{"id":"https://openalex.org/W4403260356","doi":"https://doi.org/10.1158/2767-9764.c.7487353","title":"Data from Chemotherapy Enriches for Proinflammatory Macrophage Phenotypes that Support Cancer Stem-Like Cells and Disease Progression in Ovarian Cancer","display_name":"Data from Chemotherapy Enriches for Proinflammatory Macrophage Phenotypes that Support Cancer Stem-Like Cells and Disease Progression in Ovarian Cancer","publication_year":2024,"publication_date":"2024-10-09","ids":{"openalex":"https://openalex.org/W4403260356","doi":"https://doi.org/10.1158/2767-9764.c.7487353"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.c.7487353","doi":"https://doi.org/10.1158/2767-9764.c.7487353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7487353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.c.7487353","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061669269","display_name":"Luisjesus S. Cruz","orcid":"https://orcid.org/0000-0003-2992-9182","observed_orcids":["https://orcid.org/0000-0003-2992-9182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luisjesus S. Cruz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2992-9182","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021979414","display_name":"Mikella Robinson","orcid":"https://orcid.org/0000-0001-6198-7185","observed_orcids":["https://orcid.org/0000-0001-6198-7185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikella Robinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6198-7185","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077099006","display_name":"Denay Stevenson","orcid":"https://orcid.org/0000-0003-4240-8963","observed_orcids":["https://orcid.org/0000-0003-4240-8963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denay Stevenson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4240-8963","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107266614","display_name":"Isabella C. Amador","orcid":"https://orcid.org/0009-0001-2029-8671","observed_orcids":["https://orcid.org/0009-0001-2029-8671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabella C. Amador","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-2029-8671","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054643600","display_name":"Gregory J. Jordan","orcid":"https://orcid.org/0000-0001-5777-1568","observed_orcids":["https://orcid.org/0000-0001-5777-1568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory J. Jordan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5777-1568","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113425380","display_name":"Sofia Valencia","orcid":"https://orcid.org/0009-0004-4743-8023","observed_orcids":["https://orcid.org/0009-0004-4743-8023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sofia Valencia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-4743-8023","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076365214","display_name":"Carolina Navarrete","orcid":"https://orcid.org/0009-0006-6350-6270","observed_orcids":["https://orcid.org/0009-0006-6350-6270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolina Navarrete","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-6350-6270","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059436422","display_name":"Carrie Danielle House","orcid":"https://orcid.org/0000-0002-1870-5872","observed_orcids":["https://orcid.org/0000-0002-1870-5872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrie D. House","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1870-5872","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.906000018119812},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6140000224113464},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mcp-1-ccl2","display_name":"CCL2/MCP-1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.722000002861023},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5189999938011169},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.6259999871253967},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.739870548248291},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.721100926399231},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6784245371818542},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6071289777755737},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.553735077381134},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5206891298294067},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47373783588409424},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4701668918132782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45900341868400574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3738454580307007},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35735857486724854},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33958011865615845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28356724977493286},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.17826083302497864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.148718923330307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14679601788520813},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10342580080032349}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.c.7487353","doi":"https://doi.org/10.1158/2767-9764.c.7487353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7487353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.c.7487353","doi":"https://doi.org/10.1158/2767-9764.c.7487353","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7487353","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402567131","https://openalex.org/W4384829440","https://openalex.org/W4393089054","https://openalex.org/W2956132413","https://openalex.org/W4416554660","https://openalex.org/W1965003078","https://openalex.org/W7149037504","https://openalex.org/W4362525098","https://openalex.org/W4319655509","https://openalex.org/W2089818916"],"abstract_inverted_index":{"Abstract":[0],"High-grade":[1],"serous":[2,246],"ovarian":[3,78,142,165,197,247,261,298],"cancer":[4,36,89,143,262],"remains":[5,51],"a":[6,11,22,32,193,202,209,291],"poorly":[7],"understood":[8],"disease":[9],"with":[10,260],"high":[12],"mortality":[13],"rate.":[14],"Although":[15],"most":[16,269],"patients":[17],"respond":[18],"to":[19,31,83,88,101,226,294],"cytotoxic":[20,227],"therapies,":[21],"majority":[23],"will":[24,236],"experience":[25],"recurrence.":[26],"This":[27,199],"may":[28,106],"be":[29],"due":[30],"minority":[33],"of":[34,46,72,76,115,121,180,196,223,233,240],"drug-resistant":[35],"stem-like":[37],"cells":[38,94],"(CSC)":[39],"that":[40,95,149,157,168,214,252,258,265],"survive":[41],"chemotherapy":[42,64,253],"and":[43,80,86,104,129,136,141,163,167,189,229],"are":[44,55,81,92,267],"capable":[45],"repopulating":[47],"heterogeneous":[48],"tumors.":[49],"It":[50],"unclear":[52],"how":[53],"CSCs":[54,85,140,188,217],"supported":[56],"in":[57,99,186,192,207,297],"the":[58,73,77,113,119,238,268,279],"tumor":[59],"microenvironment":[60],"(TME)":[61],"particularly":[62],"during":[63,110,182,218,289],"exposure.":[65],"Tumor-associated":[66],"macrophages":[67,135,266],"(TAM)":[68],"make":[69],"up":[70],"half":[71],"immune":[74,271],"population":[75],"TME":[79,224],"known":[82],"support":[84],"contribute":[87],"progression.":[90,263],"TAMs":[91,181],"plastic":[93],"alter":[96],"their":[97],"phenotype":[98,156],"response":[100],"environmental":[102],"stimuli":[103],"thus":[105],"influence":[107],"CSC":[108,234],"maintenance":[109,235],"chemotherapy.":[111],"Given":[112,264],"plasticity":[114],"TAMs,":[116],"we":[117],"studied":[118],"effects":[120],"carboplatin":[122,150,183],"on":[123],"macrophage":[124,256,287],"phenotypes":[125,257],"using":[126],"both":[127],"THP1-":[128],"peripheral":[130],"blood":[131],"mononuclear":[132],"cell":[133,272],"(PBMC)\u2013derived":[134],"whether":[137],"this":[138,177,276],"supports":[139,201],"progression":[144],"following":[145],"treatment.":[146,219],"We":[147,250],"found":[148],"exposure":[151,184],"induces":[152],"an":[153],"M1-like":[154,212],"proinflammatory":[155,211,255],"promotes":[158],"SOX2":[159],"expression,":[160],"spheroid":[161],"formation,":[162],"CD117+":[164],"CSCs,":[166],"macrophage-secreted":[169],"CCL2/MCP-1":[170],"is":[171],"at":[172],"least":[173],"partially":[174],"responsible":[175],"for":[176,204,216,244,281],"effect.":[178],"Depletion":[179],"results":[185],"fewer":[187],"prolonged":[190],"survival":[191],"xenograft":[194],"model":[195],"cancer.":[198,248,299],"study":[200],"role":[203],"platinum-based":[205],"chemotherapies":[206],"promoting":[208],"transient":[210],"TAM":[213],"enriches":[215],"Improving":[220],"our":[221],"understanding":[222],"responses":[225],"drugs":[228],"identifying":[230],"novel":[231],"mechanisms":[232],"enable":[237],"development":[239],"better":[241],"therapeutic":[242],"strategies":[243],"high-grade":[245],"Significance:":[249],"show":[251],"enhances":[254],"correlate":[259],"prominent":[270],"within":[273],"these":[274],"tumors,":[275],"work":[277],"provides":[278],"foundation":[280],"future":[282],"translational":[283],"studies":[284],"targeting":[285],"specific":[286],"populations":[288],"chemotherapy,":[290],"promising":[292],"approach":[293],"prevent":[295],"relapse":[296]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-10-10T00:00:00"}