{"id":"https://openalex.org/W4403083393","doi":"https://doi.org/10.1038/s41467-024-52822-4","title":"Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer","display_name":"Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer","publication_year":2024,"publication_date":"2024-10-03","ids":{"openalex":"https://openalex.org/W4403083393","doi":"https://doi.org/10.1038/s41467-024-52822-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/39362861"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-52822-4","doi":"https://doi.org/10.1038/s41467-024-52822-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-52822-4","pdf_url":"https://www.nature.com/articles/s41467-024-52822-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-52822-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074211115","display_name":"Xin Lin","orcid":"https://orcid.org/0000-0003-1867-1833","observed_orcids":["https://orcid.org/0000-0003-1867-1833"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Lin","raw_affiliation_strings":["Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA","Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067700341","display_name":"Davide Provasi","orcid":"https://orcid.org/0000-0002-2868-303X","observed_orcids":["https://orcid.org/0000-0002-2868-303X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Provasi","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-2868-303X","affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039213851","display_name":"Colleen Marie Niswender","orcid":"https://orcid.org/0000-0001-6009-8212","observed_orcids":["https://orcid.org/0000-0001-6009-8212"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen M. Niswender","raw_affiliation_strings":["Department of Pharmacology, Vanderbilt University, Nashville, TN, USA","Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA","Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, TN, USA","Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA","Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047205461","display_name":"Wesley B. Asher","orcid":"https://orcid.org/0000-0001-7437-218X","observed_orcids":["https://orcid.org/0000-0001-7437-218X"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wesley B. Asher","raw_affiliation_strings":["Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. wesley.asher@nyspi.columbia.edu","Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA. wesley.asher@nyspi.columbia.edu"],"raw_orcid":"https://orcid.org/0000-0001-7437-218X","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. wesley.asher@nyspi.columbia.edu","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA. wesley.asher@nyspi.columbia.edu","institution_ids":["https://openalex.org/I4388891851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076865147","display_name":"Jonathan A. Javitch","orcid":"https://orcid.org/0000-0001-7395-2967","observed_orcids":["https://orcid.org/0000-0001-7395-2967"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan A. Javitch","raw_affiliation_strings":["Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. jonathan.javitch@nyspi.columbia.edu","Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. jonathan.javitch@nyspi.columbia.edu","Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA. jonathan.javitch@nyspi.columbia.edu"],"raw_orcid":"https://orcid.org/0000-0001-7395-2967","affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. jonathan.javitch@nyspi.columbia.edu","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. jonathan.javitch@nyspi.columbia.edu","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA. jonathan.javitch@nyspi.columbia.edu","institution_ids":["https://openalex.org/I4388891851","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047205461","https://openalex.org/A5076865147"],"corresponding_institution_ids":["https://openalex.org/I4388891851","https://openalex.org/I78577930"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":1.7412,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85462257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"8552","last_page":"8552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/receptor-heterodimerization","display_name":"receptor heterodimerization","score":0.8870000243186951},{"id":"https://openalex.org/keywords/positive-allosteric-modulators","display_name":"positive allosteric modulators","score":0.9570000171661377},{"id":"https://openalex.org/keywords/allosteric-pocket","display_name":"allosteric pocket","score":0.7919999957084656},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cis-activation","display_name":"cis-activation","score":0.984000027179718},{"id":"https://openalex.org/keywords/receptor-activation-mechanism","display_name":"receptor activation mechanism","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2129178","wikidata":"https://www.wikidata.org/wiki/Q6590408","display_name":"Metabotropic glutamate receptor 8","level":5,"score":0.5695927143096924},{"id":"https://openalex.org/C56940625","wikidata":"https://www.wikidata.org/wiki/Q6589868","display_name":"Metabotropic glutamate receptor 6","level":5,"score":0.5691388249397278},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.5579807758331299},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.5417097806930542},{"id":"https://openalex.org/C119128870","wikidata":"https://www.wikidata.org/wiki/Q4859538","display_name":"Metabotropic glutamate receptor 2","level":5,"score":0.5363235473632812},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.5231075286865234},{"id":"https://openalex.org/C200385062","wikidata":"https://www.wikidata.org/wiki/Q6594119","display_name":"Metabotropic glutamate receptor 3","level":5,"score":0.5206781625747681},{"id":"https://openalex.org/C116592611","wikidata":"https://www.wikidata.org/wiki/Q21113349","display_name":"Metabotropic glutamate receptor 4","level":5,"score":0.4421398937702179},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.436413049697876},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.41456273198127747},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3947417438030243},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3499882221221924},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3394625186920166},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32899537682533264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2786906361579895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20873692631721497}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-024-52822-4","doi":"https://doi.org/10.1038/s41467-024-52822-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-52822-4","pdf_url":"https://www.nature.com/articles/s41467-024-52822-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:39362861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39362861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11450022","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11450022","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11450022/pdf/41467_2024_Article_52822.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52822-4","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-52822-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:3a700d9572124c27a40672d3dafdea71","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3a700d9572124c27a40672d3dafdea71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-52822-4","doi":"https://doi.org/10.1038/s41467-024-52822-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-52822-4","pdf_url":"https://www.nature.com/articles/s41467-024-52822-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1458698739","display_name":null,"funder_award_id":"R01-NS031373","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2661077754","display_name":null,"funder_award_id":"R01 NS132060","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2912530525","display_name":null,"funder_award_id":"R21 NS113614","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000038304","display_name":null,"funder_award_id":"R01 NS031373","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000215236","display_name":null,"funder_award_id":"NS031373","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000269214","display_name":null,"funder_award_id":"MH054137","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000894949","display_name":"Structure and Function of Dopamine Receptors","funder_award_id":"R01MH054137","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309008","display_name":"Hope for Depression Research Foundation","ror":"https://ror.org/01mcwn339"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403083393.pdf","grobid_xml":"https://content.openalex.org/works/W4403083393.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1483576392","https://openalex.org/W1620954807","https://openalex.org/W1965440699","https://openalex.org/W1965926793","https://openalex.org/W1974152360","https://openalex.org/W1974772449","https://openalex.org/W1985423204","https://openalex.org/W1990246915","https://openalex.org/W1995275141","https://openalex.org/W1998850010","https://openalex.org/W2000756368","https://openalex.org/W2003904213","https://openalex.org/W2007051067","https://openalex.org/W2007635892","https://openalex.org/W2013432476","https://openalex.org/W2021580832","https://openalex.org/W2025460833","https://openalex.org/W2029795919","https://openalex.org/W2038505488","https://openalex.org/W2042255217","https://openalex.org/W2061191353","https://openalex.org/W2067874558","https://openalex.org/W2068201543","https://openalex.org/W2070372666","https://openalex.org/W2075591794","https://openalex.org/W2082439372","https://openalex.org/W2106042714","https://openalex.org/W2120307371","https://openalex.org/W2132259245","https://openalex.org/W2134289201","https://openalex.org/W2135783627","https://openalex.org/W2141378780","https://openalex.org/W2143458571","https://openalex.org/W2147197593","https://openalex.org/W2147545140","https://openalex.org/W2340779338","https://openalex.org/W2425355619","https://openalex.org/W2493716076","https://openalex.org/W2725906416","https://openalex.org/W2744794320","https://openalex.org/W2795040646","https://openalex.org/W3021368381","https://openalex.org/W3036443046","https://openalex.org/W3037441091","https://openalex.org/W3037829040","https://openalex.org/W3080364644","https://openalex.org/W3111515297","https://openalex.org/W3135626302","https://openalex.org/W3149997660","https://openalex.org/W3167154410","https://openalex.org/W3167499727","https://openalex.org/W3173876705","https://openalex.org/W3176155318","https://openalex.org/W3176996497","https://openalex.org/W3194061593","https://openalex.org/W4200208453","https://openalex.org/W4214870863","https://openalex.org/W4281759591","https://openalex.org/W4293770211","https://openalex.org/W4294631614","https://openalex.org/W4353060041","https://openalex.org/W4376611984","https://openalex.org/W4379769056","https://openalex.org/W4399992754"],"related_works":["https://openalex.org/W2603012921","https://openalex.org/W2501810239","https://openalex.org/W2673294575","https://openalex.org/W2161584310","https://openalex.org/W2681369984","https://openalex.org/W118960770","https://openalex.org/W1970596941","https://openalex.org/W2016401879","https://openalex.org/W4255280185","https://openalex.org/W2082382361"],"abstract_inverted_index":{"Metabotropic":[0,201],"glutamate":[1,202],"(mGlu)":[2,203],"receptor":[3,40,187],"protomers":[4,41,108],"can":[5],"heterodimerize,":[6],"leading":[7],"to":[8,12,45,137,161,170,191,212],"different":[9],"pharmacology":[10,53,225],"compared":[11],"their":[13,115],"homodimeric":[14],"counterparts.":[15],"Here,":[16,215],"we":[17,158],"use":[18],"complemented":[19],"donor-acceptor":[20],"resonance":[21],"energy":[22],"transfer":[23],"(CODA-RET)":[24],"technology":[25],"that":[26,59,64,86,106,210],"distinguishes":[27],"signaling":[28,118],"from":[29,135,168],"defined":[30],"mGlu":[31],"heterodimers":[32,209],"or":[33],"homodimers,":[34],"together":[35],"with":[36,120],"targeted":[37,195,232],"mutagenesis":[38],"of":[39,49,109,145,177,185,221],"and":[42,51,81,141,208,223],"computational":[43],"docking,":[44],"elucidate":[46,218],"the":[47,71,93,138,146,156,165,171,182,216,219],"mechanism":[48,220],"activation":[50,222],"differential":[52,224],"in":[54,70,98,132,155,164,226],"mGlu2/4":[55,82,110,133,227],"heteromers.":[56,102],"We":[57,103],"demonstrate":[58,105],"positive":[60],"allosteric":[61,68,90],"modulators":[62],"(PAMs)":[63],"bind":[65,87],"an":[66,175],"upper":[67,126],"pocket":[69,91,127],"mGlu4":[72,128,136,172],"transmembrane":[73],"domain":[74,95],"are":[75,96,112,189],"active":[76],"at":[77],"both":[78,107,206],"mGlu4/4":[79],"homomers":[80,99],"heteromers,":[83,228],"while":[84],"those":[85],"a":[88],"lower":[89],"within":[92],"same":[94],"efficacious":[97],"but":[100],"not":[101],"further":[104],"heteromers":[111,134],"cis-activated":[113],"by":[114],"orthosteric":[116],"agonists,":[117],"independently":[119],"no":[121],"trans-activation":[122,131,163],"detected.":[123],"Intriguingly,":[124],"however,":[125],"PAMs":[129,151],"enable":[130],"mGlu2":[139,147,150,153,169],"protomer":[140],"also":[142],"enhance":[143],"cis-activation":[144,154],"protomer.":[148],"While":[149],"enhanced":[152],"heterodimer,":[157],"were":[159],"unable":[160],"detect":[162],"opposite":[166],"direction":[167],"protomer,":[173],"suggesting":[174],"asymmetry":[176],"signaling.":[178],"These":[179],"insights":[180],"into":[181],"molecular":[183],"logic":[184],"this":[186],"heteromer":[188],"critical":[190],"building":[192],"toward":[193],"precision":[194],"therapies":[196],"for":[197],"multiple":[198],"neuropsychiatric":[199],"disorders.":[200],"receptors":[204],"form":[205],"homo-":[207],"respond":[211],"ligands":[213],"differently.":[214],"authors":[217],"which":[229],"may":[230],"guide":[231],"therapy.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}