{"id":"https://openalex.org/W4403261850","doi":"https://doi.org/10.1016/j.heliyon.2024.e39029","title":"The predictive role of Systemic Inflammation Response Index (SIRI), Neutrophil-Lymphocyte Ratio (NLR), and Platelet-Lymphocyte Ratio (PLR) in the prognosis of acute coronary syndrome in a tertiary care hospital","display_name":"The predictive role of Systemic Inflammation Response Index (SIRI), Neutrophil-Lymphocyte Ratio (NLR), and Platelet-Lymphocyte Ratio (PLR) in the prognosis of acute coronary syndrome in a tertiary care hospital","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403261850","doi":"https://doi.org/10.1016/j.heliyon.2024.e39029","pmid":"https://pubmed.ncbi.nlm.nih.gov/39640781","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11620114"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e39029","doi":"https://doi.org/10.1016/j.heliyon.2024.e39029","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e39029","pdf_url":"https://www.cell.com/heliyon/pdf/S2405-8440(24)15060-8.pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cell.com/heliyon/pdf/S2405-8440(24)15060-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068681825","display_name":"Hamrish Kumar Rajakumar","orcid":"https://orcid.org/0009-0008-9642-9915","observed_orcids":["https://orcid.org/0009-0008-9642-9915"]},"institutions":[{"id":"https://openalex.org/I4405255192","display_name":"Government Medical College Omandurar","ror":"https://ror.org/02qjybw03","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255192"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Hamrish Kumar Rajakumar","raw_affiliation_strings":["Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu"],"raw_orcid":"https://orcid.org/0009-0008-9642-9915","affiliations":[{"raw_affiliation_string":"Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","institution_ids":["https://openalex.org/I4405255192"]},{"raw_affiliation_string":"Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu","institution_ids":["https://openalex.org/I4405255192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093025999","display_name":"Varsha Coimbatore Sathyabal","orcid":"https://orcid.org/0009-0009-2059-4655","observed_orcids":["https://orcid.org/0009-0009-2059-4655"]},"institutions":[{"id":"https://openalex.org/I4405255192","display_name":"Government Medical College Omandurar","ror":"https://ror.org/02qjybw03","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255192"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Varsha Coimbatore Sathyabal","raw_affiliation_strings":["Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu"],"raw_orcid":"https://orcid.org/0009-0009-2059-4655","affiliations":[{"raw_affiliation_string":"Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","institution_ids":["https://openalex.org/I4405255192"]},{"raw_affiliation_string":"Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu","institution_ids":["https://openalex.org/I4405255192"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mannar Vasanthan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405255192","display_name":"Government Medical College Omandurar","ror":"https://ror.org/02qjybw03","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255192"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mannar Vasanthan","raw_affiliation_strings":["Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","institution_ids":["https://openalex.org/I4405255192"]},{"raw_affiliation_string":"Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu","institution_ids":["https://openalex.org/I4405255192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053204886","display_name":"Ramesh Dasarathan","orcid":"https://orcid.org/0000-0002-8831-3241","observed_orcids":["https://orcid.org/0000-0002-8831-3241"]},"institutions":[{"id":"https://openalex.org/I4405255192","display_name":"Government Medical College Omandurar","ror":"https://ror.org/02qjybw03","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405255192"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ramesh Dasarathan","raw_affiliation_strings":["Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai, 02, Tamilnadu, India","institution_ids":["https://openalex.org/I4405255192"]},{"raw_affiliation_string":"Department of General Medicine, Government Medical College, Omandurar Government Estate, Chennai \u2013 02, Tamilnadu","institution_ids":["https://openalex.org/I4405255192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053204886","https://openalex.org/A5068681825","https://openalex.org/A5093025999"],"corresponding_institution_ids":["https://openalex.org/I4405255192"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":3.0708,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.93696313,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"10","issue":"20","first_page":"e39029","last_page":"e39029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.972000002861023},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-index","display_name":"systemic inflammation response index","score":0.9359999895095825},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9869999885559082},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/grace-score","display_name":"GRACE risk score","score":0.859000027179718},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.781000018119812},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7540000081062317},{"id":"https://openalex.org/keywords/complete-blood-count","display_name":"complete blood count","score":0.3199999928474426},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.5659999847412109},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.7250000238418579},{"id":"https://openalex.org/keywords/unstable-angina","display_name":"unstable angina","score":0.7110000252723694},{"id":"https://openalex.org/keywords/emergency-department-patients","display_name":"emergency department patients","score":0.5410000085830688},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.32199999690055847},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"receiver operating characteristic","score":0.6000000238418579},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8860187530517578},{"id":"https://openalex.org/C2778963024","wikidata":"https://www.wikidata.org/wiki/Q17132454","display_name":"Neutrophil to lymphocyte ratio","level":3,"score":0.6678359508514404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6284935474395752},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.618392288684845},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5197257995605469},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.42044228315353394},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.3611290752887726},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2527589201927185}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e39029","doi":"https://doi.org/10.1016/j.heliyon.2024.e39029","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e39029","pdf_url":"https://www.cell.com/heliyon/pdf/S2405-8440(24)15060-8.pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11620114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11620114","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11620114/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:39640781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39640781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3b2bc58147ce4655b931b163549378b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3b2bc58147ce4655b931b163549378b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 20, Pp e39029- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e39029","doi":"https://doi.org/10.1016/j.heliyon.2024.e39029","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e39029","pdf_url":"https://www.cell.com/heliyon/pdf/S2405-8440(24)15060-8.pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403261850.pdf","grobid_xml":"https://content.openalex.org/works/W4403261850.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W2014485536","https://openalex.org/W2024131916","https://openalex.org/W2032227357","https://openalex.org/W2048456880","https://openalex.org/W2048836565","https://openalex.org/W2058234098","https://openalex.org/W2069255298","https://openalex.org/W2070697546","https://openalex.org/W2094699166","https://openalex.org/W2099532869","https://openalex.org/W2106697674","https://openalex.org/W2114995492","https://openalex.org/W2115593266","https://openalex.org/W2136616411","https://openalex.org/W2139712049","https://openalex.org/W2146149132","https://openalex.org/W2267597338","https://openalex.org/W2273876270","https://openalex.org/W2274688333","https://openalex.org/W2299322858","https://openalex.org/W2312988948","https://openalex.org/W2408279363","https://openalex.org/W2510451671","https://openalex.org/W2759932154","https://openalex.org/W2760887263","https://openalex.org/W2768546158","https://openalex.org/W2794444757","https://openalex.org/W3008933014","https://openalex.org/W3026709714","https://openalex.org/W3046508727","https://openalex.org/W3072462011","https://openalex.org/W3212752413","https://openalex.org/W4220958265","https://openalex.org/W4225300869","https://openalex.org/W4282828953","https://openalex.org/W4311579389","https://openalex.org/W4360609506","https://openalex.org/W4378219860","https://openalex.org/W4379928227","https://openalex.org/W4381512394","https://openalex.org/W4386153206","https://openalex.org/W4389074484"],"related_works":["https://openalex.org/W3185875825","https://openalex.org/W7162314339","https://openalex.org/W4225300869","https://openalex.org/W4372331913","https://openalex.org/W6891678677","https://openalex.org/W4413885181","https://openalex.org/W3187637422","https://openalex.org/W2889147505","https://openalex.org/W3081837236","https://openalex.org/W4405402912"],"abstract_inverted_index":{"Background:":[0],"&":[1],"Objective:":[2],"Acute":[3],"coronary":[4],"syndrome":[5],"(ACS)":[6],"is":[7],"a":[8,56,70,269,287],"major":[9],"cause":[10],"of":[11,103,239,264,272,300],"mortality":[12],"globally,":[13],"with":[14,42,97,115,249],"significant":[15],"morbidity":[16],"and":[17,32,50,81,140,145,153,160,172,200,204,243,262,280,296,319],"economic":[18],"impact.":[19],"This":[20],"study":[21],"aimed":[22],"to":[23,51,100,109,147,267],"correlate":[24],"the":[25,46,53,78,149,182,191,198,201,210,214,217,230,236,240,250,258,265,278,294],"neutrophil-to-lymphocyte":[26],"ratio":[27,30],"(NLR),":[28],"platelet-to-lymphocyte":[29],"(PLR),":[31],"systemic":[33],"inflammatory":[34,58,121],"response":[35],"index":[36],"(SIRI)":[37],"values":[38],"in":[39,190,245,274,314,330],"ACS":[40,62,98,186,315,331],"patients":[41,76,114,187],"their":[43],"prognosis":[44,328],"via":[45],"GRACE":[47,154,205,231,247,275],"scoring":[48],"criteria":[49],"propose":[52],"SIRI":[54,208,244,251,266,284],"as":[55,227,286],"superior":[57,259],"marker":[59,290],"for":[60,69,291,311],"predicting":[61],"prognosis.":[63],"Methods:":[64],"Ethical":[65],"approval":[66],"was":[67],"obtained":[68],"retrospective":[71],"cross-sectional":[72],"study,":[73],"which":[74],"included":[75,158,189],"from":[77,106,302],"outpatient":[79],"department":[80],"Tamilnadu":[82],"Accident":[83],"Emergency":[84],"Initiative":[85],"Ward":[86],"at":[87],"Government":[88,92],"Medical":[89],"College,":[90],"Omandurar":[91],"Estate,":[93],"who":[94],"were":[95,143,188,195],"diagnosed":[96],"according":[99],"American":[101],"College":[102],"Cardiology":[104],"guidelines":[105],"January":[107],"2022":[108],"December":[110],"2023.":[111],"We":[112],"excluded":[113],"familial":[116],"hypercholesterolemia,":[117],"platelet":[118],"disorders,":[119],"infections,":[120],"conditions,":[122],"or":[123],"incomplete":[124],"health":[125],"records.":[126],"Data":[127],"on":[128],"demographics,":[129],"clinical":[130,309],"findings,":[131],"blood":[132],"counts,":[133],"ECGs,":[134],"cardiac":[135],"enzymes,":[136],"echocardiography,":[137],"serum":[138],"creatinine,":[139],"vital":[141],"signs":[142],"collected":[144],"analyzed":[146],"calculate":[148],"NLR,":[150,241],"PLR,":[151,202,242],"SIRI,":[152,203],"scores.":[155,206],"Statistical":[156],"analyses":[157],"Kolmogorov\u2012Smirnov":[159],"Anderson\u2012Darling":[161],"tests,":[162],"Spearman":[163],"correlation,":[164],"Kruskal\u2012Wallis":[165],"one-way":[166],"ANOVA,":[167],"GLM":[168,233],"modeling,":[169],"k-fold":[170],"cross-validation,":[171],"receiver":[173],"operating":[174],"characteristic":[175],"(ROC)":[176],"curve":[177],"analysis.":[178,192],"Results:":[179],"After":[180],"applying":[181],"exclusion":[183],"criteria,":[184],"247":[185],"Significant":[193],"associations":[194],"found":[196],"between":[197],"NLR":[199,279,295],"The":[207,283],"demonstrated":[209],"strongest":[211],"association,":[212],"whereas":[213],"PLR":[215],"had":[216],"weakest":[218],"association.":[219],"All":[220],"three":[221],"variables":[222],"significantly":[223],"influenced":[224],"prognostic":[225,289],"risk,":[226],"determined":[228],"by":[229],"score.":[232],"models":[234,325],"highlighted":[235],"predictive":[237,260],"significance":[238],"estimating":[246],"scores,":[248],"showing":[252],"potential":[253,308],"superiority.":[254],"K-fold":[255],"cross-validation":[256],"confirmed":[257],"accuracy":[261],"ability":[263],"explain":[268],"larger":[270],"proportion":[271],"variance":[273],"scores":[276],"than":[277],"PLR.":[281,297],"Conclusions:":[282],"emerges":[285],"promising":[288],"ACS,":[292],"outperforming":[293],"Its":[298],"ease":[299],"calculation":[301],"routine":[303],"hemogram":[304],"tests":[305],"underscores":[306],"its":[307],"utility":[310],"risk":[312,323],"stratification":[313],"management.":[316],"Further":[317],"validation":[318],"integration":[320],"into":[321],"existing":[322],"assessment":[324,329],"could":[326],"enhance":[327],"patients.":[332]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-10-10T00:00:00"}