{"id":"https://openalex.org/W4403406319","doi":"https://doi.org/10.1097/dss.0000000000004442","title":"Low-Level Laser and LED Therapy in Alopecia: A Systematic Review and Meta-Analysis","display_name":"Low-Level Laser and LED Therapy in Alopecia: A Systematic Review and Meta-Analysis","publication_year":2024,"publication_date":"2024-10-15","ids":{"openalex":"https://openalex.org/W4403406319","doi":"https://doi.org/10.1097/dss.0000000000004442","pmid":"https://pubmed.ncbi.nlm.nih.gov/39404126"},"language":"en","primary_location":{"id":"doi:10.1097/dss.0000000000004442","doi":"https://doi.org/10.1097/dss.0000000000004442","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dss.0000000000004442","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001663063","display_name":"Sofia M. Perez","orcid":"https://orcid.org/0009-0000-7272-206X","observed_orcids":["https://orcid.org/0009-0000-7272-206X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sofia M. Perez","raw_affiliation_strings":["All authors are affiliated with the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida","Sofia M. Perez, BS, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue RMSB 2023A, Locator Code R-250, Miami, FL 33136 or e-mail: [email\u00a0protected]","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are affiliated with the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sofia M. Perez, BS, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue RMSB 2023A, Locator Code R-250, Miami, FL 33136 or e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114268656","display_name":"Mounika Vattigunta","orcid":"https://orcid.org/0009-0006-1177-6594","observed_orcids":["https://orcid.org/0009-0006-1177-6594"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mounika Vattigunta","raw_affiliation_strings":["Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Colin Kelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin Kelly","raw_affiliation_strings":["Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090981990","display_name":"Ariel Eva Eber","orcid":"https://orcid.org/0000-0002-8802-1003","observed_orcids":["https://orcid.org/0000-0002-8802-1003"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariel Eber","raw_affiliation_strings":["All authors are affiliated with the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors are affiliated with the Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.dermatologicsurgery.org)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001663063"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":1.6265,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83632287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"51","issue":"2","first_page":"179","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/led-therapy","display_name":"LED therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.9599999785423279},{"id":"https://openalex.org/keywords/androgenetic-alopecia","display_name":"androgenetic alopecia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hair-density","display_name":"hair density","score":0.7570000290870667},{"id":"https://openalex.org/keywords/alopecia-areata","display_name":"alopecia areata","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cicatricial-alopecia","display_name":"scarring alopecia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/telogen-effluvium","display_name":"telogen effluvium","score":1.0},{"id":"https://openalex.org/keywords/chemotherapy-induced-alopecia","display_name":"chemotherapy-induced alopecia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hair-regrowth","display_name":"hair regrowth","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2777524370","wikidata":"https://www.wikidata.org/wiki/Q5075435","display_name":"Alopecia areata","level":2,"score":0.8774121999740601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8573184013366699},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7145994305610657},{"id":"https://openalex.org/C2776360568","wikidata":"https://www.wikidata.org/wiki/Q2697787","display_name":"Hair loss","level":2,"score":0.6790772676467896},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6527969241142273},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5904386043548584},{"id":"https://openalex.org/C2778023920","wikidata":"https://www.wikidata.org/wiki/Q1872556","display_name":"Low level laser therapy","level":4,"score":0.48409998416900635},{"id":"https://openalex.org/C2993195213","wikidata":"https://www.wikidata.org/wiki/Q851186","display_name":"Laser therapy","level":3,"score":0.4754102826118469},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.467231810092926},{"id":"https://openalex.org/C156300145","wikidata":"https://www.wikidata.org/wiki/Q1435091","display_name":"Vellus hair","level":3,"score":0.45951640605926514},{"id":"https://openalex.org/C2909877630","wikidata":"https://www.wikidata.org/wiki/Q5119338","display_name":"Scarring alopecia","level":3,"score":0.4232005476951599},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38013672828674316},{"id":"https://openalex.org/C2778515351","wikidata":"https://www.wikidata.org/wiki/Q9622","display_name":"Scalp","level":2,"score":0.18103304505348206},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12600982189178467},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.09054902195930481},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028022","descriptor_name":"Low-Level Light Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/dss.0000000000004442","doi":"https://doi.org/10.1097/dss.0000000000004442","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dss.0000000000004442","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},{"id":"pmid:39404126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39404126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1976818663","https://openalex.org/W2019030699","https://openalex.org/W2028130201","https://openalex.org/W2031324836","https://openalex.org/W2036397448","https://openalex.org/W2087126197","https://openalex.org/W2095520199","https://openalex.org/W2107434674","https://openalex.org/W2110166282","https://openalex.org/W2135147563","https://openalex.org/W2147052286","https://openalex.org/W2150083629","https://openalex.org/W2158621372","https://openalex.org/W2166093573","https://openalex.org/W2168336358","https://openalex.org/W2602913104","https://openalex.org/W2613068155","https://openalex.org/W2775089727","https://openalex.org/W2810049987","https://openalex.org/W2883193295","https://openalex.org/W2903677461","https://openalex.org/W2913209689","https://openalex.org/W2974080113","https://openalex.org/W3006057689","https://openalex.org/W3042795146","https://openalex.org/W3093399274","https://openalex.org/W3138423946","https://openalex.org/W3160862162","https://openalex.org/W3163043279","https://openalex.org/W3196551174","https://openalex.org/W4206848202","https://openalex.org/W4210849623","https://openalex.org/W4213028187","https://openalex.org/W4214903946","https://openalex.org/W4228996701","https://openalex.org/W4283458262","https://openalex.org/W4285047916","https://openalex.org/W4293236284","https://openalex.org/W4297477451","https://openalex.org/W4308554926","https://openalex.org/W4312179142","https://openalex.org/W4365811005","https://openalex.org/W4366503656","https://openalex.org/W4385430215","https://openalex.org/W4386117120","https://openalex.org/W4386508509","https://openalex.org/W4387563819","https://openalex.org/W4390749982"],"related_works":["https://openalex.org/W2913209689","https://openalex.org/W4417487248","https://openalex.org/W4361277960","https://openalex.org/W3042795146","https://openalex.org/W3031242594","https://openalex.org/W4416140880","https://openalex.org/W2344927296","https://openalex.org/W2265852006","https://openalex.org/W3049544346","https://openalex.org/W4413808781"],"abstract_inverted_index":{"BACKGROUND:":[0],"Low-level":[1],"laser/LED":[2],"therapy":[3],"(LLLT)":[4],"has":[5,17],"been":[6],"described":[7,96],"as":[8],"a":[9,191],"treatment":[10,193],"option":[11,194],"for":[12,32,130,186,195],"alopecia,":[13,199],"but":[14,200],"no":[15],"study":[16],"comprehensively":[18],"reviewed":[19],"its":[20,208],"efficacy":[21,209],"in":[22,68,80,119,124,169,174,210],"multiple":[23],"alopecia":[24,34,101,104,106,114,126,179,212],"types.":[25,35,213],"OBJECTIVE:":[26],"To":[27],"review":[28],"and":[29,45,84,112],"evaluate":[30],"LLLT":[31,56,86,129,189],"various":[33],"MATERIALS":[36],"AND":[37],"METHODS:":[38],"A":[39],"systematic":[40],"search":[41],"of":[42,55],"PubMed/MEDLINE,":[43],"Embase,":[44],"CENTRAL":[46],"was":[47,65,72,172,184],"conducted":[48],"to":[49,74,132,205],"identify":[50],"studies":[51,92,176,202],"assessing":[52],"the":[53,66,76],"effect":[54],"on":[57],"patients":[58,98,127,196],"diagnosed":[59],"with":[60,88,99,136,197],"alopecia.":[61],"Prespecified":[62],"outcome":[63],"measure":[64],"change":[67,118],"hair":[69,81,120,170],"density.":[70],"Meta-analysis":[71],"performed":[73],"calculate":[75],"standardized":[77],"mean":[78,117],"difference":[79],"density":[82,121,171],"before":[83],"after":[85,128],"compared":[87,135],"placebo.":[89],"RESULTS:":[90],"Thirty-eight":[91],"were":[93],"included":[94],"that":[95],"3,098":[97],"androgenetic":[100,125,198],"(2,930/3,098),":[102],"scarring":[103],"(49/3,098),":[105],"areata":[107],"(50/3,098),":[108],"telogen":[109],"effluvium":[110],"(17/3,098),":[111],"chemotherapy-induced":[113],"(32/3,098).":[115],"The":[116],"increased":[122],"significantly":[123],"4":[131],"26":[133],"weeks":[134],"placebo":[137],"(<20":[138],"weeks:":[139,154],"SMD":[140,155],"=":[141,147,151,156,162,166],"1.14;":[142],"95%":[143,158],"CI":[144,159],"[0.51-1.78];":[145],"p":[146,161],".000;":[148,163],"I":[149,164],"2":[150,165],"88.26%;":[152],">20":[153],"1.44;":[157],"[0.97-1.91];":[160],"80.81%).":[167],"Change":[168],"reported":[173],"5":[175],"evaluating":[177],"other":[178,211],"types;":[180],"however,":[181],"statistical":[182],"information":[183],"insufficient":[185],"meta-analysis.":[187],"CONCLUSION:":[188],"is":[190],"promising":[192],"future":[201],"are":[203],"needed":[204],"better":[206],"understand":[207]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-10-15T00:00:00"}
