{"id":"https://openalex.org/W4403286804","doi":"https://doi.org/10.1039/d4cc04190a","title":"Target-assisted self-cleavage DNAzyme electrochemical biosensor for MicroRNA detection with signal amplification","display_name":"Target-assisted self-cleavage DNAzyme electrochemical biosensor for MicroRNA detection with signal amplification","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4403286804","doi":"https://doi.org/10.1039/d4cc04190a","pmid":"https://pubmed.ncbi.nlm.nih.gov/39415671"},"language":"en","primary_location":{"id":"doi:10.1039/d4cc04190a","doi":"https://doi.org/10.1039/d4cc04190a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d4cc04190a","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4403286804"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114310013","display_name":"Juan Zhang","orcid":"https://orcid.org/0009-0008-4655-9615","observed_orcids":["https://orcid.org/0009-0008-4655-9615"]},"institutions":[{"id":"https://openalex.org/I16351329","display_name":"China West Normal University","ror":"https://ror.org/04s99y476","country_code":"CN","type":"education","lineage":["https://openalex.org/I16351329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Zhang","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China"],"raw_orcid":"https://orcid.org/0009-0008-4655-9615","affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China","institution_ids":["https://openalex.org/I16351329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012698218","display_name":"Benting Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16351329","display_name":"China West Normal University","ror":"https://ror.org/04s99y476","country_code":"CN","type":"education","lineage":["https://openalex.org/I16351329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Benting Xie","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China","institution_ids":["https://openalex.org/I16351329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029247451","display_name":"Haonan He","orcid":"https://orcid.org/0000-0002-1789-6259","observed_orcids":["https://orcid.org/0000-0002-1789-6259"]},"institutions":[{"id":"https://openalex.org/I16351329","display_name":"China West Normal University","ror":"https://ror.org/04s99y476","country_code":"CN","type":"education","lineage":["https://openalex.org/I16351329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haonan He","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China","institution_ids":["https://openalex.org/I16351329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019112484","display_name":"Hejun Gao","orcid":"https://orcid.org/0000-0002-4419-0702","observed_orcids":["https://orcid.org/0000-0002-4419-0702"]},"institutions":[{"id":"https://openalex.org/I16351329","display_name":"China West Normal University","ror":"https://ror.org/04s99y476","country_code":"CN","type":"education","lineage":["https://openalex.org/I16351329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hejun Gao","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China"],"raw_orcid":"https://orcid.org/0000-0002-4419-0702","affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China","institution_ids":["https://openalex.org/I16351329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027203450","display_name":"Fang Liao","orcid":"https://orcid.org/0000-0003-0375-488X","observed_orcids":["https://orcid.org/0000-0003-0375-488X"]},"institutions":[{"id":"https://openalex.org/I16351329","display_name":"China West Normal University","ror":"https://ror.org/04s99y476","country_code":"CN","type":"education","lineage":["https://openalex.org/I16351329"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fang Liao","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China","institution_ids":["https://openalex.org/I16351329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050313351","display_name":"Hongquan Fu","orcid":"https://orcid.org/0000-0001-5474-7052","observed_orcids":["https://orcid.org/0000-0001-5474-7052"]},"institutions":[{"id":"https://openalex.org/I16351329","display_name":"China West Normal University","ror":"https://ror.org/04s99y476","country_code":"CN","type":"education","lineage":["https://openalex.org/I16351329"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongquan Fu","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China"],"raw_orcid":"https://orcid.org/0000-0001-5474-7052","affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China","institution_ids":["https://openalex.org/I16351329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028535591","display_name":"Yunwen Liao","orcid":"https://orcid.org/0009-0008-4128-4392","observed_orcids":["https://orcid.org/0009-0008-4128-4392"]},"institutions":[{"id":"https://openalex.org/I16351329","display_name":"China West Normal University","ror":"https://ror.org/04s99y476","country_code":"CN","type":"education","lineage":["https://openalex.org/I16351329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunwen Liao","raw_affiliation_strings":["College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China"],"raw_orcid":"https://orcid.org/0009-0008-4128-4392","affiliations":[{"raw_affiliation_string":"College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China","institution_ids":["https://openalex.org/I16351329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027203450","https://openalex.org/A5050313351"],"corresponding_institution_ids":["https://openalex.org/I16351329"],"apc_list":null,"apc_paid":null,"fwci":1.084,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.73312829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"60","issue":"88","first_page":"12904","last_page":"12907"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dnazyme","display_name":"DNAzyme","score":0.9449999928474426},{"id":"https://openalex.org/keywords/electrochemical-biosensor","display_name":"electrochemical biosensor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microrna-detection","display_name":"microRNA detection","score":0.9829999804496765},{"id":"https://openalex.org/keywords/signal-amplification","display_name":"signal amplification","score":0.9539999961853027},{"id":"https://openalex.org/keywords/target-recycling","display_name":"target recycling","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C84211826","wikidata":"https://www.wikidata.org/wiki/Q5260078","display_name":"Deoxyribozyme","level":3,"score":0.923043966293335},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.778972327709198},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.746888279914856},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.6004940271377563},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5712437033653259},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5219247341156006},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.4519287943840027},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4129233658313751},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3441069722175598},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3029472827911377},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.2935090959072113},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.2702890634536743},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1937762200832367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14201420545578003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12703725695610046},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.10909026861190796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06593748927116394},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021881","descriptor_name":"DNA, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021881","descriptor_name":"DNA, Catalytic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055664","descriptor_name":"Electrochemical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/d4cc04190a","doi":"https://doi.org/10.1039/d4cc04190a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d4cc04190a","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},{"id":"pmid:39415671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39415671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical communications (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2126533853","display_name":null,"funder_award_id":"2022NSFSC1268","funder_id":"https://openalex.org/F4320329861","funder_display_name":"Natural Science Foundation of Sichuan Province"},{"id":"https://openalex.org/G2971009314","display_name":null,"funder_award_id":"20E037","funder_id":"https://openalex.org/F4320324420","funder_display_name":"China West Normal University"},{"id":"https://openalex.org/G3092473955","display_name":null,"funder_award_id":"2023NSFSC0966","funder_id":"https://openalex.org/F4320329861","funder_display_name":"Natural Science Foundation of Sichuan Province"},{"id":"https://openalex.org/G8104545329","display_name":null,"funder_award_id":"21E045","funder_id":"https://openalex.org/F4320324420","funder_display_name":"China West Normal University"}],"funders":[{"id":"https://openalex.org/F4320324420","display_name":"China West Normal University","ror":"https://ror.org/04s99y476"},{"id":"https://openalex.org/F4320329861","display_name":"Natural Science Foundation of Sichuan Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W2041555260","https://openalex.org/W2057913871","https://openalex.org/W2090867369","https://openalex.org/W2094844506","https://openalex.org/W2113209482","https://openalex.org/W2121466988","https://openalex.org/W2152041515","https://openalex.org/W2238347332","https://openalex.org/W2318093937","https://openalex.org/W2580095184","https://openalex.org/W2624438366","https://openalex.org/W2781622353","https://openalex.org/W2803697288","https://openalex.org/W2914411605","https://openalex.org/W2954495077","https://openalex.org/W3193927896","https://openalex.org/W4224276871","https://openalex.org/W4296180896","https://openalex.org/W4328048824","https://openalex.org/W4386950930","https://openalex.org/W4391896647","https://openalex.org/W4391987524","https://openalex.org/W4393990228","https://openalex.org/W4394600740","https://openalex.org/W4395043341","https://openalex.org/W4396496697","https://openalex.org/W4396540545","https://openalex.org/W4396954594","https://openalex.org/W4396999011","https://openalex.org/W4397011719","https://openalex.org/W4398143387","https://openalex.org/W4398225753","https://openalex.org/W4399427655","https://openalex.org/W4399557524","https://openalex.org/W4399747014"],"related_works":["https://openalex.org/W3214934450","https://openalex.org/W2082615790","https://openalex.org/W7204545680","https://openalex.org/W2513616507","https://openalex.org/W4225369884","https://openalex.org/W2892011586","https://openalex.org/W4406832671","https://openalex.org/W7214607229","https://openalex.org/W4366603569","https://openalex.org/W3175460516"],"abstract_inverted_index":{"In":[0],"this":[1],"work,":[2],"we":[3],"reported":[4],"an":[5],"electrochemical":[6],"biosensor":[7],"with":[8],"target-assisted":[9],"self-cleavage":[10],"DNAzyme":[11],"function":[12],"for":[13],"signal":[14,25],"amplified":[15],"detection":[16,31],"of":[17],"miRNA.":[18],"The":[19],"target-recycling":[20],"amplification":[21],"led":[22],"to":[23],"significant":[24],"enhancement":[26],"and":[27],"thus":[28],"offers":[29],"high":[30],"sensitivity.":[32]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-10-11T00:00:00"}