{"id":"https://openalex.org/W4403382263","doi":"https://doi.org/10.1093/jleuko/qiae228","title":"Polarization of the memory B-cell response","display_name":"Polarization of the memory B-cell response","publication_year":2024,"publication_date":"2024-10-11","ids":{"openalex":"https://openalex.org/W4403382263","doi":"https://doi.org/10.1093/jleuko/qiae228","pmid":"https://pubmed.ncbi.nlm.nih.gov/39401326","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11953070"},"language":"en","primary_location":{"id":"doi:10.1093/jleuko/qiae228","doi":"https://doi.org/10.1093/jleuko/qiae228","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jleuko/qiae228","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11953070/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090149664","display_name":"Lizzette P\u00e9rez-P\u00e9rez","orcid":"https://orcid.org/0000-0001-5881-4363","observed_orcids":["https://orcid.org/0000-0001-5881-4363"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lizzette P\u00e9rez-P\u00e9rez","raw_affiliation_strings":["Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine , 425 S Euclid Ave, St. Louis, MO 63110 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine , 425 S Euclid Ave, St. Louis, MO 63110 ,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004486300","display_name":"Brian J. Laidlaw","orcid":"https://orcid.org/0000-0001-5707-9256","observed_orcids":["https://orcid.org/0000-0001-5707-9256"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian J Laidlaw","raw_affiliation_strings":["Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine , 425 S Euclid Ave, St. Louis, MO 63110 ,"],"raw_orcid":"https://orcid.org/0000-0001-5707-9256","affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine , 425 S Euclid Ave, St. Louis, MO 63110 ,","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004486300"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.116,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.12295974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"117","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":1.0},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/germinal-center-b-cells","display_name":"germinal center B cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/type-1-immunity","display_name":"type 1 immune response","score":0.6710000038146973},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammatory-environment","display_name":"inflammatory environment","score":0.6060000061988831},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/allergy","display_name":"allergy","score":0.972000002861023},{"id":"https://openalex.org/keywords/vaccine-induced-immunity","display_name":"vaccine-induced immunity","score":0.5600000023841858},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7993022203445435},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.715708315372467},{"id":"https://openalex.org/C2779359726","wikidata":"https://www.wikidata.org/wiki/Q1195394","display_name":"Memory B cell","level":4,"score":0.6621014475822449},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6195052266120911},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6018348932266235},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5609728693962097},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5435842871665955},{"id":"https://openalex.org/C2991763054","wikidata":"https://www.wikidata.org/wiki/Q38103695","display_name":"Immunological memory","level":4,"score":0.524084746837616},{"id":"https://openalex.org/C145558887","wikidata":"https://www.wikidata.org/wiki/Q3832893","display_name":"B-1 cell","level":5,"score":0.49827146530151367},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.4898631274700165},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.41511765122413635},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3792910575866699},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3730100393295288},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3420311212539673},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.331967294216156},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2954496443271637},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.25245583057403564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2007400095462799},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06740760803222656}],"mesh":[{"descriptor_ui":"D000091245","descriptor_name":"Memory B Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000091245","descriptor_name":"Memory B Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jleuko/qiae228","doi":"https://doi.org/10.1093/jleuko/qiae228","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jleuko/qiae228","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:39401326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39401326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11953070","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11953070/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Leukoc Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11953070","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11953070/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Leukoc Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1693308951","display_name":"Enhancing the antiviral memory B cell response","funder_award_id":"DP2AI169978","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W1978153385","https://openalex.org/W1997105134","https://openalex.org/W2009342716","https://openalex.org/W2013262178","https://openalex.org/W2030707267","https://openalex.org/W2036217549","https://openalex.org/W2038453475","https://openalex.org/W2047151651","https://openalex.org/W2050931908","https://openalex.org/W2053095572","https://openalex.org/W2054144216","https://openalex.org/W2062188732","https://openalex.org/W2065906324","https://openalex.org/W2071368241","https://openalex.org/W2071380288","https://openalex.org/W2079574749","https://openalex.org/W2081613377","https://openalex.org/W2088593344","https://openalex.org/W2089017798","https://openalex.org/W2090992719","https://openalex.org/W2110840300","https://openalex.org/W2115518909","https://openalex.org/W2120203591","https://openalex.org/W2123130879","https://openalex.org/W2129973151","https://openalex.org/W2136616777","https://openalex.org/W2136752250","https://openalex.org/W2138071207","https://openalex.org/W2162420224","https://openalex.org/W2164343118","https://openalex.org/W2346243632","https://openalex.org/W2487984467","https://openalex.org/W2488623126","https://openalex.org/W2505710978","https://openalex.org/W2580955103","https://openalex.org/W2583285089","https://openalex.org/W2590316543","https://openalex.org/W2593076788","https://openalex.org/W2597889999","https://openalex.org/W2606922555","https://openalex.org/W2665840216","https://openalex.org/W2723913430","https://openalex.org/W2736031366","https://openalex.org/W2753521119","https://openalex.org/W2757209291","https://openalex.org/W2761116901","https://openalex.org/W2766086711","https://openalex.org/W2805930941","https://openalex.org/W2883136140","https://openalex.org/W2883553348","https://openalex.org/W2891316662","https://openalex.org/W2897114391","https://openalex.org/W2898365748","https://openalex.org/W2930143113","https://openalex.org/W2942470092","https://openalex.org/W2943011621","https://openalex.org/W2949631571","https://openalex.org/W2949788114","https://openalex.org/W2962936545","https://openalex.org/W2965364009","https://openalex.org/W2970458762","https://openalex.org/W2980639756","https://openalex.org/W2981540128","https://openalex.org/W2997794562","https://openalex.org/W3000591631","https://openalex.org/W3001560298","https://openalex.org/W3007855643","https://openalex.org/W3019068524","https://openalex.org/W3021948769","https://openalex.org/W3022748078","https://openalex.org/W3024987730","https://openalex.org/W3037753076","https://openalex.org/W3042639240","https://openalex.org/W3046718717","https://openalex.org/W3082387222","https://openalex.org/W3082694457","https://openalex.org/W3092396621","https://openalex.org/W3093800460","https://openalex.org/W3109372180","https://openalex.org/W3127778900","https://openalex.org/W3131451746","https://openalex.org/W3136777525","https://openalex.org/W3170319614","https://openalex.org/W3193171813","https://openalex.org/W3199734246","https://openalex.org/W3199858648","https://openalex.org/W3202029574","https://openalex.org/W3204612920","https://openalex.org/W4200041575","https://openalex.org/W4220934355","https://openalex.org/W4281725569","https://openalex.org/W4286515932","https://openalex.org/W4286586721","https://openalex.org/W4288045282","https://openalex.org/W4292589922","https://openalex.org/W4297143949","https://openalex.org/W4307633668","https://openalex.org/W4310259000","https://openalex.org/W4312187857","https://openalex.org/W4321782318","https://openalex.org/W4322492244","https://openalex.org/W4323347328","https://openalex.org/W4353060963","https://openalex.org/W4362522950","https://openalex.org/W4367176308","https://openalex.org/W4367834265","https://openalex.org/W4380605852","https://openalex.org/W4384198553","https://openalex.org/W4386601289","https://openalex.org/W4387296584","https://openalex.org/W4388835438","https://openalex.org/W4389331704","https://openalex.org/W4390702401","https://openalex.org/W4391215347","https://openalex.org/W4391593861","https://openalex.org/W4391594259","https://openalex.org/W4391640474","https://openalex.org/W4391657954","https://openalex.org/W4392240362","https://openalex.org/W4392973883","https://openalex.org/W4394567822","https://openalex.org/W4394741269","https://openalex.org/W4399735742","https://openalex.org/W4400362361","https://openalex.org/W4408575057","https://openalex.org/W4408864057","https://openalex.org/W7007920516"],"related_works":["https://openalex.org/W2090202059","https://openalex.org/W3170319614","https://openalex.org/W2048283731","https://openalex.org/W3092453598","https://openalex.org/W7118544034","https://openalex.org/W7204008527","https://openalex.org/W4283369527","https://openalex.org/W1950557481","https://openalex.org/W3188077313","https://openalex.org/W4378349154"],"abstract_inverted_index":{"Memory":[0],"B":[1,17,26,30,59,99,119],"cells":[2,5,18,31,60,100,120],"are":[3,7,32],"long-lived":[4],"that":[6,68,92],"induced":[8],"following":[9,40],"infection":[10],"or":[11,23],"vaccination.":[12],"Upon":[13],"antigen":[14],"re-encounter,":[15],"memory":[16,29,58,82,98,118],"rapidly":[19],"differentiate":[20],"into":[21],"antibody-secreting":[22],"germinal":[24],"center":[25],"cells.":[27],"While":[28],"an":[33,103],"important":[34,70,104],"component":[35],"of":[36,48,57,117],"long-term":[37],"protective":[38],"immunity":[39],"vaccination,":[41],"they":[42],"also":[43],"contribute":[44],"to":[45],"the":[46,78,93,112,115],"progression":[47],"diseases":[49],"such":[50],"as":[51],"autoimmunity":[52],"and":[53,66,72,85,110,125],"allergy.":[54],"Numerous":[55],"subsets":[56],"have":[61],"been":[62],"identified":[63],"in":[64,96,106],"mice":[65],"humans":[67],"possess":[69],"phenotypic":[71],"functional":[73],"differences.":[74],"Here,":[75],"we":[76],"review":[77],"transcriptional":[79],"circuitry":[80],"governing":[81],"B-cell":[83],"differentiation":[84],"function.":[86],"We":[87],"then":[88],"summarize":[89],"emerging":[90],"evidence":[91],"inflammatory":[94],"environment":[95],"which":[97],"develop":[101],"has":[102],"role":[105],"shaping":[107],"their":[108],"phenotype":[109],"examine":[111],"pathways":[113],"regulating":[114],"development":[116],"during":[121],"a":[122],"type":[123,126],"1-skewed":[124],"2-skewed":[127],"immune":[128],"response.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-14T00:00:00"}