{"id":"https://openalex.org/W4403112840","doi":"https://doi.org/10.33545/26646765.2024.v6.i2a.107","title":"Measurement of human sterol-o-acyltransferase 1, SOAT1 levels in Iraqi diabetic patients","display_name":"Measurement of human sterol-o-acyltransferase 1, SOAT1 levels in Iraqi diabetic patients","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4403112840","doi":"https://doi.org/10.33545/26646765.2024.v6.i2a.107"},"language":"en","primary_location":{"id":"doi:10.33545/26646765.2024.v6.i2a.107","doi":"https://doi.org/10.33545/26646765.2024.v6.i2a.107","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646765.2024.v6.i2a.107","pdf_url":"https://www.chemicaljournal.org/archives/2024/vol6issue2/PartB/6-2-11-352.pdf","source":{"id":"https://openalex.org/S4387285152","display_name":"International Journal of Chemical and Biological Sciences","issn_l":"2664-6765","issn":["2664-6765","2664-6773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chemical and Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.chemicaljournal.org/archives/2024/vol6issue2/PartB/6-2-11-352.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013346263","display_name":"Hussein Najm Abed","orcid":"https://orcid.org/0000-0003-0241-3928","observed_orcids":["https://orcid.org/0000-0003-0241-3928"]},"institutions":[{"id":"https://openalex.org/I4405254097","display_name":"Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences","ror":"https://ror.org/01dx9yw21","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405254097"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Hussein Najm Abed","raw_affiliation_strings":["Medicine College , Jabir Ibn Hayyan Medical University , Al-Najaf , Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine College , Jabir Ibn Hayyan Medical University , Al-Najaf , Iraq","institution_ids":["https://openalex.org/I4405254097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013346263"],"corresponding_institution_ids":["https://openalex.org/I4405254097"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"2","first_page":"101","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soat1","display_name":"SOAT1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9729999899864197},{"id":"https://openalex.org/keywords/diabetic-dyslipidemia","display_name":"diabetic dyslipidemia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cholesterol-esterification","display_name":"cholesterol esterification","score":0.953000009059906},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7160000205039978},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.7250000238418579},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.6500499844551086},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5630232095718384},{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.48532241582870483},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3603305518627167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3489076495170593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3486449420452118},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.23095449805259705},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33545/26646765.2024.v6.i2a.107","doi":"https://doi.org/10.33545/26646765.2024.v6.i2a.107","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646765.2024.v6.i2a.107","pdf_url":"https://www.chemicaljournal.org/archives/2024/vol6issue2/PartB/6-2-11-352.pdf","source":{"id":"https://openalex.org/S4387285152","display_name":"International Journal of Chemical and Biological Sciences","issn_l":"2664-6765","issn":["2664-6765","2664-6773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chemical and Biological Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33545/26646765.2024.v6.i2a.107","doi":"https://doi.org/10.33545/26646765.2024.v6.i2a.107","is_oa":true,"landing_page_url":"https://doi.org/10.33545/26646765.2024.v6.i2a.107","pdf_url":"https://www.chemicaljournal.org/archives/2024/vol6issue2/PartB/6-2-11-352.pdf","source":{"id":"https://openalex.org/S4387285152","display_name":"International Journal of Chemical and Biological Sciences","issn_l":"2664-6765","issn":["2664-6765","2664-6773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chemical and Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403112840.pdf","grobid_xml":"https://content.openalex.org/works/W4403112840.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391181716","https://openalex.org/W4407358568","https://openalex.org/W7158012811","https://openalex.org/W7159624964","https://openalex.org/W3125293820","https://openalex.org/W2136239223","https://openalex.org/W2182149232","https://openalex.org/W6986498749","https://openalex.org/W4403146515","https://openalex.org/W4404797874"],"abstract_inverted_index":{"Diabetes":[0],"mellitus,":[1],"which":[2,145],"known":[3],"as":[4,88],"the":[5,26,47,61,133,154,157],"constant":[6],"increase":[7],"of":[8,25,39,50,64,156],"blood":[9,113],"glucose":[10],"and":[11,28,44,107,115,139,174,189],"reduced":[12],"insulin":[13],"action.":[14],"In":[15],"Iraq,":[16],"its":[17,86],"prevalence":[18],"is":[19,137,146,161,166],"worrying,":[20],"affecting":[21],"a":[22,31,36,89,169,201],"large":[23,32],"proportion":[24],"population":[27],"leading":[29],"to":[30,84,186],"healthcare":[33],"problem.":[34],"Dyslipidemia,":[35],"major":[37],"result":[38],"diabetes,":[40],"rises":[41],"cardiovascular":[42,92,191],"risk":[43,192],"morbidity.":[45],"While":[46],"underlying":[48],"processes":[49],"diabetic":[51,82,135,142],"dyslipidemia":[52],"are":[53],"complicated,":[54],"current":[55],"research":[56,75,96],"has":[57],"thrown":[58],"light":[59],"on":[60,99],"possible":[62,170],"function":[63],"Sterol-O-acyltransferase":[65],"1":[66],"(SOAT1),":[67],"an":[68,120],"enzyme":[69,158],"involved":[70],"in":[71,80,132,140,150,159,164,193],"cholesterol":[72,176,187],"esterification.":[73],"The":[74,94,127],"investigation":[76],"measured":[77],"SOAT1":[78,125,130,183],"levels":[79,131,155,184],"Iraqi":[81,101],"patients":[83,136,143],"investigate":[85],"significance":[87],"biomarker":[90],"for":[91,123],"diseases.":[93],"case-control":[95],"took":[97],"place":[98],"200":[100],"volunteers,":[102],"comprising":[103],"100":[104,108],"healthy":[105,151],"controls":[106,152],"diabetes":[109,173,194],"patients,":[110],"by":[111],"collecting":[112],"samples":[114],"then":[116],"evaluating":[117],"them":[118],"using":[119],"ELISA":[121],"kit":[122],"measuring":[124],"levels.":[126],"findings":[128],"explained":[129],"male":[134],"26.76\u00b12.01":[138],"female":[141],"37.33\u00b11.73":[144],"significantly":[147],"lower":[148,182],"than":[149],"where":[153],"males":[160],"36.88\u00b11.79":[162],"while":[163],"females":[165],"47.33\u00b11.73,":[167],"indicating":[168,196],"relationship":[171],"between":[172],"poor":[175],"metabolism.":[177],"These":[178],"data":[179],"suggest":[180],"that":[181,197],"contribute":[185],"buildup":[188],"increased":[190],"individuals,":[195],"it":[198],"might":[199],"be":[200],"therapeutic":[202],"target.":[203]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2024-10-04T00:00:00"}