{"id":"https://openalex.org/W4403246147","doi":"https://doi.org/10.1161/res.135.suppl_1.tu148","title":"Abstract Tu148: cGAS-STING pathway promotes granulopoiesis and neutrophil differentiation in acute ischemia","display_name":"Abstract Tu148: cGAS-STING pathway promotes granulopoiesis and neutrophil differentiation in acute ischemia","publication_year":2024,"publication_date":"2024-08-02","ids":{"openalex":"https://openalex.org/W4403246147","doi":"https://doi.org/10.1161/res.135.suppl_1.tu148"},"language":"en","primary_location":{"id":"doi:10.1161/res.135.suppl_1.tu148","doi":"https://doi.org/10.1161/res.135.suppl_1.tu148","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.135.suppl_1.tu148","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101501851","display_name":"Jiankun Zhu","orcid":"https://orcid.org/0000-0002-2424-6692","observed_orcids":["https://orcid.org/0000-0002-2424-6692"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiankun Zhu","raw_affiliation_strings":["UT SOUTHWESTERN MEDICAL CENTER, Dallas, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT SOUTHWESTERN MEDICAL CENTER, Dallas, Texas, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"pablo Parra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"pablo Parra","raw_affiliation_strings":["UT SOUTHWESTERN MEDICAL CENTER, Dallas, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT SOUTHWESTERN MEDICAL CENTER, Dallas, Texas, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079679333","display_name":"Xiang Luo","orcid":"https://orcid.org/0000-0002-7647-6094","observed_orcids":["https://orcid.org/0000-0002-7647-6094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang Luo","raw_affiliation_strings":["UNIV OF TEXAS MED CTR AT DALLA, Dallas, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIV OF TEXAS MED CTR AT DALLA, Dallas, Texas, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040061958","display_name":"Dian J. Cao","orcid":"https://orcid.org/0000-0002-2457-8291","observed_orcids":["https://orcid.org/0000-0002-2457-8291"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dian Cao","raw_affiliation_strings":["UT SOUTHWESTERN MEDICAL CENTER, Dallas, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT SOUTHWESTERN MEDICAL CENTER, Dallas, Texas, United States","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"135","issue":"Suppl_1","first_page":"ATu148","last_page":"ATu148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.19269999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.9940000176429749},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/granulopoiesis","display_name":"granulopoiesis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neutrophil-granules","display_name":"neutrophil granules","score":0.7419999837875366},{"id":"https://openalex.org/keywords/mmp-8","display_name":"MMP-8","score":0.6230000257492065},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-ebpdelta","display_name":"C/EBP\u03b4","score":0.9079999923706055},{"id":"https://openalex.org/keywords/neutrophil-degranulation","display_name":"neutrophil degranulation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cd101","display_name":"CD101","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2779452902","wikidata":"https://www.wikidata.org/wiki/Q5596845","display_name":"Granulopoiesis","level":4,"score":0.9806104898452759},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.7873566150665283},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.48052725195884705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46294912695884705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4528052806854248},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.41789355874061584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41583216190338135},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.4117448031902313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3670223355293274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2464621663093567},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.12475785613059998},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.135.suppl_1.tu148","doi":"https://doi.org/10.1161/res.135.suppl_1.tu148","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.135.suppl_1.tu148","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410189446","https://openalex.org/W4400895982","https://openalex.org/W3113587369","https://openalex.org/W3138260785","https://openalex.org/W7204995856","https://openalex.org/W3014215372","https://openalex.org/W2900664372","https://openalex.org/W4387704725","https://openalex.org/W4312627018","https://openalex.org/W4385563342"],"abstract_inverted_index":{"Contemporary":[0],"evidence":[1,54],"supports":[2],"neutrophils'":[3],"complex":[4],"roles":[5],"beyond":[6],"being":[7],"the":[8,24,64,173,206,214,230,237,245,269],"simple":[9],"and":[10,44,46,90,99,120,124,128,147,175,185,208,216,221,227,286,291],"powerful":[11],"destruction":[12],"tools":[13],"in":[14,32,80,83,101,116,139,205,296,304,308],"MI.":[15,84],"However,":[16],"our":[17,194],"understanding":[18],"remains":[19],"limited.":[20],"We":[21,131],"especially":[22],"lack":[23],"knowledge":[25],"of":[26,50,63,154,172,239,248,259,272],"how":[27],"cGAS-STING":[28,36,107,135,198,260,278,302],"regulates":[29,108],"neutrophil":[30,81,109,137,203,263,287],"functions":[31,257],"acute":[33],"ischemia.":[34,144],"The":[35],"pathway":[37,74],"senses":[38],"cytosolic":[39],"DNA":[40],"to":[41,200,261],"produce":[42],"IFN":[43],"ISGs":[45],"is":[47],"a":[48,201,280],"pillar":[49],"innate":[51],"immunity.":[52],"Early":[53],"suggested":[55],"neutrophils":[56,87,149,212,223],"did":[57],"not":[58,235],"express":[59,150],"cGAS.":[60],"Taking":[61],"advantage":[62],"improved":[65],"detecting":[66],"method,":[67],"we":[68,95,111,276],"revisited":[69],"this":[70,73],"topic":[71],"because":[72],"can":[75],"play":[76],"an":[77],"essential":[78],"role":[79],"function":[82,271],"Using":[85],"purified":[86],"from":[88],"WT":[89,122],"knockout":[91],"mice":[92],"(as":[93],"control),":[94],"detected":[96],"cGAS,":[97],"STING,":[98],"IRF3":[100],"these":[102],"cells.":[103],"To":[104],"determine":[105],"if":[106],"function,":[110],"first":[112],"generated":[113],"MI":[114,217,290],"model":[115],"cGAS-/-,":[117],"STING-/-":[118],"mice,":[119],"their":[121],"littermates":[123],"performed":[125],"flow":[126],"cytometry":[127],"RNA-seq":[129],"analyses.":[130],"uncovered":[132],"that":[133,254],"inhibiting":[134,197],"decreases":[136],"production":[138],"bone":[140],"marrow":[141],"(BM)":[142],"after":[143,289],"Interestingly,":[145],"cGAS-":[146,220],"STING-deficient":[148,222],"significantly":[151],"higher":[152],"levels":[153,171],"primary":[155,240],"granule":[156,177],"molecules":[157],"such":[158],"as":[159,242,279],"MPO,":[160],"Prtn3,":[161],"Elane,":[162],"Cts-":[163],"(s,":[164],"g,":[165],"b,":[166],"l)":[167],"but":[168],"much":[169],"lower":[170],"secondary":[174],"tertiary":[176],"components,":[178],"including":[179],"Mmp9,":[180],"Mmp8,":[181],"Olfm4,":[182],"Cd177,":[183],"Lyz2,":[184],"Lyz1.":[186],"Neutrophils":[187],"acquire":[188],"granules":[189],"sequentially":[190],"during":[191],"differentiation.":[192,264],"Therefore,":[193],"data":[195,251],"suggest":[196,253,268],"leads":[199],"stagnated":[202],"differentiation":[204,288],"BM":[207],"mobilizes":[209],"CD101-":[210],"immature":[211],"into":[213,229],"circulation":[215],"hearts.":[218],"Consistently,":[219],"release":[224],"less":[225],"MMP8":[226],"MMP9":[228],"ischemic":[231],"area.":[232],"Ischemia":[233],"does":[234],"trigger":[236],"degranulation":[238],"granules,":[241],"indicated":[243],"by":[244],"minimal":[246],"changes":[247],"CD63.":[249],"Our":[250],"further":[252],"TF":[255],"C/EBP\ud835\udf39":[256],"downstream":[258],"promote":[262],"Adoptive":[265],"transfer":[266],"experiments":[267],"neutrophil-specific":[270],"cGAS-STING.":[273],"In":[274],"conclusion,":[275],"identify":[277],"novel":[281],"mechanism":[282],"promoting":[283],"emergency":[284],"granulopoiesis":[285],"uncover":[292],"its":[293],"functional":[294],"implications":[295],"ischemia-induced":[297],"remodeling.":[298],"Studies":[299],"using":[300],"Mrp8-Cre-mediated":[301],"deletion":[303],"granulocyte/macrophage":[305],"progenitors":[306],"are":[307],"progress.":[309]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-10-10T00:00:00"}
