{"id":"https://openalex.org/W4403333121","doi":"https://doi.org/10.1007/s11030-024-11005-5","title":"Exploring flavonoid derivatives as potential pancreatic lipase inhibitors for obesity management: An in silico and in vitro study","display_name":"Exploring flavonoid derivatives as potential pancreatic lipase inhibitors for obesity management: An in silico and in vitro study","publication_year":2024,"publication_date":"2024-10-11","ids":{"openalex":"https://openalex.org/W4403333121","doi":"https://doi.org/10.1007/s11030-024-11005-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/39394546"},"language":"en","primary_location":{"id":"doi:10.1007/s11030-024-11005-5","doi":"https://doi.org/10.1007/s11030-024-11005-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11030-024-11005-5","pdf_url":null,"source":{"id":"https://openalex.org/S105791650","display_name":"Molecular Diversity","issn_l":"1381-1991","issn":["1381-1991","1573-501X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Diversity","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4403333121"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028541778","display_name":"Shristi Modanwal","orcid":"https://orcid.org/0000-0002-9123-6400","observed_orcids":["https://orcid.org/0000-0002-9123-6400"]},"institutions":[{"id":"https://openalex.org/I26072440","display_name":"Indian Institute of Information Technology Allahabad","ror":"https://ror.org/03rgjt374","country_code":"IN","type":"education","lineage":["https://openalex.org/I26072440"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shristi Modanwal","raw_affiliation_strings":["Department of Applied Sciences, Indian Institute of Information of Technology Allahabad, Prayagraj, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Sciences, Indian Institute of Information of Technology Allahabad, Prayagraj, India","institution_ids":["https://openalex.org/I26072440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030784506","display_name":"Akhilesh Kumar Maurya","orcid":"https://orcid.org/0000-0003-3281-532X","observed_orcids":["https://orcid.org/0000-0003-3281-532X"]},"institutions":[{"id":"https://openalex.org/I162827531","display_name":"Indian Institute of Technology Bombay","ror":"https://ror.org/02qyf5152","country_code":"IN","type":"education","lineage":["https://openalex.org/I162827531"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akhilesh Kumar Maurya","raw_affiliation_strings":["Indian Institute of Technology Bombay, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Bombay, Mumbai, India","institution_ids":["https://openalex.org/I162827531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046294176","display_name":"Viswajit Mulpuru","orcid":"https://orcid.org/0000-0001-6471-9143","observed_orcids":["https://orcid.org/0000-0001-6471-9143"]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Viswajit Mulpuru","raw_affiliation_strings":["Vignan's Foundation for Science, Technology, and Research, Guntur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vignan's Foundation for Science, Technology, and Research, Guntur, India","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010247793","display_name":"Nidhi Mishra","orcid":"https://orcid.org/0000-0002-6028-7723","observed_orcids":["https://orcid.org/0000-0002-6028-7723"]},"institutions":[{"id":"https://openalex.org/I26072440","display_name":"Indian Institute of Information Technology Allahabad","ror":"https://ror.org/03rgjt374","country_code":"IN","type":"education","lineage":["https://openalex.org/I26072440"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Nidhi Mishra","raw_affiliation_strings":["Department of Applied Sciences, Indian Institute of Information of Technology Allahabad, Prayagraj, India. nidhimishra@iiita.ac.in","Department of Applied Sciences, Indian Institute of Information of Technology Allahabad, Prayagraj, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Sciences, Indian Institute of Information of Technology Allahabad, Prayagraj, India. nidhimishra@iiita.ac.in","institution_ids":["https://openalex.org/I26072440"]},{"raw_affiliation_string":"Department of Applied Sciences, Indian Institute of Information of Technology Allahabad, Prayagraj, India","institution_ids":["https://openalex.org/I26072440"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010247793"],"corresponding_institution_ids":["https://openalex.org/I26072440"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.9287,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71045479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"29","issue":"3","first_page":"2499","last_page":"2516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.36079999804496765,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.36079999804496765,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.27000001072883606,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavonoid-derivatives","display_name":"flavonoid derivatives","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pancreatic-lipase-inhibitors","display_name":"pancreatic lipase inhibitors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/orlistat","display_name":"orlistat","score":0.8989999890327454},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.9670000076293945},{"id":"https://openalex.org/keywords/natural-product-drug-candidates","display_name":"natural product drug candidates","score":0.6069999933242798},{"id":"https://openalex.org/keywords/adme-properties","display_name":"ADME properties","score":0.7039999961853027},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6639999747276306},{"id":"https://openalex.org/keywords/p-nitrophenyl-butyrate","display_name":"p-nitrophenyl butyrate","score":0.847000002861023},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8130530118942261},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.6304244995117188},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6296173930168152},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.6076768040657043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47899743914604187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37817448377609253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3381401002407074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3277040421962738},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27398794889450073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077403","descriptor_name":"Orlistat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11030-024-11005-5","doi":"https://doi.org/10.1007/s11030-024-11005-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11030-024-11005-5","pdf_url":null,"source":{"id":"https://openalex.org/S105791650","display_name":"Molecular Diversity","issn_l":"1381-1991","issn":["1381-1991","1573-501X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Diversity","raw_type":"journal-article"},{"id":"pmid:39394546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39394546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular diversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1588921870","display_name":null,"funder_award_id":"CST/D-2472","funder_id":"https://openalex.org/F4320325345","funder_display_name":"Council of Science and Technology, U.P."}],"funders":[{"id":"https://openalex.org/F4320325345","display_name":"Council of Science and Technology, U.P.","ror":"https://ror.org/01y25zv73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2005533903","https://openalex.org/W2070226193","https://openalex.org/W2433339928","https://openalex.org/W2594721637","https://openalex.org/W2759627991","https://openalex.org/W2904383080","https://openalex.org/W2913844514","https://openalex.org/W2945556908","https://openalex.org/W3005056868","https://openalex.org/W3029948906","https://openalex.org/W3035777501","https://openalex.org/W3048864776","https://openalex.org/W3091461122","https://openalex.org/W3092849866","https://openalex.org/W3112884091","https://openalex.org/W3133701249","https://openalex.org/W4280635480","https://openalex.org/W4292513117","https://openalex.org/W4293554402","https://openalex.org/W4313488961","https://openalex.org/W4318263858","https://openalex.org/W4319786890","https://openalex.org/W4321457612","https://openalex.org/W4360817453","https://openalex.org/W4386994110","https://openalex.org/W4389287197","https://openalex.org/W4399684418"],"related_works":["https://openalex.org/W2905505945","https://openalex.org/W4391163988","https://openalex.org/W3106071527","https://openalex.org/W4413680470","https://openalex.org/W4206459507","https://openalex.org/W3133701249","https://openalex.org/W2566405413","https://openalex.org/W4406562240","https://openalex.org/W4293149555","https://openalex.org/W7033960685"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-10-12T00:00:00"}