{"id":"https://openalex.org/W4403083310","doi":"https://doi.org/10.30978/mg-2024-3-78","title":"Pathogenetic role of changes in the colon mucous barrier in patients with ulcerative colitis and the possibility of correction","display_name":"Pathogenetic role of changes in the colon mucous barrier in patients with ulcerative colitis and the possibility of correction","publication_year":2024,"publication_date":"2024-09-19","ids":{"openalex":"https://openalex.org/W4403083310","doi":"https://doi.org/10.30978/mg-2024-3-78"},"language":"en","primary_location":{"id":"doi:10.30978/mg-2024-3-78","doi":"https://doi.org/10.30978/mg-2024-3-78","is_oa":true,"landing_page_url":"https://doi.org/10.30978/mg-2024-3-78","pdf_url":null,"source":{"id":"https://openalex.org/S4210199486","display_name":"Modern Gastroenterology","issn_l":"1727-5725","issn":["1727-5725","2521-649X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.30978/mg-2024-3-78","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006742544","display_name":"Andriy E. Dorofeyev","orcid":"https://orcid.org/0000-0002-2631-8733","observed_orcids":["https://orcid.org/0000-0002-2631-8733"]},"institutions":[{"id":"https://openalex.org/I2800007259","display_name":"Shupyk National Healthcare University of Ukraine","ror":"https://ror.org/02cyra061","country_code":"UA","type":"education","lineage":["https://openalex.org/I2800007259"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A.\u2006E. Dorofeyev","raw_affiliation_strings":["\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u043e\u0445\u043e\u0440\u043e\u043d\u0438 \u0437\u0434\u043e\u0440\u043e\u0432\u2019\u044f \u0423\u043a\u0440\u0430\u0457\u043d\u0438 \u0456\u043c\u0435\u043d\u0456\u00a0\u041f.\u00a0\u041b.\u00a0\u0428\u0443\u043f\u0438\u043a\u0430, \u041a\u0438\u0457\u0432"],"raw_orcid":"https://orcid.org/0000-0002-2631-8733","affiliations":[{"raw_affiliation_string":"\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u043e\u0445\u043e\u0440\u043e\u043d\u0438 \u0437\u0434\u043e\u0440\u043e\u0432\u2019\u044f \u0423\u043a\u0440\u0430\u0457\u043d\u0438 \u0456\u043c\u0435\u043d\u0456\u00a0\u041f.\u00a0\u041b.\u00a0\u0428\u0443\u043f\u0438\u043a\u0430, \u041a\u0438\u0457\u0432","institution_ids":["https://openalex.org/I2800007259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010744595","display_name":"\u0421. \u041c. \u0422\u043a\u0430\u0447","orcid":"https://orcid.org/0000-0003-1772-9562","observed_orcids":["https://orcid.org/0000-0003-1772-9562"]},"institutions":[{"id":"https://openalex.org/I4210109132","display_name":"Ministry of Health","ror":"https://ror.org/01sxtx626","country_code":"UA","type":"government","lineage":["https://openalex.org/I4210109132"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"S.\u2006M. Tkach","raw_affiliation_strings":["\u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0443\u043a\u043e\u0432\u043e-\u043f\u0440\u0430\u043a\u0442\u0438\u0447\u043d\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u0435\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043d\u043e\u0457 \u0445\u0456\u0440\u0443\u0440\u0433\u0456\u0457,\u0442\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0446\u0456\u0457 \u0435\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043d\u0438\u0445 \u043e\u0440\u0433\u0430\u043d\u0456\u0432 \u0456\u00a0\u0442\u043a\u0430\u043d\u0438\u043d \u041c\u041e\u0417\u00a0\u0423\u043a\u0440\u0430\u0457\u043d\u0438,\u041a\u0438\u0457\u0432"],"raw_orcid":"https://orcid.org/0000-0003-1772-9562","affiliations":[{"raw_affiliation_string":"\u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0443\u043a\u043e\u0432\u043e-\u043f\u0440\u0430\u043a\u0442\u0438\u0447\u043d\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u0435\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043d\u043e\u0457 \u0445\u0456\u0440\u0443\u0440\u0433\u0456\u0457,\u0442\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0446\u0456\u0457 \u0435\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043d\u0438\u0445 \u043e\u0440\u0433\u0430\u043d\u0456\u0432 \u0456\u00a0\u0442\u043a\u0430\u043d\u0438\u043d \u041c\u041e\u0417\u00a0\u0423\u043a\u0440\u0430\u0457\u043d\u0438,\u041a\u0438\u0457\u0432","institution_ids":["https://openalex.org/I4210109132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109536340","display_name":"Olena O. Dyadyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800007259","display_name":"Shupyk National Healthcare University of Ukraine","ror":"https://ror.org/02cyra061","country_code":"UA","type":"education","lineage":["https://openalex.org/I2800007259"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"O.\u2006O. Dyadyk","raw_affiliation_strings":["\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u043e\u0445\u043e\u0440\u043e\u043d\u0438 \u0437\u0434\u043e\u0440\u043e\u0432\u2019\u044f \u0423\u043a\u0440\u0430\u0457\u043d\u0438 \u0456\u043c\u0435\u043d\u0456\u00a0\u041f.\u00a0\u041b.\u00a0\u0428\u0443\u043f\u0438\u043a\u0430, \u041a\u0438\u0457\u0432"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u043e\u0445\u043e\u0440\u043e\u043d\u0438 \u0437\u0434\u043e\u0440\u043e\u0432\u2019\u044f \u0423\u043a\u0440\u0430\u0457\u043d\u0438 \u0456\u043c\u0435\u043d\u0456\u00a0\u041f.\u00a0\u041b.\u00a0\u0428\u0443\u043f\u0438\u043a\u0430, \u041a\u0438\u0457\u0432","institution_ids":["https://openalex.org/I2800007259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093666667","display_name":"O. M. Kryvoruk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O.\u2006M. Kryvoruk","raw_affiliation_strings":["\u041a\u043b\u0456\u043d\u0456\u0447\u043d\u0430 \u043b\u0456\u043a\u0430\u0440\u043d\u044f \u00ab\u0424\u0435\u043e\u0444\u0430\u043d\u0456\u044f\u00bb, \u041a\u0438\u0457\u0432"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041a\u043b\u0456\u043d\u0456\u0447\u043d\u0430 \u043b\u0456\u043a\u0430\u0440\u043d\u044f \u00ab\u0424\u0435\u043e\u0444\u0430\u043d\u0456\u044f\u00bb, \u041a\u0438\u0457\u0432","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5094050060","display_name":"Y. Z. Hurkalo","orcid":"https://orcid.org/0000-0002-1741-3034","observed_orcids":["https://orcid.org/0000-0002-1741-3034"]},"institutions":[{"id":"https://openalex.org/I4210128404","display_name":"Ukrainian Military Medical Academy","ror":"https://ror.org/02rv28335","country_code":"UA","type":"education","lineage":["https://openalex.org/I4210128404"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Y.\u2006Z. Hurkalo","raw_affiliation_strings":["\u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0430 \u0432\u0456\u0439\u0441\u044c\u043a\u043e\u0432\u043e-\u043c\u0435\u0434\u0438\u0447\u043d\u0430 \u0430\u043a\u0430\u0434\u0435\u043c\u0456\u044f, \u041a\u0438\u0457\u0432"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0430 \u0432\u0456\u0439\u0441\u044c\u043a\u043e\u0432\u043e-\u043c\u0435\u0434\u0438\u0447\u043d\u0430 \u0430\u043a\u0430\u0434\u0435\u043c\u0456\u044f, \u041a\u0438\u0457\u0432","institution_ids":["https://openalex.org/I4210128404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17253469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"3","first_page":"78","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/epithelial-permeability","display_name":"epithelial permeability","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6809999942779541},{"id":"https://openalex.org/keywords/bacteroidetes","display_name":"Bacteroidetes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/firmicutes","display_name":"Firmicutes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/actinobacteria","display_name":"actinobacteria","score":0.9240000247955322},{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":0.9380000233650208},{"id":"https://openalex.org/keywords/faecalibacterium-prausnitzii","display_name":"Faecalibacterium prausnitzii","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.9229493141174316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.530657172203064},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4905966818332672},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4669073224067688},{"id":"https://openalex.org/C2779890267","wikidata":"https://www.wikidata.org/wiki/Q1219805","display_name":"Mucous membrane","level":2,"score":0.43972527980804443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33853036165237427},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28545188903808594},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1120661199092865}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.30978/mg-2024-3-78","doi":"https://doi.org/10.30978/mg-2024-3-78","is_oa":true,"landing_page_url":"https://doi.org/10.30978/mg-2024-3-78","pdf_url":null,"source":{"id":"https://openalex.org/S4210199486","display_name":"Modern Gastroenterology","issn_l":"1727-5725","issn":["1727-5725","2521-649X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:ojs.journals.uran.ua:article/311688","doi":null,"is_oa":true,"landing_page_url":"http://sgastro.com.ua/article/view/311688","pdf_url":null,"source":{"id":"https://openalex.org/S4210228265","display_name":"The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy","issn_l":"2311-6382","issn":["2311-6382","2415-3605"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310322067","host_organization_name":"Ternopil Volodymyr Hnatiuk National Pedagogical University","host_organization_lineage":["https://openalex.org/P4310322067"],"host_organization_lineage_names":["Ternopil Volodymyr Hnatiuk National Pedagogical University"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Modern Gastroenterology; No. 3 (2024); 78-88","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.30978/mg-2024-3-78","doi":"https://doi.org/10.30978/mg-2024-3-78","is_oa":true,"landing_page_url":"https://doi.org/10.30978/mg-2024-3-78","pdf_url":null,"source":{"id":"https://openalex.org/S4210199486","display_name":"Modern Gastroenterology","issn_l":"1727-5725","issn":["1727-5725","2521-649X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2378399001","https://openalex.org/W2381376498","https://openalex.org/W2393318770","https://openalex.org/W2369056725","https://openalex.org/W4385147599","https://openalex.org/W3151390891","https://openalex.org/W2391150797","https://openalex.org/W4224234790","https://openalex.org/W2363553858","https://openalex.org/W2363311716"],"abstract_inverted_index":{"The":[0,100,112,143,337,431],"aim":[1],"of":[2,26,34,57,66,75,102,129,141,160,168,182,196,209,235,238,246,249,255,268,274,305,310,339,349,352,358,362,414,433,440,462,465,471,474,492,515,533,540],"this":[3],"study":[4,45,113,173],"was":[5,46,97,104,145,154,174,331,443],"to":[6,22,51,345,368,383,402,454,537,559],"evaluate":[7],"the":[8,11,24,31,53,58,63,79,92,94,130,151,158,166,183,194,197,207,223,233,236,247,250,253,261,266,285,303,322,353,356,375,412,437,466,469,490,493,501,513,525,531,538,541],"changes":[9,259,283],"in":[10,15,30,48,62,78,162,219,260,284,291,298,308,321,333,342,371,374,390,398,405,411,418,424,436,449,484,489,498,500,506,512,519,524,544,550],"colon":[12,262,286],"mucosal":[13],"barrier":[14],"patients":[16,67,71,115,125,221,242,334,343,442,546],"with":[17,68,72,133,147,176,252,265,294,335,381,421,451,530,556],"ulcerative":[18],"colitis":[19],"(UC)":[20],"and":[21,38,55,88,107,110,137,149,165,180,188,191,258,272,277,300,312,328,392,408,416,427,445,458,509,517,523,553],"analyze":[23],"efficacy":[25,54],"using":[27,222],"Zafacol":[28,59,340,434],"IQ":[29,60,341,435,535],"complex":[32,64,365,438],"therapy":[33,65,439,529],"these":[35],"patients.":[36],"Materials":[37],"methods.":[39],"A":[40],"prospective,":[41],"multicenter,":[42],"randomized,":[43],"comparative":[44],"conducted":[47,175],"parallel":[49],"groups":[50],"investigate":[52],"safety":[56],"administration":[61],"UC.":[69,336,475],"64":[70],"left\u2011sided":[73],"UC":[74,103,118,241,292,363,441,545],"medium\u2011severe":[76],"course":[77],"acute":[80],"stage":[81],"were":[82,85,217,289,480],"observed.":[83],"There":[84],"34":[86],"men":[87],"30":[89],"women":[90],"among":[91],"patients;":[93],"average":[95],"age":[96],"(46.6\u00b15.8)":[98],"years.":[99],"diagnosis":[101],"established":[105],"clinically":[106],"confirmed":[108],"endoscopically":[109],"histologically.":[111],"included":[114],"suffering":[116],"from":[117],"for":[119],"at":[120],"least":[121],"1":[122],"year.":[123],"All":[124],"underwent":[126],"endoscopic":[127,360,472],"examination":[128],"large":[131],"intestine":[132],"biopsy":[134,144],"before":[135],"treatment":[136],"after":[138,192,364],"6":[139],"weeks":[140],"therapy.":[142],"stained":[146],"hematoxylin":[148],"eosin;":[150],"PAS":[152,494],"reaction":[153,226],"performed.":[155],"To":[156],"determine":[157],"content":[159],"mucins":[161,177],"colonic":[163,399,502],"mucus":[164,275,379,485],"state":[167],"tight":[169,184],"junctions,":[170],"an":[171,306,388,409,422,482,487,496,510,548],"immunohistochemical":[172],"(MUC\u20112,":[178],"MUC\u20114)":[179],"proteins":[181],"junction":[185],"family":[186],"Claud\u20111":[187,516],"Claud\u20117.":[189],"Before":[190,230,281],"therapy,":[193,231],"status":[195],"main":[198],"bacterial":[199],"enterotypes":[200],"(Bacteroidetes,":[201],"Firmicutes,":[202],"Actinobacteria),":[203],"as":[204,206,394,396],"well":[205,395],"level":[208,348,461],"regulatory,":[210],"butyrate\u2011producing":[211,324],"bacteria":[212,325],"(Faecalibacterium":[213],"prausnitzii,":[214],"Akkermansia":[215],"muciniphila)":[216],"studied":[218],"all":[220],"polymerase":[224],"chain":[225],"qRT\u2011PCR":[227],"method.":[228],"Results.":[229],"against":[232,302],"background":[234,304],"development":[237,267],"clinical":[239,350,456,463],"symptoms,":[240],"had":[243],"a":[244,295,319,346,369,403,459,504,557],"violation":[245],"integrity":[248],"epithelium":[251],"formation":[254,276,380],"erosive\u2011ulcerative":[256],"defects":[257],"mucous":[263],"membrane":[264],"inflammatory":[269],"cell":[270],"infiltration":[271],"disorders":[273],"increased":[278,355,468],"epithelial":[279,406,507],"permeability.":[280],"treatment,":[282,366],"microbial":[287],"landscape":[288],"detected":[290],"patients,":[293],"significant":[296],"decrease":[297,370,404,505,560],"Bacteroidetes":[299],"Firmicutes":[301,426,552],"increase":[307,389,410,423,488,497,511,549],"representatives":[309],"Actinobacteria":[311],"other,":[313],"mostly":[314],"opportunistic":[315],"flora.":[316],"In":[317],"addition,":[318],"reduction":[320],"regulatory":[323],"(Akkermansia":[326],"muciniphila":[327],"Faecalibacterium":[329,428,554],"prausnitzii)":[330],"fixed":[332],"use":[338,432],"contributed":[344,401,453,536],"lower":[347,460],"activity":[351,464],"disease,":[354,467],"frequency":[357,470],"achieving":[359],"remission":[361,473],"led":[367],"active":[372],"neutrophils":[373],"cellular":[376],"infiltrate,":[377],"improved":[378],"tendencies":[382],"normalize":[384],"its":[385],"quality":[386],"characteristics,":[387],"glycoproteins":[391],"glycosaminoglycans,":[393],"MUC2":[397,499],"mucus,":[400,503],"permeability":[407],"expression":[413,514],"Claud\u00ad\u00ad1":[415],"Claud\u00ad\u00ad7":[417],"goblet":[419,521],"cells":[420,522],"Bacteroidetes,":[425,551],"prausnitzii.":[429],"Conclusions.":[430],"effective":[444],"safe.":[446],"This":[447],"drug":[448],"combination":[450],"mesalazine":[452],"positive":[455,477],"dynamics":[457,479],"Pronounced":[476],"morphological":[478],"observed:":[481],"improvement":[483],"formation,":[486],"intensity":[491],"reaction,":[495],"permeability,":[508],"Claud\u20117":[518],"both":[520],"surface":[526],"epithelium.":[527],"Complex":[528],"appointment":[532],"\u00adZafacol":[534],"normalization":[539],"intestinal":[542],"microbiome":[543],"\u2014":[547],"prausnitzii":[555],"tendency":[558],"Actinobacteria.":[561]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}