{"id":"https://openalex.org/W4403246453","doi":"https://doi.org/10.1161/res.135.suppl_1.or121","title":"Abstract Or121: Druggable Genome CRISPRi/a Screens in iPSC-Derived Cardiomyocytes Identify Therapeutic Targets for Doxorubicin-Induced Cardiotoxicity","display_name":"Abstract Or121: Druggable Genome CRISPRi/a Screens in iPSC-Derived Cardiomyocytes Identify Therapeutic Targets for Doxorubicin-Induced Cardiotoxicity","publication_year":2024,"publication_date":"2024-08-02","ids":{"openalex":"https://openalex.org/W4403246453","doi":"https://doi.org/10.1161/res.135.suppl_1.or121"},"language":"en","primary_location":{"id":"doi:10.1161/res.135.suppl_1.or121","doi":"https://doi.org/10.1161/res.135.suppl_1.or121","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.135.suppl_1.or121","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100373912","display_name":"Chun Liu","orcid":"https://orcid.org/0000-0002-8242-3896","observed_orcids":["https://orcid.org/0000-0002-8242-3896"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun Liu","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin, United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034027537","display_name":"Mengcheng Shen","orcid":"https://orcid.org/0000-0001-7037-6159","observed_orcids":["https://orcid.org/0000-0001-7037-6159"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengcheng Shen","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029082684","display_name":"Amit Manhas","orcid":"https://orcid.org/0000-0001-6044-4576","observed_orcids":["https://orcid.org/0000-0001-6044-4576"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Manhas","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032620368","display_name":"Shane Rui Zhao","orcid":"https://orcid.org/0000-0002-2137-5536","observed_orcids":["https://orcid.org/0000-0002-2137-5536"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane Zhao","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037448890","display_name":"Nadjet Belbachir","orcid":"https://orcid.org/0000-0002-6993-8326","observed_orcids":["https://orcid.org/0000-0002-6993-8326"]},"institutions":[{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadjet Belbachir","raw_affiliation_strings":["Stanford, Cardiovascular Institute, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford, Cardiovascular Institute, Stanford, California, United States","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077904148","display_name":"Masataka Nishiga","orcid":"https://orcid.org/0000-0001-5676-7671","observed_orcids":["https://orcid.org/0000-0001-5676-7671"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masataka Nishiga","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030635499","display_name":"Dilip Thomas","orcid":"https://orcid.org/0000-0001-7427-5523","observed_orcids":["https://orcid.org/0000-0001-7427-5523"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dilip Thomas","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076640237","display_name":"Angela Zhang","orcid":"https://orcid.org/0000-0003-0906-6770","observed_orcids":["https://orcid.org/0000-0003-0906-6770"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Zhang","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100654244","display_name":"Mao Zhang","orcid":"https://orcid.org/0000-0002-5283-6497","observed_orcids":["https://orcid.org/0000-0002-5283-6497"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mao Zhang","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012538840","display_name":"Joe Z. Zhang","orcid":"https://orcid.org/0009-0007-4239-7105","observed_orcids":["https://orcid.org/0009-0007-4239-7105"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Zhang","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054507908","display_name":"Arianne Caudal","orcid":"https://orcid.org/0000-0001-9836-9436","observed_orcids":["https://orcid.org/0000-0001-9836-9436"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arianne Caudal","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062744580","display_name":"Huaxiao Yang","orcid":"https://orcid.org/0000-0001-9335-8201","observed_orcids":["https://orcid.org/0000-0001-9335-8201"]},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaxiao Yang","raw_affiliation_strings":["University of North Texas, Denton, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Texas, Denton, Texas, United States","institution_ids":["https://openalex.org/I123534392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031964598","display_name":"Nazish Sayed","orcid":"https://orcid.org/0000-0002-8229-721X","observed_orcids":["https://orcid.org/0000-0002-8229-721X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nazish Sayed","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052653853","display_name":"June\u2010Wha Rhee","orcid":"https://orcid.org/0000-0002-7044-2985","observed_orcids":["https://orcid.org/0000-0002-7044-2985"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June Rhee","raw_affiliation_strings":["City of Hope, Duarte, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, California, United States","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009068819","display_name":"Lei S. Qi","orcid":"https://orcid.org/0000-0002-3965-3223","observed_orcids":["https://orcid.org/0000-0002-3965-3223"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley Qi","raw_affiliation_strings":["Stanford University, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Stanford, California, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0002-2217-1674","https://orcid.org/0000-0003-4274-0413"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Wu","raw_affiliation_strings":["STANFORD UNIV SCH OF MEDICINE, Stanford, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"STANFORD UNIV SCH OF MEDICINE, Stanford, California, United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"135","issue":"Suppl_1","first_page":"AOr121","last_page":"AOr121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7620000243186951},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cardiomyocyte-metabolism","display_name":"cardiomyocyte metabolism","score":0.6919999718666077},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/sarcomere-structure","display_name":"sarcomere structure","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cardio-oncology","display_name":"cardio-oncology","score":0.8700000047683716},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.6660000085830688},{"id":"https://openalex.org/keywords/small-molecule-screening","display_name":"small molecule screening","score":0.5960000157356262},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.909329891204834},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.8944905996322632},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6672302484512329},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45175328850746155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4510306119918823},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4187212884426117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34012722969055176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21349084377288818},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18889904022216797},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10280588269233704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.135.suppl_1.or121","doi":"https://doi.org/10.1161/res.135.suppl_1.or121","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.135.suppl_1.or121","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2094475704","https://openalex.org/W4388041187","https://openalex.org/W3011400996","https://openalex.org/W3030216814","https://openalex.org/W4323666172","https://openalex.org/W2143449387","https://openalex.org/W2056299406","https://openalex.org/W4390534911","https://openalex.org/W2738785033","https://openalex.org/W4385199638"],"abstract_inverted_index":{"Introduction:":[0],"Doxorubicin":[1],"is":[2,11,35],"a":[3,125,175,197,218],"highly":[4],"effective":[5],"chemotherapy":[6,270],"drug":[7,46,261],"whose":[8],"therapeutic":[9,70,220],"utility":[10],"significantly":[12,178],"hampered":[13],"by":[14,207],"its":[15,31,79,129],"life-threatening":[16],"adverse":[17],"cardiac":[18,212],"effects.":[19],"The":[20,134],"need":[21],"for":[22,128,235,259],"strategies":[23],"to":[24,99,113,146,196,222],"mitigate":[25],"these":[26],"cardiotoxic":[27,245],"effects":[28],"without":[29],"diminishing":[30],"efficacy":[32],"against":[33,169,224],"cancer":[34],"critical":[36],"in":[37,104,131,152,181,202],"cardio-oncology.":[38],"Hypothesis:":[39],"We":[40],"hypothesize":[41],"that":[42,72,174,190,243],"through":[43,227],"an":[44],"integrated":[45],"discovery":[47,262],"pipeline,":[48],"utilizing":[49],"patient":[50,86],"iPSC-derived":[51,87],"cardiomyocytes":[52,88],"(iCMs)":[53],"and":[54,64,106,160,164,184,211],"CRISPRi/a":[55,90,135,254],"bidirectional":[56,91],"pooled":[57,92],"screens":[58,93,136],"combined":[59],"with":[60,256],"small":[61,107],"molecule":[62,108],"screening":[63,109],"molecular":[65,111],"docking,":[66],"we":[67,172],"can":[68],"identify":[69,100],"targets":[71],"ameliorate":[73],"doxorubicin-induced":[74,225],"cardiotoxicity":[75,226],"(DIC)":[76],"while":[77],"preserving":[78],"anticancer":[80,241],"efficacy.":[81],"Methods:":[82],"Our":[83,215],"approach":[84],"included":[85],"(iCMs),":[89],"targeting":[94,229],"druggable":[95],"genome":[96],"(~2000":[97],"genes)":[98],"candidate":[101],"genes":[102],"implicated":[103],"DIC,":[105],"alongside":[110],"docking":[112],"find":[114],"potential":[115,144],"inhibitors.":[116],"Notably,":[117],"carbonic":[118],"anhydrase":[119],"12":[120],"(CA12)":[121],"was":[122],"identified":[123],"as":[124,143],"primary":[126],"hit":[127],"role":[130],"DIC.":[132,147,170],"Results:":[133],"revealed":[137],"several":[138],"novel":[139,219],"genes,":[140],"including":[141],"CA12,":[142,231],"contributors":[145],"Genetic":[148],"inhibition":[149],"of":[150,230,238,252,269],"CA12":[151,176,193],"iCMs":[153,183],"enhanced":[154],"cell":[155],"survival,":[156],"preserved":[157],"sarcomere":[158],"structure,":[159],"improved":[161],"contractile":[162],"function":[163],"calcium":[165],"handling,":[166],"effectively":[167],"protecting":[168],"Furthermore,":[171],"discovered":[173],"antagonist":[177],"attenuates":[179],"DIC":[180,206],"both":[182],"mouse":[185],"models.":[186],"Mechanistic":[187],"studies":[188],"suggested":[189],"doxorubicin":[191],"triggers":[192],"activation,":[194],"leading":[195],"metabolic":[198],"change":[199],"towards":[200],"glycolysis":[201],"cardiomyocytes,":[203],"thereby":[204],"exacerbating":[205],"disrupting":[208],"cellular":[209],"metabolism":[210],"functions.":[213],"Conclusions:":[214],"findings":[216],"propose":[217],"avenue":[221],"safeguard":[223],"the":[228,236,250],"offering":[232],"new":[233],"direction":[234],"development":[237],"more":[239],"refined":[240],"therapies":[242],"minimize":[244],"risk.":[246],"This":[247],"study":[248],"sets":[249],"stage":[251],"combining":[253],"screen":[255],"iPSC":[257],"technology":[258],"future":[260],"endeavors":[263],"aimed":[264],"at":[265],"eliminating":[266],"off-target":[267],"cardiotoxicities":[268],"agents.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}