{"id":"https://openalex.org/W4403319331","doi":"https://doi.org/10.26650/iuitfd.1464651","title":"ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY","display_name":"ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY","publication_year":2024,"publication_date":"2024-10-10","ids":{"openalex":"https://openalex.org/W4403319331","doi":"https://doi.org/10.26650/iuitfd.1464651"},"language":"en","primary_location":{"id":"doi:10.26650/iuitfd.1464651","doi":"https://doi.org/10.26650/iuitfd.1464651","is_oa":true,"landing_page_url":"https://doi.org/10.26650/iuitfd.1464651","pdf_url":null,"source":{"id":"https://openalex.org/S4210240261","display_name":"Journal of Istanbul Faculty of Medicine / \u0130stanbul T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1305-6433","issn":["1305-6433","1305-6441"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Istanbul Faculty of Medicine / \u0130stanbul T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.26650/iuitfd.1464651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080794106","display_name":"Senem Tekeo\u011flu","orcid":"https://orcid.org/0000-0001-5539-8755","observed_orcids":["https://orcid.org/0000-0001-5539-8755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Senem Tekeo\u011flu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040357278","display_name":"Duygu Temiz Karada\u011f","orcid":"https://orcid.org/0000-0002-5891-2032","observed_orcids":["https://orcid.org/0000-0002-5891-2032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duygu Temiz Karada\u011f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069186616","display_name":"\u00d6zlem \u00d6zdemir I\u015f\u0131k","orcid":"https://orcid.org/0000-0002-2985-3723","observed_orcids":["https://orcid.org/0000-0002-2985-3723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00d6zlem \u00d6zdemir I\u015f\u0131k","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109021315","display_name":"Aylin G\u00f6\u00e7o\u011flu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aylin G\u00f6\u00e7o\u011flu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000676549","display_name":"Fatma Ceyla Eraldemir","orcid":"https://orcid.org/0000-0001-9410-8554","observed_orcids":["https://orcid.org/0000-0001-9410-8554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatma Eraldemir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102320807","display_name":"Ayten Yazici","orcid":"https://orcid.org/0000-0003-2167-4509","observed_orcids":["https://orcid.org/0000-0003-2167-4509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayten Yaz\u0131c\u0131","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015504748","display_name":"Ay\u015fe \u00c7efle","orcid":"https://orcid.org/0000-0002-3273-7969","observed_orcids":["https://orcid.org/0000-0002-3273-7969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ay\u015fe \u00c7efle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"87","issue":"4","first_page":"311","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-c1q-antibodies","display_name":"anti-C1q antibodies","score":0.9139999747276306},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":1.0},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sledai","display_name":"SLEDAI","score":0.8920000195503235},{"id":"https://openalex.org/keywords/anti-dsdna-antibodies","display_name":"anti-dsDNA antibodies","score":0.8220000267028809},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.777999997138977},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.9879999756813049},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/complement-c3-and-c4","display_name":"complement C3 and C4","score":0.7979999780654907},{"id":"https://openalex.org/keywords/turkish-patients","display_name":"Turkish patients","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.62903892993927},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.5805283188819885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.532015323638916},{"id":"https://openalex.org/C3019664528","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus","level":3,"score":0.4481356739997864},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4447077214717865},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4283671975135803},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3854103684425354},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18740132451057434}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26650/iuitfd.1464651","doi":"https://doi.org/10.26650/iuitfd.1464651","is_oa":true,"landing_page_url":"https://doi.org/10.26650/iuitfd.1464651","pdf_url":null,"source":{"id":"https://openalex.org/S4210240261","display_name":"Journal of Istanbul Faculty of Medicine / \u0130stanbul T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1305-6433","issn":["1305-6433","1305-6441"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Istanbul Faculty of Medicine / \u0130stanbul T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:cf2bae3ee08a49f496ab57dfc8b0a0d6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cf2bae3ee08a49f496ab57dfc8b0a0d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0130stanbul T\u0131p Fak\u00fcltesi Dergisi, Vol 87, Iss 4, Pp 311-320 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26650/iuitfd.1464651","doi":"https://doi.org/10.26650/iuitfd.1464651","is_oa":true,"landing_page_url":"https://doi.org/10.26650/iuitfd.1464651","pdf_url":null,"source":{"id":"https://openalex.org/S4210240261","display_name":"Journal of Istanbul Faculty of Medicine / \u0130stanbul T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1305-6433","issn":["1305-6433","1305-6441"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310318354","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/P4310318354"],"host_organization_lineage_names":["Istanbul University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Istanbul Faculty of Medicine / \u0130stanbul T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2391616206","https://openalex.org/W2027351920","https://openalex.org/W2388451375","https://openalex.org/W2135882480","https://openalex.org/W2042562308","https://openalex.org/W2032525351","https://openalex.org/W2109814212","https://openalex.org/W4390168638","https://openalex.org/W2389059287","https://openalex.org/W3023297310"],"abstract_inverted_index":{"Objective:":[0],"Lupus":[1,92],"nephritis":[2,93],"(LN)":[3],"is":[4,224],"a":[5,54,201],"detrimental":[6],"consequence":[7],"of":[8,101,204,232,246],"systemic":[9,142],"lupus":[10,143,247],"erythematosus":[11,144],"(SLE).":[12],"The":[13,75,99],"anti-C1q":[14,68,76,102,120,167,183,205],"antibody":[15,77,234],"was":[16,32,78,94,104,136,184,191],"shown":[17],"to":[18,21,33,58,242],"be":[19],"related":[20],"LN,":[22,216],"or":[23,41],"global":[24],"disease":[25,42,65,145,212],"activity,":[26,66,213],"in":[27,44,70,96,107,114,178,235],"various":[28],"studies.":[29],"Our":[30,198],"purpose":[31],"determine":[34],"its":[35],"prevalence":[36],"and":[37,50,62,67,85,111,127,152,158,169,214],"association":[38,203],"with":[39,47,73,87,109,119,139,155,162,206,219],"LN":[40,164,175,188],"activity":[43,146],"Turkish":[45,236],"patients":[46,72,108],"SLE.":[48,74],"Material":[49],"Method:":[51],"We":[52],"conducted":[53],"cross-sectional":[55],"single-centre":[56],"study":[57,199,227],"investigate":[59],"the":[60,225,229,244],"clinical":[61,230],"laboratory":[63],"findings,":[64],"levels":[69],"150":[71,88],"analyzed":[79],"using":[80],"an":[81],"enzyme-linked":[82],"immunosorbent":[83],"assay":[84],"compared":[86],"healthy-control":[89],"patients.":[90,98,237],"Result:":[91],"present":[95],"72":[97],"frequency":[100],"positivity":[103],"17%":[105],"(26/150)":[106],"SLE":[110],"3%":[112],"(5/150)":[113],"control":[115],"group":[116],"(p<0.001).":[117],"Patients":[118,161],"also":[121],"had":[122,165],"anti-Sm,":[123],"direct":[124],"Coombs\u2019":[125],"test,":[126],"thrombocytopenia":[128],"more":[129],"commonly":[130],"(p=0.001,":[131],"p=0.007,":[132],"p=0.009":[133],"respectively).":[134],"Anti-C1q":[135],"positively":[137],"correlated":[138,154],"proteinuria,":[140,208],"haematuria,":[141,209],"index":[147],"(SLEDAI)":[148],"(p<0.001),":[149],"anti-dsDNA":[150,170],"(p=0.03),":[151],"negatively":[153],"C3":[156],"(p<0.001)":[157,171],"C4":[159],"(p=0.015).":[160],"active":[163,215],"higher":[166],"(p=0.01)":[168],"titres":[172],"than":[173],"inactive":[174,220],"patients,":[176],"although":[177],"multivariate":[179],"logistic":[180],"regression":[181],"analysis,":[182],"not":[185,218],"significant":[186,192,202],"for":[187,193],"history.":[189],"It":[190],"SLEDAI":[194],"severity":[195],"(p=0.036).":[196],"Conclusion:":[197],"demonstrated":[200],"SLE,":[207],"thrombocytopenia,":[210],"general":[211],"but":[217],"renal":[221],"disease.":[222],"This":[223],"first":[226],"investigating":[228],"significance":[231],"this":[233],"Further":[238],"studies":[239],"are":[240],"needed":[241],"clarify":[243],"pathogenesis":[245],"nephritis.":[248]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-10-11T00:00:00"}