{"id":"https://openalex.org/W4403230783","doi":"https://doi.org/10.1039/d4nr01638f","title":"Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes","display_name":"Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4403230783","doi":"https://doi.org/10.1039/d4nr01638f","pmid":"https://pubmed.ncbi.nlm.nih.gov/39377120"},"language":"en","primary_location":{"id":"doi:10.1039/d4nr01638f","doi":"https://doi.org/10.1039/d4nr01638f","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4nr01638f","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01638f","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01638f","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113423666","display_name":"Jaekyun Baek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaekyun Baek","raw_affiliation_strings":["Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea","Research Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338421","display_name":"Jihyun Park","orcid":"https://orcid.org/0000-0002-2396-8378","observed_orcids":["https://orcid.org/0000-0002-2396-8378"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihyun Park","raw_affiliation_strings":["Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101992968","display_name":"Youngeun Kim","orcid":"https://orcid.org/0000-0002-9404-6936","observed_orcids":["https://orcid.org/0000-0002-9404-6936","https://orcid.org/0000-0001-9259-8342"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Youngeun Kim","raw_affiliation_strings":["Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea","Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea","Research Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-9404-6936","affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Research Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101992968"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":0.1151,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35200592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"16","issue":"43","first_page":"20067","last_page":"20072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid-detection","display_name":"nucleic acid detection","score":0.9750000238418579},{"id":"https://openalex.org/keywords/isothermal-amplification","display_name":"isothermal amplification","score":0.9139999747276306},{"id":"https://openalex.org/keywords/label-free-detection","display_name":"label-free detection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sequence-specific-hybridization","display_name":"sequence-specific hybridization","score":0.8360000252723694},{"id":"https://openalex.org/keywords/attomolar-sensitivity","display_name":"attomolar sensitivity","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9324774742126465},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7578669786453247},{"id":"https://openalex.org/C60635243","wikidata":"https://www.wikidata.org/wiki/Q6675780","display_name":"Loop-mediated isothermal amplification","level":3,"score":0.7035213708877563},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6428269147872925},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4818902611732483},{"id":"https://openalex.org/C156385826","wikidata":"https://www.wikidata.org/wiki/Q1341059","display_name":"Multiple displacement amplification","level":5,"score":0.47341281175613403},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.46352869272232056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44486552476882935},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40659043192863464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30449169874191284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.296206533908844},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.2214907705783844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09375312924385071},{"id":"https://openalex.org/C78063203","wikidata":"https://www.wikidata.org/wiki/Q3062596","display_name":"DNA extraction","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/d4nr01638f","doi":"https://doi.org/10.1039/d4nr01638f","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4nr01638f","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01638f","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:39377120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39377120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/234952","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/234952","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1039/d4nr01638f","doi":"https://doi.org/10.1039/d4nr01638f","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d4nr01638f","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2024/nr/d4nr01638f","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7349215135","display_name":null,"funder_award_id":"2022M3H4A1A04096393","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G8733153001","display_name":null,"funder_award_id":"2022M3H4A1A04096393","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321292","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542"},{"id":"https://openalex.org/F4320322091","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403230783.pdf","grobid_xml":"https://content.openalex.org/works/W4403230783.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1522220566","https://openalex.org/W1966615916","https://openalex.org/W1997925861","https://openalex.org/W2014234644","https://openalex.org/W2016493882","https://openalex.org/W2058925610","https://openalex.org/W2097348296","https://openalex.org/W2105275554","https://openalex.org/W2120316582","https://openalex.org/W2129953215","https://openalex.org/W2145303234","https://openalex.org/W2153350094","https://openalex.org/W2163194887","https://openalex.org/W2164578725","https://openalex.org/W2766989075","https://openalex.org/W2911393380","https://openalex.org/W2912673401","https://openalex.org/W2936174077","https://openalex.org/W3041772724","https://openalex.org/W3112384820","https://openalex.org/W3122882833","https://openalex.org/W3135378905","https://openalex.org/W4221133409","https://openalex.org/W4306168015","https://openalex.org/W4366084190","https://openalex.org/W4375814770","https://openalex.org/W4384134093","https://openalex.org/W4390666335"],"related_works":["https://openalex.org/W2911393380","https://openalex.org/W2965554395","https://openalex.org/W2119021006","https://openalex.org/W3126819324","https://openalex.org/W3015946538","https://openalex.org/W2013599162","https://openalex.org/W7130933996","https://openalex.org/W2246838757","https://openalex.org/W2978709004","https://openalex.org/W3030092069"],"abstract_inverted_index":{"We":[0],"report":[1],"a":[2],"novel":[3],"platform":[4],"for":[5],"label-free":[6],"nucleic":[7],"acid":[8],"detection":[9],"using":[10],"isothermal":[11],"amplification":[12],"and":[13,37],"light-up":[14],"aptamer":[15,32],"probes.":[16],"This":[17],"assay":[18],"converts":[19],"double-stranded":[20],"amplicons":[21],"into":[22],"single-stranded":[23],"targets":[24],"to":[25],"enable":[26],"sequence-specific":[27],"hybridization":[28],"with":[29],"split":[30],"dapoxyl":[31],"probes,":[33],"offering":[34],"attomolar":[35],"sensitivity":[36],"single-base":[38],"specificity.":[39]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-10-09T00:00:00"}