalex.org/keywords/vision-transformer","display_name":"vision transformer","score":0.6940000057220459},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.9319999814033508},{"id":"https://openalex.org/keywords/deep-features","display_name":"deep features","score":0.5180000066757202},{"id":"https://openalex.org/keywords/clinical-risk-prediction","display_name":"clinical risk prediction","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.49884986877441406},{"id":"https://openalex.org/C3020144179","wikidata":"https://www.wikidata.org/wiki/Q10871684","display_name":"Electronic health record","level":3,"score":0.49300500750541687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47654324769973755},{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.4279436469078064},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4117286205291748},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3678688406944275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2979024052619934},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.16907063126564026},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.11856675148010254},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09861347079277039},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2024.10.14.24315487","doi":"https://doi.org/10.1101/2024.10.14.24315487","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.14.24315487","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/10/15/2024.10.14.24315487.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2024.10.14.24315487","doi":"https://doi.org/10.1101/2024.10.14.24315487","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.14.24315487","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2024/10/15/2024.10.14.24315487.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403418951.pdf","grobid_xml":"https://content.openalex.org/works/W4403418951.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W2054841768","https://openalex.org/W2071865120","https://openalex.org/W2522337762","https://openalex.org/W2527905628","https://openalex.org/W2608165987","https://openalex.org/W2766233251","https://openalex.org/W2767128594","https://openalex.org/W2784371446","https://openalex.org/W2889653218","https://openalex.org/W2889758875","https://openalex.org/W2891486030","https://openalex.org/W2893321040","https://openalex.org/W2913210476","https://openalex.org/W2919091706","https://openalex.org/W2971634681","https://openalex.org/W2978259912","https://openalex.org/W2990887778","https://openalex.org/W3003756084","https://openalex.org/W3014974815","https://openalex.org/W3054666633","https://openalex.org/W3087093127","https://openalex.org/W3107214201","https://openalex.org/W3108518804","https://openalex.org/W3126423192","https://openalex.org/W3187418919","https://openalex.org/W4225285762","https://openalex.org/W4283731422","https://openalex.org/W4287218456","https://openalex.org/W4294043910","https://openalex.org/W4316127100","https://openalex.org/W4319786781","https://openalex.org/W4362703276","https://openalex.org/W4382726719","https://openalex.org/W4391837910","https://openalex.org/W4393935425"],"related_works":["https://openalex.org/W4414262049","https://openalex.org/W4287218456","https://openalex.org/W7213550413","https://openalex.org/W4404065256","https://openalex.org/W4404222278","https://openalex.org/W4407762449","https://openalex.org/W4404064701","https://openalex.org/W4316127100","https://openalex.org/W4406188911","https://openalex.org/W7130649408"],"abstract_inverted_index":{"Abstract":[0],"Immune":[1],"checkpoint":[2],"inhibitors":[3],"(ICIs)":[4],"have":[5],"been":[6],"extensively":[7],"used":[8],"for":[9,121],"the":[10,34,140],"treatment":[11],"of":[12,30,36,82,134,145],"non-small":[13],"cell":[14],"lung":[15,72],"cancer":[16],"patients":[17,54],"in":[18],"recent":[19],"years,":[20],"providing":[21],"a":[22,27,45,92,131],"significant":[23],"survival":[24],"benefit.":[25],"However,":[26],"major":[28],"drawback":[29],"ICIs-related":[31],"immunotherapy":[32],"is":[33],"risk":[35],"developing":[37],"post-surgical":[38],"pneumonitis.":[39],"In":[40],"this":[41],"study,":[42],"we":[43],"propose":[44],"deep":[46,85],"learning-embedded,":[47],"multi-modality":[48],"prediction":[49,122,132],"approach":[50,63],"to":[51],"assess":[52],"whether":[53],"will":[55],"develop":[56],"ICI-pneumonitis":[57],"after":[58],"receiving":[59],"ICIs-based":[60],"immunotherapy.":[61],"This":[62],"utilizes":[64],"multi-modal":[65],"data,":[66],"including":[67],"clinical":[68,108,112],"data":[69],"and":[70,106,136],"pre-treatment":[71],"screening":[73],"computed":[74],"tomography":[75],"(CT)":[76],"images.":[77],"We":[78,114],"extracted":[79,126],"three":[80],"types":[81],"features:":[83],"1)":[84],"learning":[86,119],"features":[87,98,109],"from":[88,99,110],"CT":[89,100],"scans":[90,101],"using":[91,102],"pretrained":[93],"vision":[94],"transformer,":[95],"2)":[96],"radiomic":[97,104],"predefined":[103],"algorithms,":[105],"3)":[107],"patients\u2019":[111],"records.":[113],"then":[115],"compared":[116],"multiple":[117],"machine":[118],"algorithms":[120],"based":[123],"on":[124],"these":[125],"features.":[127],"Our":[128],"results":[129],"demonstrated":[130],"accuracy":[133],"0.823":[135],"an":[137],"area":[138],"under":[139],"receiver":[141],"operating":[142],"characteristic":[143],"curve":[144],"0.895.":[146]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-10-16T00:00:00"}