{"id":"https://openalex.org/W4403246604","doi":"https://doi.org/10.1161/res.135.suppl_1.mo060","title":"Abstract Mo060: SPEG mediates increased atrial fibrillation incidence in chronic kidney disease","display_name":"Abstract Mo060: SPEG mediates increased atrial fibrillation incidence in chronic kidney disease","publication_year":2024,"publication_date":"2024-08-02","ids":{"openalex":"https://openalex.org/W4403246604","doi":"https://doi.org/10.1161/res.135.suppl_1.mo060"},"language":"en","primary_location":{"id":"doi:10.1161/res.135.suppl_1.mo060","doi":"https://doi.org/10.1161/res.135.suppl_1.mo060","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.135.suppl_1.mo060","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076052344","display_name":"Jos\u00e9 Alberto Navarro\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-0317-4888","observed_orcids":["https://orcid.org/0000-0002-0317-4888"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Alberto Navarro Garcia","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079002203","display_name":"Satadru K. Lahiri","orcid":"https://orcid.org/0000-0001-9502-1530","observed_orcids":["https://orcid.org/0000-0001-9502-1530"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satadru Lahiri","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085753360","display_name":"Yuriana Aguilar-S\u00e1nchez","orcid":"https://orcid.org/0000-0002-5516-8877","observed_orcids":["https://orcid.org/0000-0002-5516-8877"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuriana Aguilar","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089864107","display_name":"Joshua A. Keefe","orcid":"https://orcid.org/0000-0002-6209-6488","observed_orcids":["https://orcid.org/0000-0002-6209-6488"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Keefe","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100689588","display_name":"Jia Song","orcid":"https://orcid.org/0000-0001-6039-6340","observed_orcids":["https://orcid.org/0000-0001-6039-6340","https://orcid.org/0009-0002-8916-9306"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Song","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Na Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000609088","display_name":"Xander H.T. Wehrens","orcid":"https://orcid.org/0000-0001-5044-672X","observed_orcids":["https://orcid.org/0000-0001-5044-672X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xander Wehrens","raw_affiliation_strings":["Baylor College of Medicine, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, Texas, United States","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"135","issue":"Suppl_1","first_page":"AMo060","last_page":"AMo060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/speg","display_name":"SPEG","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ryanodine-receptor-2","display_name":"RyR2","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ryr2-phosphorylation","display_name":"RyR2 phosphorylation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/5-6-nephrectomy-model","display_name":"5/6 nephrectomy model","score":0.8550000190734863},{"id":"https://openalex.org/keywords/left-atrial-enlargement","display_name":"left atrial enlargement","score":0.6510000228881836},{"id":"https://openalex.org/keywords/atrial-remodeling","display_name":"atrial remodeling","score":0.5320000052452087},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.7289999723434448},{"id":"https://openalex.org/keywords/atrial-electrophysiology","display_name":"atrial electrophysiology","score":0.6060000061988831},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.6940000057220459},{"id":"https://openalex.org/keywords/atrial-fibrosis","display_name":"atrial fibrosis","score":0.4659999907016754},{"id":"https://openalex.org/keywords/atrial-fibroblasts","display_name":"atrial fibroblasts","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8136782050132751},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6873763203620911},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6344856023788452},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6061918139457703},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5626217126846313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5431943535804749},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.485286682844162},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4700561761856079},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.135.suppl_1.mo060","doi":"https://doi.org/10.1161/res.135.suppl_1.mo060","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.135.suppl_1.mo060","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403817133","https://openalex.org/W2902599272","https://openalex.org/W4411145622","https://openalex.org/W4399809058","https://openalex.org/W2149662781","https://openalex.org/W6907618532","https://openalex.org/W3044917315","https://openalex.org/W2127568273","https://openalex.org/W4366083456","https://openalex.org/W2061847712"],"abstract_inverted_index":{"Introduction:":[0],"Chronic":[1],"kidney":[2],"disease":[3,110],"(CKD)":[4],"is":[5,12,32,57],"a":[6,13,298,301,355],"major":[7],"public":[8],"health":[9],"problem.":[10],"CKD":[11,97,109,148,177,185,214,220,241,257,269,328,367],"risk":[14,80,93],"factor":[15],"of":[16,26,38,61,81,94,198,219,364],"cardiovascular":[17],"morbidity":[18],"and":[19,131,164,195,286],"mortality":[20],"due":[21],"to":[22,34,107,125,244,336,359],"the":[23,36,66,79,91,317,361],"increased":[24,45,92,151,280,287,332,337,362],"incidence":[25,172,363],"atrial":[27,88,200],"fibrillation":[28],"(AF).":[29],"AF":[30,95,113,171,293,338,347,365],"onset":[31,294],"known":[33],"be":[35],"consequence":[37],"cardiomyocyte":[39],"intracellular":[40],"calcium":[41],"(Ca2+)":[42],"mishandling":[43],"where":[44],"ryanodine":[46],"receptor":[47],"type":[48],"2":[49],"(RyR2)":[50],"activity":[51,56,278,289,334],"causes":[52],"triggered":[53],"activity.":[54],"RyR2":[55,74,250,333],"regulated":[58],"by":[59,65,136,144],"phosphorylation":[60,75,130,251,306,343],"serine":[62],"2367":[63],"(S2367)":[64],"\u2018striated":[67],"muscle":[68],"preferentially":[69],"expressed":[70],"protein\u2019":[71],"(SPEG).":[72],"Reduced":[73],"at":[76,252,307,344],"S2367":[77,253],"increases":[78],"AF.":[82],"We":[83],"hypothesized":[84],"that":[85,303,320],"changes":[86,228],"in":[87,96,111,176,213,231,238,256,263,297,325,366],"SPEG":[89,132,234,308,321,353],"underly":[90],"patients.":[98,368],"Methods:":[99],"The":[100],"experimental":[101],"5/6":[102],"nephrectomy":[103],"model":[104],"was":[105,115,123,173,211,254,295,348],"used":[106,124],"mimic":[108],"mice.":[112,233],"inducibility":[114],"determined":[116],"using":[117],"intracardiac":[118],"programmed":[119],"electric":[120],"stimulation.":[121],"Echocardiography":[122],"analyze":[126],"cardiac":[127],"structure.":[128],"RYR2":[129,305,342],"levels":[133,235,322],"were":[134,142,229,236],"measured":[135],"western":[137],"blotting.":[138],"Intracellular":[139],"Ca2+":[140,273,283],"dynamics":[141],"assessed":[143],"confocal":[145],"microscopy.":[146],"Results:":[147],"mice":[149,180,186,204,215,242,258,270,299,329],"showed":[150,187],"serum":[152],"phosphate":[153],"(14.1\u00b11.4":[154],"vs":[155,160,167,182,192,206,223,247,261],"9.3\u00b10.4mg/dL;":[156],"p<0.01),":[157],"creatinine":[158],"(0.4\u00b10.1":[159],"0.8\u00b10.3":[161],"mg/dL;":[162,169],"p<0.001)":[163,225],"urea":[165],"(30.5\u00b11.1":[166],"20.9\u00b10.4":[168],"p<0.001).":[170],"4-fold":[174],"higher":[175],"respect":[178],"sham":[179,245],"(60":[181],"14.2%;":[183],"p<0.05).":[184,208,249],"longer":[188],"P":[189],"waves":[190],"(14.3\u00b10.4":[191],"12.5\u00b10.3;":[193],"p<0.01)":[194],"greater":[196],"increase":[197],"left":[199],"size":[201],"than":[202],"Sham":[203,232],"(35.0\u00b17.5":[205],"13.9\u00b14.6;":[207],"Ejection":[209],"fraction":[210],"reduced":[212,255],"after":[216],"6":[217],"weeks":[218],"progression":[221],"(57.9\u00b10.6":[222],"61.7\u00b10.8%;":[224],"while":[226],"no":[227],"observed":[230],"decreased":[237,276,324],"atria":[239,259,326],"from":[240,268,327],"compared":[243],"(0.64\u00b10.11":[246],"1.19\u00b10.13;":[248],"(0.66\u00b10.16":[260],"1.25\u00b10.26":[262],"sham;":[264],"p=0.098).":[265],"Atrial":[266],"cardiomyocytes":[267],"exhibited":[271],"altered":[272],"handling,":[274],"with":[275,300],"SERCA":[277],"(p<0.05),":[279],"spark-mediated":[281],"diastolic":[282],"leak":[284],"(p<0.01)":[285],"NCX":[288],"(p<0.05).":[290],"Finally,":[291],"CKD-induced":[292,346],"prevented":[296],"mutation":[302],"mimics":[304],"site":[309],"(S2367D":[310],"mice)":[311],"Conclusion:":[312],"This":[313],"study":[314],"shows":[315],"for":[316],"first":[318],"time":[319],"are":[323],"what":[330],"induces":[331],"leading":[335],"incidence.":[339],"By":[340],"conserving":[341],"Ser2367,":[345],"prevented.":[349],"Thus,":[350],"we":[351],"propose":[352],"as":[354],"possible":[356],"therapeutic":[357],"target":[358],"reduce":[360]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-10-10T00:00:00"}
