{"id":"https://openalex.org/W4403223236","doi":"https://doi.org/10.1016/j.str.2024.09.013","title":"Structural mechanism of HP1\u237a-dependent transcriptional repression and chromatin compaction","display_name":"Structural mechanism of HP1\u237a-dependent transcriptional repression and chromatin compaction","publication_year":2024,"publication_date":"2024-10-08","ids":{"openalex":"https://openalex.org/W4403223236","doi":"https://doi.org/10.1016/j.str.2024.09.013","pmid":"https://pubmed.ncbi.nlm.nih.gov/38076844","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10705452"},"language":"en","primary_location":{"id":"doi:10.1016/j.str.2024.09.013","doi":"https://doi.org/10.1016/j.str.2024.09.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2024.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.str.2024.09.013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079448592","display_name":"Vladyslava Sokolova","orcid":"https://orcid.org/0000-0002-0645-7891","observed_orcids":["https://orcid.org/0000-0002-0645-7891"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladyslava Sokolova","raw_affiliation_strings":["Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033415673","display_name":"Jacob A. Miratsky","orcid":"https://orcid.org/0009-0009-1070-6772","observed_orcids":["https://orcid.org/0009-0009-1070-6772"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Miratsky","raw_affiliation_strings":["School of Molecular Sciences, Arizona State University, Tempe, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Sciences, Arizona State University, Tempe, AZ, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035839007","display_name":"Vladimir V. Svetlov","orcid":"https://orcid.org/0000-0002-1977-4271","observed_orcids":["https://orcid.org/0000-0002-1977-4271"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Svetlov","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA","Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA","Howard Hughes Medical Institute, Chevy Chase, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010967667","display_name":"Michael D. Brenowitz","orcid":"https://orcid.org/0000-0003-0048-1716","observed_orcids":["https://orcid.org/0000-0003-0048-1716"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Brenowitz","raw_affiliation_strings":["Departments of Biochemistry and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061232477","display_name":"John Vant","orcid":"https://orcid.org/0000-0003-0627-4603","observed_orcids":["https://orcid.org/0000-0003-0627-4603"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Vant","raw_affiliation_strings":["School of Molecular Sciences, Arizona State University, Tempe, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Sciences, Arizona State University, Tempe, AZ, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072479324","display_name":"Tyler Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler S. Lewis","raw_affiliation_strings":["Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062808829","display_name":"Kelly A. Dryden","orcid":"https://orcid.org/0000-0003-1351-1080","observed_orcids":["https://orcid.org/0000-0003-1351-1080"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Dryden","raw_affiliation_strings":["Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22903, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062308269","display_name":"Gahyun Lee","orcid":"https://orcid.org/0009-0008-1464-1809","observed_orcids":["https://orcid.org/0009-0008-1464-1809"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gahyun Lee","raw_affiliation_strings":["Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076593417","display_name":"Shayan Sarkar","orcid":"https://orcid.org/0000-0002-5197-9656","observed_orcids":["https://orcid.org/0000-0002-5197-9656","https://orcid.org/0000-0003-0865-1767"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shayan Sarkar","raw_affiliation_strings":["Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053345072","display_name":"Evgeny Nudler","orcid":"https://orcid.org/0000-0002-8811-3071","observed_orcids":["https://orcid.org/0000-0002-8811-3071"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evgeny Nudler","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA","Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA","Howard Hughes Medical Institute, Chevy Chase, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070279915","display_name":"Abhishek Singharoy","orcid":"https://orcid.org/0000-0002-9000-2397","observed_orcids":["https://orcid.org/0000-0002-9000-2397"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhishek Singharoy","raw_affiliation_strings":["School of Molecular Sciences, Arizona State University, Tempe, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Sciences, Arizona State University, Tempe, AZ, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004281997","display_name":"Dongyan Tan","orcid":"https://orcid.org/0000-0002-6796-6745","observed_orcids":["https://orcid.org/0000-0002-6796-6745"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dongyan Tan","raw_affiliation_strings":["Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA. Electronic address: dongyan.tan@stonybrook.edu","Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-6796-6745","affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA. Electronic address: dongyan.tan@stonybrook.edu","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5004281997"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":{"value":9350,"currency":"USD","value_usd":9350},"fwci":1.4909,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.82185022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"32","issue":"11","first_page":"2094","last_page":"2106.e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hp1alpha","display_name":"HP1\u03b1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hp1","display_name":"HP1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7630000114440918},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/heterochromatin-maintenance","display_name":"heterochromatin maintenance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/dna-accessibility","display_name":"DNA accessibility","score":0.5260000228881836},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.8960000276565552},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.9361375570297241},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.858687698841095},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.71356201171875},{"id":"https://openalex.org/C179138559","wikidata":"https://www.wikidata.org/wiki/Q24740158","display_name":"Chromodomain","level":5,"score":0.6232279539108276},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6103073954582214},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5959231853485107},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5422412753105164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5307447910308838},{"id":"https://openalex.org/C193646685","wikidata":"https://www.wikidata.org/wiki/Q1826830","display_name":"Linker DNA","level":5,"score":0.4819338321685791},{"id":"https://openalex.org/C164974683","wikidata":"https://www.wikidata.org/wiki/Q1044051","display_name":"Chromatosome","level":5,"score":0.43939775228500366},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.4332141876220703},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.41635578870773315},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4117634892463684},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.40846526622772217},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34219449758529663},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1079709529876709},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08934059739112854},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.08874183893203735}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.str.2024.09.013","doi":"https://doi.org/10.1016/j.str.2024.09.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2024.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},{"id":"doi:10.1101/2023.11.30.569387","doi":"https://doi.org/10.1101/2023.11.30.569387","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.11.30.569387","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/30/2023.11.30.569387.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38076844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38076844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:39383876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39383876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11560701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11560701","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11560701/pdf/nihms-2025446.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Structure","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10705452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10705452","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10705452/pdf/nihpp-2023.11.30.569387v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:osti.gov:2475684","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/2475684","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.str.2024.09.013","doi":"https://doi.org/10.1016/j.str.2024.09.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2024.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1095337402","display_name":"Dynamics and Regulation of Chromatin in DNA Metabolism","funder_award_id":"5r35gm133611-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1168517235","display_name":null,"funder_award_id":"SCR_019031","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1168951598","display_name":null,"funder_award_id":"G20-RR31199","funder_id":"https://openalex.org/F4320332643","funder_display_name":"School of Medicine"},{"id":"https://openalex.org/G2991708791","display_name":"300 keV Liquid Helium Robotic Microscope","funder_award_id":"S10RR025067","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3203201490","display_name":null,"funder_award_id":"S10-RR025067","funder_id":"https://openalex.org/F4320332643","funder_display_name":"School of Medicine"},{"id":"https://openalex.org/G3388457521","display_name":null,"funder_award_id":"KP1607011","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3634906849","display_name":null,"funder_award_id":"R35GM133611","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3756692939","display_name":"Molecular Electron Microscopy Core Facility Improvements","funder_award_id":"G20RR031199","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3801718436","display_name":"CAREER: Regulation of Chromatin by Histone Variants","funder_award_id":"1942049","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4170587222","display_name":null,"funder_award_id":"U24-GM116790","funder_id":"https://openalex.org/F4320332643","funder_display_name":"School of Medicine"},{"id":"https://openalex.org/G4394693114","display_name":"A 200KV CRYO-TEM FOR IMAGING BIOLOGICAL STRUCTURES","funder_award_id":"1s10od012272-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4565997878","display_name":null,"funder_award_id":"1S10OD012272-01A1","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5996226504","display_name":null,"funder_award_id":"SCR_019031","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6208637950","display_name":"UVA molecular electron microscopy core for the Mid-Atlantic region","funder_award_id":"U24GM116790","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8775485830","display_name":null,"funder_award_id":"KP1607011","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G9000183233","display_name":null,"funder_award_id":"1R35GM133611","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332643","display_name":"School of Medicine","ror":"https://ror.org/03r0ha626"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1522804264","https://openalex.org/W1571482483","https://openalex.org/W1575224321","https://openalex.org/W1945772050","https://openalex.org/W1974227032","https://openalex.org/W1975135992","https://openalex.org/W1975196538","https://openalex.org/W1975317507","https://openalex.org/W1976242374","https://openalex.org/W1977387171","https://openalex.org/W1978282766","https://openalex.org/W1980606696","https://openalex.org/W1983159345","https://openalex.org/W1985036194","https://openalex.org/W1989324954","https://openalex.org/W1993822465","https://openalex.org/W1993891331","https://openalex.org/W2012383380","https://openalex.org/W2012935454","https://openalex.org/W2013571070","https://openalex.org/W2015697863","https://openalex.org/W2024295388","https://openalex.org/W2026501344","https://openalex.org/W2027933092","https://openalex.org/W2033172828","https://openalex.org/W2044576840","https://openalex.org/W2048645295","https://openalex.org/W2049846825","https://openalex.org/W2068690942","https://openalex.org/W2083910309","https://openalex.org/W2086556990","https://openalex.org/W2087103327","https://openalex.org/W2090571513","https://openalex.org/W2099540110","https://openalex.org/W2101645956","https://openalex.org/W2110399580","https://openalex.org/W2113857452","https://openalex.org/W2113904137","https://openalex.org/W2114088699","https://openalex.org/W2124026197","https://openalex.org/W2127205858","https://openalex.org/W2144792857","https://openalex.org/W2147403429","https://openalex.org/W2150374310","https://openalex.org/W2152740117","https://openalex.org/W2154062872","https://openalex.org/W2157129908","https://openalex.org/W2169295181","https://openalex.org/W2277366394","https://openalex.org/W2338344824","https://openalex.org/W2469449201","https://openalex.org/W2587625522","https://openalex.org/W2589191412","https://openalex.org/W2694038906","https://openalex.org/W2722642526","https://openalex.org/W2739969873","https://openalex.org/W2784047279","https://openalex.org/W2793402357","https://openalex.org/W2834492593","https://openalex.org/W2894727674","https://openalex.org/W2899714098","https://openalex.org/W2953320394","https://openalex.org/W2966215858","https://openalex.org/W2970929986","https://openalex.org/W2980597982","https://openalex.org/W3048230532","https://openalex.org/W3083406432","https://openalex.org/W3093247712","https://openalex.org/W3133544846","https://openalex.org/W3177828909","https://openalex.org/W3177858566","https://openalex.org/W3200545562","https://openalex.org/W3207804469","https://openalex.org/W3211795435","https://openalex.org/W4210384175","https://openalex.org/W4310720009","https://openalex.org/W4320896410"],"related_works":["https://openalex.org/W2800637891","https://openalex.org/W2021409414","https://openalex.org/W4391657600","https://openalex.org/W2784047279","https://openalex.org/W2044576840","https://openalex.org/W2834492593","https://openalex.org/W7029198109","https://openalex.org/W2086112519","https://openalex.org/W2139712884","https://openalex.org/W2789324748"],"abstract_inverted_index":{"Heterochromatin":[0],"protein":[1],"1":[2],"(HP1)":[3],"plays":[4],"a":[5,33,92,149],"central":[6],"role":[7,176],"in":[8,141,156,163,179],"establishing":[9],"and":[10,20,43,133,159],"maintaining":[11],"constitutive":[12],"heterochromatin.":[13],"However,":[14],"the":[15,38,48,62,79,86,118,123,130,142,164,174],"mechanisms":[16],"underlying":[17],"HP1-nucleosome":[18],"interactions":[19,39],"their":[21],"contributions":[22],"to":[23,36,56,103,181],"heterochromatin":[24,157],"functions":[25,155],"remain":[26],"elusive.":[27],"In":[28],"this":[29],"study,":[30],"we":[31],"employed":[32],"multidisciplinary":[34],"approach":[35],"unravel":[37],"between":[40],"human":[41],"HP1\u03b1":[42,53,63,115,154],"nucleosomes.":[44],"We":[45],"have":[46],"elucidated":[47],"cryo-EM":[49],"structure":[50],"of":[51,81,120,144,166,177],"an":[52,57],"dimer":[54,64],"bound":[55],"H2A.Z":[58],"nucleosome,":[59],"revealing":[60],"that":[61,114,151],"interfaces":[65],"with":[66],"nucleosomes":[67],"at":[68,78,85],"two":[69],"distinct":[70],"sites.":[71],"The":[72],"primary":[73],"binding":[74,95,116],"site":[75,96],"is":[76,97],"located":[77],"N-terminus":[80],"histone":[82,100],"H3,":[83],"specifically":[84],"trimethylated":[87],"K9":[88],"(K9me3)":[89],"region,":[90],"while":[91,136],"novel":[93],"secondary":[94],"situated":[98],"near":[99,129],"H2B,":[101],"close":[102],"nucleosome":[104,131],"superhelical":[105],"location":[106],"4":[107],"(SHL4).":[108],"Our":[109],"biochemical":[110],"data":[111],"further":[112],"demonstrates":[113],"influences":[117],"dynamics":[119],"DNA":[121,127,139,182],"on":[122,173],"nucleosome.":[124],"It":[125],"promotes":[126],"unwrapping":[128],"entry":[132],"exit":[134],"sites":[135],"concurrently":[137],"restricting":[138],"accessibility":[140],"vicinity":[143],"SHL4.":[145],"This":[146],"study":[147],"offers":[148],"model":[150],"explains":[152],"how":[153],"maintenance":[158],"gene":[160],"silencing,":[161],"particularly":[162],"context":[165],"H3K9me-dependent":[167],"mechanisms.":[168],"Additionally,":[169],"it":[170],"sheds":[171],"light":[172],"H3K9me-independent":[175],"HP1":[178],"responding":[180],"damage.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-10-09T00:00:00"}
